Senior Level Quantitative Technology Director Jobs
Senior level quantitative technology director jobs place experienced professionals in command of model risk frameworks, algorithmic infrastructure, and the cross-functional teams that deliver quantitative solutions at scale. Openings are concentrated across Investment & Asset Management, Technology & Software, and Banking & Financial Services, with 58% offering remote or hybrid arrangements and employers like Two Sigma, JPMorganChase, and Chicago Trading Company hiring at this level now.
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Showing 5 of 20+ Senior Level Quantitative Technology Director jobs
INTRODUCTION
Working at Moffitt is both a career and a mission: to contribute to the prevention and cure of cancer.
As the only National Cancer Institute-designated Comprehensive Cancer Center based in Florida, Moffitt employs some of the best and brightest minds from around the world. Join a dedicated team of nearly 11,000 who are shaping the future we envision. Moffitt has been recognized as a Best and Brightest Company to Work For in the Nation and is continually named one of the Tampa Bay Times’ Top Workplaces.
SUMMARY
Associate Center Director of Physical & Quantitative Science
Moffitt Cancer Center (Moffitt), a stand-alone NCI-designated Comprehensive Cancer Center, is seeking a visionary and collaborative leader to serve as the Associate Center Director (ACD) and Division Chief of Physical & Quantitative Science. This newly reimagined, senior academic leadership role will be responsible for driving transformative research innovation in artificial intelligence (AI), machine learning, mathematical oncology, systems biology, biostatistics, and bioinformatics in oncology. The ACD is responsible for providing strategic vision, scientific leadership, and administrative oversight for the Division across multiple disciplines within the Departments of Biostatistics & Bioinformatics (Bios2), Integrated Mathematical Oncology (IMO), and Machine Learning (ML), as well as one or more future departments in the Division. This role offers a unique opportunity to shape and expand Moffitt’s strengths in physical and quantitative science through interdisciplinary research and strategic growth. A primary responsibility of this role will be to foster collaborations across research and clinical faculty and senior administration to build expertise, academic departments, research infrastructure, and team science partnerships that advance innovative approaches to advance cancer prevention, diagnosis, and treatment. This leader will have significant authority and responsibility for the academic and research mission of Moffitt, which has nationally recognized research programs in Clinical, Discovery, Physical & Quantitative, Population, and Translational Sciences. The ACD serves as an institutional leader to advance Moffitt’s singular mission to contribute to the prevention and cure of cancer.
Position highlights include the following:
- Advance impact and visibility of Moffitt’s Physical & Quantitative Science research at the local, state, national and international levels
- Further strengthen and grow exceptional physical and quantitative science research programs in the Departments of Biostatistics & Bioinformatics, Integrated Mathematical Oncology, Machine Learning, and one or more new academic departments
- Recruit talented faculty and staff dedicated to physical and quantitative research, leveraging highly competitive faculty recruitment packages
THE IDEAL CANDIDATE WILL:
- Have a national/international reputation in cancer-related physical and/or quantitative science research with an exceptional track record of peer reviewed extramural research funding
- Be a thought leader in the fields of physical and/or quantitative science who will anticipate and drive new research directions and opportunities
- Have exceptional leadership and mentorship skills to advance the careers of faculty, trainees, and staff
- Understand and advance catchment area needs through research
PRIMARY RESPONSIBILITIES FOR THE LEADERSHIP ROLE WILL INCLUDE:
- Administrative and academic leadership: Oversees the Division of Physical & Quantitative Science; as Division Chief, leads Chairs and Division Administration in a productive, collaborative academic research environment
- Scientific leadership: Works with other leaders to advance high impact transdisciplinary research across research and clinical departments and programs; provides guidance to Shared Resources (Cores) aligned with the Division of Physical & Quantitative Science; contributes to CCSG competing and non-competing applications; and mentors Core directors, faculty, trainees, and staff
- Center-wide leadership: Serves as member of the Research Executive Committee, the Research Institute Steering Committee, the Scientific Leadership Committee, and the Leadership Council; represents the Division of Physical & Quantitative Science in oversight and governance venues; ensures the Division of Physical & Quantitative Science develops and sustains robust shared initiatives with the Offices of Community Outreach & Engagement, Research Education & Training, and Research Career Development
- Maintains top tier research programs: Maintains active extramurally funded research programs; publishes original reports in high impact peer-reviewed journals; provides service to professional societies; and contributes to teaching and mentoring of faculty, staff, fellows, and graduate students
CREDENTIALS AND QUALIFICATIONS FOR ELIGIBLE CANDIDATES INCLUDE:
- Doctoral degree (PhD, DrPH, or equivalent) in systems biology, engineering, biomathematics, biostatistics, bioinformatics, machine learning, artificial intelligence, quantitative science, computer science, or a related field
- Senior Member/Professor rank is preferred, along with a history of academic excellence and sustained peer-reviewed extramural funding by NCI or other institutes of NIH
- Previous experience in a Cancer Center Support Grant (CCSG) leadership role, research program or other specific CCSG role, with experience in developing/reviewing the P30 grant as well as participation in program review
- Track record of successfully working across complex research and clinical environments
To formally apply, visit our internal careers page and apply to req R-78. Please be sure to attach a single PDF or Word file which includes your CV and cover letter. Review of applications will begin immediately.
