Alnylam Visa Sponsorship Jobs USA
Alnylam Pharmaceuticals is a pioneering RNAi therapeutics company with a consistent track record of sponsoring international talent across H-1B visa, E-3 visa, and Green Card pathways. For scientists, engineers, and business professionals targeting biotech, Alnylam is a genuine sponsorship-friendly employer worth pursuing.
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The Oncology Research group at Alnylam is seeking a highly motivated Senior Associate Scientist skilled in bioconjugation chemistry to join our growing interdisciplinary team aimed at developing RNAi therapeutics against cancer. The successful candidate will have hands-on expertise in the design and execution of protein conjugation experiments, as well as a strong working knowledge of the purification and characterization of protein conjugates with oligonucleotide or small molecule payloads. This position will work closely with colleagues in chemistry, biology and in vivo pharmacology to support various oncology drug discovery projects. The candidate must be motivated, have strong interpersonal and communication skills, and be able to work on a highly collaborative team.
This position is onsite and will be primarily located in Cambridge, MA.
Key Responsibilities
- Independently plan and carry out protein conjugation experiments with oligonucleotide or other payloads to support in vitro and in vivo experiments.
- Improve upon or develop purification methods for novel protein conjugates using FPLC, HPLC and TFF.
- Design, synthesize and purify oligonucleotides modified with biorthogonal handles (e.g. maleimide, Azide, MeTz) for protein conjugation chemistry.
- Develop automation and/or plate-based protocols for the high throughput generation of new protein conjugates.
- Effectively troubleshoot synthetic and process challenges and independently come up with solutions.
- Support group by contributing to the maintenance of laboratory infrastructure and equipment.
- Keep detailed and complete records in an electronic lab notebook and regularly communicate results to the team to progress drug discovery efforts.
Qualifications
- BS/MS degree in Chemistry, Chemical Biology, or a related field with 3-5 years of hands-on industry experience in protein conjugation chemistry.
- Deep expertise in biorthogonal chemistry with prior experience applying this knowledge to protein conjugation is required.
- Experience working with antibody-oligonucleotide conjugates is strongly preferred.
- Proficiency in synthetic chemistry lab techniques and strong working knowledge of instrumentation such as FPLC, analytical and prep HPLC (IEX, SEC, RP), LC-MS, TFF, UV-Vis spectrometry, etc.
- Experience with automation and/or plate-based protocols to improve conjugate throughput is a plus.
- Passionate about scientific discovery and eager to learn new skills and contribute to the success of the organization.
- Strong organizational, communication, and critical thinking skills.
- Excellent communicator, execution-focused and team-oriented.
- Good record keeping abilities to adequately document protocols and experimental data, experience with Benchling ELN is a plus.
U.S. Pay Range
$80,000.00 - $120,000.00
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).
Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k) with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.
About Alnylam
We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.
At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.
Overview
The Oncology Research group at Alnylam is seeking a highly motivated Senior Associate Scientist skilled in bioconjugation chemistry to join our growing interdisciplinary team aimed at developing RNAi therapeutics against cancer. The successful candidate will have hands-on expertise in the design and execution of protein conjugation experiments, as well as a strong working knowledge of the purification and characterization of protein conjugates with oligonucleotide or small molecule payloads. This position will work closely with colleagues in chemistry, biology and in vivo pharmacology to support various oncology drug discovery projects. The candidate must be motivated, have strong interpersonal and communication skills, and be able to work on a highly collaborative team.
This position is onsite and will be primarily located in Cambridge, MA.
Key Responsibilities
- Independently plan and carry out protein conjugation experiments with oligonucleotide or other payloads to support in vitro and in vivo experiments.
- Improve upon or develop purification methods for novel protein conjugates using FPLC, HPLC and TFF.
- Design, synthesize and purify oligonucleotides modified with biorthogonal handles (e.g. maleimide, Azide, MeTz) for protein conjugation chemistry.
- Develop automation and/or plate-based protocols for the high throughput generation of new protein conjugates.
- Effectively troubleshoot synthetic and process challenges and independently come up with solutions.
- Support group by contributing to the maintenance of laboratory infrastructure and equipment.
- Keep detailed and complete records in an electronic lab notebook and regularly communicate results to the team to progress drug discovery efforts.
Qualifications
- BS/MS degree in Chemistry, Chemical Biology, or a related field with 3-5 years of hands-on industry experience in protein conjugation chemistry.
- Deep expertise in biorthogonal chemistry with prior experience applying this knowledge to protein conjugation is required.
