Acute Care Nurse Practitioner Jobs in South Carolina

Acute Care Nurse Practitioner jobs in South Carolina are open across Columbia, Greenville, and Clinton and other South Carolina metros, with employers like Prisma Health and Fresenius Medical Care hiring at every experience level. Find a role that fits below and apply directly.

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Overview

Open roles54+
Top employerPrisma Health
Top cityColumbia, SC
Cities hiring8
Work type98% On-site
Top industryHealthcare

Showing 5 of 54+ Acute Care Nurse Practitioner jobs

Prisma Health
Registered Nurse (RN)-Acute Care, Emergency Department
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Prisma Health
Added 2d ago
Registered Nurse (RN)-Acute Care, Emergency Department
Prisma Health
Simpsonville, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Associate's
10,000+

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Prisma Health
Registered Nurse (RN)-Acute Care, OR Pre-Op
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Prisma Health
Added 3d ago
Registered Nurse (RN)-Acute Care, OR Pre-Op
Prisma Health
Greenville, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Associate's
10,000+

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Prisma Health
Registered Nurse (RN) - Acute Care, Women's Specialty
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Prisma Health
Added 3d ago
Registered Nurse (RN) - Acute Care, Women's Specialty
Prisma Health
Greenville, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Associate's
10,000+

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Prisma Health
Registered Nurse (RN) - Acute Care, Emergency Dept
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Prisma Health
Added 4d ago
Registered Nurse (RN) - Acute Care, Emergency Dept
Prisma Health
Seneca, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Associate's
10,000+

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Prisma Health
Registered Nurse (RN) Acute Care
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Prisma Health
Added 6d ago
Registered Nurse (RN) Acute Care
Prisma Health
Greer, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Associate's
10,000+

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See All 54 Acute Care Nurse Practitioner Jobs in South Carolina

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Acute Care Nurse Practitioner Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Columbia
17 jobs
Greenville
16 jobs
Clinton
6 jobs
Seneca
5 jobs
Simpsonville
5 jobs
Greer
2 jobs
Sumter
2 jobs
Florence
1 jobs

Acute Care Nurse Practitioner Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

  • Prisma Health
    Prisma Health53
  • Fresenius Medical Care
    Fresenius Medical Care1

Top Industries Hiring

  • Healthcare & Medical Services54
  • Consulting & Professional Services15

What South Carolina Employers Look For

The qualifications that appear most often in acute care nurse practitioner jobs across South Carolina.

  • Master of Science in Nursing or Doctor of Nursing Practice from an accredited program
  • ACNPC-AG or AGACNP certification from ANCC or AACN
  • Active unrestricted RN and APRN licensure in the state of employment
  • Minimum one to two years of acute or critical care clinical experience as an RN or NP
  • Current BLS, ACLS, and often PALS certification
  • Proficiency with electronic health record systems such as Epic or Cerner

Acute Care Nurse Practitioner Jobs in South Carolina: Frequently Asked Questions

How many acute care nurse practitioner jobs are there in South Carolina?

There are 54+ acute care nurse practitioner openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Columbia, Greenville, and Clinton. New positions post regularly as employers across South Carolina hire.

How much do acute care nurse practitioners make in South Carolina?

Acute care nurse practitioners in South Carolina earn a median of about $123,290 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $97,080 for the lowest 10% to over $160,170 for the top 10%. Pay rises with experience, specialty, and employer.

Which South Carolina cities have the most acute care nurse practitioner jobs?

Columbia, Greenville, and Clinton have the most acute care nurse practitioner openings in South Carolina right now, with additional roles spread across smaller metros statewide.

Which companies hire acute care nurse practitioners in South Carolina?

Employers hiring acute care nurse practitioners in South Carolina include Prisma Health and Fresenius Medical Care, based on current listings on Migrate Mate as of June 2026.

Are there remote acute care nurse practitioner jobs in South Carolina?

Yes. About 2% of acute care nurse practitioner openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.

How do I apply for acute care nurse practitioner jobs in South Carolina?

You can apply to acute care nurse practitioner jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.

See All 54 Acute Care Nurse Practitioner Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

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