Senior Clinical Trial Manager Jobs in USA with Visa Sponsorship
Senior Clinical Trial Manager roles attract strong H-1B visa and O-1 visa sponsorship from large pharmaceutical companies, CROs, and academic medical centers. These positions require a life sciences degree and direct trial oversight experience, which satisfies specialty occupation requirements with minimal pushback from USCIS. For detailed occupation requirements, see the O*NET profile.
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Get Access To All JobsCompany Overview
ImmunityBio, Inc. (NASDAQ: IBRX) is a commercial-stage biotechnology company developing cell and immunotherapy products that are designed to help strengthen each patient’s natural immune system, potentially enabling it to outsmart the disease and eliminate cancerous or infected cells. We envision a day when we no longer fear cancer, but can conquer it, thanks to the biological wonder that is the human immune system. Our scientists are working to develop novel therapies that harness that inherent power by amplifying both branches of the immune system, attacking cancerous or infected cells today while building immunological memory for tomorrow. The goal: to reprogram the patient’s immune system and treat the host rather than just the disease.
Why ImmunityBio?
* ImmunityBio is developing cutting-edge technology with the goal to transform the lives of patients with cancer and develop next-generation therapies and vaccines that complement, harness and amplify the immune system to defeat cancers and infectious diseases.
* Opportunity to join a publicly traded biopharmaceutical company with headquarters in Southern California.
* Work with a collaborative team with the ability to work across different areas of the company.
* Ability to join a growing company with professional development opportunities.
Position Summary
Responsible for managing the activities of several global clinical studies including assisting in the development of study-related documents, study site management, and patient data monitoring. Provide guidance to clinical sites on a daily basis including protocol interpretation and protocol safety compliance.
Essential Functions
* Assist Clinical Project Manager in the development and management of company-sponsored global clinical trials
* Lead in reviewing completed assignments by members of the clinical development group
* Lead/assist in the development and management of revisions to study-related documents such as the informed consent, laboratory manual, pharmacy manual, case report forms (CRFs) and other study execution tools.
* Provide support in site recruitment, site initiation, site payments and site close-out.
* Help to oversee the training of new clinical site staff or site training for protocol amendments.
* Liaise with the in-house team to ensure collection of updated regulatory documents as needed.
* Help to provide guidance to clinical sites on a daily basis including protocol interpretation and protocol safety compliance.
* Lead/Assist in the training of clinical development group staff.
* Assist CPM to prepare and update clinical trial updates for Clinical Development team
* Provide support for summarizing and maintaining patient treatment, response and survival data for active studies.
* Other duties as assigned
Education & Experience
* Bachelor’s degree with 7+ years of relevant experience in clinical research required
Knowledge, Skills, & Abilities
* Proficiency in MS Word, Excel, PowerPoint, Outlook
* Excellent written/oral communication skills as well as strong organizational and multi-tasking skills.
* Understand the job-specific system and processes as defined by the company’s SOPs and adhere to the requirements listed in those documents. If any of the procedure or process requirements are unclear or ambiguous, it is the responsibility of the employee to notify his/her supervisor or manager.
* Maintain corporate confidentiality at all times.
Working Environment / Physical Environment
* This position works either on site in El Segundo, CA or remotely depending on the individual’s geographical location
* This position will be exposed to an in-lab environment.
* This position will travel approximately 20% of the time.
* Must possess mobility to work in a standard office setting and to use standard office equipment, including a computer.
* Lift and carry materials weighing up to 20 pounds.
This position is eligible for a discretionary bonus and equity award. The annual base pay range for this position is below. The specific rate will depend on the successful candidate’s qualifications, prior experience as well as geographic location.
National Market (all markets unless identified as Premium)
$143,000 (entry-level qualifications) to $157,300 (highly experienced) annually
Premium Market (Premium markets include Los Angeles, San Diego, San Francisco, New York City, Chicago, & Boston)
$150,000 (entry-level qualifications) to $165,000 (highly experienced) annually
The application window is anticipated to close on 60 days from when it is posted or sooner if the position is filled or closed.
ImmunityBio employees are as valuable as the people we serve. We have built a resource of robust benefit offerings to best support the total wellbeing of our team members and their families. Our competitive total rewards benefits package, for eligible employees, include:
* Medical, Dental and Vision Plan Options
* Health and Financial Wellness Programs
* Employer Assistance Program (EAP)
* Company Paid and Voluntary Life/AD&D, Short-Term and Long-Term Disability
* Healthcare and Dependent Care Flexible Spending Accounts
* 401(k) Retirement Plan with Company Match
* 529 Education Savings Program
* Voluntary Legal Services, Identity Theft Protection, Pet Insurance and Employee Discounts, Rewards and Perks
* Paid Time Off (PTO) includes: 11 Holidays
* Exempt Employees are eligible for Unlimited PTO
* Non-Exempt Employees are eligible for 10 Vacation Days, 56 Hours of Health Pay, 2 Personal Days and 1 Cultural Day
We are committed to providing you with the tools and resources you need to optimize your Health and Wellness.
