Physician Assistant Jobs in Columbia, SC

Physician assistant jobs in Columbia, South Carolina are concentrated in the Midlands medical corridor, the Vista district, and Forest Acres, with strong demand across hospital systems, urgent care networks, and specialty clinics. Employers hiring right now include Prisma Health, Lexington Health, and Prisma Health Urgent Care. Find a role that fits below and apply directly.

Find Physician Assistant Jobs

Overview

Open roles36
Top employerPrisma Health
Work type100% On-site
Top credentialMaster's
Companies hiring8

Showing 5 of 36+ Physician Assistant jobs

Prisma Health
Nurse Practitioner / Physician Assistant - Colorectal Surgery - Columbia
We won't show you this job again
Prisma Health
Added 1w ago
Nurse Practitioner / Physician Assistant - Colorectal Surgery - Columbia
Prisma Health
Columbia, South Carolina
Business Development
Corporate Development & M&A
Executive Leadership & C-Suite
BLS Certification
10,000+

Have you applied for this role?

Curana Health
Nurse Practitioner or Physician Assistant - Sat and Sun
We won't show you this job again
Curana Health
Added 2w ago
Nurse Practitioner or Physician Assistant - Sat and Sun
Curana Health
Columbia, South Carolina
Business Analysis
Data Analytics
Project Management
Master's degree in nursing
1,001-5,000

Have you applied for this role?

Prisma Health Urgent Care
Urgent Care Nurse Practitioner or Physician Assistant- Columbia, SC (Float)
We won't show you this job again
Prisma Health Urgent Care
Added 2w ago
Urgent Care Nurse Practitioner or Physician Assistant- Columbia, SC (Float)
Prisma Health Urgent Care
Columbia, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
BLS Certification

Have you applied for this role?

Prisma Health Urgent Care
Urgent Care Nurse Practitioner or Physician Assistant- Parkridge, SC
We won't show you this job again
Prisma Health Urgent Care
Added 2w ago
Urgent Care Nurse Practitioner or Physician Assistant- Parkridge, SC
Prisma Health Urgent Care
Columbia, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing

Have you applied for this role?

Prisma Health Urgent Care
Urgent Care Nurse Practitioner or Physician Assistant- Columbia, SC (Five Points)
We won't show you this job again
Prisma Health Urgent Care
Added 2w ago
Urgent Care Nurse Practitioner or Physician Assistant- Columbia, SC (Five Points)
Prisma Health Urgent Care
Columbia, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
BLS Certification

Have you applied for this role?

See All 36 Physician Assistant Jobs in Columbia

Find roles in Columbia that match your experience and apply in just a few clicks.

Find Physician Assistant Jobs

Physician Assistant Job Market in Columbia

Who's Hiring

  • Prisma Health
    Prisma Health21
  • Lexington Health
    Lexington Health6
  • Prisma Health Urgent Care
    Prisma Health Urgent Care4
  • Optum
    Optum1
  • Curana Health
    Curana Health1

Top Industries Hiring

  • Healthcare & Medical Services26
  • Consulting & Professional Services8
  • Agriculture & Farming1

Physician Assistant Jobs in Columbia: Frequently Asked Questions

How do I get a physician assistant job in Columbia?

The strongest path into Columbia's PA market is through its large hospital systems and the network of specialty and urgent care clinics that surround them in areas like Forest Acres, Northeast Columbia, and the Midlands corridor. Candidates with surgical, emergency medicine, or primary care rotations stand out. Applying directly to health system career portals and targeting multisite clinic groups gives you the best local traction.

Which companies hire physician assistants in Columbia?

Employers hiring physician assistants in Columbia right now include Prisma Health, Lexington Health, and Prisma Health Urgent Care, based on current listings on Migrate Mate as of July 2026. Columbia's market is anchored by academic medical centers, large regional health systems, and a growing layer of independent specialty and urgent care practices throughout the metro.

Are there remote physician assistant jobs in Columbia?

Yes, though remote opportunities are limited for physician assistants given the hands-on, patient-facing nature of most roles. About 0% of physician assistant openings tied to Columbia are remote or hybrid as of July 2026, and those roles tend to be in telemedicine triage, utilization review, or care management functions connected to Columbia's larger health system employers.

How can I get a physician assistant job in Columbia with little or no experience?

The most realistic entry path in Columbia is through large health system residency or post-graduate training programs, which give new graduates supervised clinical hours in a structured setting. Multisite urgent care groups and federally qualified health centers in the Midlands region also hire new graduates into supervised roles. Demonstrating strong rotation performance and local clinical connections accelerates hiring in a market where most openings are filled through internal referrals.

Which industries hire the most physician assistants in Columbia?

The sectors hiring the most physician assistants in Columbia are Healthcare & Medical Services, Consulting & Professional Services, and Agriculture & Farming, based on current listings on Migrate Mate as of July 2026. Columbia's role as a state capital and home to a major research university health system drives consistent demand across those sectors, reinforced by the region's expanding network of outpatient specialty and primary care facilities.

See All 36 Physician Assistant Jobs in Columbia

Find roles in Columbia that match your experience and apply in just a few clicks.

Find Physician Assistant Jobs