ML Engineer Visa Sponsorship Jobs in Massachusetts
Massachusetts is one of the strongest states for ML engineer visa sponsorship, with major employers like Amazon, Microsoft, HubSpot, and Wayfair concentrated in Greater Boston and Cambridge. The Route 128 tech corridor and a dense cluster of biotech and AI research firms create steady demand for machine learning talent requiring H-1B visa and other work visa support.
Find ML Engineer JobsOverview
Showing 5 of 619+ ML Engineer Jobs in Massachusetts with Visa Sponsorship
See all 619+ ML Engineer Jobs in Massachusetts with Visa Sponsorship
Sign up for free to unlock all listings, filter by visa type, and get alerts for new ML Engineer Jobs in Massachusetts with Visa Sponsorship.
Get Access To All JobsJob Title: Protein ML Senior Principal Data Scientist
Location: Waltham, MA
About the Job:
As Protein ML Senior Principal Data Scientist within our Vaccines R&D Data and Computational Sciences team, you'll design and deploy state-of-the-art machine learning models that predict protein properties and accelerate the development of next-generation vaccines. Ready to get started?
In this role, you will harness the power of protein language models and foundational AI to predict immunogenicity, stability, and manufacturability — properties that are critical to bringing safe, effective vaccines to the world. Working at the interface of computational and experimental science, you will collaborate closely with antigen design and bench lab teams to iteratively refine protein property predictors and translate computational insights into real-world vaccine candidates.
Join the team protecting half a billion lives every year with next-gen science, mRNA innovation, and AI-driven breakthroughs. In Vaccines, you'll help advance prevention on a global scale - and shape the future of immunization.
Main Responsibilities:
- Develop state-of-the-art protein property prediction models with a focus on immunogenicity, stability, and manufacturability to support vaccine design.
- Leverage and refine language-based foundational protein representations to accelerate the identification and optimization of vaccine candidates.
- Analyze complex relationships between protein sequences, structures, and functional data to uncover generalizable representations applicable across vaccine programs.
- Collaborate with structural biology, protein design, and bench lab teams to shape the strategy for protein modeling and to iteratively improve model quality.
- Maintain the modeling codebase according to best coding practices, ensuring results are robust, reproducible, and well-documented.
- Mentor and upskill colleagues on the latest advances in protein modeling tools and techniques, fostering a culture of continuous learning and scientific rigor.
- Communicate scientific findings clearly and compellingly to a broad range of internal and external stakeholders, adapting the level of detail to each audience.
About You:
Education
- PhD degree in Computational Biology, Data Science, Applied Mathematics, Biophysics or a closely related field.
Experience
- 2+ years of industry or academic setting experience.
Preferred Qualifications
- Exceptional track record in computational biology, encompassing protein language models, biophysics, and the development of AI-based predictive models; prior experience with immunogenicity predictors is a plus.
- Advanced proficiency in Python, R, and SQL, with hands-on experience in PyTorch and AI-based structural modeling tools such as AlphaFold, OpenFold, and Boltz.
- Deep knowledge of protein representation models such as ESM.
- Familiarity with molecular dynamics, next-generation sequencing analysis, and deep mutational scanning is an advantage.
- Familiarity with agentic tools such as Claude Code for automated software engineering strongly preferred.
- Demonstrated ability to communicate fluently — in writing and in person — across computational and bench lab teams, adapting messaging to diverse audiences including senior leadership.
- Proven ability to mentor junior colleagues and lead collaboratively in the area of protein modeling.
- Strong problem-solving, communication, and collaboration skills across multidisciplinary teams.
Language
- Fluent English required.
Why choose us?
- Bring the miracles of science to life alongside a supportive, future-focused team.
- Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
- Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
- Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
- Work at the forefront of AI-driven research, smart manufacturing, and groundbreaking mRNA platforms that are redefining the future of immunology.
- Help protect half a billion people every year, contributing to one of the largest global vaccination efforts in healthcare.
- Develop your career with access to mentoring, international mobility programs, and opportunities to grow across four continents.
Sanofi US Services and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.
Job Title: Protein ML Senior Principal Data Scientist
Location: Waltham, MA
About the Job:
As Protein ML Senior Principal Data Scientist within our Vaccines R&D Data and Computational Sciences team, you'll design and deploy state-of-the-art machine learning models that predict protein properties and accelerate the development of next-generation vaccines. Ready to get started?
In this role, you will harness the power of protein language models and foundational AI to predict immunogenicity, stability, and manufacturability — properties that are critical to bringing safe, effective vaccines to the world. Working at the interface of computational and experimental science, you will collaborate closely with antigen design and bench lab teams to iteratively refine protein property predictors and translate computational insights into real-world vaccine candidates.
Join the team protecting half a billion lives every year with next-gen science, mRNA innovation, and AI-driven breakthroughs. In Vaccines, you'll help advance prevention on a global scale - and shape the future of immunization.
