COO Jobs in St. Louis, MO

COO jobs in St. Louis are in active demand, concentrated in the Central West End, Clayton, and the Cortex Innovation District across healthcare systems, financial services, logistics, and emerging tech. Employers hiring right now include SSM Health, CRB, and Weissman. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles63
Top employerSSM Health
Work type68% Hybrid
Top credentialMaster's degree in business administration
Companies hiring14

Showing 5 of 63+ COO jobs

St. Louis Integrated Health Network
Assistant Director of Community Care Hub Operations
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St. Louis Integrated Health Network
Added 1d ago
Assistant Director of Community Care Hub Operations
St. Louis Integrated Health Network
St. Louis, Missouri
Account Management
Business Development
Customer Success
$62k - $72k/yr
11-50

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Kairos Academies
Director of Operations
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Kairos Academies
Added 1d ago
Director of Operations
Kairos Academies
St. Louis, Missouri
Compliance & Legal
Compliance & Risk
Human Resources
On-Site
High school

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SSM Health
Business Operations Program Director
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SSM Health
Added 2d ago
Business Operations Program Director
SSM Health
St. Louis, Missouri
Executive Leadership & C-Suite
Program Management
Project Management
Bachelor's degree
10,000+

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Cedarhurst Senior Living
Regional Director of Operations (KY, IL, IN, MO)
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Cedarhurst Senior Living
Added 3d ago
Regional Director of Operations (KY, IL, IN, MO)
Cedarhurst Senior Living
St. Louis, Missouri
Executive Leadership & C-Suite
Program Management
Project Management
Bachelor's degree in business administration
1,001-5,000

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A
Director of Finance & Operations
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A
Added 3d ago
Director of Finance & Operations
ArchCity Defenders
St. Louis, Missouri
Customer Service
Customer Support
Hospitality & Guest Services
Master's degree in business administration

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See All 63 COO Jobs in St. Louis

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COO Job Market in St. Louis

Who's Hiring

SSM Health
SSM Health8 open roles
CRB
CRB4 open roles
Weissman
Weissman4 open roles

COO Jobs in St. Louis: Frequently Asked Questions

How do I get a coo job in St. Louis?

The strongest path in St. Louis runs through its dominant sectors: healthcare systems, regional banks and insurance companies, logistics and supply chain firms, and the growing cluster of tech and biotech companies in the Cortex Innovation District. Candidates who can show direct P&L ownership and cross-functional leadership in those industries stand out. Building relationships through local business organizations in Clayton and downtown also gives you a real edge in this relationship-driven market.

Which companies hire coos in St. Louis?

Employers hiring coos in St. Louis right now include SSM Health, CRB, and Weissman, based on current listings on Migrate Mate as of September 2026. St. Louis draws a mix of large regional anchors in healthcare and financial services alongside privately held mid-market companies looking for operators who can scale.

Are there remote coo jobs in St. Louis?

Yes, though coo roles are less remote-friendly than most executive positions because the job centers on day-to-day operational leadership that often requires an on-site presence. About 68% of coo openings tied to St. Louis are remote or hybrid as of September 2026, with hybrid arrangements most common in technology-oriented and professional services firms in the Clayton and Cortex corridors.

How can I get a coo job in St. Louis with little or no experience?

The most realistic entry path is moving into an operations director or VP of operations role at one of St. Louis's many mid-market manufacturers, healthcare groups, or logistics companies, which frequently promote internally before looking outside. Roles like operations manager, director of business operations, or chief of staff at a regional firm give you the P&L and cross-functional exposure that local boards and founders look for when filling a coo seat.

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