At ImmunityBio, we are an equal opportunity employer dedicated to diversity in the workplace. Our policy is to provide equal employment opportunities to all qualified persons without regard to race, gender, color, disability, national origin, age, religion, union affiliation, sexual orientation, veteran status, citizenship, gender identity and/or expression, or other status protected by law.
Company Overview
ImmunityBio, Inc. (NASDAQ: IBRX) is a commercial-stage biotechnology company developing cell and immunotherapy products that are designed to help strengthen each patient’s natural immune system, potentially enabling it to outsmart the disease and eliminate cancerous or infected cells. We envision a day when we no longer fear cancer, but can conquer it, thanks to the biological wonder that is the human immune system. Our scientists are working to develop novel therapies that harness that inherent power by amplifying both branches of the immune system, attacking cancerous or infected cells today while building immunological memory for tomorrow. The goal: to reprogram the patient’s immune system and treat the host rather than just the disease.
Why ImmunityBio?
* ImmunityBio is developing cutting-edge technology with the goal to transform the lives of patients with cancer and develop next-generation therapies and vaccines that complement, harness and amplify the immune system to defeat cancers and infectious diseases.
* Opportunity to join a publicly traded biopharmaceutical company with headquarters in Southern California.
* Work with a collaborative team with the ability to work across different areas of the company.
* Ability to join a growing company with professional development opportunities.
Position Summary
Responsible for managing the activities of several global clinical studies including assisting in the development of study-related documents, study site management, and patient data monitoring. Provide guidance to clinical sites on a daily basis including protocol interpretation and protocol safety compliance.
Essential Functions
* Assist Clinical Project Manager in the development and management of company-sponsored global clinical trials
* Lead in reviewing completed assignments by members of the clinical development group
* Lead/assist in the development and management of revisions to study-related documents such as the informed consent, laboratory manual, pharmacy manual, case report forms (CRFs) and other study execution tools.
* Provide support in site recruitment, site initiation, site payments and site close-out.
* Help to oversee the training of new clinical site staff or site training for protocol amendments.
* Liaise with the in-house team to ensure collection of updated regulatory documents as needed.
* Help to provide guidance to clinical sites on a daily basis including protocol interpretation and protocol safety compliance.
* Lead/Assist in the training of clinical development group staff.
* Assist CPM to prepare and update clinical trial updates for Clinical Development team
* Provide support for summarizing and maintaining patient treatment, response and survival data for active studies.
* Other duties as assigned
Education & Experience
* Bachelor’s degree with 7+ years of relevant experience in clinical research required
Knowledge, Skills, & Abilities
* Proficiency in MS Word, Excel, PowerPoint, Outlook
* Excellent written/oral communication skills as well as strong organizational and multi-tasking skills.
* Understand the job-specific system and processes as defined by the company’s SOPs and adhere to the requirements listed in those documents. If any of the procedure or process requirements are unclear or ambiguous, it is the responsibility of the employee to notify his/her supervisor or manager.
* Maintain corporate confidentiality at all times.
Working Environment / Physical Environment
* This position works either on site in El Segundo, CA or remotely depending on the individual’s geographical location
* This position will be exposed to an in-lab environment.
* This position will travel approximately 20% of the time.
* Must possess mobility to work in a standard office setting and to use standard office equipment, including a computer.
* Lift and carry materials weighing up to 20 pounds.
This position is eligible for a discretionary bonus and equity award. The annual base pay range for this position is below. The specific rate will depend on the successful candidate’s qualifications, prior experience as well as geographic location.
National Market (all markets unless identified as Premium)
$143,000 (entry-level qualifications) to $157,300 (highly experienced) annually
Premium Market (Premium markets include Los Angeles, San Diego, San Francisco, New York City, Chicago, & Boston)
$150,000 (entry-level qualifications) to $165,000 (highly experienced) annually
The application window is anticipated to close on 60 days from when it is posted or sooner if the position is filled or closed.
