Software Engineer Visa Sponsorship Jobs in California
California is the largest market for software engineer visa sponsorship in the United States, driven by Silicon Valley giants like Google, Apple, Meta, and Salesforce alongside thousands of startups across San Francisco, San Jose, and Los Angeles. The state's concentration of H-1B-dependent tech employers makes it one of the most active states for international software engineering hires.
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INTRODUCTION
Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon’s discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real-time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets.
POSITION
Are you a passionate Software Engineer looking to bring cutting-edge software solutions to drug discovery? Join our mission to bring novel therapeutics to patients and be at the forefront of driving innovation through technology. As a Software Engineer 2, you will leverage your expertise to develop and implement software solutions that drive our groundbreaking scientific initiatives.
ABOUT YOU
The ideal candidate for this role thrives at the intersection of software and scientific discovery. You are proficient with production-quality Python codebases and can contribute to, maintain, and extend these codebases in a robust and scalable way. At the same time, you understand the fast pace of scientific discovery, and can collaborate with scientists to clarify requirements, focus on result rather than implementation, and keep projects moving forward. You are a strong communicator, especially to non-engineers, as well as a strong team player, always ready to pitch in to help a colleague. You are a continual learner with a growth mindset, eager to learn from your colleagues and expand your talents in a supportive environment and are excited about our mission to bring drugs to patients.
WHAT YOU’LL DO
- Work with scientists to understand data generated by early drug discovery projects and provide custom analyses and/or production software solutions to answer key questions about the data.
- Build, maintain, and extend tools that deliver machine-learning-based as well as classical algorithmic solutions to scientists.
- Contribute to the continuous improvement of software development processes, tools, and methodologies.
- Conduct thorough code reviews, promoting best practices and identifying opportunities for code optimization and enhancement.
- Collaborate with team members, sharing insights and fostering a culture of knowledge sharing and learning.
- Uphold ethical and data privacy standards in all software engineering activities.
QUALIFICATIONS
- BS in Computer Science, Mathematics, Physics, Bioinformatics, Biophysics, or a related field, plus 2 years of relevant experience, or equivalent work experience.
- Demonstrated experience (2+ years) with Python; familiarity with scientific programming packages (pandas, numpy) and/or machine learning frameworks (TensorFlow) a plus.
- Undergraduate level biology knowledge required; experience manipulating and analyzing biologically relevant data sets strongly desired (e.g. sequencing data, cellular imaging data, etc).
- Introductory coursework on deep learning or other modern ML approaches, or equivalent work experience, a plus.
- Familiarity with basic software best practices (CI/CD, unit testing, version control, etc.) highly preferred.
- Strong analytical and problem-solving skills, with the ability to think critically and creatively to overcome technical challenges.
- Effective communication skills to collaborate with diverse teams, both technical and non-technical, especially across disciplines.
- Demonstrated ability to thrive in a fast-paced, dynamic work environment.
At Eikon, employee compensation also includes bonus and equity compensation, in addition to several generous benefit programs, including:
- 401k plan with company matching
- Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%)
- Mental health and wellness benefits
- Weeklong summer and winter holiday shutdowns
- Generous paid time off and holiday policies
- Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies
- Enhanced parental leave benefit
- Daily subsidized lunch program when on-site
The expected salary range for this role is $135,000 to $147,250 depending on skills, competency, and the market demand for your expertise.
Eikon is proud to be an equal opportunity employer and will consider all qualified applicants for employment. We are currently not accepting any new third-party agencies or firms at this time. Please do not forward unsolicited agency resumes to our website, employees or Human Resources. Eikon Therapeutics will not pay fees to any third-party agency or firm associated with unsolicited resumes.

INTRODUCTION
Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon’s discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real-time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets.
POSITION
Are you a passionate Software Engineer looking to bring cutting-edge software solutions to drug discovery? Join our mission to bring novel therapeutics to patients and be at the forefront of driving innovation through technology. As a Software Engineer 2, you will leverage your expertise to develop and implement software solutions that drive our groundbreaking scientific initiatives.
ABOUT YOU
The ideal candidate for this role thrives at the intersection of software and scientific discovery. You are proficient with production-quality Python codebases and can contribute to, maintain, and extend these codebases in a robust and scalable way. At the same time, you understand the fast pace of scientific discovery, and can collaborate with scientists to clarify requirements, focus on result rather than implementation, and keep projects moving forward. You are a strong communicator, especially to non-engineers, as well as a strong team player, always ready to pitch in to help a colleague. You are a continual learner with a growth mindset, eager to learn from your colleagues and expand your talents in a supportive environment and are excited about our mission to bring drugs to patients.
