Senior IT Engineer Jobs in San Francisco, CA
Senior IT Engineer jobs in San Francisco are concentrated in SoMa, the Financial District, and Mission Bay, driven by demand across enterprise software, cloud infrastructure, fintech, and healthcare technology. Employers hiring right now include Sephora, PwC, and Axon. Find a role that fits below and apply directly.
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Showing 5 of 140+ Senior IT Engineer jobs
Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN® dual-masked T-cell engagers across validated targets in solid tumor indications. Vir Biotechnology also has a preclinical portfolio of programs across a range of infectious diseases and oncologic malignancies.
Vir Biotechnology has exclusive rights to the universal PRO-XTEN® masking platform for oncology and infectious disease. PRO-XTEN® is a trademark of Amunix Pharmaceuticals, Inc., a Sanofi company.
We believe the success of our colleagues drives the success of our mission. We are committed to creating a company where everyone feels supported and encouraged to give their best.
THE OPPORTUNITY
Vir Biotechnology is seeking a Senior Infrastructure & IT Security Engineer (Temp Staff) to join our IT team. This is a senior, hands-on individual contributor role that combines IT infrastructure engineering and security operations. In this role, you will help maintain, secure, troubleshoot, and continuously improve the technology that enables Vir Bio's business and scientific mission, spanning endpoints, identity platforms, cloud services, servers, networking, virtualization, and security tools.
The successful candidate is an execution-focused technology professional who enjoys solving complex technical challenges, takes ownership from problem identification through resolution, and balances security, reliability, and user experience. You are a collaborative partner who can navigate ambiguity, communicate clearly, document thoroughly, and identify opportunities to strengthen systems, automate processes, and improve operational excellence.
This role is located in our San Francisco headquarters with an expectation of 4 days per week in office.
WHAT YOU'LL DO
What You'll Do
Infrastructure Engineering & Operations
- Implement, maintain, and enhance infrastructure across cloud, on-premises, and hybrid environments
- Administer and support Windows, macOS, Windows Server, and Linux environments, including patching, monitoring, troubleshooting, and lifecycle management
- Support AWS infrastructure, enterprise networking, virtualization platforms, and remote access technologies
- Manage identity, access management, endpoint technologies, and core infrastructure services
- Troubleshoot complex issues spanning endpoints, applications, cloud services, networks, and third-party systems
- Develop automation and scripting solutions to improve efficiency, consistency, and operational visibility
- Execute infrastructure changes in accordance with established security, architecture, and change management standards
- Maintain technical documentation, runbooks, implementation procedures, and recovery plans
IT Security Operations
- Monitor, investigate, and respond to security events, alerts, vulnerabilities, and incidents across the technology environment
- Support endpoint protection, identity security, privileged access, vulnerability management, logging, and other security technologies
- Partner with stakeholders to identify, assess, and remediate security risks and configuration gaps
- Support identity and access platforms, including Microsoft Entra ID, Active Directory, and Okta
- Participate in incident response activities, including investigation, containment, remediation, recovery, and documentation
- Assist with audit, compliance, and security review activities by collecting technical evidence and validating controls
- Contribute to the continuous improvement of security monitoring, processes, documentation, and operational procedures
- Help strengthen Vir's security posture by identifying opportunities to improve controls, visibility, and response capabilities
Across both areas, you will serve as a senior technical resource, partnering closely with IT, Security, business stakeholders, managed service providers, and vendors to resolve complex issues, implement technical solutions, and drive operational excellence through clear communication, documentation, and continuous improvement.
WHO YOU ARE AND WHAT YOU BRING
- Extensive hands-on experience in infrastructure engineering, systems administration, cybersecurity, or a related enterprise IT role
- Strong experience supporting and securing Windows, macOS, Windows Server, and Linux environments
- Experience with cloud technologies, preferably AWS, along with enterprise networking, identity and access management, and endpoint management solutions
- Hands-on experience investigating security events, responding to incidents, and remediating vulnerabilities and operational risks
- Experience supporting enterprise security technologies, including endpoint protection, privileged access, firewalls, and remote access solutions
- Strong scripting and automation skills using PowerShell, Python, or similar technologies
- Demonstrated ability to troubleshoot complex issues across multiple systems and stakeholders
- Strong communication and documentation skills, with the ability to clearly explain technical risks and solutions to both technical and non-technical audiences
- Ability to work independently, manage competing priorities, and drive issues through resolution
- Experience in a regulated industry (biotechnology, pharmaceutical, healthcare, or similar), familiarity with security frameworks such as NIST or CIS Controls, and relevant cloud, infrastructure, networking, or security certifications are preferred
WHO WE ARE AND WHAT WE OFFER
The expected hourly range for this position is $65.00 to $90.00. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors.
