Principal Technician Jobs
Principal Technician jobs are open across manufacturing, defense, semiconductor, and energy sectors, with specializations in process engineering, systems integration, and quality assurance, from mid-career contributor to lead and principal-level roles. See the openings below and apply to the ones that match your experience.
Find Principal Technician JobsOverview
Showing 5 of 32+ Principal Technician jobs
About Curium
Curium is the world’s largest nuclear medicine company with more than a century of industry experience. We develop, manufacture and distribute world-class radiopharmaceutical products to help patients around the globe. Our proven heritage combined with a pioneering approach are the hallmarks to deliver innovation, excellence and unparalleled service.
With manufacturing facilities across Europe and the United States, Curium delivers SPECT, PET and therapeutic radiopharmaceutical solutions for life-threatening diseases to over 14 million patients annually. The name ‘Curium’ honors the legacy of pioneering radioactive researchers Marie and Pierre Curie, after whom the radioactive element curium was named and emphasizes our focus on nuclear medicine. The tagline ‘Life Forward’ represents our commitment to securing a brighter future for all those we serve: An enhanced quality of care for our patients. A trusted partner to our customers. A supportive employer to our valued team.
Summary of Position
The role of a Principal Manufacturing Technician is to perform all tasks associated with operating equipment through formulation, preparation, dispensing and packaging of aseptically filled radiopharmaceutical processes, according to cGMP guidelines to meet production demands. The Principal Manufacturing Technician will work with advanced automated equipment, in the creation of new products, and serve as one of several lead technicians while coordinating work in accordance with standard operating procedures (SOP’s).
Work schedule: Sunday - Wednesday 2am -12:30pm. Ability to work overtime when necessary.
Essential Functions
- Ensure a safe and quality working environment through training, awareness, and compliance to safety guidelines, SOP’s as well as US and international regulations (i.e. FDA, HC, EU, TGA, etc.).
- Perform and document tasks associated with the production of radiopharmaceuticals in accordance with Federal and/or State guidelines in a cGMP environment.
- Participate and perform effectively in a team environment and interact with multiple departments to ensure the operational success of the area.
- This position will coordinate with Staging, Warehouse, Label Control, and Production Supervisors to plan, schedule, and execute all aspects of the area.
- Monitor and inspect product quality to ensure compliance with standards and specifications.
- Must pass Visual Acuity, Color Vision Test and Respiratory Test as required for process needs.
- Adhere to all applicable regulations, policies, and procedures for health, safety, and environmental compliance.
- Perform Batch Record calculations, reviews and maintain all documentation according to cGMP Guidelines.
- Follow detailed instructions and communicate effectively, both written and verbally.
- Set up, operate, monitor, and clean production equipment and processes in accordance with current good manufacturing practices and standard operating procedures.
- Ensures the maintenance and cleanliness of department, premises, and equipment.
- Order and maintain inventory of materials and supplies.
- Act as demonstrators and/or qualifiers for processes and procedures during the training of new employees.
- Troubleshoot problems with equipment, devices, or products.
- Must maintain operational compliance with US and international regulatory agencies and guidelines (i.e. FDA, EU, HC, TGA, PIC/S, ISO, USP, NRC, cGMP, etc.).
- Works with leadership to improve operations.
- Must be willing to attend additional training when required.
- Demonstrates willingness to be flexible to the needs of the department and business, including outside of the department.
- Takes ownership and is an active member with continuous improvement activities including: reliability team meetings, root cause analysis, SOP and Batch record improvements, Kaizen events, and Customer Complaints.
Requirements
- High School Diploma or equivalent required.
- Six or more years of relevant work experience is required, preferably in a pharmaceutical or manufacturing industry.
- Proven high performer capable of meeting or exceeding goals on time as well as meeting objectives of the team.
- Exemplary team building, leadership behavior and a proven collaborative attitude.
- Experience working in an FDA-regulated cGMP environment is preferred.
