Associate Director Clinical Data Management Jobs
Associate Director Clinical Data Management jobs are open across pharmaceutical, biotechnology, medical device, and CRO industries, from senior manager to executive level, with specializations in oncology trials, regulatory submissions, and data standards such as CDISC. Find a role that fits from the openings below and apply directly.
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X4 is focused on restoring healthy immune system function by developing novel therapeutics to treat chronic neutropenic disorders, including WHIM syndrome, a rare primary immunodeficiency. We are advancing a novel, late-stage clinical candidate, mavorixafor, that we believe has the potential to become a new standard of care for patients with these disorders. We know that developing innovative, new medicines is challenging, and we invite new colleagues who share our values and commitment to join us in achieving our mission.
This opportunity will …
Provide strategic and operational leadership for clinical data management activities across one or more clinical development programs. The Associate Director will oversee CRO partners and vendors, drive data quality and inspection readiness, support regulatory submissions, and ensure the timely delivery of high-quality clinical trial data.
This role will serve as a key cross-functional leader, partnering with Clinical Operations, Biostatistics, Statistical Programming, Medical Writing, Pharmacovigilance, Regulatory Affairs, and external vendors to deliver study objectives while maintaining compliance with regulatory requirements and industry standards.
Accountabilities and Responsibilities:
Clinical Data Management Leadership
- Lead and oversee all clinical data management activities for assigned clinical trials from protocol development through database lock and study closeout.
- Develop and execute data management strategies that support program timelines, quality objectives, and regulatory submission readiness.
- Ensure consistent application of Good Clinical Practice (GCP), ICH guidelines, company SOPs, and industry best practices.
- Provide leadership and guidance to CROs and vendors performing outsourced data management activities.
- Serve as the primary sponsor representative for outsourced data management activities.
- Establish governance and performance oversight processes, including KPIs, quality metrics, and issue escalation pathways.
-
Review and approve vendor deliverables, including:
- Data Management Plans
- CRF specifications
- Edit Check Specifications
- Data Review Plans
- Database Validation Documentation
- Data Transfer Specifications
- Reconciliation Plans
- Monitor CRO performance and ensure accountability for quality, timelines, and budget adherence.
- Establish and monitor key study metrics related to data quality, data cleaning, query management, and database readiness.
- Lead ongoing review of data trends and identify risks requiring mitigation.
- Ensure audit and inspection readiness through comprehensive documentation and process compliance.
- Support internal audits and health authority inspections as the data management subject matter expert.
- Serve as the Data Management representative on Clinical Study Teams and Development Teams.
- Effectively communicate study status, risks, mitigation plans, and performance metrics to leadership.
- Foster strong collaborative relationships with internal teams and external partners.
- Identify opportunities to improve clinical data management processes, systems, and efficiencies.
- Contribute to the development and maintenance of SOPs, work instructions, templates, and best practices.
- Support implementation of innovative technologies and risk-based approaches to data management.
Requirements: Proven Experience, Skills, and Education:
- Minimum 8+ years of clinical data management experience within biotechnology, pharmaceutical, or CRO environments.
- Minimum 3+ years of leadership experience overseeing clinical data management activities and vendor relationships.
- Experience supporting Phase 2, Phase 3, and regulatory submission programs.
- Experience overseeing outsourced clinical data management models.
- Strategic thinker with strong operational execution skills.
- Excellent vendor management capabilities.
- Effective problem-solving and risk management abilities.
- Excellent written and verbal communication skills.
- Commitment to patient-focused drug development and data quality excellence
- Rare disease experience preferred.
Strong understanding of:
- ICH-GCP
- FDA and EMA regulations
- CDISC standards (SDTM and related submission requirements)
- Clinical trial data lifecycle
- Risk-based quality management principles
This position is based in Boston, MA, and offers a flexible hybrid work model with a minimum of 2 days/week in the office.
We encourage you to learn more about X4 Pharmaceuticals. Click on the links below!
About Us
Pipeline
X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law.
Please note that effective January 1, 2022, as a condition of employment at X4 Pharmaceuticals, all employees and new hires must have received their complete dose of the COVID-19 vaccine, unless they have been granted an exemption.
