Principal Scientist Jobs in Texas

Principal Scientist jobs in Texas are concentrated in the state's life sciences, energy research, and semiconductor sectors, with demand active at every level from associate scientist through senior principal. The largest hiring hubs are Houston, Dallas-Fort Worth, and Austin, where employers like ExxonMobil, Texas Instruments, and MD Anderson Cancer Center consistently maintain principal scientist openings. The most sought-after specialties in Texas are analytical chemistry, computational biology, and materials science. Find a role that fits below and apply directly.

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Overview

Open roles17
Top employerHP
Top cityAustin, TX
Cities hiring8
Work type75% Hybrid
Top industryMedia

Showing 5 of 17+ Principal Scientist jobs

Principal Consultant, Engineer or Scientist- Sustainable Operations
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Added 3d ago
Principal Consultant, Engineer or Scientist- Sustainable Operations
Environmental Resources Management
Houston, Texas
Compliance & Risk
Environmental Engineering
Environmental Science
Specialized Engineering
Hybrid
Bachelor of Science
1,001-5,000

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Principal Data Scientist
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Added 5d ago
Principal Data Scientist
D.R. Horton
Arlington, Texas
Customer Support
Software Engineering
Technical Program Management
Experience equivalent to degree accepted
5,001-10,000

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LEAD COMPUTER SCIENTIST - PRINCIPAL COMPUTER SCIENTIST - PRINCIPAL ENGINEER - RF Systems
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Added 5d ago
LEAD COMPUTER SCIENTIST - PRINCIPAL COMPUTER SCIENTIST - PRINCIPAL ENGINEER - RF Systems
Southwest Research Institute
San Antonio, Texas
AI (Artificial Intelligence)
Data Science
Bachelor's degree in mechanical engineering
1,001-5,000

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Principal Scientist
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Added 1w ago
Principal Scientist
Precision for Medicine
Houston, Texas
Biotech & Life Sciences
Clinical Support
Laboratory Science
$111k - $166k/yr
501-1,000

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Principal Scientist
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Added 1w ago
Principal Scientist
Precision Medicine Group
Houston, Texas
Biotech & Life Sciences
Clinical Support
Laboratory Science
$111k - $166k/yr
1,001-5,000

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See All 17 Principal Scientist Jobs in Texas

Find roles in Texas that match your experience and apply in just a few clicks.

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Principal Scientist Jobs by City in Texas

Where Texas roles are concentrated, by current openings.

Austin
5 jobs
Houston
3 jobs
Plano
2 jobs
San Antonio
2 jobs
Dallas
1 job
Frisco
1 job
Spring
1 job
Arlington
1 job

Principal Scientist Job Market in Texas

A snapshot from current Texas openings, updated as new roles post.

Who's Hiring

HP2 open roles
AMD1 open role
Vericast1 open role

Top Industries Hiring

  • Media & Entertainment
  • Technology & Software
  • Banking & Financial Services

What Texas Employers Look For

The qualifications that appear most often in principal scientist jobs across Texas.

  • PhD in a relevant scientific discipline such as chemistry, biology, or materials science
  • Minimum eight years of industry research experience with a strong publication or patent record
  • Demonstrated ability to lead cross-functional research teams and mentor junior scientists
  • Deep expertise in at least one core methodology relevant to Texas industries such as spectroscopy, genomics, or reservoir characterization
  • Experience managing research budgets, grant applications, or large-scale project timelines
  • Proficiency with scientific software platforms and statistical analysis tools used in Texas industry settings

Principal Scientist Jobs in Texas: Frequently Asked Questions

How do you become a principal scientist in Texas?

The path to principal scientist in Texas typically starts with a doctoral degree in a relevant field followed by postdoctoral or industry research experience. No state-issued license governs the title, but Texas employers in regulated industries such as environmental science or clinical research may require specific certifications such as a Registered Environmental Manager credential or Good Laboratory Practice training. Advancement comes through demonstrated research leadership and a strong record of published or patented work.

Which companies hire principal scientists in Texas?

Employers hiring principal scientists in Texas right now include HP, AMD, and Vericast, based on current listings on Migrate Mate as of November 2026. Texas's concentration of energy majors, semiconductor manufacturers, and large academic medical centers means demand is spread across multiple industries rather than dominated by a single sector.

Which Texas cities have the most principal scientist jobs?

Austin, Houston, and Plano have the most principal scientist openings in Texas. Houston leads because of its dense concentration of petrochemical, energy research, and medical center employers, while Dallas-Fort Worth draws openings from semiconductor and biotech companies headquartered in the region, and Austin's growing life sciences and tech cluster anchors demand in Central Texas.

Are there remote principal scientist jobs in Texas?

Yes, but they're less common than in purely desk-based roles because principal scientist work often involves laboratory equipment, on-site collaboration, and hands-on research. About 100% of principal scientist openings tied to Texas are remote or hybrid as of November 2026. The tasks most likely to be performed remotely are data analysis, computational modeling, and scientific writing rather than bench or field work.

How can I get hired as a principal scientist in Texas with little or no experience?

The most realistic entry path is through a postdoctoral research position at a Texas institution such as MD Anderson Cancer Center, UT Southwestern, or Rice University, which regularly run structured postdoc programs that feed directly into industry roles. Candidates without a doctorate can move laterally from adjacent roles like research scientist, staff scientist, or senior research associate at Texas energy or biotech companies, then build toward principal-level responsibilities over time. A strong publication record or patent portfolio accelerates that transition significantly.

Where can I find and apply to principal scientist jobs in Texas?

You can find and apply to principal scientist jobs in Texas on Migrate Mate, which lists current openings across the state's major hiring hubs and industries. Search the listings to find roles that match your specialization and experience level, then apply directly to the ones that fit.

See All 17 Principal Scientist Jobs in Texas

Find roles in Texas that match your experience and apply in just a few clicks.

Find Principal Scientist Jobs