J-1 Visa Senior ML Engineer Jobs
Senior ML Engineer roles in the U.S. are accessible to international professionals through the J-1 visa under the Research Scholar or Trainee program category, depending on your career stage. A U.S. Department of State-designated sponsor organization issues your DS-2019 and arranges sponsorship, while the hiring company serves as your host.
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The Chu Lab — Department of Genome Sciences, University of Virginia School of Medicine
The Chu Lab in the Department of Genome Sciences at the University of Virginia (UVA) School of Medicine is seeking to fill Postdoctoral Researcher positions in computational biology and machine learning. The lab develops modern machine learning, generative modeling, and statistical learning frameworks to decipher single-cell and spatial transcriptomics data, with the goal of uncovering cellular and tissue dynamics underlying cancer, inflammation, and tissue senescence.
ROLE AND RESPONSIBILITIES
Successful candidates will lead one or more of the following ongoing projects:
- Developing neural differential equation and continuous-time dynamical models for spatial and single-cell transcriptomics to dissect cell–cell interactions and perturbation responses in complex tissue microenvironments.
- Building generative models of single-cell and spatial data to characterize cellular and tissue heterogeneity in cancer, inflammation, and tissue senescence.
- Developing next-generation deep-learning and statistical deconvolution methods for inferring gene regulation from bulk, single-cell, and spatial-omics data.
Candidates are also encouraged to develop independent research directions aligned with the lab's interests.
About the PI
The lab is led by Dr. Tinyi Chu, who joined UVA as Assistant Professor in 2026. Dr. Chu received his Ph.D. in Computational Biology from Cornell University and subsequently completed postdoctoral training at Memorial Sloan Kettering Cancer Center and Yale University. His work has appeared as first- or co-first-author publications in Nature Cancer, Nature Genetics, and Cell Stem Cell, spanning statistical method development, cancer transcriptional regulation, and spatial transcriptomics. He is the lead developer of widely used open-source software including BayesPrism, a Bayesian deconvolution framework selected as a Nature Cancer 2022 highlight. Dr. Chu's research has been recognized by a Damon Runyon Quantitative Biology Fellowship and is currently supported by an NIH K99/R00 Pathway to Independence Award (NHGRI) and substantial UVA institutional startup funding — providing a strongly resourced environment for ambitious, long-horizon methodological research.
MENTORSHIP AND CAREER DEVELOPMENT
The Chu Lab is built on the philosophy of "Mentorship as Collaboration," where trainees are valued as scientific collaborators rather than assistants. As a postdoctoral scientist in a newly established lab, you will receive individualized mentorship tailored to your career goals, defined by genuine intellectual exchange, direct technical engagement in algorithm and model development, and shared co-ownership of the science.
- Active Collaboration. The PI maintains an open-door policy, meets regularly with trainees, and is deeply involved to support their algorithm and model development.
- Scientific Independence. You will be supported to develop and lead your own research ideas with the freedom and computational resources required to pursue them.
- Grant Writing and Career Transition. Leveraging the PI's recent successful K99/R00 transition, you will receive step-by-step training in scientific writing, proposal preparation, and fellowship applications. Postdocs are supported and encouraged to apply for independent fellowships.
- Visibility. Full support for presenting at top-tier venues spanning machine learning and computational biology, and active assistance in building your professional network across academia and industry.
ENVIRONMENT
The Chu Lab is part of a vibrant interdisciplinary research community at UVA, with active collaborations across the UVA School of Medicine. The lab has full access to UVA's high-performance computing resources and core facilities supporting genomics and imaging.
Charlottesville, Virginia is a highly livable university town nestled at the foothills of the Blue Ridge Mountains, known for its excellent quality of life, affordability relative to other U.S. research hubs, and rich cultural and outdoor offerings.
MINIMUM QUALIFICATIONS
Ph.D. (or equivalent) in Computer Science, Applied Mathematics, Statistics, Computational Biology, Biophysics, Engineering, or a related quantitative discipline, in hand by the appointment start date.
PREFERRED QUALIFICATIONS
- Strong foundational knowledge in mathematics and statistics
- Proficiency in PyTorch (or equivalent deep-learning frameworks)
- At least one peer-reviewed publication in the previous area of research (not necessarily biology-related)
- Genuine intellectual curiosity for solving biological problems through quantitative approaches
- Prior experience with spatial transcriptomics, single-cell omics, or related biological datasets is a plus but not required — candidates from purely computational backgrounds are strongly encouraged to apply; domain-specific biological knowledge can be acquired on the job
This is a 12-month appointment with the possibility of renewal contingent upon satisfactory performance and the availability of funding. Salary is commensurate with education and experience.
Postdoctoral employment is temporary and is normally limited to an individual who has been awarded a Ph.D. or equivalent doctorate within the previous five years and who will be involved in full-time research or scholarship at the University. Employment as a Postdoctoral Research Associate is viewed as training and is preparatory for a full-time academic or research career, is supervised by a senior scholar, and allows the appointee to publish the results of his/her research or scholarship during the training period.
