Principal Medical Writer Jobs in South Carolina
Principal Medical Writer jobs in South Carolina are concentrated in the Columbia, Charleston, and Greenville markets, where life sciences companies, contract research organizations, and academic health systems drive consistent demand for senior-level regulatory and clinical documentation expertise. Employers with a lasting presence in the state include SCANA-related healthcare subsidiaries, Clemson University's research enterprise, and Pharmaceutical Product Development, which maintains operations across the Southeast. The most in-demand specialties are regulatory affairs writing, clinical study reports, and submissions documentation for oncology and cardiovascular therapeutic areas. Scan the live roles below and apply to whichever ones fit.
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Continue to Grow with GXO.
At GXO, we know our greatest asset is people like you - energetic, innovative people of all experience levels and talents who make GXO a great place to work. Your career matters to us because your passion and excitement will help keep our company moving forward.
1st Shift, Monday - Friday 8:00am - 5:00pm
Join XPO Logistics, a company named among the most admired in the world by Fortune magazine and one of America’s best employers by Forbes. At XPO, we look for employees who like a challenge and can communicate effectively in all situations. As the Technical Writer, you will develop documentation, end-user manuals, reports, correspondence, meeting minutes, specifications, client notifications and presentations. Become a part of our dynamic team, and we'll help you develop your career to a level that will exceed your expectations.
Pay, benefits and more.
We are eager to attract the best, so we offer competitive compensation and a generous benefits package, including full health insurance (medical, dental and vision), life insurance, disability and more.
Logistics done differently.
As the Technical Writer, you will develop documentation, end-user manuals, reports, correspondence, meeting minutes, specifications, client notifications and presentations. Become a part of our dynamic team, and we'll help you develop your career to a level that will exceed your expectations.
What you’ll do on a typical day:
- Support the business development process by preparing required documentation
- Draft meeting minutes, often with short turnaround times
- Create original content on many subjects utilizing source material
- Work cross-functionally with IT, Operations, Engineering, Human Resources and Facilities teams
- Assist with the publication of documents, including the coordination of company personnel, print vendors and other subcontractors
- Follow procedures for document publication, including getting appropriate approvals, assessing storage methods, etc.
- Organize, track, update and store electronic and hard copy versions of documentation in a secure environment
- Assist personnel by proofreading documents and providing editorial, design and application guidance
What you need to succeed at XPO:
At a minimum, you’ll need:
- Bachelor’s degree or equivalent related work or military experience
- 1 year of writing experience in a formal technical writing curriculum with report writing requirements
- Google Workspace
- Exposure to Safety topics ie: workplace
- Experience with Microsoft Office (Word, Excel and Outlook) and technical writing software (word processing, page layout, etc.)
It’d be great if you also have:
- A degree in English, Communications, Journalism or a closely related field, or a Technical Writing certification
- Experience with Adobe Acrobat, Visio and OneNote
- Excellent verbal and written communication skills
- Ability to work with and understand engineers, developers and others whose work is the basis for technical documentation
Be part of something big.
We are proud to be an Equal Opportunity employer including Disabled/Veterans.
GXO adheres to CDC, OSHA and state and local requirements regarding COVID safety. All employees and visitors are expected to comply with GXO policies which are in place to safeguard our employees and customers.
All applicants who receive a conditional offer of employment may be required to take and pass a pre-employment drug test.
The above statements are intended to describe the general nature and level of work being performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all responsibilities, duties and skills required of personnel so classified. All employees may be required to perform duties outside of their normal responsibilities from time to time, as needed.
See All 15 Principal Medical Writer Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Principal Medical Writer JobsPrincipal Medical Writer Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Principal Medical Writer Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring



Top Industries Hiring
- Technology & Software
- Consulting & Professional Services
What South Carolina Employers Look For
The qualifications that appear most often in principal medical writer jobs across South Carolina.
- Bachelor's or advanced degree in life sciences, pharmacy, nursing, or a related field
- Minimum five years of regulatory or clinical medical writing experience
- Demonstrated expertise in ICH, FDA, and EMA submission document standards
- Experience leading writing teams or mentoring junior medical writers on complex projects
- Proficiency with eCTD publishing tools and electronic document management systems
- Strong command of AMA style and scientific manuscript preparation conventions
Principal Medical Writer Jobs in South Carolina: Frequently Asked Questions
How do you become a principal medical writer in South Carolina?
The path to a principal medical writer role in South Carolina typically begins with a degree in a life science, pharmacy, or clinical field followed by several years in regulatory or clinical writing roles. South Carolina does not require a state-issued license for medical writers, but employers in the Columbia and Charleston life sciences corridors strongly favor candidates who hold or pursue the Board of Editors in the Life Sciences certification or the American Medical Writers Association credential, both of which signal senior-level competence to hiring managers at CROs and academic medical centers in the state.
Which companies hire principal medical writers in South Carolina?
Employers hiring principal medical writers in South Carolina right now include Infojini, TIAG, and Geodesicx, based on current listings on Migrate Mate as of July 2026. South Carolina's growing cluster of contract research organizations and academic health system research offices in Columbia and Charleston makes the state a consistent source of senior writing openings outside of traditional pharmaceutical hubs.
Which South Carolina cities have the most principal medical writer jobs?
Columbia, North Charleston, and Rock Hill account for the most principal medical writer openings in South Carolina. Columbia leads because of its concentration of state government health agencies, university research programs, and CRO offices, while Charleston benefits from the Medical University of South Carolina's clinical trial infrastructure and the biotech employers that have grown around it, and Greenville reflects the Upstate's expanding advanced manufacturing and healthcare research base.
Are there remote principal medical writer jobs in South Carolina?
Yes, and more than most fields. Medical writing is primarily a desk and documentation role with no requirement for physical presence, making it one of the more remote-accessible senior positions in life sciences. About 0% of principal medical writer openings tied to South Carolina are remote or hybrid as of July 2026, reflecting the broader industry norm for regulatory and clinical documentation work. Regulatory submissions writing and clinical study report authorship are the functions most consistently offered on a fully remote basis.
How can I get hired as a principal medical writer in South Carolina with little or no experience?
The most realistic entry point is moving into medical writing from an adjacent clinical, research, or scientific communication role at one of South Carolina's academic health systems or CROs. The Medical University of South Carolina and Clemson University's research offices regularly bring on junior research writers and clinical research coordinators, roles that build the documentation skills and therapeutic area knowledge that principal-level positions require. Completing the AMWA Essential Skills Certificate while in a coordinator or associate writer role is the credential that most consistently accelerates promotion within South Carolina employers.
Where can I find and apply to principal medical writer jobs in South Carolina?
You can find and apply to principal medical writer jobs in South Carolina on Migrate Mate, which lists current openings tied to the state. Search the available roles, identify the ones that match your experience and therapeutic area background, and apply directly to whichever positions fit your goals.
See All 15 Principal Medical Writer Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Principal Medical Writer Jobs