Clinical Project Lead Jobs
Clinical Project Lead jobs are open across pharmaceuticals, biotechnology, medical devices, and contract research organizations, from associate to director level, with specializations in oncology, clinical operations, and regulatory affairs. See the openings below and apply to the ones that match your experience.
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Theradex Oncology is a full-service CRO specializing in oncology. The company manages global oncology trials and programs. The company was founded in 1982 working with the National Cancer Institute, which led to its expansion to working with industry sponsors developing cancer therapeutics. As a service-based company we support both domestic and international sponsors in the conduct of both early and late phase trials.
As part of Theradex Oncology, you will have the opportunity to work with one of the largest professional teams focused solely on the development of cancer therapies. Cancer research continues to evolve as new therapies and therapeutic approaches are discovered, as part of the team you will work to support our sponsors in the development of these therapies. Theradex Oncology is an environment for highly motivated individuals who want to make a difference.
Opportunity
Clinical Project Manager or Sr Clinical Project Manager based on experience.
Location: USA Remote
Theradex Project Managers oversee global phase I – III oncology clinical trials from feasibility and startup through closeout to ensure processes, timelines, contracts, ICH/GCP adherence and quality standards are met. As a key point of contact you'll interface directly with sponsors, vendors, cross-functional team members and investigative sites. You'll identify and evaluate risks, interpret data on complex issues and implement solutions to ensure successful completion of oncology trials.
- Clinical Project Leadership: Drive the successful execution and proactive management of clinical projects. Serve as the subject matter expert for assigned protocols and provide guidance to cross-functional study teams.
- Study Oversight: Monitor study enrollment, retention, and metrics to identify trends and act on deviations. Develop and implement strategic solutions for recruitment and retention challenges. Ensure accurate study information is reflected in status reports and clinical trial platforms.
- Risk and Quality Management: Proactively identify and communicate operational risks, aligning with the study team on mitigation strategies. Oversee the development and adherence to study-specific oversight and Corrective and Preventive Action (CAPA) plans.
- Compliance and Audits: Manage the Trial Master File (TMF) for Clinical Operations documentation and ensure inspection readiness. Collaborate with Quality Assurance for internal and external audits.
- Budget and Timelines: Proactively manage study-specific timelines and budgets. Review and approve invoices and timesheets. Identify and initiate Change Order (CO) activities as required to maintain project scope.
- Team Management: Lead and manage the day-to-day activities of the study team, including leading team meetings and conducting study-specific training.
What You Need:
-
BS required – preferably in a life science field or related filed (includes RN degree)
MS or PhD preferred - Healthcare professional with at least 4 years of clinical experience, or Science Graduate with at least 4 years experience in clinical research (minimum 5 years for Sr level), with a track record in successfully managing clinical trial sites
- Prior project management experience required
- High level of proficiency with Excel and MS Office; ability to master various electronic platforms for data entry and clinical trial management
- Experience with oncology clinical trials and/or cancer therapies is highly preferred
- Prior involvement with CAR-T or other gene/cell therapies is highly preferred
- Prior experience in a CRO/pharmaceutical environment preferred (required for senior level project managers)
- Must be fluent in English (verbal and written)
- Well-developed critical thinking and analytical skills, with the ability to anticipate problems relating to projects and to develop and implement solutions
- Able to seek out multiple and diverse perspectives; open to continuously refining your approach based on feedback and new information
- Knowledgeable of the initiation, conduct, and completion of clinical trials, study endpoints, and clinical databases
- Well-developed and effective written and verbal communication skills, including report writing, preparing, and delivering presentations, and various correspondence and meeting platforms
- Effective knowledge of the drug development process
- Thorough knowledge of current European and North American regulations and any applicable guidelines
- Highly effective ability to set and meet personal short- and long-term goals
Additional Requirements
- Ability to travel up to 30% when required, domestic and/or global
- Valid Driver’s License an advantage
- Basic knowledge of one (or more) European language an advantage
What We Offer
At Theradex we offer a supportive culture that puts people first. Our employees are eligible to participate in our comprehensive benefits package which includes medical, dental and vision coverage; life insurance, disability insurance (STD/LTD), company matched 401(k), very competitive tuition reimbursement, generous vacation/sick plans, flexible work schedules, employee discounts and other company provided benefits. The annual base salary for this position ranges from $105,000-$165,000 with bonus potential. We will assess the specific title and level of entry during the interview and assessment process since the actual salary offer will be based on a number of factors, including but not limited to the candidate’s qualifications, experience, skills, and competencies for the role.