This position will sponsor applicants for work visas who meet the qualifications.
Start date is available immediately; the start date is flexible.
This position will remain open until filled. The University will perform background checks on all new hires prior to employment.
TO APPLY:
Please apply through Careers at UVA, and search for R0083959.
Complete an application online with the following documents:
- CV
- Cover letter
- Contact information for 3 references.
Upload all materials into the resume submission field, multiple documents can be submitted into this one field. Alternatively, merge all documents into one PDF for submission. Applications that do not contain all required documents will not receive full consideration.
Internal applicants: Search and apply for jobs on the UVA Internal Careers website.
For questions about the application process, please contact Bill Crane, Academic Recruiter at Xer5ff@virginia.edu
The University of Virginia is an equal opportunity employer. All interested persons are encouraged to apply, including veterans and individuals with disabilities. Learn more about UVA’s commitment to non-discrimination and equal opportunity employment.
INTRODUCTION
The Chu Lab — Department of Genome Sciences, University of Virginia School of Medicine
The Chu Lab in the Department of Genome Sciences at the University of Virginia (UVA) School of Medicine is seeking to fill Postdoctoral Researcher positions in computational biology and machine learning. The lab develops modern machine learning, generative modeling, and statistical learning frameworks to decipher single-cell and spatial transcriptomics data, with the goal of uncovering cellular and tissue dynamics underlying cancer, inflammation, and tissue senescence.
ROLE AND RESPONSIBILITIES
Successful candidates will lead one or more of the following ongoing projects:
- Developing neural differential equation and continuous-time dynamical models for spatial and single-cell transcriptomics to dissect cell–cell interactions and perturbation responses in complex tissue microenvironments.
- Building generative models of single-cell and spatial data to characterize cellular and tissue heterogeneity in cancer, inflammation, and tissue senescence.
- Developing next-generation deep-learning and statistical deconvolution methods for inferring gene regulation from bulk, single-cell, and spatial-omics data.
Candidates are also encouraged to develop independent research directions aligned with the lab's interests.
About the PI
The lab is led by Dr. Tinyi Chu, who joined UVA as Assistant Professor in 2026. Dr. Chu received his Ph.D. in Computational Biology from Cornell University and subsequently completed postdoctoral training at Memorial Sloan Kettering Cancer Center and Yale University. His work has appeared as first- or co-first-author publications in Nature Cancer, Nature Genetics, and Cell Stem Cell, spanning statistical method development, cancer transcriptional regulation, and spatial transcriptomics. He is the lead developer of widely used open-source software including BayesPrism, a Bayesian deconvolution framework selected as a Nature Cancer 2022 highlight. Dr. Chu's research has been recognized by a Damon Runyon Quantitative Biology Fellowship and is currently supported by an NIH K99/R00 Pathway to Independence Award (NHGRI) and substantial UVA institutional startup funding — providing a strongly resourced environment for ambitious, long-horizon methodological research.
MENTORSHIP AND CAREER DEVELOPMENT
The Chu Lab is built on the philosophy of "Mentorship as Collaboration," where trainees are valued as scientific collaborators rather than assistants. As a postdoctoral scientist in a newly established lab, you will receive individualized mentorship tailored to your career goals, defined by genuine intellectual exchange, direct technical engagement in algorithm and model development, and shared co-ownership of the science.
- Active Collaboration. The PI maintains an open-door policy, meets regularly with trainees, and is deeply involved to support their algorithm and model development.
- Scientific Independence. You will be supported to develop and lead your own research ideas with the freedom and computational resources required to pursue them.
- Grant Writing and Career Transition. Leveraging the PI's recent successful K99/R00 transition, you will receive step-by-step training in scientific writing, proposal preparation, and fellowship applications. Postdocs are supported and encouraged to apply for independent fellowships.
- Visibility. Full support for presenting at top-tier venues spanning machine learning and computational biology, and active assistance in building your professional network across academia and industry.
ENVIRONMENT
The Chu Lab is part of a vibrant interdisciplinary research community at UVA, with active collaborations across the UVA School of Medicine. The lab has full access to UVA's high-performance computing resources and core facilities supporting genomics and imaging.
Charlottesville, Virginia is a highly livable university town nestled at the foothills of the Blue Ridge Mountains, known for its excellent quality of life, affordability relative to other U.S. research hubs, and rich cultural and outdoor offerings.
MINIMUM QUALIFICATIONS
Ph.D. (or equivalent) in Computer Science, Applied Mathematics, Statistics, Computational Biology, Biophysics, Engineering, or a related quantitative discipline, in hand by the appointment start date.
PREFERRED QUALIFICATIONS
- Strong foundational knowledge in mathematics and statistics
- Proficiency in PyTorch (or equivalent deep-learning frameworks)
- At least one peer-reviewed publication in the previous area of research (not necessarily biology-related)
- Genuine intellectual curiosity for solving biological problems through quantitative approaches
- Prior experience with spatial transcriptomics, single-cell omics, or related biological datasets is a plus but not required — candidates from purely computational backgrounds are strongly encouraged to apply; domain-specific biological knowledge can be acquired on the job
This is a 12-month appointment with the possibility of renewal contingent upon satisfactory performance and the availability of funding. Salary is commensurate with education and experience.
