Software Applications Engineer Jobs in Houston, TX
Software Applications Engineer jobs in Houston are concentrated in the Energy Corridor, Greenway Plaza, and the Texas Medical Center, with strong demand from energy technology, aerospace, and healthcare IT. Employers actively hiring include Houston Methodist, Citi, and Kirkland & Ellis. Find a role that fits below and apply directly.
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INTRODUCTION
The Senior Applications Systems Analyst at The University of Texas MD Anderson Cancer Center plays a critical role in advancing enterprise development and integration efforts within the Enterprise Dev & Integration department. The Senior Applications Systems Analyst provides technical and functional expertise in developing and supporting secure, web-based data collection, storage, integration, and reporting systems while also mentoring team members and contributing to complex system design and implementation. The Senior Applications Systems Analyst is essential in shaping system scope, guiding analysis, and ensuring high-quality delivery across projects.
The Senior Applications Systems Analyst contributes to mission-critical systems that support clinical, research, and operational excellence, working in a collaborative environment that values innovation, technical leadership, and continuous improvement.
The ideal candidate brings a strong educational foundation in computer science or data science, along with demonstrated experience in software development, relational databases, and Python. This individual is experienced in enterprise systems, thrives in analytical and design-driven environments, and is capable of mentoring others while contributing to both technical execution and strategic direction.
Minimum $106,500 - Midpoint $133,000 - Maximum $159,500
Work Location: 100% remote within Texas, with onsite presence in the medical center a few times per month. Prefer a local candidate.
Why Us?
This role offers the opportunity to drive impactful technical solutions that directly support UT MD Anderson's mission to eliminate cancer. As a Senior Applications Systems Analyst, you will lead complex projects, mentor team members, and work with cutting-edge technologies in a collaborative and flexible environment that supports professional growth and work-life balance.
- Employer-paid medical coverage starting day one for employees working 30+ hours/week, plus optional group dental, vision, life, AD&D, and disability insurance.
- Accruals for PTO and Extended Illness Bank, plus paid holidays, wellness, childcare, and other leave options.
- Tuition Assistance Program after six months of service and access to extensive wellness, fitness, and employee resource groups.
- Defined-benefit pension through the Teachers Retirement System, voluntary retirement plans, and employer-paid life and reduced salary protection programs.
Responsibilities
Application & Systems Development and Support
- Write and test code using C#, Microsoft .NET, JavaScript, and HTML5
- Develop and support secure web-based applications for data collection, storage, and reporting
- Work with Microsoft SQL and Oracle databases to maintain and enhance system performance
- Provide ongoing technical support to customers and stakeholders
- Participate in assigned development and integration projects
Analysis & System Design
- Conduct project analysis to define system scope and objectives
- Collaborate with project resources to gather and document requirements
- Design and modify complex information systems aligned to organizational needs
- Perform research and analysis to support system improvements and innovation
Documentation
- Document code to ensure maintainability and knowledge transfer
- Develop technical and functional documentation for systems
- Create user guides and supporting materials for end users
Mentoring & Leadership
- Provide technical mentorship and guidance to team members
- Share expertise in development tools and best practices
- Support team development through knowledge sharing and collaboration
- May serve as a product owner when assigned
ADDITIONAL DUTIES
- Perform other duties as assigned
Education
- Required: Bachelor's Degree
- Preferred: Bachelor's or Master's degree in Computer Science or Data Science degree.
WORK EXPERIENCE
- Required: 5 years Experience in epic software, domain, analysis, design, project management, or programming.
- May substitute required education degree with additional years of equivalent experience on a one to one basis.
Preferred: At least 5 years of software development experience, 3 years relational database experience, 3 years of Python experience.
The University of Texas MD Anderson Cancer Center offers excellent benefits, including medical, dental, paid time off, retirement, tuition benefits, educational opportunities, and individual and team recognition.
This position may be responsible for maintaining the security and integrity of critical infrastructure, as defined in Section 113.001(2) of the Texas Business and Commerce Code and therefore may require routine reviews and screening. The ability to satisfy and maintain all requirements necessary to ensure the continued security and integrity of such infrastructure is a condition of hire and continued employment.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state, or local laws unless such distinction is required by law.
Additional Information
- Requisition ID: 181430
- Employment Status: Full-Time
- Employee Status: Regular
- Work Week: Days
- Minimum Salary: US Dollar (USD) 106,500
- Midpoint Salary: US Dollar (USD) 133,000
- Maximum Salary: US Dollar (USD) 159,500
- FLSA: exempt and not eligible for overtime pay
- Fund Type: Soft
- Work Location: Remote (within Texas only)
- Pivotal Position: Yes
- Referral Bonus Available?: No
- Relocation Assistance Available?: No
LI-Remote
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Find JobsSoftware Applications Engineer Job Market in Houston
Who's Hiring
- Houston Methodist5

- Citi2

- Kirkland & Ellis2

- Zeeco1

- Draper1

Top Industries Hiring
- Healthcare & Medical Services6
- Energy3
- Technology & Software3
- Construction & Real Estate3
- Manufacturing2
Software Applications Engineer Jobs in Houston: Frequently Asked Questions
How do I get a software applications engineer job in Houston?
Focus your search on Houston's energy technology, aerospace and defense, and healthcare IT sectors, which consistently drive the most local openings. The Energy Corridor, Greenway Plaza, and downtown Houston are the densest hiring clusters. Candidates who demonstrate experience integrating software with industrial systems, embedded hardware, or clinical platforms have a clear edge in this market over those with purely web-focused backgrounds.
Which companies hire software applications engineers in Houston?
Companies currently hiring software applications engineers in Houston include Houston Methodist, Citi, and Kirkland & Ellis, per current listings on Migrate Mate as of June 2026. Houston's employer mix skews heavily toward energy operators, aerospace contractors, and large hospital systems, all of which maintain in-house engineering teams and hire on a rolling basis.
Are there remote software applications engineer jobs in Houston?
Yes, though availability depends on the role: software applications engineers doing pure application development or integration work are frequently remote-eligible, while roles tied to on-site industrial control systems or lab environments typically require a physical presence. About 27% of software applications engineer openings tied to Houston are remote or hybrid as of June 2026, and the energy and healthcare sectors offer the most hybrid arrangements locally.
How can I get a software applications engineer job in Houston with little or no experience?
The most realistic entry path in Houston is targeting junior or associate engineer roles at mid-size energy technology vendors and healthcare IT firms in the Medical Center and Greenway Plaza areas, which hire regularly at the entry level. Internships with Houston-area aerospace contractors or oilfield services companies also convert to full-time roles at a high rate. Building a portfolio that demonstrates API integration, embedded systems, or clinical workflow automation aligns directly with what Houston employers prioritize.
Which industries hire the most software applications engineers in Houston?
The sectors hiring the most software applications engineers in Houston are Healthcare & Medical Services, Energy, and Technology & Software, based on current listings on Migrate Mate as of June 2026. Houston's role as a global energy hub and home to the Texas Medical Center means demand is driven by the need to build and maintain mission-critical applications in both industrial and clinical environments.
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