Chief Operating Officer Jobs in St. Louis, MO

Chief Operating Officer jobs in St. Louis concentrate in healthcare, financial services, and logistics, with openings spread across Clayton, the Central West End, and downtown's emerging tech corridor. Employers actively hiring right now include Washington University in St. Louis, Clayco, and Weissman. See the openings below and apply to the ones that match your experience.

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Overview

Open roles64
Top employerWashington University in St. Louis
Work type58% Hybrid
Top credentialBachelor's degree
Companies hiring15

Showing 5 of 64+ Chief Operating Officer jobs

Director of Business Operations
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Added 3d ago
Director of Business Operations
Srote & Co Architects
St. Louis, Missouri
Business Development
Customer Service
Customer Success
$90k - $120k/yr
On-Site
11-50

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Chief Financial and Operating Officer (CFOO)
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Added 4d ago
Chief Financial and Operating Officer (CFOO)
FORSYTH SCHOOL
St. Louis, Missouri
Compensation & Benefits
Human Resources
Human Resources (HR) — Generalist
Learning & Development
$125k - $155k/yr
Bachelor's degree in finance

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Director - Vicariate Operations
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Added 4d ago
Director - Vicariate Operations
Archdiocese of St. Louis
St. Louis, Missouri
Administrative & Office Support
Business Operations
Project Management
Bachelor's degree
1,001-5,000

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Director of Affordable Housing Operations, Multifamily
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Added 1w ago
Director of Affordable Housing Operations, Multifamily
Cushman & Wakefield
St. Louis, Missouri
Account Management
Business Development
Partnerships & Business Development
$128k - $150k/yr
Hybrid
Bachelor's degree in finance
10,000+

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Associate Director of Operations- Habilitation
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Added 1w ago
Associate Director of Operations- Habilitation
BAYADA Home Health Care
St. Louis, Missouri
Account Management
Customer Service
Customer Support
Bachelor's degree
10,000+

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See All 64 Chief Operating Officer Jobs in St. Louis

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Chief Operating Officer Job Market in St. Louis

Who's Hiring

  • Washington University in St. Louis11
  • Clayco4
  • Weissman4
  • Blink Health4
  • FORSYTH SCHOOL4

Top Industries Hiring

  • Education

Chief Operating Officer Jobs in St. Louis: Frequently Asked Questions

How do I get a chief operating officer job in St. Louis?

The strongest path into a chief operating officer role in St. Louis runs through the city's healthcare systems, regional banks, and distribution and logistics companies, which consistently need operations leadership. Clayton and downtown St. Louis concentrate the most senior postings. Candidates with cross-functional P&L ownership, experience scaling teams, and familiarity with supply chain or regulated-industry compliance stand out most in this market.

Which companies hire chief operating officers in St. Louis?

St. Louis chief operating officer roles are posted by Washington University in St. Louis, Clayco, and Weissman and others right now, based on current listings on Migrate Mate as of November 2026. The hiring base skews toward large healthcare networks, Fortune 500 headquarters, and regional financial institutions that maintain significant operational leadership teams in the St. Louis metro.

Are there remote chief operating officer jobs in St. Louis?

Yes, though remote availability is limited for this role since chief operating officers typically oversee in-person teams, facilities, and daily operations. About 58% of chief operating officer openings tied to St. Louis are remote or hybrid as of November 2026, with the hybrid arrangements most common in technology firms and professional services companies based in Clayton or Midtown.

How can I get a chief operating officer job in St. Louis with little or no experience?

The most realistic entry path is building toward the role through operations manager or director of operations positions at St. Louis's mid-sized healthcare organizations, logistics companies, or regional nonprofits, which regularly promote from within. Roles in project management, supply chain coordination, or clinical operations at BJC HealthCare, SSM Health, or similar large employers create direct stepping stones to the COO level over time.

Which industries hire the most chief operating officers in St. Louis?

St. Louis chief operating officer roles concentrate in Education, based on current listings on Migrate Mate as of November 2026. St. Louis's deep roots in healthcare, agribusiness, and financial services mean those sectors maintain the largest ongoing need for senior operations leadership across both corporate headquarters and regional divisions.

See All 64 Chief Operating Officer Jobs in St. Louis

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Find Chief Operating Officer Jobs