Chief Operating Officer Jobs in St. Louis, MO

Chief Operating Officer jobs in St. Louis concentrate in healthcare, financial services, and logistics, with openings spread across Clayton, the Central West End, and downtown's emerging tech corridor. Employers actively hiring right now include Mercy, PARIC, and Amedisys. See the openings below and apply to the ones that match your experience.

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Overview

Open roles18
Top employerMercy
Work type67% On-site
Top credentialMaster's degree in business administration
Companies hiring18

Showing 5 of 18+ Chief Operating Officer jobs

R
Director of Operations
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R
New 1m ago
Director of Operations
Refurbiture
St. Louis, Missouri
Business Strategy
Product Management
Project Management
On-Site

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University Missouri St.Louis
Associate Director of Clinical Operations
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University Missouri St.Louis
New 1m ago
Associate Director of Clinical Operations
University Missouri St.Louis
St. Louis, Missouri
Business Development
Events & Tourism
Executive Leadership & C-Suite
Project Management
Master's degree in business administration
201-500

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SK Security
Director of Operations
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SK Security
New 1m ago
Director of Operations
SK Security
St. Louis, Missouri
Business Development
Events & Tourism
Executive Leadership & C-Suite
Project Management
On-Site
Bachelor's degree in business administration
51-200

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Security Finance
Director of Operations- Tennessee
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Security Finance
New 1m ago
Director of Operations- Tennessee
Security Finance
St. Louis, Missouri
Business Development
Events & Tourism
Executive Leadership & C-Suite
Project Management
1,001-5,000

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Mercy
Director - Throughput - Nursing & Operations, Mercy South
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Mercy
New 1m ago
Director - Throughput - Nursing & Operations, Mercy South
Mercy
St. Louis, Missouri
Healthcare Administration
Human Resources
Nursing
Master's degree in business
10,000+

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See All 18 Chief Operating Officer Jobs in St. Louis

Find roles in St. Louis that match your experience and apply in just a few clicks.

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Chief Operating Officer Job Market in St. Louis

Who's Hiring

  • Mercy
    Mercy1
  • PARIC
    PARIC1
  • Amedisys
    Amedisys1
  • P
    Plug Tech1
  • R
    Refurbiture1

Top Industries Hiring

  • Healthcare & Medical Services1

Chief Operating Officer Jobs in St. Louis: Frequently Asked Questions

How do I get a chief operating officer job in St. Louis?

The strongest path into a chief operating officer role in St. Louis runs through the city's healthcare systems, regional banks, and distribution and logistics companies, which consistently need operations leadership. Clayton and downtown St. Louis concentrate the most senior postings. Candidates with cross-functional P&L ownership, experience scaling teams, and familiarity with supply chain or regulated-industry compliance stand out most in this market.

Which companies hire chief operating officers in St. Louis?

St. Louis chief operating officer roles are posted by Mercy, PARIC, and Amedisys and others right now, based on current listings on Migrate Mate as of July 2026. The hiring base skews toward large healthcare networks, Fortune 500 headquarters, and regional financial institutions that maintain significant operational leadership teams in the St. Louis metro.

Are there remote chief operating officer jobs in St. Louis?

Yes, though remote availability is limited for this role since chief operating officers typically oversee in-person teams, facilities, and daily operations. About 33% of chief operating officer openings tied to St. Louis are remote or hybrid as of July 2026, with the hybrid arrangements most common in technology firms and professional services companies based in Clayton or Midtown.

How can I get a chief operating officer job in St. Louis with little or no experience?

The most realistic entry path is building toward the role through operations manager or director of operations positions at St. Louis's mid-sized healthcare organizations, logistics companies, or regional nonprofits, which regularly promote from within. Roles in project management, supply chain coordination, or clinical operations at BJC HealthCare, SSM Health, or similar large employers create direct stepping stones to the COO level over time.

Which industries hire the most chief operating officers in St. Louis?

St. Louis chief operating officer roles concentrate in Healthcare & Medical Services, based on current listings on Migrate Mate as of July 2026. St. Louis's deep roots in healthcare, agribusiness, and financial services mean those sectors maintain the largest ongoing need for senior operations leadership across both corporate headquarters and regional divisions.

See All 18 Chief Operating Officer Jobs in St. Louis

Find roles in St. Louis that match your experience and apply in just a few clicks.

Find Chief Operating Officer Jobs