Director of Information Systems Jobs in USA with Visa Sponsorship
Director of Information Systems roles qualify as H-1B visa specialty occupations, making employer sponsorship a realistic path for international candidates with a relevant bachelor's degree. Large enterprises and healthcare systems file LCAs regularly for this title. No lottery exemptions apply, but the PERM green card route is well-established for senior IT leadership roles.
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Get Access To All JobsWho We Are:
Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.
What We Do:
We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we submitted a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.
About the Role:
We are seeking a Senior Manager/Associate Director, Enterprise Information Systems to join our Information Technology (IT) team.
The position reports to the Director, Enterprise Information Systems and will serve as the primary IT system owner for Xenon’s future Human Capital Management (HCM) system as well as other key HR systems. This individual will play a key role in the implementation of Workday HCM, including Payroll, at Xenon, ensuring the system configuration fits the functional requirements and the appropriate controls (including SOX) are in place. This individual will also partner with leaders across HR, Finance, IT, and other functions as needed to drive adoption, operations, and ongoing enhancements to the HCM ecosystem, as well as support other G&A systems.
This position will be based out of Boston, MA, USA in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. This role is a hybrid position, requiring a minimum of 2 days per week in the office.
Responsibilities:
- Partnering with key HR and Finance stakeholders, manage and facilitate the implementation and adoption of Xenon’s HCM platform (Workday HCM) including design, configuration, testing, documentation, and adoption. Communicate key updates to relevant stakeholders to ensure the implementation meets milestones within agreed-to timelines.
- Support HCM-related process improvement initiatives across HR, Finance and other functions as needed.
- Collaborate with HR and Finance leadership on platform governance including developing a platform roadmap and prioritizing and coordinating change requests, enhancements and support tickets.
- Collaborate with Xenon’s Architecture Review Board to ensure the system design is consistent with company standards for security, infrastructure, and data architecture.
- Provide technical guidance and support on all Computer Software Assurance (CSA) deliverables and change control activities.
- Author, review, and approve applicable Software Development Lifecycle (SDLC) and CSA deliverables, and coordinate assurance and other testing activities.
- Develop, review, and approve procedures defining System Administration activities.
- Develop and manage the ongoing support model including onboarding and managing a qualified Application Management Services (AMS) provider.
- Ensure ongoing compliance with Xenon procedures including SaaS Release Management, Change Management, Problem Management, etc.
- Perform user administration and manage licensing and role-based access controls within the HCM.
- Own the SOX IT General Controls (ITGCs) related to the HCM – including collaborating with internal and external auditors to test and enhance controls as needed.
- Collaborate with colleagues to design, build and support technical integrations to/from the HCM.
- Serve as the IT System Owner for other key HR systems as needed.
- Support other G&A systems, including Oracle Fusion Cloud ERP and other Finance systems.
- Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics, and ensure policies are understood and followed by direct reports, if any.
- Some international travel may be required.
- Other duties as assigned.
QUALIFICATIONS
- Bachelor’s degree in Information Systems, Computer Science, Business Administration or related field.
- Minimum of 5-8 years of relevant experience, preferably in the Life Sciences industry.
- Proven experience as an HCM functional owner, HCM manager, or super user – preferably with Workday HCM implementation experience.
- Workday Pro Certification, e.g. HCM, Payroll, etc., a plus.
- Strong understanding of HR and Payroll business processes and SOX, including segregation of duties (SoD) principles.
- Knowledge of user management and role-based access controls. Knowledge of Workday security a plus.
- Experience with Computer Software Assurance/GxP Computer System Validation.
- Experience managing external consultants and vendors.
- Experience collaborating with HR and Finance counterparts to prioritize support and enhancement requests.
- Experience with system integrations (APIs, data flows, connectors).
Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short- & long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.
Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.
Compensation Range: $150K - $226.1K
Who We Are:
Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.
What We Do:
We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we submitted a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.
About the Role:
We are seeking a Senior Manager/Associate Director, Enterprise Information Systems to join our Information Technology (IT) team.
The position reports to the Director, Enterprise Information Systems and will serve as the primary IT system owner for Xenon’s future Human Capital Management (HCM) system as well as other key HR systems. This individual will play a key role in the implementation of Workday HCM, including Payroll, at Xenon, ensuring the system configuration fits the functional requirements and the appropriate controls (including SOX) are in place. This individual will also partner with leaders across HR, Finance, IT, and other functions as needed to drive adoption, operations, and ongoing enhancements to the HCM ecosystem, as well as support other G&A systems.
This position will be based out of Boston, MA, USA in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. This role is a hybrid position, requiring a minimum of 2 days per week in the office.
Responsibilities:
- Partnering with key HR and Finance stakeholders, manage and facilitate the implementation and adoption of Xenon’s HCM platform (Workday HCM) including design, configuration, testing, documentation, and adoption. Communicate key updates to relevant stakeholders to ensure the implementation meets milestones within agreed-to timelines.
- Support HCM-related process improvement initiatives across HR, Finance and other functions as needed.
- Collaborate with HR and Finance leadership on platform governance including developing a platform roadmap and prioritizing and coordinating change requests, enhancements and support tickets.
- Collaborate with Xenon’s Architecture Review Board to ensure the system design is consistent with company standards for security, infrastructure, and data architecture.
- Provide technical guidance and support on all Computer Software Assurance (CSA) deliverables and change control activities.