- Experience working with antibody-oligonucleotide conjugates is strongly preferred.
- Proficiency in synthetic chemistry lab techniques and strong working knowledge of instrumentation such as FPLC, analytical and prep HPLC (IEX, SEC, RP), LC-MS, TFF, UV-Vis spectrometry, etc.
- Experience with automation and/or plate-based protocols to improve conjugate throughput is a plus.
- Passionate about scientific discovery and eager to learn new skills and contribute to the success of the organization.
- Strong organizational, communication, and critical thinking skills.
- Excellent communicator, execution-focused and team-oriented.
- Good record keeping abilities to adequately document protocols and experimental data, experience with Benchling ELN is a plus.
U.S. Pay Range
$80,000.00 - $120,000.00
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).
Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k) with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.
About Alnylam
We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.
At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.
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Get Access To All JobsTips for Finding Alnylam Visa Sponsorship Jobs USA
Target roles aligned with RNAi research and drug development
Alnylam's core work in RNA interference therapeutics drives demand for scientists, bioinformaticians, and clinical researchers. Roles closest to its pipeline, discovery, translational medicine, and regulatory affairs, have the strongest sponsorship history at the company.
Understand which visa pathways Alnylam uses
Alnylam sponsors H-1B, E-3, and Green Card pathways including EB-2 and EB-3. If you're an Australian national, the E-3 route is worth raising directly with recruiters, as Alnylam has demonstrated willingness to use it.
Position your application around specialized technical expertise
Biotech sponsors prioritize candidates with hard-to-find skills. Emphasize expertise in areas like genomics, clinical development, biostatistics, or CMC manufacturing, specializations that justify the investment in sponsorship over a domestic hire.
Raise visa sponsorship early, but professionally
Alnylam is an active sponsor, so the conversation won't catch recruiters off guard. Mention your visa status in the initial screen rather than waiting, it helps hiring managers plan timelines and avoids wasted effort late in the process.
Look beyond Cambridge HQ for sponsorship opportunities
Alnylam operates across multiple functions including commercial, medical affairs, and corporate roles, not just lab-based positions. Manufacturing and operations roles tied to its growing product portfolio can also be strong sponsorship candidates.
Use a verified sponsor database to find open roles
Not every job posting discloses sponsorship willingness upfront. Migrate Mate surfaces verified sponsors so you can filter by real sponsorship history, helping you focus your search on Alnylam roles confirmed to support visa applicants.
Frequently Asked Questions
Does Alnylam sponsor H-1B visas?
Yes, Alnylam sponsors H-1B visas and has a consistent track record of doing so across its scientific, clinical, and corporate functions. The company operates in a highly specialized field where international talent is often essential, making it a reliably active H-1B sponsor. Roles in drug discovery, bioinformatics, clinical development, and regulatory affairs tend to see the most H-1B sponsorship activity.
Which visa types does Alnylam sponsor?
Alnylam sponsors H-1B visas, E-3 visas for Australian nationals, and Green Card pathways including EB-2 and EB-3 classifications. The company's willingness to support both nonimmigrant and immigrant visa categories signals a long-term investment in its sponsored employees. If you're unsure which pathway applies to your situation, it's worth discussing directly with Alnylam's HR team during the offer stage.
What types of roles at Alnylam are most likely to receive visa sponsorship?
Sponsorship at Alnylam is most common in roles that require deep scientific or technical expertise, think research scientists, clinical pharmacologists, biostatisticians, and regulatory specialists. That said, the company also sponsors professionals in finance, legal, and commercial functions when the right candidate requires it. Roles tied to its active drug pipeline and global clinical trials tend to have the strongest sponsorship demand.
How do I find open sponsored roles at Alnylam?
The most efficient approach is to search a platform that verifies sponsorship history rather than relying on job postings alone, which often omit visa details. Migrate Mate lets you filter by confirmed sponsors like Alnylam, so you can see active openings alongside real sponsorship data. From there, applying directly through Alnylam's careers portal gives you the cleanest path to their recruiting team.
How do I approach the sponsorship conversation when applying to Alnylam?
Alnylam's track record as an active sponsor means recruiters are familiar with the process and won't be surprised by the conversation. Disclose your visa status during the initial recruiter screen, frame it matter-of-factly, and come prepared with a basic understanding of which visa type applies to you, H-1B, E-3, or otherwise. Demonstrating that you understand your own pathway signals preparedness and saves time for both sides.