- Must be capable of providing front line troubleshooting of manufacturing equipment and process issues, properly elevating concerns, and issues to appropriate personnel.
- Willingness to work rotating shifts, weekends, and overtime, as necessary.
- Willingness to work in plant producing radioactive materials and requiring all employees to participate in safety programs designed to minimize potential and/or actual exposure levels.
- This position will coordinate with Staging, Warehouse, Label Control, and Production Supervisors to plan, schedule, and execute all aspects of the area.
- Acts as a team lead/supervision role in the absence of supervision.
Working Conditions:
- Willingness to work in plant producing radioactive materials and requiring all employees to participate in safety programs designed to minimize potential and/or actual exposure levels.
- Responsibilities include the ability to lift up to 70 pounds, kneeling, crouching, twisting the upper body, walking, bending, stooping, pushing, pulling, reaching, must be able to physically negotiate stairs and evacuation ladders with or without accommodation, wear and operate safety equipment, enter vessels, and inspect equipment.
- Material handling devices (e.g., hand truck, fork truck, and conveyors) are used when possible, however, use of proper lifting and movement techniques is necessary to prevent injury.
- Must be willing to wear a variety of Personal Protective Equipment (PPE) and hearing protection as needed.
- May be required to sit or stand for long periods of 8+ hours a day while performing duties.
- Must possess good hand-eye coordination; close attention to detail is required.
- Must be able to work indoors and outdoors with exposure to mechanical/moving parts, hazards including corrosive, flammable and toxic material, dust, dirt, odors, and irritants.
- Willingness to complete safety training within allotted timeframes, and work in a team-based environment.
- Must be able to work outside of regular work hours, including off shift, weekend, and holiday work as business needs require.
Disclaimer
The above statements are intended to describe the general nature and level of work being performed by employees assigned to this classification. They are not intended to be construed as an exhaustive list of all responsibilities, duties and skills required of employees assigned to this position.
Equal Opportunity Employer
Curium is an equal opportunity employer and believes everyone deserves respect, dignity and equality. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
About Curium
Curium is the world’s largest nuclear medicine company with more than a century of industry experience. We develop, manufacture and distribute world-class radiopharmaceutical products to help patients around the globe. Our proven heritage combined with a pioneering approach are the hallmarks to deliver innovation, excellence and unparalleled service.
With manufacturing facilities across Europe and the United States, Curium delivers SPECT, PET and therapeutic radiopharmaceutical solutions for life-threatening diseases to over 14 million patients annually. The name ‘Curium’ honors the legacy of pioneering radioactive researchers Marie and Pierre Curie, after whom the radioactive element curium was named and emphasizes our focus on nuclear medicine. The tagline ‘Life Forward’ represents our commitment to securing a brighter future for all those we serve: An enhanced quality of care for our patients. A trusted partner to our customers. A supportive employer to our valued team.
Summary of Position
The role of a Principal Manufacturing Technician is to perform all tasks associated with operating equipment through formulation, preparation, dispensing and packaging of aseptically filled radiopharmaceutical processes, according to cGMP guidelines to meet production demands. The Principal Manufacturing Technician will work with advanced automated equipment, in the creation of new products, and serve as one of several lead technicians while coordinating work in accordance with standard operating procedures (SOP’s).
Work schedule: Sunday - Wednesday 2am -12:30pm. Ability to work overtime when necessary.
Essential Functions
- Ensure a safe and quality working environment through training, awareness, and compliance to safety guidelines, SOP’s as well as US and international regulations (i.e. FDA, HC, EU, TGA, etc.).
- Perform and document tasks associated with the production of radiopharmaceuticals in accordance with Federal and/or State guidelines in a cGMP environment.
- Participate and perform effectively in a team environment and interact with multiple departments to ensure the operational success of the area.
- This position will coordinate with Staging, Warehouse, Label Control, and Production Supervisors to plan, schedule, and execute all aspects of the area.
- Monitor and inspect product quality to ensure compliance with standards and specifications.