X4 is focused on restoring healthy immune system function by developing novel therapeutics to treat chronic neutropenic disorders, including WHIM syndrome, a rare primary immunodeficiency. We are advancing a novel, late-stage clinical candidate, mavorixafor, that we believe has the potential to become a new standard of care for patients with these disorders. We know that developing innovative, new medicines is challenging, and we invite new colleagues who share our values and commitment to join us in achieving our mission.
This opportunity will …
Provide strategic and operational leadership for clinical data management activities across one or more clinical development programs. The Associate Director will oversee CRO partners and vendors, drive data quality and inspection readiness, support regulatory submissions, and ensure the timely delivery of high-quality clinical trial data.
This role will serve as a key cross-functional leader, partnering with Clinical Operations, Biostatistics, Statistical Programming, Medical Writing, Pharmacovigilance, Regulatory Affairs, and external vendors to deliver study objectives while maintaining compliance with regulatory requirements and industry standards.
Accountabilities and Responsibilities:
Clinical Data Management Leadership
- Lead and oversee all clinical data management activities for assigned clinical trials from protocol development through database lock and study closeout.
- Develop and execute data management strategies that support program timelines, quality objectives, and regulatory submission readiness.
- Ensure consistent application of Good Clinical Practice (GCP), ICH guidelines, company SOPs, and industry best practices.
- Provide leadership and guidance to CROs and vendors performing outsourced data management activities.
- Serve as the primary sponsor representative for outsourced data management activities.
- Establish governance and performance oversight processes, including KPIs, quality metrics, and issue escalation pathways.
-
Review and approve vendor deliverables, including:
- Data Management Plans
- CRF specifications
- Edit Check Specifications
- Data Review Plans
- Database Validation Documentation
- Data Transfer Specifications
- Reconciliation Plans
- Monitor CRO performance and ensure accountability for quality, timelines, and budget adherence.
- Establish and monitor key study metrics related to data quality, data cleaning, query management, and database readiness.
- Lead ongoing review of data trends and identify risks requiring mitigation.
- Ensure audit and inspection readiness through comprehensive documentation and process compliance.
- Support internal audits and health authority inspections as the data management subject matter expert.
- Serve as the Data Management representative on Clinical Study Teams and Development Teams.
- Effectively communicate study status, risks, mitigation plans, and performance metrics to leadership.
- Foster strong collaborative relationships with internal teams and external partners.
- Identify opportunities to improve clinical data management processes, systems, and efficiencies.
- Contribute to the development and maintenance of SOPs, work instructions, templates, and best practices.
- Support implementation of innovative technologies and risk-based approaches to data management.
Requirements: Proven Experience, Skills, and Education:
- Minimum 8+ years of clinical data management experience within biotechnology, pharmaceutical, or CRO environments.
- Minimum 3+ years of leadership experience overseeing clinical data management activities and vendor relationships.
- Experience supporting Phase 2, Phase 3, and regulatory submission programs.
- Experience overseeing outsourced clinical data management models.
- Strategic thinker with strong operational execution skills.
- Excellent vendor management capabilities.
- Effective problem-solving and risk management abilities.
- Excellent written and verbal communication skills.
- Commitment to patient-focused drug development and data quality excellence
- Rare disease experience preferred.
Strong understanding of:
- ICH-GCP
- FDA and EMA regulations
- CDISC standards (SDTM and related submission requirements)
- Clinical trial data lifecycle
- Risk-based quality management principles
This position is based in Boston, MA, and offers a flexible hybrid work model with a minimum of 2 days/week in the office.
We encourage you to learn more about X4 Pharmaceuticals. Click on the links below!
About Us
Pipeline
X4 Pharmaceuticals is an Equal Opportunity and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law.
Please note that effective January 1, 2022, as a condition of employment at X4 Pharmaceuticals, all employees and new hires must have received their complete dose of the COVID-19 vaccine, unless they have been granted an exemption.
Associate Director Clinical Data Management Jobs by Experience Level
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Who's Hiring
Top Industries Hiring
- Biotechnology & Pharmaceuticals
- Healthcare & Medical Services
What Employers Look For
The qualifications that appear most often in associate director clinical data management jobs.
