Mid Level Senior Clinical Informatics Specialist Jobs
Mid level senior clinical informatics specialist jobs go to professionals ready to own clinical system implementations end to end, lead workflow optimization projects, and guide junior analysts without waiting for direction. Roles are concentrated across Healthcare & Medical Services, Technology & Software, and Education, with a strong mix of remote and hybrid settings, and employers like Cone Health, Novant Health, and Optum hiring at this level now.
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Optum is a global organization that delivers care, aided by technology to help millions of people live healthier lives. The work you do with our team will directly improve health outcomes by connecting people with the care, pharmacy benefits, data and resources they need to feel their best. Here, you will find a culture guided by inclusion, talented peers, comprehensive benefits and career development opportunities. Come make an impact on the communities we serve as you help us advance health optimization on a global scale. Join us to start Caring. Connecting. Growing together.
The Medical Director Clinical Informatics will lead and develop innovative approaches to clinical decision support (CDS) content authoring in support of electronic health record (EHR) embedded applications. This role will primarily be responsible for deeply understanding and translating clinical practice guidelines from their native narrative form into structured logic representations that faithfully interprets and disambiguates the guidelines. This work will be done with attention to detail and incorporate adherence to clinical ontologies/terminologies, information model and interoperability standards. The role will work collaboratively with our technical teams on transforming the structured logic into executable content, maintenance and QA of the content. In addition, this role will serve as a thought leader in helping to optimize our content development pipeline including thoughtfully incorporating Artificial Intelligence (AI) into the process.
You'll enjoy the flexibility to work remotely * from anywhere within the U.S. as you take on some tough challenges. For all hires in the Minneapolis or Washington, D.C. area, you will be required to work in the office a minimum of four days per week.
Primary Responsibilities:
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Author, maintain, and support QA of CDS content
- Translate clinical guidelines from a narrative format into a structured logical representation
- Break down clinical guidelines to the semantically precise clinical concepts referenced in the Clinical Guideline
- Collaborate with peer reviewers to ensure that content is clinically accurate, current, and supported by the best available evidence from the medical literature
- Collaborate with clinical terminologists to identify and represent clinical concepts using industry standard terminologies
- Partner with technical informaticists for implementation of the logical structured representation of the content using well defined data structures and algorithms
- Act as a content and process steward related to the development of clinical content, author and maintain policies related to curation
- Provide training and support for content authoring colleagues to leverage the tools, process and policies of content development
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Clinical Product Development
- Participate in cross functional collaboration between clinical content, clinical product and software development teams to optimize utilization of clinical content in relevant clinical workflows within clinical applications embedded and external to the HER
- Provide clinical informatics and clinical subject matter expertise and best practices to cross functional clinical product design to improve user adoption and experience of clinical applications
- Train new teams of content authors in the use of tools, techniques, and best practices for content authoring
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Innovation/Leadership
- Design, test and implement new methods and process related to clinical content development
- Collaborate in the development of ongoing strategy related to incorporation of AI capabilities into content development pipeline ensuring appropriate safeguards
- Provide thought leadership internally on clinical content development best practices
You'll be rewarded and recognized for your performance in an environment that will challenge you and give you clear direction on what it takes to succeed in your role as well as provide development for other roles you may be interested in.
Required Qualifications:
- Medical Graduate (MD/DO or MBBS)
- 5+ years of experience in Clinical Informatics
- 2+ years of clinical practice experience
- 2+ years of experience related to CDS
- Experience collaborating with Clinical subject matter experts, product and software architects
- Experience with evidence-based medicine framework
- Significant experience translating clinical guidelines into structured logical representation
- Experience with FHIR
- Experience with leveraging AI, Large Language Models, generative AI in informatics process
- Deep understanding and use of clinical terminology
Preferred Qualifications:
- Current and non-restricted MD license
- Board certification in Clinical Informatics
- Advanced degree in Clinical Informatics, Healthcare, or related clinical discipline
- Experience authoring and maintaining clinical terminology content
- Experience with clinical terminology content authoring platforms
- Experience with Clinical Quality Language
- Experience with CPG on FHIR
- Experience with decision modeling frameworks
All employees working remotely will be required to adhere to UnitedHealth Group's Telecommuter Policy
Pay is based on several factors including but not limited to local labor markets, education, work experience, certifications, etc. In addition to your salary, we offer benefits such as, a comprehensive benefits package, incentive and recognition programs, equity stock purchase and 401k contribution (all benefits are subject to eligibility requirements). No matter where or when you begin a career with us, you'll find a far-reaching choice of benefits and incentives. The salary for this role will range from $217,508 - $372,870 annually based on full-time employment. We comply with all minimum wage laws as applicable.
Application Deadline: This will be posted for a minimum of 2 business days or until a sufficient candidate pool has been collected. Job posting may come down early due to volume of applicants.
At UnitedHealth Group, our mission is to help people live healthier lives and make the health system work better for everyone. We believe everyone-of every race, gender, sexuality, age, location and income-deserves the opportunity to live their healthiest life. Today, however, there are still far too many barriers to good health which are disproportionately experienced by people of color, historically marginalized groups and those with lower incomes. We are committed to mitigating our impact on the environment and enabling and delivering equitable care that addresses health disparities and improves health outcomes - an enterprise priority reflected in our mission.
UnitedHealth Group is an Equal Employment Opportunity employer under applicable law and qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, sexual orientation, gender identity, disability, or protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations.
UnitedHealth Group is a drug - free workplace. Candidates are required to pass a drug test before beginning employment.
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Mid Level Senior Clinical Informatics Specialist Jobs: Frequently Asked Questions
How do I get a mid level senior clinical informatics specialist job?
Position your experience around ownership rather than participation. Hiring managers at this level want to see that you have led a clinical system build-out, driven an EHR optimization initiative, or served as the primary point of contact between clinical staff and IT. Highlight measurable outcomes, name the platforms you have configured, and show that your decisions improved workflows without requiring constant escalation.
Which companies hire mid level senior clinical informatics specialists?
Companies hiring mid level senior clinical informatics specialists right now include Cone Health, Novant Health, and Optum, based on current listings on Migrate Mate as of September 2026. Hiring at this level comes primarily from health systems, academic medical centers, and large managed care organizations that need specialists who can operate independently across clinical and technical teams.
Are there remote mid level senior clinical informatics specialist jobs?
Yes, though availability varies by employer and project phase. About 46% of mid level senior clinical informatics specialist openings are remote or hybrid as of September 2026, reflecting health systems' growing comfort with distributed informatics teams for roles that do not require hands-on bedside presence. Implementation-heavy roles may still require periodic on-site work during go-live periods.
How do I move up to a mid level senior clinical informatics specialist role?
The path into mid level requires building depth beyond basic EHR support. Focus on taking ownership of a full project cycle, whether a module build, a clinical decision support tool, or a data quality initiative. Demonstrating that you can translate clinical needs into technical requirements, measure your own outcomes, and train others signals the independence that separates mid level candidates from junior ones.
Which industries hire the most mid level senior clinical informatics specialists?
Mid Level senior clinical informatics specialist roles concentrate in Healthcare & Medical Services, Technology & Software, and Education, based on current listings on Migrate Mate as of September 2026. These sectors drive the most hiring because they operate large, complex clinical environments where optimizing EHR workflows and clinical data systems at scale requires experienced specialists who can work with minimal supervision.