- Must pass Visual Acuity, Color Vision Test and Respiratory Test as required for process needs.
- Adhere to all applicable regulations, policies, and procedures for health, safety, and environmental compliance.
- Perform Batch Record calculations, reviews and maintain all documentation according to cGMP Guidelines.
- Follow detailed instructions and communicate effectively, both written and verbally.
- Set up, operate, monitor, and clean production equipment and processes in accordance with current good manufacturing practices and standard operating procedures.
- Ensures the maintenance and cleanliness of department, premises, and equipment.
- Order and maintain inventory of materials and supplies.
- Act as demonstrators and/or qualifiers for processes and procedures during the training of new employees.
- Troubleshoot problems with equipment, devices, or products.
- Must maintain operational compliance with US and international regulatory agencies and guidelines (i.e. FDA, EU, HC, TGA, PIC/S, ISO, USP, NRC, cGMP, etc.).
- Works with leadership to improve operations.
- Must be willing to attend additional training when required.
- Demonstrates willingness to be flexible to the needs of the department and business, including outside of the department.
- Takes ownership and is an active member with continuous improvement activities including: reliability team meetings, root cause analysis, SOP and Batch record improvements, Kaizen events, and Customer Complaints.
Requirements
- High School Diploma or equivalent required.
- Six or more years of relevant work experience is required, preferably in a pharmaceutical or manufacturing industry.
- Proven high performer capable of meeting or exceeding goals on time as well as meeting objectives of the team.
- Exemplary team building, leadership behavior and a proven collaborative attitude.
- Experience working in an FDA-regulated cGMP environment is preferred.
- Must be capable of providing front line troubleshooting of manufacturing equipment and process issues, properly elevating concerns, and issues to appropriate personnel.
- Willingness to work rotating shifts, weekends, and overtime, as necessary.
- Willingness to work in plant producing radioactive materials and requiring all employees to participate in safety programs designed to minimize potential and/or actual exposure levels.
- This position will coordinate with Staging, Warehouse, Label Control, and Production Supervisors to plan, schedule, and execute all aspects of the area.
- Acts as a team lead/supervision role in the absence of supervision.
Working Conditions:
- Willingness to work in plant producing radioactive materials and requiring all employees to participate in safety programs designed to minimize potential and/or actual exposure levels.
- Responsibilities include the ability to lift up to 70 pounds, kneeling, crouching, twisting the upper body, walking, bending, stooping, pushing, pulling, reaching, must be able to physically negotiate stairs and evacuation ladders with or without accommodation, wear and operate safety equipment, enter vessels, and inspect equipment.
- Material handling devices (e.g., hand truck, fork truck, and conveyors) are used when possible, however, use of proper lifting and movement techniques is necessary to prevent injury.
- Must be willing to wear a variety of Personal Protective Equipment (PPE) and hearing protection as needed.
- May be required to sit or stand for long periods of 8+ hours a day while performing duties.
- Must possess good hand-eye coordination; close attention to detail is required.
- Must be able to work indoors and outdoors with exposure to mechanical/moving parts, hazards including corrosive, flammable and toxic material, dust, dirt, odors, and irritants.
- Willingness to complete safety training within allotted timeframes, and work in a team-based environment.
- Must be able to work outside of regular work hours, including off shift, weekend, and holiday work as business needs require.
Disclaimer
The above statements are intended to describe the general nature and level of work being performed by employees assigned to this classification. They are not intended to be construed as an exhaustive list of all responsibilities, duties and skills required of employees assigned to this position.
Equal Opportunity Employer
Curium is an equal opportunity employer and believes everyone deserves respect, dignity and equality. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
Principal Technician Jobs by Experience Level
See All 32 Principal Technician Jobs
Find roles that match your experience and apply in just a few clicks.
Find Principal Technician JobsPrincipal Technician Job Market
Who's Hiring
Top Industries Hiring
- Electronics & Hardware
- Construction & Real Estate
What Employers Look For
The qualifications that appear most often in principal technician jobs.