Questions regarding the opportunity may be directed to Chair of the Search Committee, Dr. Heather Jim at Heather.Jim@moffitt.org.
LOCATION
Tampa Bay Area
Moffitt Cancer Center is located in Tampa Florida, a thriving metropolitan city that provides its residents a high quality of life. The Tampa Bay area has become a hub for ground-breaking research, welcoming individuals from around the globe. This diverse city is characterized by a rich culture, year-round activities for all, beautiful beaches, amazing cuisine and more.
EQUAL EMPLOYMENT OPPORTUNITY
Moffitt is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, or protected veteran or disabled status. Moffitt seeks candidates whose skills and personal and professional experience have prepared them to contribute to our commitment to diversity and excellence.
SALARY RANGE
Salary ranges posted for this position represent the expected base pay range for the role. Actual compensation may vary based on location and a variety of job-related factors, including experience, skills, education, and internal equity among Team Members in similar positions.
We are committed to maintaining fair and equitable pay practices and regularly review compensation to ensure alignment across our workforce.
INTRODUCTION
Working at Moffitt is both a career and a mission: to contribute to the prevention and cure of cancer.
As the only National Cancer Institute-designated Comprehensive Cancer Center based in Florida, Moffitt employs some of the best and brightest minds from around the world. Join a dedicated team of nearly 11,000 who are shaping the future we envision. Moffitt has been recognized as a Best and Brightest Company to Work For in the Nation and is continually named one of the Tampa Bay Times’ Top Workplaces.
SUMMARY
Associate Center Director of Physical & Quantitative Science
Moffitt Cancer Center (Moffitt), a stand-alone NCI-designated Comprehensive Cancer Center, is seeking a visionary and collaborative leader to serve as the Associate Center Director (ACD) and Division Chief of Physical & Quantitative Science. This newly reimagined, senior academic leadership role will be responsible for driving transformative research innovation in artificial intelligence (AI), machine learning, mathematical oncology, systems biology, biostatistics, and bioinformatics in oncology. The ACD is responsible for providing strategic vision, scientific leadership, and administrative oversight for the Division across multiple disciplines within the Departments of Biostatistics & Bioinformatics (Bios2), Integrated Mathematical Oncology (IMO), and Machine Learning (ML), as well as one or more future departments in the Division. This role offers a unique opportunity to shape and expand Moffitt’s strengths in physical and quantitative science through interdisciplinary research and strategic growth. A primary responsibility of this role will be to foster collaborations across research and clinical faculty and senior administration to build expertise, academic departments, research infrastructure, and team science partnerships that advance innovative approaches to advance cancer prevention, diagnosis, and treatment. This leader will have significant authority and responsibility for the academic and research mission of Moffitt, which has nationally recognized research programs in Clinical, Discovery, Physical & Quantitative, Population, and Translational Sciences. The ACD serves as an institutional leader to advance Moffitt’s singular mission to contribute to the prevention and cure of cancer.
