Mid Level Clinical Trial Manager Jobs
Mid level clinical trial manager jobs go to professionals ready to own trial protocols end to end, coordinate cross-functional teams, and resolve site-level issues with minimal oversight. Openings run across Biotechnology & Pharmaceuticals, Healthcare & Medical Services, and Medical Devices, with 21% remote or hybrid availability, and employers like Medpace, Heartflow, and IQVIA hiring at this level now.
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Showing 4 of 22+ Mid Level Clinical Trial Manager jobs
Job Title: Clinical Trial Manager
Location: North Carolina
Summary
We are seeking an experienced Clinical Trial Manager (CTM) to oversee the clinical operations, quality, timelines, resources, and deliverables of assigned clinical studies. The ideal candidate will have 5+ years of clinical research experience with strong knowledge of clinical monitoring, ICH-GCP, FDA regulations, study start-up, TMF management, and clinical trial operations. This role will primarily support low-to-moderate complexity studies and work closely with cross-functional clinical teams, project managers, study sites, and clients.
Responsibilities
- Manage clinical operational and quality activities for assigned studies in compliance with ICH-GCP, FDA guidelines, and study-specific requirements.
- Develop and maintain Monitoring Plans, Monitoring Guidelines, Data Quality Plans, and clinical tracking tools.
- Ensure timely setup, maintenance, and quality of Trial Master Files (TMF) and essential study documentation.
- Monitor study timelines, milestones, metrics, clinical deliverables, CRF collection, query resolution, and monitoring visit reports.
- Lead clinical team meetings and coordinate resources, responsibilities, timelines, and deliverables.
- Conduct or co-monitor clinical trials and perform Accompanied Field Visits (AFVs) when required.
- Identify study risks, delays, and resource constraints and implement appropriate recovery actions.
- Support study start-up, ethics committee submissions, regulatory submissions, and resolution of committee queries.
- Communicate with clinical sites regarding protocols, patient participation, CRF completion, and study-related issues.
- Collaborate with Project Managers and cross-functional teams for client meetings, study planning, handoffs, and project execution.
- Support clinical resource management, workload allocation, budgeting, forecasting, and financial tracking.
- Ensure clinical activities remain within contractual scope, timelines, quality, and budget requirements.
- Ensure timely archiving of study documents and materials.
Requirements
- Bachelor’s degree or equivalent relevant education/qualification.
- 5+ years of relevant clinical research or clinical trial experience.
- Hands-on experience in clinical trial operations and clinical monitoring.
- Strong understanding of ICH-GCP, FDA regulations, and clinical research requirements.
- Experience with TMF, CRFs, monitoring reports, clinical tracking, and query management.
- Knowledge of study start-up, site management, and ethics/regulatory submissions.
- Strong leadership, mentoring, communication, and team coordination skills.
- Excellent planning, organizational, prioritization, and problem-solving abilities.
- Ability to work effectively in a matrix, multicultural, and changing environment.
- Strong attention to detail and sound judgment/decision-making skills.
- Understanding of clinical trial budgets, forecasting, resource allocation, and financial management.
- Proficiency with Microsoft Office tools including Excel, Word, and Outlook.
- Excellent written and verbal English communication skills.
Job Title: Clinical Trial Manager
Location: North Carolina
Summary
We are seeking an experienced Clinical Trial Manager (CTM) to oversee the clinical operations, quality, timelines, resources, and deliverables of assigned clinical studies. The ideal candidate will have 5+ years of clinical research experience with strong knowledge of clinical monitoring, ICH-GCP, FDA regulations, study start-up, TMF management, and clinical trial operations. This role will primarily support low-to-moderate complexity studies and work closely with cross-functional clinical teams, project managers, study sites, and clients.
Responsibilities
- Manage clinical operational and quality activities for assigned studies in compliance with ICH-GCP, FDA guidelines, and study-specific requirements.
- Develop and maintain Monitoring Plans, Monitoring Guidelines, Data Quality Plans, and clinical tracking tools.
- Ensure timely setup, maintenance, and quality of Trial Master Files (TMF) and essential study documentation.
- Monitor study timelines, milestones, metrics, clinical deliverables, CRF collection, query resolution, and monitoring visit reports.
- Lead clinical team meetings and coordinate resources, responsibilities, timelines, and deliverables.
- Conduct or co-monitor clinical trials and perform Accompanied Field Visits (AFVs) when required.
- Identify study risks, delays, and resource constraints and implement appropriate recovery actions.
- Support study start-up, ethics committee submissions, regulatory submissions, and resolution of committee queries.
- Communicate with clinical sites regarding protocols, patient participation, CRF completion, and study-related issues.
- Collaborate with Project Managers and cross-functional teams for client meetings, study planning, handoffs, and project execution.
- Support clinical resource management, workload allocation, budgeting, forecasting, and financial tracking.
- Ensure clinical activities remain within contractual scope, timelines, quality, and budget requirements.
- Ensure timely archiving of study documents and materials.
Requirements
- Bachelor’s degree or equivalent relevant education/qualification.
- 5+ years of relevant clinical research or clinical trial experience.
- Hands-on experience in clinical trial operations and clinical monitoring.
- Strong understanding of ICH-GCP, FDA regulations, and clinical research requirements.
- Experience with TMF, CRFs, monitoring reports, clinical tracking, and query management.
- Knowledge of study start-up, site management, and ethics/regulatory submissions.
- Strong leadership, mentoring, communication, and team coordination skills.
- Excellent planning, organizational, prioritization, and problem-solving abilities.
- Ability to work effectively in a matrix, multicultural, and changing environment.
- Strong attention to detail and sound judgment/decision-making skills.
- Understanding of clinical trial budgets, forecasting, resource allocation, and financial management.
- Proficiency with Microsoft Office tools including Excel, Word, and Outlook.
- Excellent written and verbal English communication skills.
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Mid Level Clinical Trial Manager Jobs: Frequently Asked Questions
How do I get a mid level clinical trial manager job?
Position your experience around direct trial ownership, not just support tasks. Highlight protocols you managed from startup through closeout, vendor relationships you led, and any regulatory submissions you contributed to. Applications that show concrete responsibility for timelines, budgets, or site performance stand out. Tailor your materials to the therapeutic area and phase focus listed in each job description.
Which companies hire mid level clinical trial managers?
Companies hiring mid level clinical trial managers right now include Medpace, Heartflow, and IQVIA, based on current listings on Migrate Mate as of August 2026. Hiring at this level comes primarily from contract research organizations, mid-size biotechs, and large pharmaceutical sponsors running active Phase II and Phase III programs.
Are there remote mid level clinical trial manager jobs?
Yes, though most roles still include periodic site travel. About 21% of mid level clinical trial manager openings are remote or hybrid as of August 2026, reflecting industry adoption of remote monitoring models. Fully on-site roles tend to be concentrated at sponsor sites running early-phase or complex device trials.
How do I move up to a mid level clinical trial manager role?
The path typically runs through demonstrated ownership rather than time alone. Build it by taking lead responsibility on a protocol or site activation, completing a Good Clinical Practice certification, and accumulating measurable results like on-time enrollment or clean audit records. Volunteering for cross-functional projects and mentoring newer coordinators signals readiness for the accountability mid level roles require.
Which industries hire the most mid level clinical trial managers?
Mid Level clinical trial manager roles concentrate in Biotechnology & Pharmaceuticals, Healthcare & Medical Services, and Medical Devices, based on current listings on Migrate Mate as of August 2026. Those sectors drive hiring at this level because they run the highest volumes of interventional studies requiring experienced managers who can operate with limited oversight across multiple active sites.