Contract Nurse RN Jobs in South Carolina

Contract Nurse RN jobs in South Carolina are open across Columbia, Greenville, and Seneca and other South Carolina metros, with employers like Prisma Health hiring at every experience level. Find a role that fits below and apply directly.

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Overview

Open roles40+
Top employerPrisma Health
Top cityColumbia, SC
Cities hiring9
Work type100% On-site
Top industryHealthcare

Showing 5 of 40+ Contract Nurse RN jobs

Prisma Health
Nurse Practitioner/Physician Assistant
We won't show you this job again
Prisma Health
Added 5d ago
Nurse Practitioner/Physician Assistant
Prisma Health
Columbia, South Carolina
Nursing
Medical Specialists
Healthcare Administration
Physicians
Patient Services & Wellbeing
On-Site
Bachelor's
10,000+

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Prisma Health
Physician Assistant / Nurse Practitioner
We won't show you this job again
Prisma Health
Added 5d ago
Physician Assistant / Nurse Practitioner
Prisma Health
Sumter, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Bachelor's
10,000+

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Prisma Health
Nurse Practitioner
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Prisma Health
Added 5d ago
Nurse Practitioner
Prisma Health
Columbia, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Master's
10,000+

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Prisma Health
Nurse Practitioner
We won't show you this job again
Prisma Health
Added 6d ago
Nurse Practitioner
Prisma Health
Greenville, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Master's
10,000+

Have you applied for this role?

Prisma Health
Nurse Practitioner / Physician Assistant
We won't show you this job again
Prisma Health
Added 1w ago
Nurse Practitioner / Physician Assistant
Prisma Health
Columbia, South Carolina
Nursing
Medical Specialists
Healthcare Administration
Physicians
Patient Services & Wellbeing
On-Site
Bachelor's
10,000+

Have you applied for this role?

See All 40 Contract Nurse RN Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

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Contract Nurse RN Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Columbia
14 jobs
Greenville
14 jobs
Seneca
4 jobs
Clinton
2 jobs
Simpsonville
2 jobs
Easley
1 jobs
Greenwood
1 jobs
Powdersville
1 jobs
Sumter
1 jobs

Contract Nurse RN Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

  • Prisma Health
    Prisma Health40

Top Industries Hiring

  • Healthcare & Medical Services40
  • Consulting & Professional Services1

What South Carolina Employers Look For

The qualifications that appear most often in contract nurse RN jobs across South Carolina.

  • Active RN license in the state of employment or a Nurse Licensure Compact license
  • Current BLS certification from the American Heart Association
  • Minimum one to two years of recent acute care or specialty unit experience
  • ACLS or PALS certification depending on unit type and patient population
  • Proficiency with an electronic health record system such as Epic or Cerner
  • Ability to complete credentialing, drug screening, and background check before start date

Contract Nurse RN Jobs in South Carolina: Frequently Asked Questions

How many contract nurse RN jobs are there in South Carolina?

There are 40+ contract nurse RN openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Columbia, Greenville, and Seneca. New positions post regularly as employers across South Carolina hire.

How much do contract nurse RNs make in South Carolina?

Contract nurse RNs in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.

Which South Carolina cities have the most contract nurse RN jobs?

Columbia, Greenville, and Seneca have the most contract nurse RN openings in South Carolina right now, with additional roles spread across smaller metros statewide.

Which companies hire contract nurse RNs in South Carolina?

Employers hiring contract nurse RNs in South Carolina include Prisma Health, based on current listings on Migrate Mate as of June 2026.

Are there remote contract nurse RN jobs in South Carolina?

Yes. About 0% of contract nurse RN openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.

How do I apply for contract nurse RN jobs in South Carolina?

You can apply to contract nurse RN jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.

See All 40 Contract Nurse RN Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

Find Contract Nurse RN Jobs