- Author, review, and approve applicable Software Development Lifecycle (SDLC) and CSA deliverables, and coordinate assurance and other testing activities.
- Develop, review, and approve procedures defining System Administration activities.
- Develop and manage the ongoing support model including onboarding and managing a qualified Application Management Services (AMS) provider.
- Ensure ongoing compliance with Xenon procedures including SaaS Release Management, Change Management, Problem Management, etc.
- Perform user administration and manage licensing and role-based access controls within the HCM.
- Own the SOX IT General Controls (ITGCs) related to the HCM – including collaborating with internal and external auditors to test and enhance controls as needed.
- Collaborate with colleagues to design, build and support technical integrations to/from the HCM.
- Serve as the IT System Owner for other key HR systems as needed.
- Support other G&A systems, including Oracle Fusion Cloud ERP and other Finance systems.
- Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics, and ensure policies are understood and followed by direct reports, if any.
- Some international travel may be required.
- Other duties as assigned.
QUALIFICATIONS
- Bachelor’s degree in Information Systems, Computer Science, Business Administration or related field.
- Minimum of 5-8 years of relevant experience, preferably in the Life Sciences industry.
- Proven experience as an HCM functional owner, HCM manager, or super user – preferably with Workday HCM implementation experience.
- Workday Pro Certification, e.g. HCM, Payroll, etc., a plus.
- Strong understanding of HR and Payroll business processes and SOX, including segregation of duties (SoD) principles.
- Knowledge of user management and role-based access controls. Knowledge of Workday security a plus.
- Experience with Computer Software Assurance/GxP Computer System Validation.
- Experience managing external consultants and vendors.
- Experience collaborating with HR and Finance counterparts to prioritize support and enhancement requests.
- Experience with system integrations (APIs, data flows, connectors).
Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short- & long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.
Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.
Compensation Range: $150K - $226.1K
See all 118+ Director of Information Systems Jobs
Sign up for free to unlock all listings, filter by visa type, and get alerts for new Director of Information Systems roles.
Get Access To All JobsTips for Finding Director of Information Systems Jobs
Align your degree to the role
USCIS requires a directly related field for specialty occupation approval. A degree in computer science, information systems, or MIS maps cleanly. A business degree alone can trigger an RFE, so document any graduate coursework that bridges the gap.
Target organizations with PERM filing history
Directors of Information Systems often reach the green card stage within two to four years. Prioritize employers in healthcare, financial services, and government contracting, sectors that routinely file PERM labor certifications for senior IT leadership roles.
Search verified sponsoring employers on Migrate Mate
Filter by Director of Information Systems roles on Migrate Mate to find employers with confirmed LCA filing history for this title. This cuts out companies that list the role but have never navigated H-1B sponsorship for it.
Clarify the LCA prevailing wage tier early
Use the OFLC Wage Search to look up the prevailing wage for your target metro before you receive an offer. Directors of Information Systems typically fall at Level III or IV. An offer below that threshold will fail the LCA certification stage.
Get your I-140 filed while still in H-1B status
Once your employer files an EB-2 or EB-3 I-140 petition, your priority date locks in. For candidates from most countries, approval protects your place in the green card queue even if you change employers later under AC21 portability rules.
Treat the job description as a legal document
PERM requires the employer to advertise the role at the minimum requirements, not your actual qualifications. If your offer letter lists a master's degree as preferred, that preference can complicate PERM if no equivalent U.S. worker applied. Review the job description language with your employer before the posting goes live.
Frequently Asked Questions
Does a Director of Information Systems role qualify as a specialty occupation for H-1B purposes?
Yes. USCIS recognizes Director of Information Systems as a specialty occupation because the role normally requires a bachelor's degree or higher in a directly related field such as computer science, information systems, or management information systems. If the job description allows any bachelor's degree, the employer should explicitly connect the IT management duties to a specific field to reduce RFE risk.
Which visa types realistically support sponsorship for this role?
H-1B is the most common path for international candidates. Australian nationals can use the E-3 visa, and Canadian or Mexican nationals may qualify under TN visa if the role maps to a recognized USMCA profession. Directors of Information Systems with significant accomplishments may also qualify for an O-1A. For long-term residence, EB-2 or EB-3 green card sponsorship through PERM is well-established at this seniority level.
How do I find employers who have actually sponsored this role before?
Migrate Mate shows employers with verified LCA filing history for Director of Information Systems positions, so you can prioritize companies that have completed the sponsorship process for this title rather than those encountering it for the first time.
Does my degree field matter, or is any bachelor's degree sufficient?
Field matters. USCIS expects a direct relationship between your degree and the job duties. Computer science, information systems, MIS, or a related technical field are the safest fit. A general business degree can support the application if you supplement it with graduate coursework in IT or certifications, but expect closer scrutiny and a possible RFE on specialty occupation grounds.
What makes PERM labor certification more complex for a Director of Information Systems than for lower-level IT roles?
At the director level, employers often want to list preferred qualifications like specific enterprise platforms, an MBA, or ten-plus years of experience. PERM restricts the job posting to minimum requirements, so any preferred qualifications must be stripped out. If the employer posted the role with elevated requirements before starting PERM, DOL may require a fresh recruitment cycle, adding months to the timeline.
What is the prevailing wage requirement for sponsored Director of Information Systems jobs?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.