This position is not eligible for company provided sponsorship or relocation.
Theradex is an Equal Opportunity Employer.
Theradex Oncology is a full-service CRO specializing in oncology. The company manages global oncology trials and programs. The company was founded in 1982 working with the National Cancer Institute, which led to its expansion to working with industry sponsors developing cancer therapeutics. As a service-based company we support both domestic and international sponsors in the conduct of both early and late phase trials.
As part of Theradex Oncology, you will have the opportunity to work with one of the largest professional teams focused solely on the development of cancer therapies. Cancer research continues to evolve as new therapies and therapeutic approaches are discovered, as part of the team you will work to support our sponsors in the development of these therapies. Theradex Oncology is an environment for highly motivated individuals who want to make a difference.
Opportunity
Clinical Project Manager or Sr Clinical Project Manager based on experience.
Location: USA Remote
Theradex Project Managers oversee global phase I – III oncology clinical trials from feasibility and startup through closeout to ensure processes, timelines, contracts, ICH/GCP adherence and quality standards are met. As a key point of contact you'll interface directly with sponsors, vendors, cross-functional team members and investigative sites. You'll identify and evaluate risks, interpret data on complex issues and implement solutions to ensure successful completion of oncology trials.
- Clinical Project Leadership: Drive the successful execution and proactive management of clinical projects. Serve as the subject matter expert for assigned protocols and provide guidance to cross-functional study teams.
- Study Oversight: Monitor study enrollment, retention, and metrics to identify trends and act on deviations. Develop and implement strategic solutions for recruitment and retention challenges. Ensure accurate study information is reflected in status reports and clinical trial platforms.
- Risk and Quality Management: Proactively identify and communicate operational risks, aligning with the study team on mitigation strategies. Oversee the development and adherence to study-specific oversight and Corrective and Preventive Action (CAPA) plans.
- Compliance and Audits: Manage the Trial Master File (TMF) for Clinical Operations documentation and ensure inspection readiness. Collaborate with Quality Assurance for internal and external audits.
- Budget and Timelines: Proactively manage study-specific timelines and budgets. Review and approve invoices and timesheets. Identify and initiate Change Order (CO) activities as required to maintain project scope.
- Team Management: Lead and manage the day-to-day activities of the study team, including leading team meetings and conducting study-specific training.
What You Need:
-
BS required – preferably in a life science field or related filed (includes RN degree)
MS or PhD preferred - Healthcare professional with at least 4 years of clinical experience, or Science Graduate with at least 4 years experience in clinical research (minimum 5 years for Sr level), with a track record in successfully managing clinical trial sites
- Prior project management experience required
- High level of proficiency with Excel and MS Office; ability to master various electronic platforms for data entry and clinical trial management
- Experience with oncology clinical trials and/or cancer therapies is highly preferred
- Prior involvement with CAR-T or other gene/cell therapies is highly preferred
- Prior experience in a CRO/pharmaceutical environment preferred (required for senior level project managers)
- Must be fluent in English (verbal and written)
- Well-developed critical thinking and analytical skills, with the ability to anticipate problems relating to projects and to develop and implement solutions
- Able to seek out multiple and diverse perspectives; open to continuously refining your approach based on feedback and new information
- Knowledgeable of the initiation, conduct, and completion of clinical trials, study endpoints, and clinical databases
- Well-developed and effective written and verbal communication skills, including report writing, preparing, and delivering presentations, and various correspondence and meeting platforms
- Effective knowledge of the drug development process
- Thorough knowledge of current European and North American regulations and any applicable guidelines
- Highly effective ability to set and meet personal short- and long-term goals
Additional Requirements
- Ability to travel up to 30% when required, domestic and/or global
- Valid Driver’s License an advantage
- Basic knowledge of one (or more) European language an advantage
What We Offer
At Theradex we offer a supportive culture that puts people first. Our employees are eligible to participate in our comprehensive benefits package which includes medical, dental and vision coverage; life insurance, disability insurance (STD/LTD), company matched 401(k), very competitive tuition reimbursement, generous vacation/sick plans, flexible work schedules, employee discounts and other company provided benefits. The annual base salary for this position ranges from $105,000-$165,000 with bonus potential. We will assess the specific title and level of entry during the interview and assessment process since the actual salary offer will be based on a number of factors, including but not limited to the candidate’s qualifications, experience, skills, and competencies for the role.
This position is not eligible for company provided sponsorship or relocation.
