Physician Assistant Jobs in South Carolina

Physician Assistant jobs in South Carolina concentrate in primary care, emergency medicine, and hospital-based specialty services, with demand spread across entry-level through senior clinical roles. The heaviest hiring is in and around Charleston, Columbia, and Greenville, where large systems such as MUSC Health, Prisma Health, and Bon Secours anchor consistent openings. Surgical specialties, urgent care, and orthopedics see the strongest recurring demand across the state. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles51
Top employerPrisma Health Urgent Care
Top cityCharleston, SC
Cities hiring29
Work type86% On-site
Top industryHealthcare

Showing 5 of 51+ Physician Assistant jobs

Nurse Practitioner / Physician Assistant (FT or PT)
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Nurse Practitioner / Physician Assistant (FT or PT)
West Coast Wound & Skin Care
Charleston, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
On-Site
CPR Certification

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Advanced Practice Provider (APP, APRN, PA)
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Advanced Practice Provider (APP, APRN, PA)
Commonwealth Pain & Spine
Columbia, South Carolina
Allied Health
Healthcare Administration
Nursing
201-500

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Nurse Practitioner or Physician Assistant | Beaufort SC
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Nurse Practitioner or Physician Assistant | Beaufort SC
Prisma Health Urgent Care
Port Royal, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing

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Physician Assistant- Neurosurgery
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Physician Assistant- Neurosurgery
Midlands Orthopaedics and Neurosurgery
Columbia, South Carolina
Community & Nonprofit Services
Creative Arts & Performance
Sports & Fitness
51-200

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Locum MD (Medical Doctor) Hematology Oncology
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Locum MD (Medical Doctor) Hematology Oncology
77 Consultants
Loris, South Carolina
Clinical Support
Healthcare Administration
Medical Specialists
ACLS Certification

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Physician Assistant Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Charleston
5 jobs
Anderson
4 jobs
Columbia
4 jobs
Lexington
3 jobs
Aiken
2 jobs
Georgetown
2 jobs
Greenville
2 jobs
Spartanburg
2 jobs
Moncks Corner
2 jobs

Physician Assistant Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

  • Prisma Health Urgent Care15
  • 77 Consultants3
  • Michelin2
  • PruittHealth2
  • Curana Health2

Top Industries Hiring

  • Healthcare & Medical Services
  • Education
  • Insurance

What South Carolina Employers Look For

The qualifications that appear most often in physician assistant jobs across South Carolina.

  • Active Physician Assistant license issued or recognized by the South Carolina Board of Medical Examiners
  • National certification from NCCPA with current PA-C credential in good standing
  • Master's degree from an ARC-PA accredited physician assistant program
  • DEA registration or eligibility to obtain one for prescribing roles
  • Minimum one to two years of clinical experience in a relevant specialty
  • Current BLS certification and ACLS certification for hospital-based positions

Physician Assistant Jobs in South Carolina: Frequently Asked Questions

How do you become a physician assistant in South Carolina?

You must hold an active license issued by the South Carolina Board of Medical Examiners, which requires graduating from an ARC-PA accredited program and passing the PANCE exam administered by NCCPA. After earning your PA-C credential, you apply directly to the Board for state licensure. South Carolina also requires PAs to practice under a supervising physician agreement, so securing that physician relationship is a necessary step before starting work.

How much do physician assistants make in South Carolina?

Physician assistants in South Carolina earn a median of about $122,490 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $77,620 for the lowest 10% to over $158,860 for the top 10%. Pay rises with experience, specialty, and employer.

Which companies hire physician assistants in South Carolina?

Companies currently hiring physician assistants in South Carolina include Prisma Health Urgent Care, 77 Consultants, and Michelin, per current listings on Migrate Mate as of October 2026. South Carolina's largest health systems and regional hospital networks account for the majority of consistent openings across the state.

Which South Carolina cities have the most physician assistant jobs?

Charleston, Anderson, and Columbia have the most physician assistant openings in South Carolina. Charleston drives demand through MUSC Health's academic medical campus and a growing network of specialty practices, Columbia anchors state government health services and Prisma Health's flagship facilities, and Greenville reflects the rapid population and healthcare infrastructure growth in the Upstate region.

Are there remote physician assistant jobs in South Carolina?

Yes, but they're rare. About 14% of physician assistant openings tied to South Carolina are remote or hybrid as of October 2026, reflecting the hands-on clinical nature of most PA roles. The exceptions tend to be in telemedicine, utilization review, or case management positions where direct patient contact is limited.

How can I get hired as a physician assistant in South Carolina with little or no experience?

The most realistic entry path is through new-graduate residency or fellowship programs, and South Carolina employers such as MUSC Health and Prisma Health have offered structured post-graduate PA training in areas like hospital medicine and primary care. Candidates without direct PA experience who hold clinical background as a paramedic, surgical technologist, or registered nurse gain a meaningful edge. Completing your South Carolina Board of Medical Examiners licensure before applying and targeting urgent care or outpatient primary care roles will open more doors than pursuing competitive specialty positions immediately.

Where can I find and apply to physician assistant jobs in South Carolina?

You can find and apply to physician assistant jobs in South Carolina on Migrate Mate, which lists current openings across the state. Search the available roles, identify the ones that match your specialty and experience, and apply directly to the positions that fit.

See All 51 Physician Assistant Jobs in South Carolina

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