Infrastructure And Operations Jobs in USA with Visa Sponsorship
Infrastructure and operations roles span system administration, cloud infrastructure, network engineering, and IT operations management, most of which qualify as specialty occupations under H-1B visa. Employers in finance, healthcare, and tech regularly sponsor these positions, and the E-3 visa is an underused option for Australian candidates. For detailed occupation requirements, see the O*NET profile.
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Get Access To All JobsINTRODUCTION
Karyopharm is seeking a Manager/Senior Manager, IT Infrastructure & Operations to serve as a senior individual contributor owning the architecture, reliability, and evolution of the company’s infrastructure environment, reporting to the VP, Information Technology. This is a hands-on role operating with a high degree of autonomy, partnering across IT, Security, and the business to design and run scalable, secure infrastructure across a mix of cloud and legacy systems in a regulated environment. This individual will lead complex initiatives end-to-end, drive modernization, and improve operational maturity across cloud and on-prem environments. Operating within a lean IT team, the role requires strong ownership, hands-on execution, and the ability to mentor others and influence infrastructure strategy without direct people management.
KEY RESPONSIBILITIES
Technical Leadership & Execution
- Serve as the senior technical lead for infrastructure design, architecture, and operations.
- Own and execute complex infrastructure initiatives end-to-end (design → build → optimize).
- Act as an escalation point for critical incidents and complex system issues.
- Lead by example through hands-on engineering, troubleshooting, and implementation work.
- Mentor and guide engineers through technical challenges, design reviews, and best practices (without direct management responsibility).
- Collaborate with IT Business Partners to identify and align solutions that balance meeting business needs and technical complexity.
Infrastructure Strategy & Modernization
- Drive cloud-first and hybrid infrastructure strategy, including migration from legacy systems.
- Design and implement scalable solutions across AWS/Azure, on-prem systems, and networking layers.
- Partner with IT leadership to shape long-term infrastructure roadmaps and technical standards.
- Evaluate emerging technologies and recommend adoption aligned with business needs.
Operational Excellence & Reliability
- Design and enhance monitoring, alerting, and observability frameworks.
- Improve system reliability through proactive engineering (capacity planning, performance tuning, resilience design).
- Lead root cause analysis (RCA) and implement long-term fixes to reduce incident recurrence.
- Optimize operational workflows, including ticket triage, escalation paths, and service ownership.
- Define and monitor KPIs, SLAs, and SLOs to ensure service health and performance.
Security, Compliance & Risk Management
- Partner closely with Cybersecurity to ensure infrastructure aligns with SOX, GxP, and enterprise security standards.
- Implement secure architecture patterns (identity, access, network segmentation, encryption).
- Support audit readiness through strong documentation, system configuration visibility, and asset management.
- Lead infrastructure contributions to disaster recovery (DR) and business continuity planning (BCP).
Cross-Functional Collaboration & Influence
- Work across teams (Applications, Data, Security, PMO) to deliver infrastructure solutions that support business initiatives.
- Act as a trusted advisor to leadership on infrastructure capabilities, risks, and trade-offs.
- Collaborate with vendors and partners to evaluate and implement solutions.
- Drive alignment and adoption of infrastructure standards without formal authority.
BASIC QUALIFICATIONS
Candidate Profile & Requirements:
- Bachelor’s degree in Computer Science, Information Technology, or equivalent experience.
- 8–10+ years of deep, hands-on IT infrastructure experience.
- Proven ability to operate independently and lead large technical initiatives without direct reports.
- Strong expertise in:
- Microsoft ecosystem (Windows Server, Active Directory, Azure AD, O365)
- Cloud platforms (AWS and/or Azure)
- Networking (firewalls, routing, VPNs, VLANs, subnets), specifically Fortinet
- Virtualization (VMware, Hyper-V)
- Experience with automation (scripting, Terraform/CloudFormation, etc.)
- Strong troubleshooting and systems thinking skills across complex environments.
- Experience working in regulated environments (SOX, GxP) preferred.
- Excellent communication skills with ability to translate technical concepts to non-technical stakeholders.
PREFERRED QUALIFICATIONS
- AWS Certified Solutions Architect or SysOps Administrator
- Microsoft Azure Administrator/Architect
- ITIL Foundation (or strong operational process experience)
COMPENSATION
- The anticipated base salary range for this position is $130 K - $175 K USD.
At Karyopharm, base pay is one part of a competitive total rewards package that includes comprehensive benefits (medical, dental, vision, 401(k), and more), equity and the potential to receive annual target bonuses. Actual pay is based on factors such as location, experience, skills, education, and internal equity. We maintain broad salary ranges to reflect market conditions and the specialized nature of our work.