Theradex is an Equal Opportunity Employer.
Clinical Project Lead Jobs by Experience Level
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Find Clinical Project Lead JobsClinical Project Lead Job Market
Who's Hiring
- サイネオス・ヘルス35
- Medpace8
- IQVIA6
- Syneos Health5
- Massachusetts General Hospital5
Top Industries Hiring
- Healthcare & Medical Services14
- Biotechnology & Pharmaceuticals10
- Education4
- Medical Devices2
- Distribution & Wholesale2
What Employers Look For
The qualifications that appear most often in clinical project lead jobs.
- Bachelor's or master's degree in life sciences, nursing, or a related clinical field
- Five or more years of clinical trial management experience across multiple phases
- Demonstrated experience managing cross-functional teams and CRO partnerships
- Proficiency with clinical trial management systems such as Veeva Vault or Medidata Rave
- PMP, RAPS, or ACRP certification preferred by most mid-to-large sponsors
- Strong working knowledge of ICH-GCP guidelines and FDA regulatory requirements
Tips for Your Clinical Project Lead Job Search
Tailor your resume to trial phases
Hiring managers scan for the specific trial phases you've owned, so list Phase I, II, or III experience explicitly rather than burying it in a general summary. Matching your resume's language to the job posting's phase focus gets you past initial screening.
Highlight your CRO and sponsor experience
Employers distinguish between CRO-side and sponsor-side backgrounds because the accountability and pace differ sharply. Name both if you have them, and clarify the size and therapeutic area of each study you led so reviewers can benchmark your scope quickly.
Apply early to roles that fit
Migrate Mate lists clinical project lead openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Filter by therapeutic area before applying
Oncology, rare disease, and CNS roles each carry distinct regulatory and operational demands. Applying to openings that match your therapeutic background rather than casting wide saves time and puts you in front of teams who actually need your specific experience.
Prepare a budget ownership story for interviews
Interviewers for clinical project lead roles almost always probe study budget management. Bring a specific example of a budget variance you caught early, how you escalated it, and what the outcome was. Vague answers about budget awareness rarely satisfy.
Negotiate start date around site activation timelines
If you're negotiating an offer while wrapping up an active study, propose a start date tied to a concrete milestone like site close-out or final data lock. Hiring teams in clinical operations understand study timelines and respond better to that framing than a generic notice period.
Clinical Project Lead Jobs: Frequently Asked Questions
Which companies are hiring the most clinical project leads?
サイネオス・ヘルス, Medpace, and IQVIA are hiring the most clinical project leads right now, with openings concentrated in California, Massachusetts, and New Jersey, based on current listings on Migrate Mate as of November 2026. Mid-size biotechs and large CROs tend to post the highest volume of these roles year-round.
How many clinical project lead jobs are remote?
About 79% of clinical project lead openings are fully remote or hybrid as of November 2026, reflecting the site-oversight and vendor management nature of the role. Sponsor-side positions with centralized monitoring responsibilities tend to offer the most remote flexibility, while roles requiring frequent site visits are more likely to be on-site or regionally based.
How do you become a clinical project lead?
Start by building several years of hands-on experience as a clinical research associate or clinical trial coordinator, gaining direct site management and monitoring experience. Move into a team lead or study manager role to demonstrate cross-functional oversight, then pursue a formal project lead position. Earning GCP certification and familiarity with a major clinical trial management system strengthens your candidacy considerably.
Can you get hired as a clinical project lead without direct project lead experience?
Yes, especially at smaller biotechs and CROs that promote from within. Candidates who have led sub-teams, managed site relationships independently, or owned a workstream during a larger trial often qualify for associate project lead roles. Framing your existing experience around budget tracking, vendor coordination, and timeline ownership closes the gap more effectively than emphasizing your title.
What does the clinical project lead interview process look like?
Most processes run three to four rounds. An initial recruiter screen is followed by a hiring manager conversation focused on your trial management background and therapeutic experience. A panel interview with cross-functional stakeholders, often including clinical operations and regulatory colleagues, comes next. Some employers add a written case study or scenario exercise asking you to triage a study delay or budget issue before a final offer conversation.
Where can I find and apply to clinical project lead jobs?
You can find and apply to clinical project lead jobs on Migrate Mate, which lists current openings from across the United States. Search for roles that match your therapeutic area, seniority level, and location preference, then apply directly to each listing that fits your background.
See All 190+ Clinical Project Lead Jobs
Find roles that match your experience and apply in just a few clicks.
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