Principal Scientist Jobs in Pennsylvania

Job Description

We aspire to be the premier research-intensive biopharmaceutical company with over 130-year history. We’re at the forefront of research to deliver innovative health solutions that advance the prevention and treatment of diseases in people and animals. Our success is driven by putting patients first, operating with the highest integrity, and committing fully to our vision to make a difference in the lives of people globally. With our varied pipeline of oncology, immunology, vaccines, biologics, small molecules, and newer modalities, we are at the forefront of research to advance the prevention and treatment of diseases such as cancer, cardiometabolic diseases, eye diseases, and infectious diseases.

Our Company's Research Laboratories nonclinical drug safety department at West Point, Pennsylvania site is seeking an experienced anatomic pathologist to join a highly collaborative team of scientists (12 anatomic pathologists, 3 clinical pathologists, and approximately 40 exceptional laboratory scientists), working at a GLP-compliant facility with state-of-the-art anatomic, molecular and clinical pathology laboratories. This role is intended for an accomplished Pathologist with proven toxicological pathology and drug development experience with preferably immunology and biologics expertise who operates as a recognized subject‑matter expert and influences strategy from early discovery through late‑stage development. Our team works on a varied pipeline, participating in a wide variety of GLP-toxicology study types, many of which are run in-house, in addition to early discovery and investigative studies.

Pathologists at our company are integral members and leaders of collaborative cross functional scientific teams, addressing challenges from early discoveries to late development. Our Company’s pathologists provide scientific leadership in the design and conduct of postmortem evaluation of studies and integrate the interpretation of postmortem data into the safety profile of drug candidates. Our Company's pathologists have a variety of opportunities to learn and grow as professional scientists and drug developers through daily study related activities and collaborative works with multiple program development teams.

Key responsibilities for this scientific role include:

• Employ both routine H&E evaluations as well as other specialized techniques to characterize the safety profile of new drugs from toxicology and investigative studies
• Work independently to analyze data, interpret and determine the significance of results for postmortem evaluations, review literature and design experiments to help teams solve scientific problems and advance programs
• Demonstrate scientific leadership with partnering broadly with toxicology, safety pharmacology, and translational teams to define mechanisms of toxicity, assess human relevance, and guide risk mitigation strategies for programs including immunology and biologics programs.
• Utilizing additional tools and applications that are all available on-site, including:
• An industry-leading suite of on-site in vitro and in vivo assay capabilities
• Access to robust historical controls slide archive and data base
• Digital Pathology
• Transmission electron microscopy
• Immunohistochemistry and in situ hybridization
• Quantitative digital image analysis and targeted machine learning applications
• Contribute to developing novel biomarkers and predictive models to de-risk drug candidates for safety-related liabilities
• Our Company's pathologists also serve as nonclinical drug safety department leads on drug development teams, overseeing the design and execution of studies, and generation of regulatory strategy and communications with global regulatory agencies to support the development of drug candidates
• Our Company's pathologists work in a hybrid work environment and routinely interact with each other, share slides and opinions/experiences, and help each other learn and grow

Minimum education required:

• Doctor of Veterinary Medicine (DVM)

Preferred:

• PhD in Immunology, Toxicology, Pathology, or related discipline

Required experience and skills:

• 10 years or more experience as a pathologist in biotech, pharma or at a CRO
• Demonstrated proficiency in histomorphologic evaluation and interpretation of toxicology studies
• Love to collaborate with varied cross-functional teams and communicate openly and often with colleagues
• Residency in anatomic / toxicologic pathology
• ACVP, ECVP-board certification or equivalent in anatomic pathology

Preferred experience and skills:

• Strong knowledge of drug discovery, development and regulatory processes, including experience on drug development project teams
• Experience in supporting immunology and biologics programs
• Experience serving as pathology lead for programs, or external due diligence as lead or subject matter expertise
• Strong scientific leadership beyond individual studies, demonstrated growth and enterprise mindset, including cross-functional partnership, and cross ‑program influence and mentoring/management of other pathologists

Required Skills:
Analytical Assays, Analytical Assays, Assay Development, Biomedical Sciences, Biotechnology, Clinical Assays, Clinical Data Interpretation, Clinical Judgment, Clinical Safety, Drug Development, Drug Discovery Research, Drug Research, Histopathology, Immunochemistry, Immunology Research, Innovation, In Vitro Research, In Vivo Models, Laboratory Processes, Medical Biology, Molecular Diagnostic Techniques, Pathogenesis, Pharmaceutical Research, Post Mortem Analysis, Safety Pharmacology {+ 3 more}

Preferred Skills:
Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

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The salary range for this role is
$231,900.00 - $365,000.00
This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:
Domestic/International

VISA Sponsorship:
Yes

Travel Requirements:
No Travel Required

Flexible Work Arrangements:
Hybrid

Shift:
Not Indicated

Valid Driving License:
No

Hazardous Material(s):
N/A

Job Posting End Date:
09/10/2026*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID: R413107