Position highlights include the following:
- Advance impact and visibility of Moffitt’s Physical & Quantitative Science research at the local, state, national and international levels
- Further strengthen and grow exceptional physical and quantitative science research programs in the Departments of Biostatistics & Bioinformatics, Integrated Mathematical Oncology, Machine Learning, and one or more new academic departments
- Recruit talented faculty and staff dedicated to physical and quantitative research, leveraging highly competitive faculty recruitment packages
THE IDEAL CANDIDATE WILL:
- Have a national/international reputation in cancer-related physical and/or quantitative science research with an exceptional track record of peer reviewed extramural research funding
- Be a thought leader in the fields of physical and/or quantitative science who will anticipate and drive new research directions and opportunities
- Have exceptional leadership and mentorship skills to advance the careers of faculty, trainees, and staff
- Understand and advance catchment area needs through research
PRIMARY RESPONSIBILITIES FOR THE LEADERSHIP ROLE WILL INCLUDE:
- Administrative and academic leadership: Oversees the Division of Physical & Quantitative Science; as Division Chief, leads Chairs and Division Administration in a productive, collaborative academic research environment
- Scientific leadership: Works with other leaders to advance high impact transdisciplinary research across research and clinical departments and programs; provides guidance to Shared Resources (Cores) aligned with the Division of Physical & Quantitative Science; contributes to CCSG competing and non-competing applications; and mentors Core directors, faculty, trainees, and staff
- Center-wide leadership: Serves as member of the Research Executive Committee, the Research Institute Steering Committee, the Scientific Leadership Committee, and the Leadership Council; represents the Division of Physical & Quantitative Science in oversight and governance venues; ensures the Division of Physical & Quantitative Science develops and sustains robust shared initiatives with the Offices of Community Outreach & Engagement, Research Education & Training, and Research Career Development
- Maintains top tier research programs: Maintains active extramurally funded research programs; publishes original reports in high impact peer-reviewed journals; provides service to professional societies; and contributes to teaching and mentoring of faculty, staff, fellows, and graduate students
CREDENTIALS AND QUALIFICATIONS FOR ELIGIBLE CANDIDATES INCLUDE:
- Doctoral degree (PhD, DrPH, or equivalent) in systems biology, engineering, biomathematics, biostatistics, bioinformatics, machine learning, artificial intelligence, quantitative science, computer science, or a related field
- Senior Member/Professor rank is preferred, along with a history of academic excellence and sustained peer-reviewed extramural funding by NCI or other institutes of NIH
- Previous experience in a Cancer Center Support Grant (CCSG) leadership role, research program or other specific CCSG role, with experience in developing/reviewing the P30 grant as well as participation in program review
- Track record of successfully working across complex research and clinical environments
To formally apply, visit our internal careers page and apply to req R-78. Please be sure to attach a single PDF or Word file which includes your CV and cover letter. Review of applications will begin immediately.
Questions regarding the opportunity may be directed to Chair of the Search Committee, Dr. Heather Jim at Heather.Jim@moffitt.org.
LOCATION
Tampa Bay Area
Moffitt Cancer Center is located in Tampa Florida, a thriving metropolitan city that provides its residents a high quality of life. The Tampa Bay area has become a hub for ground-breaking research, welcoming individuals from around the globe. This diverse city is characterized by a rich culture, year-round activities for all, beautiful beaches, amazing cuisine and more.
EQUAL EMPLOYMENT OPPORTUNITY
Moffitt is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, or protected veteran or disabled status. Moffitt seeks candidates whose skills and personal and professional experience have prepared them to contribute to our commitment to diversity and excellence.
SALARY RANGE
Salary ranges posted for this position represent the expected base pay range for the role. Actual compensation may vary based on location and a variety of job-related factors, including experience, skills, education, and internal equity among Team Members in similar positions.
We are committed to maintaining fair and equitable pay practices and regularly review compensation to ensure alignment across our workforce.
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Who's Hiring
Top Industries Hiring
- Investment & Asset Management14
- Technology & Software6
- Banking & Financial Services4
- Fintech1
- Insurance1
Senior Level Quantitative Technology Director Jobs: Frequently Asked Questions
How do I get a senior level quantitative technology director job?
Employers at this level look for candidates who have owned quantitative systems end-to-end, not just contributed to them. Demonstrating that you have set technical direction, navigated model governance, and developed junior talent positions you ahead of peers. A portfolio of delivered production systems, published research, or cross-organizational leadership carries more weight than credentials alone at the senior level.
Which companies hire senior level quantitative technology directors?
Companies hiring senior level quantitative technology directors right now include Two Sigma, JPMorganChase, and Chicago Trading Company, based on current listings on Migrate Mate as of November 2026. Hiring at this level tends to come from large financial institutions, technology firms with quantitative research functions, and consulting organizations building out advanced analytics capabilities.
Are there remote senior level quantitative technology director jobs?
Yes, though on-site and hybrid arrangements remain common given the collaborative and oversight demands of director-level work. About 58% of senior level quantitative technology director openings are remote or hybrid as of November 2026, giving experienced candidates meaningful flexibility while most organizations still expect some presence for strategy and stakeholder alignment.
What makes a quantitative technology director role senior level?
Senior level roles are distinguished by the scope of accountability rather than task complexity alone. At this stage, you own the technical roadmap for quantitative systems, make final calls on model design and infrastructure trade-offs, and are responsible for the performance of the team executing that work. Mentoring mid-level quantitative professionals and influencing firm-wide standards are expected, not optional.
Which industries hire the most senior level quantitative technology directors?
Senior Level quantitative technology director roles concentrate in Investment & Asset Management, Technology & Software, and Banking & Financial Services, based on current listings on Migrate Mate as of November 2026. These sectors drive hiring at this level because they depend on production-grade quantitative systems where director-level oversight directly affects risk, revenue, or competitive differentiation.