- Five or more years of hands-on technical experience in a relevant discipline or industry
- Proficiency with diagnostic tools, test equipment, and industry-standard documentation systems
- Associate or bachelor's degree in electronics, engineering technology, or a closely related field
- Experience reading and interpreting schematics, technical drawings, and process specifications
- Relevant professional certification such as Six Sigma, OSHA, CompTIA, or a discipline-specific credential
- Demonstrated ability to mentor junior technicians and lead troubleshooting efforts on complex systems
Tips for Your Principal Technician Job Search
Tailor your resume to technical depth
Principal technician postings reward candidates who show ownership of complex systems, not just participation. Quantify the scope of equipment you've maintained, processes you've owned, or cross-functional teams you've supported to separate your resume from generalist applicants.
Highlight your certifications upfront
Certifications like Six Sigma, OSHA, CompTIA, or discipline-specific credentials often appear as hard filters in applicant tracking systems. List them in a dedicated section near the top of your resume so automated screening tools and hiring managers catch them immediately.
Apply early to roles that fit
Migrate Mate lists principal technician openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Filter openings by technical environment
Principal technician roles differ sharply by environment, whether cleanroom, field, lab, or production floor. Search with environment-specific keywords alongside your specialization to surface openings where your hands-on context translates directly instead of requiring a steep adjustment.
Prepare a system-failure walk-through story
Interviewers at the principal level routinely ask you to walk through a critical failure you diagnosed and resolved. Prepare a specific, structured account covering what failed, how you isolated the root cause, what you fixed, and what you changed in the process afterward.
Negotiate scope and autonomy, not just pay
Principal technicians often have leverage to negotiate the complexity of assignments, equipment ownership, and cross-team authority. Clarify during the offer stage which decisions you can make independently versus which require engineering sign-off, since those boundaries define your day-to-day role.
Principal Technician Jobs: Frequently Asked Questions
Which companies are hiring the most principal technicians?
The companies hiring the most principal technicians right now include GlobalFoundries, Nordson, and Fluor, with the largest share of openings in New York, California, and Texas, based on current listings on Migrate Mate as of November 2026. Defense contractors, semiconductor manufacturers, and energy companies tend to post the highest volume of principal-level technician roles.
How many principal technician jobs are remote?
About 20% of principal technician openings are fully remote or hybrid as of November 2026, reflecting the hands-on nature of most roles in this category. Sub-areas with the highest remote share include technical documentation, systems validation, and quality assurance roles that don't require a physical lab or production floor presence.
How do you become a principal technician?
Start by building a foundation in your discipline through a two- or four-year degree in electronics, engineering technology, or a related technical field, then accumulate hands-on experience maintaining, troubleshooting, and owning complex systems. Earn certifications relevant to your industry, take on progressively independent assignments, and develop the ability to mentor others before targeting principal-level postings.
Can you get a principal technician job without much experience?
Moving directly into a principal technician role with little experience is uncommon because employers expect you to have already owned complex technical problems independently. The practical path is to build several years in mid-level technician or specialist roles, document specific systems you've owned, pursue certifications that signal depth, and target smaller organizations where principal titles carry slightly lower thresholds.
What does the principal technician interview process look like?
Most principal technician interviews include an initial screening with a recruiter or HR contact, followed by a technical interview where you walk through past troubleshooting scenarios and demonstrate familiarity with relevant tools and systems. Later rounds often involve a panel with engineers or operations leads who assess your ability to work cross-functionally and lead technical decisions under pressure.
Where can I find and apply to principal technician jobs?
You can find and apply to principal technician jobs on Migrate Mate, which lists current openings from across the United States. Search for roles that match your specialization and experience level, then apply directly to each listing that fits your background.
See All 32 Principal Technician Jobs
Find roles that match your experience and apply in just a few clicks.
Find Principal Technician Jobs