Nursing Supervisor Jobs in South Carolina
Nursing Supervisor jobs in South Carolina are concentrated in Columbia, Charleston, and Greenville, where major health systems such as MUSC Health, Prisma Health, and Bon Secours St. Francis maintain large inpatient and outpatient campuses that rely on experienced supervisory staff. Demand is strongest in med-surg, critical care, and behavioral health, with openings at every seniority level from charge nurse stepping into supervision to seasoned directors overseeing multi-unit teams. South Carolina's growing coastal and upstate populations have made it one of the Southeast's more active markets for clinical leadership talent. Find a role that fits below and apply directly.
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Extraordinary Careers. Endless Possibilities.
With the nation’s largest home infusion provider, there is no limit to the growth of your career.
Option Care Health, Inc. is the largest independent home and alternate site infusion services provider in the United States. With over 8,000 team members including 5,000 clinicians, we work compassionately to elevate standards of care for patients with acute and chronic conditions in all 50 states. Through our clinical leadership, expertise and national scale, Option Care Health is re-imagining the infusion care experience for patients, customers and team members.
Join a company that is taking action to develop an inclusive, respectful, engaging and rewarding culture for all team members. At Option Care Health your voice is heard, your work is valued, and you’re empowered to grow. Cultivating a team with a variety of talents, backgrounds and perspectives makes us stronger, innovative, and more impactful. Our organization requires extraordinary people to provide extraordinary care, so we are investing in a culture that attracts, hires and retains the best and brightest talent in healthcare.
Job Description Summary:
A Nursing Supervisor is a licensed professional who provides direct and indirect patient care services under a physician’s plan of care and in accordance with the policies and procedures of Option Care Health, the state’s professional standards, and regulatory entities. The Nursing Supervisor is responsible for providing and overseeing complete patient assessment, care planning, patient, and caregiver education, evaluating progress toward goals and recommendations for changes in the plan of care. The Nursing Supervisors additional competencies allow for independence in the practice of the specialty and positions the Nursing Supervisor to train and oversee pertinent competencies. Clinical competency is maintained by providing direct patient care 20-40% of the time. In a Medicare Certified Home Health agency, this position may also serve as the alternate administrator and or alternate director of nursing.**The Nurse Supervisor/Nurse Manager/Regional Nurse Manager, Director, Nursing, or a designated registered nurse (RN) acting on their behalf, must be physically present on the premises or immediately accessible via telecommunication at all times during operating hours when patients are receiving infusion services.**
Job Description:
Job Responsibilities (listed in order of importance and/or time spent)
- Competent in the clinical management of home infusion patients including Patient management skills, the Nursing Process, the rules of Federal, state, and local regulatory entities that oversee and control the provision of care in a Home Health Agency.
- Knowledgeable of documentation and billing requirements for home health/ infusion care goods and services.
- Determines suitability of patients for home care.
- Supervises, monitors, and evaluates the quality and effectiveness of patient care, including, when appropriate, in home evaluations of field staff.
- Reviews and monitors appropriateness of Nursing Care Plans and directs the staff to modify the plan as needed.
- Acts as Administrator and/or Director of Nursing of the Home Health Agency for Medicare certified home health agencies in the absence of a director or Manager of Nursing.
- Manages daily activities with regards to effective operations and communications and ensures the office remains in compliance with all regulating and accreditation entities. Complies with reporting requirements, ensures policy and procedure, compliance and monitors and evaluates medical supply usage.
- Participates in the process for assessing, managing, and reporting nursing operational and financial data to the Regional Nurse Manager, Area Director of Nursing, and/or Director of Operations. Supports the development and implementation of the Plan of Care for each patient.
- Develops, implements, evaluates, and participates in office specific continuing education and orientation programs. Assists the Director of Operations, Area Director of Nursing and/or the Nurse Manager in the recruitment, development, and monitoring of new staff. Coordinates and participates in on-call responsibilities. Maintains confidentiality of patient and proprietary information.
- Participates as a member of or directs the professional advisory committee, infection prevention and process improvement teams, including conducting chart audits. Identifies opportunities for improvement and communicates to the Nurse Manager, Area Director of Nursing and/or Director of Operations. Speaks knowledgeably of the scope of services that are available through Option Care and provides support to sales professionals on an ongoing basis.
Supervisory Responsibilities
Does this position have supervisory responsibilities?
(i.e. hiring, recommending/approving promotions and pay increases, scheduling, performance reviews, discipline, etc.)
No
Yes X
Basic Education and/or Experience Requirements
- Registered Nurse with a license in the current state of practice with 1 year of nursing supervisory/charge experience, or at least 3 years of relevant nursing experience with demonstrated progression.
- Required certification in CPR.
- Member of a state or national professional organization.
Basic Qualifications & Interests (BQIs)
- Access to a reliable means of transportation, which will enable the incumbents to make home visits to treat/attend to their patients. If such means of transportation would include a personal vehicle, a valid driver’s license and a proof of insurance would be required.
- Experience applying knowledge of local, State, Federal, accrediting body, and OSHA rules and regulations.
- Experience providing customer service to internal and external customers, including meeting quality standards for services, and evaluation of customer satisfaction.
- Experience in the indirect management of team members, including assisting in the development, training, and assignment of work/projects to other members of a team.
- Experience using time management skills such as prioritizing/organizing and tracking details and meeting deadlines of multiple projects with varying completion dates.
