Physician Assistant Jobs in South Carolina

Physician Assistant jobs in South Carolina are open across Columbia, Greenwood, and Charleston and other South Carolina metros, with employers like Prisma Health, Medical University of South Carolina, and Self Regional Healthcare hiring at every experience level. Find a role that fits below and apply directly.

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Overview

Open roles155+
Top employerPrisma Health
Top cityColumbia, SC
Cities hiring33
Work type100% On-site
Top industryHealthcare

Showing 5 of 155+ Physician Assistant jobs

University of South Carolina
Physician Assistant (Specialized)
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University of South Carolina
New 7h ago
Physician Assistant (Specialized)
University of South Carolina
Richland, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
$95k - $148k/yr
On-Site
Bachelor's
5,001-10,000

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University of South Carolina
Physician Assistant (Specialized)
We won't show you this job again
University of South Carolina
New 7h ago
Physician Assistant (Specialized)
University of South Carolina
Richland, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
$95k - $148k/yr
On-Site
Bachelor's
5,001-10,000

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Medical University of South Carolina
Advanced Practice Provider (NP/PA)
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Medical University of South Carolina
Added 3d ago
Advanced Practice Provider (NP/PA)
Medical University of South Carolina
Columbia, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
None
10,000+

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Prisma Health
Nurse Practitioner/Physician Assistant
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Prisma Health
Added 5d ago
Nurse Practitioner/Physician Assistant
Prisma Health
Columbia, South Carolina
Nursing
Medical Specialists
Healthcare Administration
Physicians
Patient Services & Wellbeing
On-Site
Bachelor's
10,000+

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Prisma Health
Physician Assistant / Nurse Practitioner
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Prisma Health
Added 5d ago
Physician Assistant / Nurse Practitioner
Prisma Health
Sumter, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Bachelor's
10,000+

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Physician Assistant Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Columbia
42 jobs
Greenwood
23 jobs
Charleston
21 jobs
Greenville
21 jobs
Seneca
5 jobs
West Columbia
4 jobs
Florence
2 jobs
Fort Mill
2 jobs
Mount Pleasant
2 jobs

Physician Assistant Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

  • Prisma Health
    Prisma Health59
  • Medical University of South Carolina
    Medical University of South Carolina36
  • Self Regional Healthcare
    Self Regional Healthcare24
  • Lexington Health
    Lexington Health11
  • CVS Health
    CVS Health9

Top Industries Hiring

  • Healthcare & Medical Services127
  • Consulting & Professional Services19
  • Education17
  • Biotechnology & Pharmaceuticals2
  • Construction & Real Estate1

What South Carolina Employers Look For

The qualifications that appear most often in physician assistant jobs across South Carolina.

  • Master of Science in Physician Assistant Studies from an ARC-PA-accredited program
  • Current NCCPA certification (PANCE passage or maintenance of certification)
  • Active state PA license or eligibility for licensure in the hiring state
  • Two or more years of clinical experience in a relevant specialty setting
  • Proficiency with electronic health records systems such as Epic or Cerner
  • Current BLS certification and ACLS certification for acute care or hospital roles

Physician Assistant Jobs in South Carolina: Frequently Asked Questions

How many physician assistant jobs are there in South Carolina?

There are 155+ physician assistant openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Columbia, Greenwood, and Charleston. New positions post regularly as employers across South Carolina hire.

How much do physician assistants make in South Carolina?

Physician assistants in South Carolina earn a median of about $122,490 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $77,620 for the lowest 10% to over $158,860 for the top 10%. Pay rises with experience, specialty, and employer.

Which South Carolina cities have the most physician assistant jobs?

Columbia, Greenwood, and Charleston have the most physician assistant openings in South Carolina right now, with additional roles spread across smaller metros statewide.

Which companies hire physician assistants in South Carolina?

Employers hiring physician assistants in South Carolina include Prisma Health, Medical University of South Carolina, and Self Regional Healthcare, based on current listings on Migrate Mate as of June 2026.

Are there remote physician assistant jobs in South Carolina?

Yes. About 0% of physician assistant openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.

How do I apply for physician assistant jobs in South Carolina?

You can apply to physician assistant jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.

See All 155+ Physician Assistant Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

Find Physician Assistant Jobs