OUR VALUE PROPOSITION
This is a uniquely exciting time to join Karyopharm Therapeutics where we are pioneering the science of nuclear export inhibition to develop differentiated therapies for patients with cancer. We are building upon an established commercial foundation in multiple myeloma while advancing the potential of selinexor across additional hematologic and solid tumor cancers including myelofibrosis and TP53 wild-type endometrial cancer, areas where patients continue to face significant unmet needs. Our lead therapy, XPOVIO ® (selinexor), is a first-in-class inhibitor of exportin 1 (XPO1) and is approved in the U.S. for adults with relapsed or refractory multiple myeloma, with approvals in more than 50 countries and territories outside the U.S. We are also exploring opportunities to evaluate XPO1 inhibition across myeloproliferative neoplasms and TP53 wild-type driven solid tumors using next-generation compounds, including eltanexor. As we prepare for our next phase of growth, we are continuing to invest in critical capabilities across the organization to support future opportunities and deepen our impact in oncology. We are looking for talented people who are motivated by meaningful work, energized by growth and momentum, and excited by the opportunity to help shape what comes next in a collaborative, fast-moving environment where individual contributions are visible and valued.
INTRODUCTION
Karyopharm is seeking a Manager/Senior Manager, IT Infrastructure & Operations to serve as a senior individual contributor owning the architecture, reliability, and evolution of the company’s infrastructure environment, reporting to the VP, Information Technology. This is a hands-on role operating with a high degree of autonomy, partnering across IT, Security, and the business to design and run scalable, secure infrastructure across a mix of cloud and legacy systems in a regulated environment. This individual will lead complex initiatives end-to-end, drive modernization, and improve operational maturity across cloud and on-prem environments. Operating within a lean IT team, the role requires strong ownership, hands-on execution, and the ability to mentor others and influence infrastructure strategy without direct people management.
KEY RESPONSIBILITIES
Technical Leadership & Execution
- Serve as the senior technical lead for infrastructure design, architecture, and operations.
- Own and execute complex infrastructure initiatives end-to-end (design → build → optimize).
- Act as an escalation point for critical incidents and complex system issues.
- Lead by example through hands-on engineering, troubleshooting, and implementation work.
- Mentor and guide engineers through technical challenges, design reviews, and best practices (without direct management responsibility).
- Collaborate with IT Business Partners to identify and align solutions that balance meeting business needs and technical complexity.
Infrastructure Strategy & Modernization
- Drive cloud-first and hybrid infrastructure strategy, including migration from legacy systems.
- Design and implement scalable solutions across AWS/Azure, on-prem systems, and networking layers.
- Partner with IT leadership to shape long-term infrastructure roadmaps and technical standards.
- Evaluate emerging technologies and recommend adoption aligned with business needs.
Operational Excellence & Reliability
- Design and enhance monitoring, alerting, and observability frameworks.
- Improve system reliability through proactive engineering (capacity planning, performance tuning, resilience design).
- Lead root cause analysis (RCA) and implement long-term fixes to reduce incident recurrence.
- Optimize operational workflows, including ticket triage, escalation paths, and service ownership.
- Define and monitor KPIs, SLAs, and SLOs to ensure service health and performance.
Security, Compliance & Risk Management
- Partner closely with Cybersecurity to ensure infrastructure aligns with SOX, GxP, and enterprise security standards.
- Implement secure architecture patterns (identity, access, network segmentation, encryption).
- Support audit readiness through strong documentation, system configuration visibility, and asset management.
- Lead infrastructure contributions to disaster recovery (DR) and business continuity planning (BCP).
Cross-Functional Collaboration & Influence
- Work across teams (Applications, Data, Security, PMO) to deliver infrastructure solutions that support business initiatives.
- Act as a trusted advisor to leadership on infrastructure capabilities, risks, and trade-offs.
- Collaborate with vendors and partners to evaluate and implement solutions.
- Drive alignment and adoption of infrastructure standards without formal authority.
BASIC QUALIFICATIONS
Candidate Profile & Requirements:
- Bachelor’s degree in Computer Science, Information Technology, or equivalent experience.
- 8–10+ years of deep, hands-on IT infrastructure experience.
- Proven ability to operate independently and lead large technical initiatives without direct reports.
- Strong expertise in:
- Microsoft ecosystem (Windows Server, Active Directory, Azure AD, O365)
- Cloud platforms (AWS and/or Azure)
- Networking (firewalls, routing, VPNs, VLANs, subnets), specifically Fortinet
- Virtualization (VMware, Hyper-V)
- Experience with automation (scripting, Terraform/CloudFormation, etc.)
- Strong troubleshooting and systems thinking skills across complex environments.
- Experience working in regulated environments (SOX, GxP) preferred.
- Excellent communication skills with ability to translate technical concepts to non-technical stakeholders.
PREFERRED QUALIFICATIONS
- AWS Certified Solutions Architect or SysOps Administrator
- Microsoft Azure Administrator/Architect
- ITIL Foundation (or strong operational process experience)
COMPENSATION
- The anticipated base salary range for this position is $130 K - $175 K USD.
At Karyopharm, base pay is one part of a competitive total rewards package that includes comprehensive benefits (medical, dental, vision, 401(k), and more), equity and the potential to receive annual target bonuses. Actual pay is based on factors such as location, experience, skills, education, and internal equity. We maintain broad salary ranges to reflect market conditions and the specialized nature of our work.