Applicants must currently be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.
All employment decisions at Vir Biotechnology are based on legitimate, non-discriminatory business requirements, job duties and individual qualifications. Employment decisions are made without regard to any legally protected characteristics.
This commitment extends to all management practices and decisions, including recruitment and hiring, compensation, appraisal systems, promotions, training and career development programs. Vir Biotechnology also strongly commits to providing employees with a work environment free of unlawful conduct or harassment.
Vir Biotechnology Human Resources leads recruitment and employment for Vir Biotechnology. Unsolicited resumes sent to the company from recruiters do not constitute any type of relationship between the recruiter and Vir Biotechnology and do not obligate us to pay fees should we hire from those resumes. We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring manager or employees.
For hires based in the United States, Vir Biotechnology, participates in E-Verify.
Candidate Privacy Notice
Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN® dual-masked T-cell engagers across validated targets in solid tumor indications. Vir Biotechnology also has a preclinical portfolio of programs across a range of infectious diseases and oncologic malignancies.
Vir Biotechnology has exclusive rights to the universal PRO-XTEN® masking platform for oncology and infectious disease. PRO-XTEN® is a trademark of Amunix Pharmaceuticals, Inc., a Sanofi company.
We believe the success of our colleagues drives the success of our mission. We are committed to creating a company where everyone feels supported and encouraged to give their best.
THE OPPORTUNITY
Vir Biotechnology is seeking a Senior Infrastructure & IT Security Engineer (Temp Staff) to join our IT team. This is a senior, hands-on individual contributor role that combines IT infrastructure engineering and security operations. In this role, you will help maintain, secure, troubleshoot, and continuously improve the technology that enables Vir Bio's business and scientific mission, spanning endpoints, identity platforms, cloud services, servers, networking, virtualization, and security tools.
The successful candidate is an execution-focused technology professional who enjoys solving complex technical challenges, takes ownership from problem identification through resolution, and balances security, reliability, and user experience. You are a collaborative partner who can navigate ambiguity, communicate clearly, document thoroughly, and identify opportunities to strengthen systems, automate processes, and improve operational excellence.
This role is located in our San Francisco headquarters with an expectation of 4 days per week in office.
WHAT YOU'LL DO
What You'll Do
Infrastructure Engineering & Operations
- Implement, maintain, and enhance infrastructure across cloud, on-premises, and hybrid environments
- Administer and support Windows, macOS, Windows Server, and Linux environments, including patching, monitoring, troubleshooting, and lifecycle management
- Support AWS infrastructure, enterprise networking, virtualization platforms, and remote access technologies
- Manage identity, access management, endpoint technologies, and core infrastructure services
- Troubleshoot complex issues spanning endpoints, applications, cloud services, networks, and third-party systems
- Develop automation and scripting solutions to improve efficiency, consistency, and operational visibility
- Execute infrastructure changes in accordance with established security, architecture, and change management standards
- Maintain technical documentation, runbooks, implementation procedures, and recovery plans
IT Security Operations
- Monitor, investigate, and respond to security events, alerts, vulnerabilities, and incidents across the technology environment
- Support endpoint protection, identity security, privileged access, vulnerability management, logging, and other security technologies
- Partner with stakeholders to identify, assess, and remediate security risks and configuration gaps
- Support identity and access platforms, including Microsoft Entra ID, Active Directory, and Okta
- Participate in incident response activities, including investigation, containment, remediation, recovery, and documentation
- Assist with audit, compliance, and security review activities by collecting technical evidence and validating controls
- Contribute to the continuous improvement of security monitoring, processes, documentation, and operational procedures
- Help strengthen Vir's security posture by identifying opportunities to improve controls, visibility, and response capabilities
Across both areas, you will serve as a senior technical resource, partnering closely with IT, Security, business stakeholders, managed service providers, and vendors to resolve complex issues, implement technical solutions, and drive operational excellence through clear communication, documentation, and continuous improvement.