Main Responsibilities:
- Develop state-of-the-art protein property prediction models with a focus on immunogenicity, stability, and manufacturability to support vaccine design.
- Leverage and refine language-based foundational protein representations to accelerate the identification and optimization of vaccine candidates.
- Analyze complex relationships between protein sequences, structures, and functional data to uncover generalizable representations applicable across vaccine programs.
- Collaborate with structural biology, protein design, and bench lab teams to shape the strategy for protein modeling and to iteratively improve model quality.
- Maintain the modeling codebase according to best coding practices, ensuring results are robust, reproducible, and well-documented.
- Mentor and upskill colleagues on the latest advances in protein modeling tools and techniques, fostering a culture of continuous learning and scientific rigor.
- Communicate scientific findings clearly and compellingly to a broad range of internal and external stakeholders, adapting the level of detail to each audience.
About You:
Education
- PhD degree in Computational Biology, Data Science, Applied Mathematics, Biophysics or a closely related field.
Experience
- 2+ years of industry or academic setting experience.
Preferred Qualifications
- Exceptional track record in computational biology, encompassing protein language models, biophysics, and the development of AI-based predictive models; prior experience with immunogenicity predictors is a plus.
- Advanced proficiency in Python, R, and SQL, with hands-on experience in PyTorch and AI-based structural modeling tools such as AlphaFold, OpenFold, and Boltz.
- Deep knowledge of protein representation models such as ESM.
- Familiarity with molecular dynamics, next-generation sequencing analysis, and deep mutational scanning is an advantage.
- Familiarity with agentic tools such as Claude Code for automated software engineering strongly preferred.
- Demonstrated ability to communicate fluently — in writing and in person — across computational and bench lab teams, adapting messaging to diverse audiences including senior leadership.
- Proven ability to mentor junior colleagues and lead collaboratively in the area of protein modeling.
- Strong problem-solving, communication, and collaboration skills across multidisciplinary teams.
Language
- Fluent English required.
Why choose us?
- Bring the miracles of science to life alongside a supportive, future-focused team.
- Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
- Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
- Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
- Work at the forefront of AI-driven research, smart manufacturing, and groundbreaking mRNA platforms that are redefining the future of immunology.
- Help protect half a billion people every year, contributing to one of the largest global vaccination efforts in healthcare.
- Develop your career with access to mentoring, international mobility programs, and opportunities to grow across four continents.
Sanofi US Services and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.
ML Engineer Job Roles in Massachusetts
See all 619+ ML Engineer Jobs in Massachusetts
Sign up for free to filter by visa type, set job alerts, and find employers with verified sponsorship history.
Search ML Engineer Jobs in MassachusettsML Engineer Jobs in Massachusetts: Frequently Asked Questions
Which companies sponsor visas for ML engineers in Massachusetts?
Several large employers in Massachusetts have a documented history of sponsoring work visas for ML engineers. Amazon, Microsoft, Wayfair, HubSpot, and Biogen consistently file H-1B petitions for machine learning roles. Boston-area AI startups and biotech firms, including those clustered around Kendall Square in Cambridge, also sponsor regularly, though their volume is smaller than enterprise employers.
Which visa types are most common for ML engineer roles in Massachusetts?
The H-1B is by far the most common visa for ML engineers in Massachusetts, as the role qualifies as a specialty occupation requiring at least a bachelor's degree in computer science, statistics, or a related field. Candidates with extraordinary ability may qualify for the O-1A. Recent graduates on F-1 OPT, particularly those with STEM degrees, can work for up to three years before needing employer-sponsored H-1B status.
How to find ml engineer visa sponsorship jobs in Massachusetts?
Migrate Mate filters job listings specifically by visa sponsorship availability, making it easier to identify ML engineer roles in Massachusetts where employers are actively open to sponsoring. Rather than sorting through general job boards, you can search directly for machine learning positions in Boston, Cambridge, and surrounding tech hubs where sponsorship is confirmed, saving time during a job search that often runs on a tight visa timeline.
Which cities in Massachusetts have the most ML engineer sponsorship jobs?
Boston and Cambridge together account for the majority of ML engineer sponsorship activity in Massachusetts. Cambridge's Kendall Square is particularly dense with AI-focused companies and research institutions. Waltham and Burlington along the Route 128 corridor host established tech and biotech employers who regularly sponsor. Worcester has a smaller but growing presence tied to university-affiliated research and regional tech employers.
Are there any Massachusetts-specific factors ML engineers should know about visa sponsorship?
Massachusetts employers sponsoring H-1B workers must meet Department of Labor prevailing wage requirements, which in the Boston metro area reflect a high-cost, competitive market for ML talent. The state's strong university pipeline, including MIT, Harvard, and Northeastern, means many sponsored candidates transition from F-1 OPT. Biotech and AI research firms in the area often sponsor for highly specialized roles, which can strengthen the specialty occupation determination in an H-1B petition.
What is the prevailing wage for sponsored ml engineer jobs in Massachusetts?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.