OUR VALUE PROPOSITION
This is a uniquely exciting time to join Karyopharm Therapeutics where we are pioneering the science of nuclear export inhibition to develop differentiated therapies for patients with cancer. We are building upon an established commercial foundation in multiple myeloma while advancing the potential of selinexor across additional hematologic and solid tumor cancers including myelofibrosis and TP53 wild-type endometrial cancer, areas where patients continue to face significant unmet needs. Our lead therapy, XPOVIO ® (selinexor), is a first-in-class inhibitor of exportin 1 (XPO1) and is approved in the U.S. for adults with relapsed or refractory multiple myeloma, with approvals in more than 50 countries and territories outside the U.S. We are also exploring opportunities to evaluate XPO1 inhibition across myeloproliferative neoplasms and TP53 wild-type driven solid tumors using next-generation compounds, including eltanexor. As we prepare for our next phase of growth, we are continuing to invest in critical capabilities across the organization to support future opportunities and deepen our impact in oncology. We are looking for talented people who are motivated by meaningful work, energized by growth and momentum, and excited by the opportunity to help shape what comes next in a collaborative, fast-moving environment where individual contributions are visible and valued.
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Get Access To All JobsTips for Finding Infrastructure And Operations Jobs
Target industries with established sponsorship track records
Financial services, healthcare systems, and large tech companies file LCAs for infrastructure roles consistently. Filtering by industry before applying saves time and increases your odds of landing an employer already comfortable with the sponsorship process.
Understand how your role maps to specialty occupation criteria
USCIS requires that the position normally require a bachelor's degree in a specific field. Systems administrators and network engineers sometimes face RFEs, so having a degree in computer science, IT, or a directly related field strengthens your petition considerably.
Cloud certifications can reinforce your specialty occupation case
AWS, Azure, and GCP certifications don't replace a degree, but they signal that the role requires specialized knowledge. Employers who list certifications as requirements are easier to petition for because the job complexity is easier to document.
Australian candidates should ask about the E-3 visa specifically
The E-3 has no lottery, no annual cap pressure, and processes faster than H-1B. Many infrastructure employers don't know to offer it unprompted, so raising it early in conversations with HR can open doors that H-1B lottery odds might otherwise close.
Document your scope of responsibility in writing before your petition
Infrastructure roles vary widely in complexity. A job managing five servers is different from architecting a multi-region cloud environment. Detailed documentation of systems owned, team size, and technical decisions made helps USCIS understand why the role genuinely requires degree-level expertise.
Start sponsorship conversations before you apply, not after the offer
Employers often hesitate at the offer stage if sponsorship hasn't been discussed. Bringing it up during early interviews, framed around your visa type and timeline, gives hiring managers time to get legal sign-off and avoids last-minute surprises.
Frequently Asked Questions
Do infrastructure and operations roles qualify as specialty occupations for H-1B purposes?
Most do, but the determination is role-specific. Senior cloud engineers, network architects, and DevOps engineers with defined technical scopes typically qualify. General IT support or help desk roles often don't. The key is whether the position normally requires a bachelor's degree in a specific field like computer science, information systems, or a closely related discipline. Roles with broad, generalist duties are more likely to receive an RFE.
What degree do I need to sponsor an infrastructure or operations role?
A bachelor's degree in computer science, information technology, information systems, or electrical engineering is the strongest fit. Degrees in unrelated fields can work if your coursework directly supports the technical requirements of the role, but the employer will need to document the connection carefully. Candidates without a four-year degree may qualify using the three-for-one rule, where three years of specialized work experience substitutes for one year of education.
How often does USCIS approve H-1B petitions for infrastructure roles?
USCIS doesn't publish approval rates by job title, but infrastructure and operations roles with clear specialty occupation documentation generally see strong approval rates. Roles with vague job descriptions or duties that don't require a specific degree are more vulnerable to RFEs and denials. Working with an immigration attorney to tighten the job description and supporting documentation before filing meaningfully reduces that risk.
Is the E-3 visa a realistic option for Australian infrastructure professionals?
Yes, and it's underused in this field. Infrastructure and operations roles in cloud, networking, and systems management routinely qualify as specialty occupations under E-3 visa, the same standard that applies to H-1B visa. The E-3 visa skips the lottery entirely, renews in two-year increments without a cap, and can be processed through Australian consulates without changing status inside the U.S. Australian candidates browsing sponsoring employers can find relevant openings on Migrate Mate.
What should I expect from the sponsorship timeline for an infrastructure role?
H-1B petitions filed in the standard cap season have an October 1 start date, meaning you could wait six or more months from offer to first day of work. E-3 petitions filed inside the U.S. typically take two to three months. Consular E-3 processing in Australia is faster, often two to four weeks from appointment. Employers already familiar with IT sponsorship move more quickly because they have existing relationships with immigration counsel and established internal workflows.
What is the prevailing wage requirement for sponsored Infrastructure And Operations jobs?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.