- Bachelor's or advanced degree in life sciences, statistics, or a related field
- Minimum seven to ten years of clinical data management experience in pharma or biotech
- Hands-on experience with EDC systems such as Medidata Rave, Oracle InForm, or Veeva Vault
- Proficiency in CDISC standards including CDASH, SDTM, and ADaM
- Demonstrated experience leading and mentoring clinical data management teams
- Knowledge of ICH E6 Good Clinical Practice guidelines and 21 CFR Part 11 compliance
Tips for Your Associate Director Clinical Data Management Job Search
Quantify your data management wins
Hiring managers at this level want to see scale and impact. Cite the number of studies you oversaw simultaneously, the size of teams you led, and how your process improvements reduced database lock timelines or query resolution rates.
Highlight CDISC and 21 CFR Part 11 fluency
Most job postings at this level explicitly require CDASH, SDTM, and ADaM expertise alongside regulatory compliance knowledge. If your resume buries these under a generic skills section, move them to a prominent summary line so they clear applicant tracking systems immediately.
Target postings by phase and therapeutic area
Oncology, rare disease, and late-phase trials each have distinct data management complexity. Filter openings by the therapeutic area where your strongest study experience sits so your application speaks directly to the complexity the team is already managing.
Apply early to roles that fit
Migrate Mate lists associate director clinical data management openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Prepare for a technical panel interview
Expect a multi-round process where at least one session includes clinical data managers or bioinformatics leads who will probe your EDC platform choices, your SAS or R validation practices, and how you handle protocol amendments mid-study. Prepare concrete examples for each area.
Negotiate scope, not just compensation
At the associate director level, the breadth of your portfolio, access to cross-functional leadership, and whether you own vendor oversight or just execution all shape your trajectory. Clarify those boundaries during the offer stage before accepting.
Associate Director Clinical Data Management Jobs: Frequently Asked Questions
Which companies are hiring the most associate director clinical data managements?
The companies hiring the most associate director clinical data managements right now include PTC Therapeutics, BioNTech, and Regeneron, with the largest share of openings in Massachusetts, California, and New Jersey, based on current listings on Migrate Mate as of September 2026. Large CROs and mid-size biopharmaceutical companies tend to post the highest volume of roles at this level.
How many associate director clinical data management jobs are remote?
About 50% of associate director clinical data management openings are fully remote or hybrid as of September 2026, reflecting the function's historically strong remote infrastructure. Roles focused on data standards oversight, vendor management, and regulatory submission support tend to be the most amenable to fully remote arrangements compared to site-facing or hands-on EDC build positions.
How do you become an associate director clinical data management?
You typically progress into this role by first building several years of hands-on experience as a clinical data manager or senior clinical data manager, then moving into a lead or principal role where you manage cross-functional study teams. Deepening your expertise in CDISC standards, EDC platforms, and regulatory compliance, combined with demonstrated team leadership, positions you for the associate director step.
Can you get hired as an associate director clinical data management without direct leadership experience?
Most employers expect at least some formal or informal team leadership before hiring at the associate director level, but relevant depth can compensate for limited direct reports. Candidates who have led cross-functional study teams, served as a subject matter expert on CDISC implementation projects, or managed external data vendors often compete effectively even without a traditional management title on their resume.
What does the associate director clinical data management interview process look like?
The process typically runs three to four rounds, starting with a recruiter screen focused on background and level fit, followed by a hiring manager conversation about leadership philosophy and therapeutic area experience. A technical panel with clinical data managers or biostatistics colleagues then probes EDC choices, CDISC implementation decisions, and regulatory compliance scenarios. A final round with senior leadership or cross-functional stakeholders usually closes the process.
Where can I find and apply to associate director clinical data management jobs?
You can find and apply to associate director clinical data management jobs on Migrate Mate, which lists current openings from employers across the United States. Search the available roles, find the ones that match your experience and target therapeutic area, and apply directly to each listing from the page.
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Find roles that match your experience and apply in just a few clicks.
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