Clinical Manager Jobs in Cambridge, MA
Clinical Manager jobs in Cambridge, Massachusetts concentrate in Kendall Square, East Cambridge, and the Alewife corridor, driven by demand from biotech, academic medical, and life sciences employers including Relay Therapeutics, Sodexo, and IPSEN. Opportunities range from outpatient and inpatient program management to clinical operations leadership. See the openings below and apply to the ones that match your experience.
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About This Role
The Senior Manager, Clinical Trial Lead (CTL) is responsible for leading the operational planning, execution, and delivery of one or more clinical studies across the development lifecycle. This role manages study timelines, budgets, CRO and vendor partnerships, risk mitigation, and cross-functional collaboration through leadership of the Study Management Team (SMT). Key objectives include delivering studies on time, within budget, and in compliance with GCP, regulatory requirements, and quality standards while ensuring patient safety and data integrity. Acting as the central operational leader, the CTL drives protocol feasibility, study execution, and informed decision-making across stakeholders. The role brings value by ensuring operational excellence, proactive issue management, and successful study delivery that advances development program goals. As a core member of Clinical Operations, the CTL partners closely with Medical, Biostatistics, Regulatory, Data Management, and external partners to support broader program and asset strategies.
What You’ll Do:
- Lead the operational planning, execution, and delivery of one or more clinical studies.
- Chair the Study Management Team (SMT) and drive cross-functional study execution.
- Partner with Medical, Biostatistics, Regulatory, and other stakeholders to develop operationally feasible protocols and study strategies.
- Evaluate study feasibility and develop comprehensive operational, monitoring, quality, and risk management plans.
- Manage study timelines, budgets, forecasts, and governance deliverables to ensure on-time, on-budget execution.
- Identify, assess, and mitigate operational risks while maintaining patient safety, data integrity, and regulatory compliance.
- Oversee CROs, vendors, and outsourced partnerships, ensuring performance, milestone achievement, and effective issue resolution.
- Monitor study performance and conduct ongoing data reviews to identify and address quality, safety, or execution issues.
- Maintain accurate, inspection-ready study documentation and data within clinical trial management systems.
- Champion process improvements, operational excellence, and best practices across studies and development programs.
Who You Are:
You are a clinical operations leader who drives the successful planning, execution, and delivery of complex clinical trials, expertly managing timelines, budgets, CRO partnerships, risks, and cross-functional teams while maintaining the highest standards of quality, compliance, patient safety, and data integrity.
You thrive in a fast-paced development environment, leveraging your clinical trial management expertise, strategic problem-solving skills, and collaborative leadership style to ensure studies are delivered on time, within budget, and aligned with broader program objectives.
Required Skills
- Bachelors degree in a scientific discipline
- 6 + years in clinical operations management, overseeing outsourced clinical trials per quality, timeline, and budget expectations, preferably with a sponsor company and a CRO
- Scientific and clinical expertise with strong project management, risk assessment, contingency planning, and communication skills.
- Working knowledge of clinical development across Phase I-IV studies and cross-functional drug development.
- Demonstrated experience managing CROs, vendors, and outsourced clinical trials, including governance, performance oversight, budgets, quality, and outsourcing strategies.
- Expertise in GCP, ICH guidelines, and global regulatory requirements for clinical development.
- Proven ability to develop and execute operational plans that support successful clinical trial delivery.
Preferred Skills
- Experience in Immunology, Rare Disease, or Neurology
This position can be based in either Cambridge, MA or RTP, NC. The pay range posted encompasses the pay range for both potential work locations. Actual pay will be determined by the selected candidate’s work location, as well as relevant experience and qualifications.
Job Level: Management
Additional Information
Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.
Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.
In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families physical, financial, emotional, and social well-being ; including, but not limited to:
- Medical, Dental, Vision, & Life insurances
- Fitness & Wellness programs including a fitness reimbursement
- Short- and Long-Term Disability insurance
- A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
- Up to 12 company paid holidays + 3 paid days off for Personal Significance
- 80 hours of sick time per calendar year
- Paid Maternity and Parental Leave benefit
- 401(k) program participation with company matched contributions
- Employee stock purchase plan
- Tuition reimbursement of up to $10,000 per calendar year
- Employee Resource Groups participation
Why Biogen?
We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.
At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired.
All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.
About This Role
The Senior Manager, Clinical Trial Lead (CTL) is responsible for leading the operational planning, execution, and delivery of one or more clinical studies across the development lifecycle. This role manages study timelines, budgets, CRO and vendor partnerships, risk mitigation, and cross-functional collaboration through leadership of the Study Management Team (SMT). Key objectives include delivering studies on time, within budget, and in compliance with GCP, regulatory requirements, and quality standards while ensuring patient safety and data integrity. Acting as the central operational leader, the CTL drives protocol feasibility, study execution, and informed decision-making across stakeholders. The role brings value by ensuring operational excellence, proactive issue management, and successful study delivery that advances development program goals. As a core member of Clinical Operations, the CTL partners closely with Medical, Biostatistics, Regulatory, Data Management, and external partners to support broader program and asset strategies.
What You’ll Do:
- Lead the operational planning, execution, and delivery of one or more clinical studies.
- Chair the Study Management Team (SMT) and drive cross-functional study execution.
- Partner with Medical, Biostatistics, Regulatory, and other stakeholders to develop operationally feasible protocols and study strategies.
