Senior AI Software Engineer Jobs in Houston, TX
Senior AI Software Engineer jobs in Houston are in strong demand, concentrated in the Energy Corridor, Greenway Plaza, and the Texas Medical Center, across energy tech, healthcare AI, and aerospace. Employers actively hiring include Rice University, SLB, and Bot Auto. Scan the live roles below and apply to whichever ones fit.
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Software Engineer - AI Integrations — First Distributors (Houston, TX)
We're a Houston industrial PVF distributor building a platform that intakes customer inquiries and produces structured, priced quotations.
The software is live with our own sales team today and we're building toward agents that can run the full quoting workflow end to end.
You'd be the third engineer on the team, working directly with the CEO. You'll have unusually high ownership over architecture, product direction, and how we solve difficult technical problems.
What you'll work on
- Workflow automation: tool use, multi-step processes, third-party integrations, retries, exception handling, and knowing when software should hand a problem to a human
- Production backend systems: Python/FastAPI services, PostgreSQL data modeling, background jobs, APIs, authentication, observability, and integrations with external systems
- Full-stack delivery: making changes across the backend and our React/TypeScript web application when necessary to ship a complete solution.
- Reliable AI pipelines: combining LLMs, deterministic methods, rules, confidence scoring, validation, retries, and human review rather than treating every problem as a prompt
- Evaluation infrastructure: golden datasets, regression suites, and accuracy metrics we actually trust before shipping a prompt or model change
What we're looking for
- 3+ years of production backend engineering in Python; you write real services, not notebooks
- Hands-on experience shipping LLM-backed features to actual users, prompt design, structured output, function calling, handling non-determinism
- Comfortable in a startup environment: no PM, no QA, no ticket queue. You'll talk to the sales reps yourself and decide what to build
- Strong SQL and data-modeling instincts
- A rigorous approach to reliability: you measure before you optimize and want to know whether a change actually improved the system
- Good judgment about when not to use an LLM and when deterministic code, rules, or traditional algorithms are the better solution
- You measure before you optimize. If you've built or wanted to build an eval harness because you were tired of guessing whether a change helped, you'll fit in well with our team.
- A rigorous approach to reliability. You want to measure whether a change actually improved the system rather than relying on a few good examples.
- Ability to take ownership of an ambiguous problem: investigate it, propose an approach, implement it, test it, deploy it, and iterate based on real user feedback
Especially valuable experience
- Experience working at an early-stage startup or on a small engineering team where you owned major features end to end.
Where is the Role Located
- Houston, TX – near IAH Airport
- Role is on-site with the option to work from home on Fridays
Why this role is different
This isn't an AI demo looking for a use case. The software is already processing real RFQs for a real industrial distributor, and every mistake/win has a potential impact on actual high-dollar purchasing and quoting decisions.
You'll also be joining extremely early. The engineering team is small, and you’ll have direct access to leadership and users.
You won't be joining to own one narrow layer of the stack. We want engineers who can understand the business problem, determine the right technical solution, and carry it all the way into production.
As employee number 3, this role comes with significant upside potential and upward mobility as our vision takes shape and the company grows.
Pay: $100,000.00 - $150,000.00 per year
Benefits:
- Dental insurance
- Health insurance
Application Question(s):
- Why do you believe you would be a good fit for our team?
- What interests you in this position?
- This role is in person near the IAH airport in Houston, TX. Will you be able to work from 8am-5pm on-site?
Work Location: In person
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Find JobsSenior AI Software Engineer Job Market in Houston
Who's Hiring
- Rice University23

- SLB8

- Bot Auto8

- Deloitte8

- Accenture8

Top Industries Hiring
- Education
Senior AI Software Engineer Jobs in Houston: Frequently Asked Questions
How do I get a senior ai software engineer job in Houston?
Focus on Houston's dominant sectors: energy tech, health systems, and aerospace, where AI is being built into core operations, not just added on. Large industrial companies in the Energy Corridor and hospital networks in the Medical Center hire senior AI engineers directly. Candidates who can demonstrate production-grade model deployment, not just research experience, and who have worked on domain-specific data problems stand out in this market.
Which companies hire senior ai software engineers in Houston?
Companies currently hiring senior ai software engineers in Houston include Rice University, SLB, and Bot Auto, per current listings on Migrate Mate as of November 2026. Houston's hiring mix skews toward large enterprises in energy, healthcare, and defense contracting, alongside a growing number of AI-native startups in Midtown and the Innovation District.
Are there remote senior ai software engineer jobs in Houston?
Yes, though many roles require at least some on-site presence given the industry-specific and data-sensitive nature of AI work in Houston's energy and healthcare sectors. About 85% of senior ai software engineer openings tied to Houston are remote or hybrid as of November 2026, with fully remote options most common in software-focused companies rather than industrial or clinical settings.
How can I get a senior ai software engineer job in Houston with little or no experience?
The most realistic entry path in Houston is through a junior or mid-level data science or machine learning engineer role at one of the city's large energy companies or hospital systems, both of which run internal AI teams and promote from within. Houston also has a growing startup scene in Midtown where smaller teams hire generalists willing to build quickly. Building a portfolio of applied projects in energy forecasting or clinical data analysis sharpens your fit for local employers.
Which industries hire the most senior ai software engineers in Houston?
The sectors hiring the most senior ai software engineers in Houston are Education, based on current listings on Migrate Mate as of November 2026. Houston's concentration of energy majors, world-class hospital networks, and NASA-adjacent aerospace contractors creates sustained, specialized demand for senior AI talent that goes well beyond what most cities outside the coasts can offer.
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