Chief Operating Officer Jobs in St. Louis, MO

Chief Operating Officer jobs in St. Louis concentrate in healthcare, financial services, and logistics, with openings spread across Clayton, the Central West End, and downtown's emerging tech corridor. Employers actively hiring right now include SSM Health, CRB, and Weissman. See the openings below and apply to the ones that match your experience.

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Overview

Open roles63
Top employerSSM Health
Work type68% Hybrid
Top credentialMaster's degree in business administration
Companies hiring14

Showing 5 of 63+ Chief Operating Officer jobs

St. Louis Integrated Health Network
Assistant Director of Community Care Hub Operations
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St. Louis Integrated Health Network
Added 1d ago
Assistant Director of Community Care Hub Operations
St. Louis Integrated Health Network
St. Louis, Missouri
Account Management
Business Development
Customer Success
$62k - $72k/yr
11-50

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Kairos Academies
Director of Operations
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Kairos Academies
Added 1d ago
Director of Operations
Kairos Academies
St. Louis, Missouri
Compliance & Legal
Compliance & Risk
Human Resources
On-Site
High school

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SSM Health
Business Operations Program Director
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SSM Health
Added 2d ago
Business Operations Program Director
SSM Health
St. Louis, Missouri
Executive Leadership & C-Suite
Program Management
Project Management
Bachelor's degree
10,000+

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Cedarhurst Senior Living
Regional Director of Operations (KY, IL, IN, MO)
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Cedarhurst Senior Living
Added 3d ago
Regional Director of Operations (KY, IL, IN, MO)
Cedarhurst Senior Living
St. Louis, Missouri
Executive Leadership & C-Suite
Program Management
Project Management
Bachelor's degree in business administration
1,001-5,000

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A
Director of Finance & Operations
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A
Added 3d ago
Director of Finance & Operations
ArchCity Defenders
St. Louis, Missouri
Customer Service
Customer Support
Hospitality & Guest Services
Master's degree in business administration

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See All 63 Chief Operating Officer Jobs in St. Louis

Find roles in St. Louis that match your experience and apply in just a few clicks.

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Chief Operating Officer Job Market in St. Louis

Who's Hiring

SSM Health
SSM Health8 open roles
CRB
CRB4 open roles
Weissman
Weissman4 open roles

Chief Operating Officer Jobs in St. Louis: Frequently Asked Questions

How do I get a chief operating officer job in St. Louis?

The strongest path into a chief operating officer role in St. Louis runs through the city's healthcare systems, regional banks, and distribution and logistics companies, which consistently need operations leadership. Clayton and downtown St. Louis concentrate the most senior postings. Candidates with cross-functional P&L ownership, experience scaling teams, and familiarity with supply chain or regulated-industry compliance stand out most in this market.

Which companies hire chief operating officers in St. Louis?

St. Louis chief operating officer roles are posted by SSM Health, CRB, and Weissman and others right now, based on current listings on Migrate Mate as of September 2026. The hiring base skews toward large healthcare networks, Fortune 500 headquarters, and regional financial institutions that maintain significant operational leadership teams in the St. Louis metro.

Are there remote chief operating officer jobs in St. Louis?

Yes, though remote availability is limited for this role since chief operating officers typically oversee in-person teams, facilities, and daily operations. About 68% of chief operating officer openings tied to St. Louis are remote or hybrid as of September 2026, with the hybrid arrangements most common in technology firms and professional services companies based in Clayton or Midtown.

How can I get a chief operating officer job in St. Louis with little or no experience?

The most realistic entry path is building toward the role through operations manager or director of operations positions at St. Louis's mid-sized healthcare organizations, logistics companies, or regional nonprofits, which regularly promote from within. Roles in project management, supply chain coordination, or clinical operations at BJC HealthCare, SSM Health, or similar large employers create direct stepping stones to the COO level over time.

See All 63 Chief Operating Officer Jobs in St. Louis

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