- Evaluate study feasibility and develop comprehensive operational, monitoring, quality, and risk management plans.
- Manage study timelines, budgets, forecasts, and governance deliverables to ensure on-time, on-budget execution.
- Identify, assess, and mitigate operational risks while maintaining patient safety, data integrity, and regulatory compliance.
- Oversee CROs, vendors, and outsourced partnerships, ensuring performance, milestone achievement, and effective issue resolution.
- Monitor study performance and conduct ongoing data reviews to identify and address quality, safety, or execution issues.
- Maintain accurate, inspection-ready study documentation and data within clinical trial management systems.
- Champion process improvements, operational excellence, and best practices across studies and development programs.
Who You Are:
You are a clinical operations leader who drives the successful planning, execution, and delivery of complex clinical trials, expertly managing timelines, budgets, CRO partnerships, risks, and cross-functional teams while maintaining the highest standards of quality, compliance, patient safety, and data integrity.
You thrive in a fast-paced development environment, leveraging your clinical trial management expertise, strategic problem-solving skills, and collaborative leadership style to ensure studies are delivered on time, within budget, and aligned with broader program objectives.
Required Skills
- Bachelors degree in a scientific discipline
- 6 + years in clinical operations management, overseeing outsourced clinical trials per quality, timeline, and budget expectations, preferably with a sponsor company and a CRO
- Scientific and clinical expertise with strong project management, risk assessment, contingency planning, and communication skills.
- Working knowledge of clinical development across Phase I-IV studies and cross-functional drug development.
- Demonstrated experience managing CROs, vendors, and outsourced clinical trials, including governance, performance oversight, budgets, quality, and outsourcing strategies.
- Expertise in GCP, ICH guidelines, and global regulatory requirements for clinical development.
- Proven ability to develop and execute operational plans that support successful clinical trial delivery.
Preferred Skills
- Experience in Immunology, Rare Disease, or Neurology
This position can be based in either Cambridge, MA or RTP, NC. The pay range posted encompasses the pay range for both potential work locations. Actual pay will be determined by the selected candidate’s work location, as well as relevant experience and qualifications.
Job Level: Management
Additional Information
Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.
Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.
In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families physical, financial, emotional, and social well-being ; including, but not limited to:
- Medical, Dental, Vision, & Life insurances
- Fitness & Wellness programs including a fitness reimbursement
- Short- and Long-Term Disability insurance
- A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
- Up to 12 company paid holidays + 3 paid days off for Personal Significance
- 80 hours of sick time per calendar year
- Paid Maternity and Parental Leave benefit
- 401(k) program participation with company matched contributions
- Employee stock purchase plan
- Tuition reimbursement of up to $10,000 per calendar year
- Employee Resource Groups participation
Why Biogen?
We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.
At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired.
All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.
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Find Clinical Manager JobsClinical Manager Job Market in Cambridge
Who's Hiring
- Relay Therapeutics44
- Sodexo22
- IPSEN11
- Biogen11
- Pfizer11
Top Industries Hiring
- Science & Research11
- Biotechnology & Pharmaceuticals11
- Consulting & Professional Services11
Clinical Manager Jobs in Cambridge: Frequently Asked Questions
How do I get a clinical manager job in Cambridge?
Focus your search on Kendall Square's dense biotech and pharma cluster, the academic medical centers anchored near Harvard and MIT, and the growing life sciences corridor along the Alewife corridor. Employers in Cambridge typically prioritize candidates with direct program or departmental leadership experience, familiarity with regulated clinical environments, and a demonstrated ability to manage multidisciplinary teams. Tailoring your resume to the specific sector, whether research-driven biotech or ambulatory care, gives you a meaningful edge in this competitive local market.
Which companies hire clinical managers in Cambridge?
Employers hiring clinical managers in Cambridge right now include Relay Therapeutics, Sodexo, and IPSEN, based on current listings on Migrate Mate as of October 2026. Cambridge's employer mix leans heavily toward research hospitals, biotechnology firms, and specialty care organizations, many of which maintain both clinical and operational management roles across their Cambridge campuses.
Are there remote clinical manager jobs in Cambridge?
Yes, but with limits. Clinical manager roles are often tied to on-site oversight of staff and patient-facing programs, making fully remote positions less common than in purely desk-based fields. About 57% of clinical manager openings tied to Cambridge are remote or hybrid as of October 2026, and those arrangements tend to concentrate in care coordination, utilization management, and clinical operations roles where direct facility presence is less essential.
How can I get a clinical manager job in Cambridge with little or no experience?
The most realistic entry path in Cambridge is moving into a team lead or senior clinician role at one of the city's academic medical affiliates or larger biotech-sponsored clinical programs, then stepping into management from there. Cambridge employers frequently hire charge nurses, senior coordinators, and clinical supervisors as developmental roles before promoting into full management. Volunteering for quality improvement or compliance projects within your current organization also signals readiness for the supervisory responsibilities Cambridge employers expect.
Which industries hire the most clinical managers in Cambridge?
The sectors hiring the most clinical managers in Cambridge are Science & Research, Biotechnology & Pharmaceuticals, and Consulting & Professional Services, based on current listings on Migrate Mate as of October 2026. Cambridge's concentration of research institutions, biotechnology campuses, and hospital-affiliated outpatient programs creates sustained demand for clinical managers who can operate at the intersection of patient care delivery and organizational leadership.
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