Business Operations Leader Jobs in San Francisco, CA

Business Operations Leader jobs in San Francisco are concentrated in SoMa, the Financial District, and Mission Bay, driven by demand from tech platforms, fintech firms, and healthcare organizations. Employers hiring right now include Genentech, Benchling, and Databricks. Find a role that fits below and apply directly.

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Overview

Open roles29
Top employerGenentech
Work type67% On-site
Top credentialBachelor's
Companies hiring15

Showing 5 of 29+ Business Operations Leader jobs

SERVAL
Commercial Sales Leader
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SERVAL
Added 1d ago
Commercial Sales Leader
SERVAL
San Francisco, California
On-Site
None
1,001-5,000

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Amazon.com
Leader, Quality, GES NA Ops Engineering
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Amazon.com
Added 1w ago
Leader, Quality, GES NA Ops Engineering
Amazon.com
San Francisco, California
Quality Control
Project & Program Management
Specialized Engineering
Project Management
Engineering (Non-Software)
$173k - $257k/yr
Bachelor's
10,000+

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Altos Labs
Senior Director, Project Team Leader / Executive Committee Business Manager
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Altos Labs
Added 1w ago
Senior Director, Project Team Leader / Executive Committee Business Manager
Altos Labs
San Francisco, California
Project & Program Management
Strategy & Corporate Development
Project Management
Program Management
Business Strategy
$402k/yr
On-Site
Doctorate

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Genentech
Senior Director, Project Team Leader
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Genentech
Added 1w ago
Senior Director, Project Team Leader
Genentech
San Francisco, California
Project & Program Management
Project Management
Program Management
$247k - $459k/yr
Master's
10,000+

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Genentech
Senior Director, Project Team Leader
We won't show you this job again
Genentech
Added 1w ago
Senior Director, Project Team Leader
Genentech
San Francisco, California
Project & Program Management
Project Management
Program Management
$247k - $459k/yr
Master's
10,000+

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See All 29 Business Operations Leader Jobs in San Francisco

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Business Operations Leader Job Market in San Francisco

Who's Hiring

  • Genentech
    Genentech6
  • Benchling
    Benchling4
  • Databricks
    Databricks3
  • Amazon Web Services
    Amazon Web Services3
  • EY
    EY2

Top Industries Hiring

  • Technology & Software6
  • Medical Devices5
  • Banking & Financial Services3
  • Science & Research2
  • Accounting & Auditing2

Business Operations Leader Jobs in San Francisco: Frequently Asked Questions

How do I get a business operations leader job in San Francisco?

Target San Francisco's tech, fintech, and healthcare sectors, where demand for business operations leaders is strongest. Jobs concentrate in SoMa, the Financial District, and Mission Bay, with companies ranging from growth-stage startups to large enterprise firms. Candidates who combine cross-functional project experience with data fluency stand out locally. Familiarity with fast-moving, product-led organizations is a meaningful edge in this market.

Which companies hire business operations leaders in San Francisco?

San Francisco business operations leader roles are posted by Genentech, Benchling, and Databricks and others right now, based on current listings on Migrate Mate as of June 2026. The local market reflects a mix of established tech companies, venture-backed startups, and large financial services firms, all of which maintain ongoing operational leadership needs.

Are there remote business operations leader jobs in San Francisco?

Yes, though availability depends on the role's scope, since positions overseeing physical operations or team coordination are typically on-site. About 33% of business operations leader openings tied to San Francisco are remote or hybrid as of June 2026, reflecting the city's tech-heavy employer base. Strategic planning, analytics, and vendor management functions tend to offer the most remote flexibility locally.

How can I get a business operations leader job in San Francisco with little or no experience?

The most realistic entry path is through an operations coordinator or business analyst role at a San Francisco startup or mid-size tech company, where smaller teams give junior hires broader exposure. Many SoMa and Mission Bay employers hire for operations rotational programs or chief-of-staff support roles that build toward leadership. Demonstrating process improvement work, even from internships or school projects, gives candidates a concrete edge with local hiring managers.

Which industries hire the most business operations leaders in San Francisco?

San Francisco business operations leader roles concentrate in Technology & Software, Medical Devices, and Banking & Financial Services, based on current listings on Migrate Mate as of June 2026. These sectors dominate because San Francisco's economy is anchored by high-growth technology companies, a dense fintech corridor in the Financial District, and an expanding life sciences and healthcare presence around Mission Bay.

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