ImmunityBio employees are as valuable as the people we serve. We have built a resource of robust benefit offerings to best support the total wellbeing of our team members and their families. Our competitive total rewards benefits package, for eligible employees, include:
* Medical, Dental and Vision Plan Options
* Health and Financial Wellness Programs
* Employer Assistance Program (EAP)
* Company Paid and Voluntary Life/AD&D, Short-Term and Long-Term Disability
* Healthcare and Dependent Care Flexible Spending Accounts
* 401(k) Retirement Plan with Company Match
* 529 Education Savings Program
* Voluntary Legal Services, Identity Theft Protection, Pet Insurance and Employee Discounts, Rewards and Perks
* Paid Time Off (PTO) includes: 11 Holidays
* Exempt Employees are eligible for Unlimited PTO
* Non-Exempt Employees are eligible for 10 Vacation Days, 56 Hours of Health Pay, 2 Personal Days and 1 Cultural Day
We are committed to providing you with the tools and resources you need to optimize your Health and Wellness.
At ImmunityBio, we are an equal opportunity employer dedicated to diversity in the workplace. Our policy is to provide equal employment opportunities to all qualified persons without regard to race, gender, color, disability, national origin, age, religion, union affiliation, sexual orientation, veteran status, citizenship, gender identity and/or expression, or other status protected by law.
See all 47+ Senior Clinical Trial Manager jobs
Sign up for free to unlock all listings, filter by visa type, and get alerts for new Senior Clinical Trial Manager roles.
Get Access To All JobsTips for Finding Visa Sponsorship as a Senior Clinical Trial Manager
Target CROs and large pharma sponsors first
Contract research organizations like ICON, Labcorp Drug Development, and Syneos Health sponsor visas regularly and have established immigration processes. Large pharma companies with dedicated HR immigration teams move faster and make fewer errors on petitions.
Document your GCP training and protocol experience
USCIS will scrutinize whether your background directly supports a specialty occupation. A portfolio of GCP certifications, IRB submissions, and protocol deviation reports strengthens the specialty occupation argument beyond your degree alone.
Clarify your monitoring versus management scope early
Senior CTM roles involve budget oversight, vendor management, and cross-functional leadership, not just site monitoring. Make sure your job offer letter and employer support letter reflect the full scope, which directly supports the H-1B specialty occupation determination.
Ask about cap-exempt sponsorship if working near academia
CTM roles at academic medical centers and nonprofit research institutions can qualify for cap-exempt H-1B filings. This bypasses the lottery entirely, giving you a direct path to approval without waiting for the annual registration window.
Consider O-1A if you have published research or regulatory achievements
Senior CTMs with published clinical research, regulatory submissions as a named contributor, or speaking engagements at major conferences like DIA may qualify for O-1A. It has no cap, no lottery, and is employer-filed without labor certification.
Use Migrate Mate to find confirmed sponsoring employers
Not every company that posts a Senior CTM role will sponsor visas. Migrate Mate filters job listings to show employers who have an active sponsorship track record, saving you from spending weeks applying to companies that will reject you at the offer stage.
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Find Senior Clinical Trial Manager JobsFrequently Asked Questions
Does a Senior Clinical Trial Manager role qualify as a specialty occupation for H-1B purposes?
Yes, Senior CTM roles consistently qualify as specialty occupations because the position normally requires at least a bachelor's degree in a life sciences, nursing, pharmacy, or related field. USCIS has approved petitions for this title across pharma and CRO employers. The key is that the employer's job description must state a degree in a specific field is required, not merely preferred.
Which visa types are most common for Senior Clinical Trial Managers?
H-1B is by far the most common. TN visas are an option for Canadian and Mexican nationals with a relevant life sciences degree. O-1A is increasingly viable for CTMs who have published research, served on FDA advisory panels, or held leadership roles in major industry organizations. L-1 applies if you're transferring within a multinational CRO or pharma company from a foreign office.
Do I need a master's degree or PhD to get sponsored as a Senior CTM?
No, a bachelor's degree in a qualifying field is sufficient for H-1B sponsorship in most cases. However, a master's or PhD strengthens your petition, particularly if your undergraduate field is not a direct match for the role. Some employers require an advanced degree for senior-level positions, so check individual job descriptions carefully before applying.
How selective are pharmaceutical companies about sponsoring Senior CTMs compared to junior roles?
Pharma companies and CROs are generally more willing to sponsor at the senior level because the role is harder to fill domestically and the business case is easier to justify. Senior CTMs with Phase II or Phase III oncology or rare disease trial experience are especially sought after. That said, sponsorship decisions vary by employer, so use Migrate Mate to identify companies with a documented history of sponsoring this role.
Can a Senior CTM role at a university hospital qualify for a cap-exempt H-1B?
Yes, if the academic medical center qualifies as a nonprofit research organization or is affiliated with a university, the H-1B petition may be filed cap-exempt. This means no lottery, no registration window, and the ability to file any time of year with a relatively fast processing timeline. Confirm the institution's cap-exempt status with their HR or legal team before counting on this pathway.
What is the prevailing wage requirement for sponsored Senior Clinical Trial Manager jobs?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.
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