- Basic level skill in Microsoft Word (for example: opening a document, cutting, pasting, and aligning text, selecting font type and size, changing margins and column width, sorting, inserting bullets, pictures and dates, using find and replace, undo, spell check, track changes, review pane and/or print functions).
- Basic level skill in Microsoft Excel (for example: opening a workbook, inserting a row, selecting font style and size, formatting cells as currency, using copy, paste and save functions, aligning text, selecting cells, renaming a worksheet, inserting a column, selecting a chart style, inserting a worksheet, setting margins, selecting page orientation, using spell check and/or printing worksheets).
- Basic skill level in Microsoft PowerPoint (for example: inserting, rearranging, hiding, and deleting slides, navigating between slides, increasing list level, adding, centering and editing text, changing views, inserting a table or a note, moving objects, printing outline view and/or running a slide show).
- Experience developing ways of accomplishing goals with little or no supervision, depending on oneself to complete objectives and determining when escalation of issues is necessary.
Travel Requirements: (if required)
Willing to travel at least 50% of the time for business purposes (within state and out of state).
Preferred Qualifications & Interests (PQIs)
- BSN
- CRNI or other professional certification.
- At least 1 year of supervisory experience in a hospital or home health care setting is preferred.
- At least 1 year of experience in the indirect management of team members, including assisting in the development, training, and assignment of work/projects to other team members is preferred.
This job description is to be used as a guide for accomplishing Company and department objectives, and only covers the primary functions and responsibilities of the position. It is in no way to be construed as an all-encompassing list of duties.
Due to state pay transparency laws, the full range for the position is below:
Salary to be determined by the applicant's education, experience, knowledge, skills, and abilities, as well as internal equity and alignment with market data.
Pay Range is $80,588.55-$134,299.83Benefits:
- Medical, Dental, & Vision Insurance
- Paid Time off
- Bonding Time Off
- 401K Retirement Savings Plan with Company Match
- HSA Company Match
- Flexible Spending Accounts
- Tuition Reimbursement
- myFlexPay
- Family Support
- Mental Health Services
- Company Paid Life Insurance
- Award/Recognition Programs
Option Care Health subscribes to a policy of equal employment opportunity, making employment available without regard to race, color, religion, national origin, citizenship status according to the Immigration Reform and Control Act of 1986, sex, sexual orientation, gender identity, age, disability, veteran status, or genetic information.
Posted: Aug 11, 2026
See All 8 Nursing Supervisor Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Nursing Supervisor JobsNursing Supervisor Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Nursing Supervisor Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring



Top Industries Hiring
- Healthcare & Medical Services
What South Carolina Employers Look For
The qualifications that appear most often in nursing supervisor jobs across South Carolina.
- Active registered nurse license recognized by the South Carolina Board of Nursing
- Minimum of three to five years of clinical nursing experience in an acute care setting
- Prior charge nurse, team lead, or supervisory responsibility in a hospital or facility
- Bachelor of Science in Nursing with a Master of Science in Nursing preferred for larger systems
- Proficiency with electronic health record platforms such as Epic or Meditech
- Strong knowledge of Joint Commission standards, staffing ratios, and regulatory compliance
Nursing Supervisor Jobs in South Carolina: Frequently Asked Questions
How do you become a nursing supervisor in South Carolina?
You must hold an active registered nurse license issued or recognized by the South Carolina Board of Nursing, which requires passing the NCLEX-RN exam. Most employers also expect a Bachelor of Science in Nursing and several years of direct clinical experience before moving into a supervisory role. Earning a certification such as Nurse Executive through the American Nurses Credentialing Center strengthens candidacy and is increasingly expected at larger South Carolina health systems.
Which companies hire nursing supervisors in South Carolina?
South Carolina nursing supervisor roles are posted by Saber Healthcare, McLeod Health, and Option Care Health and others right now, based on current listings on Migrate Mate as of August 2026. South Carolina's largest hiring activity comes from integrated health systems with multiple campuses across Columbia, Charleston, and the Upstate region.
Which South Carolina cities have the most nursing supervisor jobs?
Spartanburg, Florence, and Abbeville have the most nursing supervisor openings in South Carolina right now. Columbia leads because it is home to large academic medical centers and state government health facilities, while Charleston's growth as a regional destination has expanded MUSC Health's footprint considerably, and Greenville's Upstate corridor has grown rapidly around Prisma Health and a cluster of specialty and rehabilitation facilities.
Are there remote nursing supervisor jobs in South Carolina?
Yes, but they're rare. About 0% of nursing supervisor openings tied to South Carolina are remote or hybrid as of August 2026, which reflects how hands-on the role is by nature. The portions most likely to allow remote or hybrid scheduling are administrative duties such as scheduling, compliance reporting, and staff education, while direct floor oversight remains on-site.
How can I get hired as a nursing supervisor in South Carolina with little or no experience?
The most realistic path is moving into a charge nurse or assistant nurse manager role first, which large South Carolina employers such as Prisma Health and MUSC Health routinely use as a pipeline for supervisory staff. Completing a nurse leadership residency or a unit-based preceptorship at one of these systems builds the competencies hospitals look for before promoting into full supervision. Holding a BSN and pursuing a Nurse Executive certification signals readiness even when formal supervisory hours are limited.
Where can I find and apply to nursing supervisor jobs in South Carolina?
You can find and apply to nursing supervisor jobs in South Carolina on Migrate Mate, which lists current openings from employers across the state. Find the roles that fit your experience and specialization and apply directly from each listing.
See All 8 Nursing Supervisor Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Nursing Supervisor Jobs