WHAT YOU’LL DO
- Work with scientists to understand data generated by early drug discovery projects and provide custom analyses and/or production software solutions to answer key questions about the data.
- Build, maintain, and extend tools that deliver machine-learning-based as well as classical algorithmic solutions to scientists.
- Contribute to the continuous improvement of software development processes, tools, and methodologies.
- Conduct thorough code reviews, promoting best practices and identifying opportunities for code optimization and enhancement.
- Collaborate with team members, sharing insights and fostering a culture of knowledge sharing and learning.
- Uphold ethical and data privacy standards in all software engineering activities.
QUALIFICATIONS
- BS in Computer Science, Mathematics, Physics, Bioinformatics, Biophysics, or a related field, plus 2 years of relevant experience, or equivalent work experience.
- Demonstrated experience (2+ years) with Python; familiarity with scientific programming packages (pandas, numpy) and/or machine learning frameworks (TensorFlow) a plus.
- Undergraduate level biology knowledge required; experience manipulating and analyzing biologically relevant data sets strongly desired (e.g. sequencing data, cellular imaging data, etc).
- Introductory coursework on deep learning or other modern ML approaches, or equivalent work experience, a plus.
- Familiarity with basic software best practices (CI/CD, unit testing, version control, etc.) highly preferred.
- Strong analytical and problem-solving skills, with the ability to think critically and creatively to overcome technical challenges.
- Effective communication skills to collaborate with diverse teams, both technical and non-technical, especially across disciplines.
- Demonstrated ability to thrive in a fast-paced, dynamic work environment.
At Eikon, employee compensation also includes bonus and equity compensation, in addition to several generous benefit programs, including:
- 401k plan with company matching
- Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%)
- Mental health and wellness benefits
- Weeklong summer and winter holiday shutdowns
- Generous paid time off and holiday policies
- Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies
- Enhanced parental leave benefit
- Daily subsidized lunch program when on-site
The expected salary range for this role is $135,000 to $147,250 depending on skills, competency, and the market demand for your expertise.
Eikon is proud to be an equal opportunity employer and will consider all qualified applicants for employment. We are currently not accepting any new third-party agencies or firms at this time. Please do not forward unsolicited agency resumes to our website, employees or Human Resources. Eikon Therapeutics will not pay fees to any third-party agency or firm associated with unsolicited resumes.
Software Engineer Job Roles in California
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Search Software Engineer Jobs in CaliforniaSoftware Engineer Jobs in California: Frequently Asked Questions
Which companies sponsor visas for software engineers in California?
California's largest H-1B sponsors for software engineering roles include Google, Apple, Meta, Amazon, Salesforce, Intel, Nvidia, Adobe, and Intuit, along with hundreds of mid-size and early-stage startups headquartered in the Bay Area and Los Angeles. Both large tech employers and well-funded startups regularly file H-1B petitions for software engineers, though each company has its own internal sponsorship policies and timelines.
Which visa types are most common for software engineer roles in California?
The H-1B is by far the most common visa for software engineers in California, given the role typically qualifies as a specialty occupation requiring at least a bachelor's degree in computer science or a related field. L-1B visas are used by multinational companies transferring engineers with specialized knowledge. Australian citizens may qualify for the E-3, which has no lottery and is employer-sponsored similarly to the H-1B.
Which cities in California have the most software engineer sponsorship jobs?
San Jose and the broader South Bay corridor, including Sunnyvale, Mountain View, and Santa Clara, have the highest concentration of software engineer sponsorship roles due to the density of major tech campuses. San Francisco follows closely, particularly for startup and fintech employers. Los Angeles has grown significantly as a tech hub, with strong demand from entertainment technology, e-commerce, and aerospace software companies.
How to find software engineer visa sponsorship jobs in California?
Migrate Mate is built specifically for international software engineers looking for visa sponsorship jobs in California. Every listing on Migrate Mate is filtered to show employers with a documented history of sponsoring work visas, so you're not wasting applications on companies that won't sponsor. You can filter by California location and software engineering roles to see active openings from Bay Area, Los Angeles, and San Diego employers.
Are there any California-specific factors software engineers should know before applying for sponsored roles?
California enforces its own labor protections that interact with federal H-1B prevailing wage requirements, so sponsored software engineers in the state are generally offered wages benchmarked to some of the highest prevailing wage levels in the country given the cost of living in tech hubs like San Francisco and San Jose. California also has a strong university-to-industry pipeline through UC Berkeley, Stanford, UCLA, and USC, meaning many employers are experienced with OPT-to-H-1B transitions for recent graduates.
What is the prevailing wage for sponsored software engineer jobs in California?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.
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