Postdoctoral employment is temporary and is normally limited to an individual who has been awarded a Ph.D. or equivalent doctorate within the previous five years and who will be involved in full-time research or scholarship at the University. Employment as a Postdoctoral Research Associate is viewed as training and is preparatory for a full-time academic or research career, is supervised by a senior scholar, and allows the appointee to publish the results of his/her research or scholarship during the training period.
This position will sponsor applicants for work visas who meet the qualifications.
Start date is available immediately; the start date is flexible.
This position will remain open until filled. The University will perform background checks on all new hires prior to employment.
TO APPLY:
Please apply through Careers at UVA, and search for R0083959.
Complete an application online with the following documents:
- CV
- Cover letter
- Contact information for 3 references.
Upload all materials into the resume submission field, multiple documents can be submitted into this one field. Alternatively, merge all documents into one PDF for submission. Applications that do not contain all required documents will not receive full consideration.
Internal applicants: Search and apply for jobs on the UVA Internal Careers website.
For questions about the application process, please contact Bill Crane, Academic Recruiter at Xer5ff@virginia.edu
The University of Virginia is an equal opportunity employer. All interested persons are encouraged to apply, including veterans and individuals with disabilities. Learn more about UVA’s commitment to non-discrimination and equal opportunity employment.
See all 30+ J-1 Visa Senior ML Engineer Jobs
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Get Access To All JobsTips for Finding J-1 Visa Sponsorship as a Senior ML Engineer
Align your credentials to specialty occupation standards
Before applying, verify that your ML engineering background maps to a specialty occupation under O*NET. Reviewers look for degree-level training in computer science, statistics, or a directly related field, not just years of experience.
Flag the two-year home residency requirement early
Research Scholar and some Trainee J-1 visa categories carry a two-year home residency requirement if your role is government-funded or on the Skills List. Confirm your country and funding source with your designated sponsor before accepting any offer.
Target host employers with established training plan experience
Host companies must co-sign a formal training plan (DS-7002) with your designated sponsor. Look for research labs, AI teams at universities, and tech firms that have hosted J-1 Trainees or Research Scholars before, because they already understand that document.
Search for J-1-compatible roles on Migrate Mate
Use Migrate Mate to filter Senior ML Engineer roles at employers who have a history of international sponsorship. That signal narrows your outreach to companies already familiar with hosting J-1 exchange visitors, saving time on cold applications.
Negotiate start dates around DS-2019 processing windows
Your designated sponsor, whether IIE, Cultural Vistas, or another State Department-authorized organization, typically needs four to six weeks to issue the DS-2019 after the host employer signs the training plan. Build that window into your offer negotiation.
Match your program category to your career stage precisely
The Trainee category applies if you graduated within the last 12 months or have under five years of experience. Research Scholar applies to post-doctoral and established researchers. Applying under the wrong category is the most common reason designated sponsors reject otherwise complete applications.
Senior ML Engineer J-1 Visa: Frequently Asked Questions
Which J-1 program category fits a Senior ML Engineer?
It depends on your career stage. The Trainee category fits candidates who graduated within the past 12 months or have fewer than five years of professional ML experience. Research Scholar applies to those conducting independent research at a university or research institute. Established industry professionals working on applied ML at a corporate lab may qualify under the Specialist category, subject to designated sponsor approval.
Who actually sponsors my J-1 visa if the employer is just the host?
A U.S. Department of State-designated sponsor organization, such as IIE, Cultural Vistas, or AIPT, issues your DS-2019 and holds legal responsibility for your J-1 program. Your hiring company is the host employer, not the visa sponsor. The host signs the training plan and supervises your work, but the designated sponsor monitors compliance and maintains your SEVIS record throughout your program.
Does a two-year home residency requirement affect Senior ML Engineers?
It can. If your J-1 program is funded by your home government or a U.S. government agency, or if your home country appears on the Exchange Visitor Skills List, a two-year home residency requirement applies before you can change to most other U.S. visa categories. ML engineering roles at federally funded research institutions or national labs carry real risk here, so clarify funding sources with your designated sponsor before signing anything.
How do I find host employers open to J-1 exchange visitors?
Many companies that hire internationally for ML roles have never hosted a J-1 exchange visitor specifically, because J-1 differs structurally from H-1B visa and employer-sponsored visas. Migrate Mate surfaces Senior ML Engineer roles at employers with documented international sponsorship history, which is the fastest way to identify hosts already comfortable with the process rather than educating a company from scratch.
What documents does a host employer need to co-sign before my DS-2019 is issued?
The host employer must complete and sign the DS-7002 Training or Internship Placement Plan, which details your ML-specific learning objectives, supervision structure, and program duration. Your designated sponsor reviews this document for compliance before issuing the DS-2019. Vague or generic training plans, ones that read as regular employment rather than structured exchange, are the leading cause of DS-7002 rejections.