COO Jobs in St. Louis, MO

COO jobs in St. Louis are in active demand, concentrated in the Central West End, Clayton, and the Cortex Innovation District across healthcare systems, financial services, logistics, and emerging tech. Employers hiring right now include Mercy, PARIC, and Amedisys. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles18
Top employerMercy
Work type67% On-site
Top credentialMaster's degree in business administration
Companies hiring18

Showing 5 of 18+ COO jobs

R
Director of Operations
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R
New 1m ago
Director of Operations
Refurbiture
St. Louis, Missouri
Business Strategy
Product Management
Project Management
On-Site

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University Missouri St.Louis
Associate Director of Clinical Operations
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University Missouri St.Louis
New 1m ago
Associate Director of Clinical Operations
University Missouri St.Louis
St. Louis, Missouri
Business Development
Events & Tourism
Executive Leadership & C-Suite
Project Management
Master's degree in business administration
201-500

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SK Security
Director of Operations
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SK Security
New 1m ago
Director of Operations
SK Security
St. Louis, Missouri
Business Development
Events & Tourism
Executive Leadership & C-Suite
Project Management
On-Site
Bachelor's degree in business administration
51-200

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Security Finance
Director of Operations- Tennessee
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Security Finance
New 1m ago
Director of Operations- Tennessee
Security Finance
St. Louis, Missouri
Business Development
Events & Tourism
Executive Leadership & C-Suite
Project Management
1,001-5,000

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Mercy
Director - Throughput - Nursing & Operations, Mercy South
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Mercy
New 1m ago
Director - Throughput - Nursing & Operations, Mercy South
Mercy
St. Louis, Missouri
Healthcare Administration
Human Resources
Nursing
Master's degree in business
10,000+

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See All 18 COO Jobs in St. Louis

Find roles in St. Louis that match your experience and apply in just a few clicks.

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COO Job Market in St. Louis

Who's Hiring

  • Mercy
    Mercy1
  • PARIC
    PARIC1
  • Amedisys
    Amedisys1
  • P
    Plug Tech1
  • R
    Refurbiture1

Top Industries Hiring

  • Healthcare & Medical Services1

COO Jobs in St. Louis: Frequently Asked Questions

How do I get a coo job in St. Louis?

The strongest path in St. Louis runs through its dominant sectors: healthcare systems, regional banks and insurance companies, logistics and supply chain firms, and the growing cluster of tech and biotech companies in the Cortex Innovation District. Candidates who can show direct P&L ownership and cross-functional leadership in those industries stand out. Building relationships through local business organizations in Clayton and downtown also gives you a real edge in this relationship-driven market.

Which companies hire coos in St. Louis?

Employers hiring coos in St. Louis right now include Mercy, PARIC, and Amedisys, based on current listings on Migrate Mate as of July 2026. St. Louis draws a mix of large regional anchors in healthcare and financial services alongside privately held mid-market companies looking for operators who can scale.

Are there remote coo jobs in St. Louis?

Yes, though coo roles are less remote-friendly than most executive positions because the job centers on day-to-day operational leadership that often requires an on-site presence. About 33% of coo openings tied to St. Louis are remote or hybrid as of July 2026, with hybrid arrangements most common in technology-oriented and professional services firms in the Clayton and Cortex corridors.

How can I get a coo job in St. Louis with little or no experience?

The most realistic entry path is moving into an operations director or VP of operations role at one of St. Louis's many mid-market manufacturers, healthcare groups, or logistics companies, which frequently promote internally before looking outside. Roles like operations manager, director of business operations, or chief of staff at a regional firm give you the P&L and cross-functional exposure that local boards and founders look for when filling a coo seat.

Which industries hire the most coos in St. Louis?

The sectors hiring the most coos in St. Louis are Healthcare & Medical Services, based on current listings on Migrate Mate as of July 2026. St. Louis's deep roots in healthcare, financial services, and logistics create steady executive-level demand as established organizations expand and regional firms continue to grow.

See All 18 COO Jobs in St. Louis

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