WHO YOU ARE AND WHAT YOU BRING
- Extensive hands-on experience in infrastructure engineering, systems administration, cybersecurity, or a related enterprise IT role
- Strong experience supporting and securing Windows, macOS, Windows Server, and Linux environments
- Experience with cloud technologies, preferably AWS, along with enterprise networking, identity and access management, and endpoint management solutions
- Hands-on experience investigating security events, responding to incidents, and remediating vulnerabilities and operational risks
- Experience supporting enterprise security technologies, including endpoint protection, privileged access, firewalls, and remote access solutions
- Strong scripting and automation skills using PowerShell, Python, or similar technologies
- Demonstrated ability to troubleshoot complex issues across multiple systems and stakeholders
- Strong communication and documentation skills, with the ability to clearly explain technical risks and solutions to both technical and non-technical audiences
- Ability to work independently, manage competing priorities, and drive issues through resolution
- Experience in a regulated industry (biotechnology, pharmaceutical, healthcare, or similar), familiarity with security frameworks such as NIST or CIS Controls, and relevant cloud, infrastructure, networking, or security certifications are preferred
WHO WE ARE AND WHAT WE OFFER
The expected hourly range for this position is $65.00 to $90.00. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors.
Applicants must currently be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.
All employment decisions at Vir Biotechnology are based on legitimate, non-discriminatory business requirements, job duties and individual qualifications. Employment decisions are made without regard to any legally protected characteristics.
This commitment extends to all management practices and decisions, including recruitment and hiring, compensation, appraisal systems, promotions, training and career development programs. Vir Biotechnology also strongly commits to providing employees with a work environment free of unlawful conduct or harassment.
Vir Biotechnology Human Resources leads recruitment and employment for Vir Biotechnology. Unsolicited resumes sent to the company from recruiters do not constitute any type of relationship between the recruiter and Vir Biotechnology and do not obligate us to pay fees should we hire from those resumes. We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring manager or employees.
For hires based in the United States, Vir Biotechnology, participates in E-Verify.
Candidate Privacy Notice
See All 140+ Senior IT Engineer Jobs in San Francisco
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Find Senior IT Engineer JobsSenior IT Engineer Job Market in San Francisco
Who's Hiring
- Sephora10
- PwC5
- Axon5
- Drata5
- CRUSOE5
Top Industries Hiring
- Technology & Software21
- Science & Research5
- Government & Public Sector5
- Banking & Financial Services5
- Investment & Asset Management5
Senior IT Engineer Jobs in San Francisco: Frequently Asked Questions
How do I get a senior it engineer job in San Francisco?
Focus on the sectors that hire most heavily in San Francisco: enterprise software, fintech, cloud infrastructure, and biotech. Employers in SoMa, the Financial District, and Mission Bay consistently post senior-level openings. Candidates with hands-on experience in cloud platforms, network architecture, or systems integration get the most traction here. Tailoring your application to the specific stack or environment each company uses gives you a clear edge over generalist applicants.
Which companies hire senior it engineers in San Francisco?
Companies currently hiring senior it engineers in San Francisco include Sephora, PwC, and Axon, per current listings on Migrate Mate as of September 2026. San Francisco's employer mix runs from global technology firms and major financial institutions to fast-growing healthtech and SaaS companies, so openings appear across a wide range of industries and company sizes.
Are there remote senior it engineer jobs in San Francisco?
Yes, though it varies by specialization: roles focused on software, cloud, and analytics tend to be remote-friendly, while positions requiring hands-on data center or on-site infrastructure work are mostly in person. About 73% of senior it engineer openings tied to San Francisco are remote or hybrid as of September 2026, reflecting the city's strong technology culture. Cloud engineering and IT management roles within San Francisco's SaaS and fintech sectors are the most likely to offer remote flexibility.
How can I get a senior it engineer job in San Francisco with little or no experience?
The most realistic entry path is targeting associate or mid-level IT roles at San Francisco's many mid-size SaaS and fintech companies, which tend to hire more junior talent and promote from within. Contract and project-based positions at technology services firms in SoMa are another common door in. Building experience with cloud platforms and earning vendor certifications strengthens applications significantly in this market. Local professional groups and university alumni networks tied to UCSF and SF State also connect candidates to early-career openings.
Which industries hire the most senior it engineers in San Francisco?
Most senior it engineer openings in San Francisco sit in Technology & Software, Science & Research, and Government & Public Sector, per current listings on Migrate Mate as of September 2026. San Francisco's concentration of enterprise software headquarters, financial technology companies, and biotech and healthcare organizations in neighborhoods like Mission Bay and the Financial District makes those sectors the primary drivers of local demand.
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