Contract Nurse RN Jobs in South Carolina
Contract Nurse RN jobs in South Carolina are open across Columbia, Greenville, and Seneca and other South Carolina metros, with employers like Prisma Health hiring at every experience level. Find a role that fits below and apply directly.
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Job Summary
Works under the supervision of a physician to give quality treatment, referral and follow-up care in a medical or hospital setting.
Accountabilities
- Performs health histories, physical exams, individual and group health education. - 20%
- Orders diagnostic laboratory tests and radiological tests, including special testing such as CTs, MRIs, ultrasound, and contrast studies with physician approval. - 20%
- Interprets physical findings, lab and x-ray results, makes diagnoses, and formulates and carries out treatment plan, prescribing medication in accordance to state licensing laws. - 20%
- Refers cases to immediate supervising physician when patient conditions are complicated, exceed the Physician Assistant’s limit of care or level of training. - 20%
- Provides emergency care to prevent the loss of life, limb or eyesight. Institutes emergency procedures in accordance with level of training. - 10%
- Supports clinic function by participating in policy development, operational improvement and the implementation of policies and improvements. - 10%
Minimum Qualifications
- Education - Bachelor's degree in a Physician Assistant program approved by an accredited medical body such as CAHEA, American Medical Association or the Association of Medical College.
- Experience - No previous experience required
Required Licensures
- NCCPA certification and current Physician Assistant licensure in the state in which the team member is working.
- BLS
Other Required Skills/Knowledge
- Knowledge of a wide variety of medical conditions/diseases/types of injuries; excellent communication skills.
- National Commission on Certification of Physician Assistants, Certificate of Added Qualification in Emergency Medicine - NCCPA CAQ in EM - Preferred
Work Shift
Variable (United States of America)
Location
9 Medical Park Rd Richland
Facility
3464 Pediatric Pulmonology 9 Med Park 505
Department
34641000 Pediatric Pulmonology 9 Med Park 505-Practice Operations
Share your talent with us! Our vision is simple: to transform healthcare for the benefits of the communities we serve. The transformation of healthcare requires talented individuals in every role here at Prisma Health.
See All 40 Contract Nurse RN Jobs in South Carolina
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Find Contract Nurse RN JobsContract Nurse RN Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Contract Nurse RN Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- Prisma Health40

Top Industries Hiring
- Healthcare & Medical Services40
- Consulting & Professional Services1
What South Carolina Employers Look For
The qualifications that appear most often in contract nurse RN jobs across South Carolina.
- Active RN license in the state of employment or a Nurse Licensure Compact license
- Current BLS certification from the American Heart Association
- Minimum one to two years of recent acute care or specialty unit experience
- ACLS or PALS certification depending on unit type and patient population
- Proficiency with an electronic health record system such as Epic or Cerner
- Ability to complete credentialing, drug screening, and background check before start date
Contract Nurse RN Jobs in South Carolina: Frequently Asked Questions
How many contract nurse RN jobs are there in South Carolina?
There are 40+ contract nurse RN openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Columbia, Greenville, and Seneca. New positions post regularly as employers across South Carolina hire.
How much do contract nurse RNs make in South Carolina?
Contract nurse RNs in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.
Which South Carolina cities have the most contract nurse RN jobs?
Columbia, Greenville, and Seneca have the most contract nurse RN openings in South Carolina right now, with additional roles spread across smaller metros statewide.
Which companies hire contract nurse RNs in South Carolina?
Employers hiring contract nurse RNs in South Carolina include Prisma Health, based on current listings on Migrate Mate as of June 2026.
Are there remote contract nurse RN jobs in South Carolina?
Yes. About 0% of contract nurse RN openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.
How do I apply for contract nurse RN jobs in South Carolina?
You can apply to contract nurse RN jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.
See All 40 Contract Nurse RN Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Contract Nurse RN Jobs