Principal Scientist Jobs in Illinois

Principal Scientist jobs in Illinois are concentrated in pharmaceutical research, biotechnology, agricultural science, and materials chemistry, with demand at every level from early-career researcher through senior principal scientist. Chicago, the North Shore suburbs of Gurnee and Waukegan, and the Deerfield-Lake County research corridor are the busiest hiring areas, anchored by long-established employers such as AbbVie, Baxter International, and Archer Daniels Midland. The most sought-after specializations include oncology drug discovery, analytical chemistry, and agricultural biotechnology. Find a role that fits below and apply directly.

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Overview

Open roles25
Top employerAbbVie
Top cityNorth Chicago, IL
Cities hiring5
Work type50% On-site
Top industryBiotechnology

Showing 5 of 25+ Principal Scientist jobs

Tate & Lyle
Associate Principal Scientist, Analytical & Material Science
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Tate & Lyle
Added 2d ago
Associate Principal Scientist, Analytical & Material Science
Tate & Lyle
Hoffman Estates, Illinois
Account Management
Customer Service
Customer Success
$71k - $104k/yr
Master's degree
1,001-5,000

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AbbVie
Principal Research Scientist I
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AbbVie
Added 3d ago
Principal Research Scientist I
AbbVie
North Chicago, Illinois
Educational Administration
K-12 Teaching
Teaching & Instruction
$125k - $237k/yr
Master's degree
10,000+

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AbbVie
Principal Research Scientist II, Molecular Profiling and Drug Delivery (MPDD)
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AbbVie
Added 5d ago
Principal Research Scientist II, Molecular Profiling and Drug Delivery (MPDD)
AbbVie
North Chicago, Illinois
Customer Service
Customer Support
$142k - $269k/yr
Doctoral degree in chemistry
10,000+

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AbbVie
R00148615 - Principal Scientist I, Energy Homeostasis
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AbbVie
Added 6d ago
R00148615 - Principal Scientist I, Energy Homeostasis
AbbVie
North Chicago, Illinois
Business Strategy
Product Management
$125k - $237k/yr
Hybrid
Doctoral degree in neuroscience
10,000+

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AbbVie
Principal Research Scientist II Central Core Function Operations Leader
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AbbVie
Added 1w ago
Principal Research Scientist II Central Core Function Operations Leader
AbbVie
North Chicago, Illinois
Business Analysis
Data Analytics
Data Science
$142k - $269k/yr
Bachelor of Science
10,000+

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See All 25 Principal Scientist Jobs in Illinois

Find roles in Illinois that match your experience and apply in just a few clicks.

Find Principal Scientist Jobs

Principal Scientist Jobs by City in Illinois

Where Illinois roles are concentrated, by current openings.

North Chicago
15 jobs
Chicago
5 jobs
Glenview
3 jobs
Broadview
1 job
Hoffman Estates
1 job

Principal Scientist Job Market in Illinois

A snapshot from current Illinois openings, updated as new roles post.

Who's Hiring

  • AbbVie
    AbbVie15
  • Kraft Heinz
    Kraft Heinz3
  • Okta
    Okta1
  • Tempus AI
    Tempus AI1
  • Capital One
    Capital One1

Top Industries Hiring

  • Biotechnology & Pharmaceuticals
  • Food & Beverage
  • Agriculture & Farming
  • Banking & Financial Services

What Illinois Employers Look For

The qualifications that appear most often in principal scientist jobs across Illinois.

  • Ph.D. in a relevant scientific discipline such as chemistry, biology, or biochemistry
  • Minimum five to eight years of post-doctoral or industry research experience in Illinois-dominant sectors
  • Demonstrated ability to lead multi-disciplinary research teams and mentor junior scientists
  • Expertise in experimental design, data analysis, and peer-reviewed publication or patent authorship
  • Proficiency with regulatory frameworks relevant to pharmaceutical or agricultural product development
  • Strong cross-functional collaboration skills with clinical, regulatory, and commercial teams

Principal Scientist Jobs in Illinois: Frequently Asked Questions

How do you become a principal scientist in Illinois?

Becoming a principal scientist in Illinois typically requires an advanced degree, usually a Ph.D., in a field aligned with the target industry such as chemistry, molecular biology, or materials science. Illinois does not issue a state license specific to the principal scientist title, so hiring decisions center on advanced education, peer-reviewed research output, and progressively senior laboratory or program leadership experience gained at Illinois research institutions or industry employers.

Which companies hire principal scientists in Illinois?

Employers hiring principal scientists in Illinois right now include AbbVie, Kraft Heinz, and Okta, based on current listings on Migrate Mate as of August 2026. Illinois's dense concentration of pharmaceutical headquarters and agricultural science companies along the I-294 corridor and Lake County means principal scientist openings appear year-round across multiple disciplines.

Which Illinois cities have the most principal scientist jobs?

North Chicago, Chicago, and Glenview have the most principal scientist openings in Illinois. Chicago drives volume through its large hospital systems and university-affiliated research centers, while suburban Lake County and the North Shore corridor concentrate pharmaceutical and biotech postings because AbbVie, Baxter, and several specialty drug companies maintain major research campuses there.

Are there remote principal scientist jobs in Illinois?

Yes, but they're rare. About 50% of principal scientist openings tied to Illinois are remote or hybrid as of August 2026, reflecting the hands-on laboratory nature of most roles in the state's pharmaceutical and biotech sectors. The sub-functions most likely to offer remote flexibility are computational biology, bioinformatics, and regulatory or scientific affairs roles that do not require bench work.

How can I get hired as a principal scientist in Illinois with little or no experience?

The most realistic entry path is a post-doctoral fellowship at an Illinois research university such as the University of Illinois Urbana-Champaign or Northwestern University, which pipeline directly into industry roles. Large Illinois employers including AbbVie and Baxter run structured early-talent programs that recruit from these institutions. Candidates can also move laterally from research associate or scientist roles into principal scientist tracks by building a record of independent project ownership and publication.

Where can I find and apply to principal scientist jobs in Illinois?

You can find and apply to principal scientist jobs in Illinois on Migrate Mate, which lists current Illinois openings across pharmaceutical, biotech, agricultural science, and materials research employers. Find the roles that fit your background and apply directly from the listings on this page.

See All 25 Principal Scientist Jobs in Illinois

Find roles in Illinois that match your experience and apply in just a few clicks.

Find Principal Scientist Jobs