ICU Registered Nurse Jobs in South Carolina

ICU Registered Nurse jobs in South Carolina are in strong and consistent demand, concentrated across major hospital systems, academic medical centers, and regional trauma facilities serving a growing state population. The heaviest hiring is in Columbia, Greenville, and Charleston, where large health systems like MUSC Health, Prisma Health, and Bon Secours St. Francis Health System anchor the market at every level from new graduate to senior charge nurse. Critical care subspecialties including cardiac ICU, surgical ICU, and neuro ICU see the most consistent openings. See the openings below and apply to the ones that match your experience.

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Overview

Open roles62
Top employerPrisma Health
Top cityColumbia, SC
Cities hiring23
Work type100% On-site
Top industryHealthcare

Showing 5 of 62+ ICU Registered Nurse jobs

Spartanburg Regional Healthcare System
Experienced Registered Nurse (RN) -Part-time - ICU - PMC
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Spartanburg Regional Healthcare System
Added 1d ago
Experienced Registered Nurse (RN) -Part-time - ICU - PMC
Spartanburg Regional Healthcare System
Greer, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
Bachelor of Science in Nursing

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Spartanburg Regional Healthcare System
Registered Nurse (RN) - Pediatric ICU (PICU)
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Spartanburg Regional Healthcare System
Added 1d ago
Registered Nurse (RN) - Pediatric ICU (PICU)
Spartanburg Regional Healthcare System
Spartanburg, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing

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Carolina Pines Regional Medical Center
RN-ICU Weekends
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Carolina Pines Regional Medical Center
Added 2d ago
RN-ICU Weekends
Carolina Pines Regional Medical Center
Hartsville, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
PALS Certification
501-1,000

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Prisma Health
Registered Nurse (RN)-Acute Care, Pediatric ICU, FT, Night
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Prisma Health
Added 2d ago
Registered Nurse (RN)-Acute Care, Pediatric ICU, FT, Night
Prisma Health
Greenville, South Carolina
Business Operations
Compliance & Legal
Compliance & Risk
Nursing Diploma
10,000+

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Lexington Health
RN - Step Down ICU (SDICU)
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Lexington Health
Added 2d ago
RN - Step Down ICU (SDICU)
Lexington Health
West Columbia, South Carolina
Cloud & DevOps
Data Analytics
IT Support
Bachelor of Science
5,001-10,000

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ICU Registered Nurse Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Rock Hill
6 jobs
West Columbia
6 jobs
Charleston
5 jobs
Aiken
4 jobs
Greer
4 jobs
Fort Mill
3 jobs
Greenville
3 jobs
Spartanburg
3 jobs

ICU Registered Nurse Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

  • Prisma Health
    Prisma Health14
  • American Traveler
    American Traveler8
  • Lexington Health
    Lexington Health7
  • Spartanburg Regional Healthcare System
    Spartanburg Regional Healthcare System6
  • Tenet Healthcare
    Tenet Healthcare5

Top Industries Hiring

  • Healthcare & Medical Services
  • Non-Profit & Social Services

What South Carolina Employers Look For

The qualifications that appear most often in ICU registered nurse jobs across South Carolina.

  • Active South Carolina RN license or multistate Compact license recognized in South Carolina
  • Current BLS and ACLS certification required for all ICU positions
  • Minimum one to two years of acute care or critical care nursing experience
  • Bachelor of Science in Nursing preferred or required by most major health systems
  • Proficiency with mechanical ventilators, hemodynamic monitoring, and vasoactive drips
  • CCRN certification preferred and often required for senior or charge nurse roles

ICU Registered Nurse Jobs in South Carolina: Frequently Asked Questions

How do you become a icu registered nurse in South Carolina?

You must hold an active registered nurse license issued or recognized by the South Carolina Board of Nursing, which requires passing the NCLEX-RN after completing an accredited nursing program. To work specifically in an ICU, most South Carolina hospitals require or strongly prefer at least one year of acute care experience, often gained in a med-surg or step-down unit, before transitioning to critical care. Completing a critical care internship offered by larger systems like Prisma Health or MUSC Health can replace that prior experience requirement for new graduates.

How much do ICU registered nurses make in South Carolina?

ICU registered nurses in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.

Which companies hire icu registered nurses in South Carolina?

Employers hiring icu registered nurses in South Carolina right now include Prisma Health, American Traveler, and Lexington Health, based on current listings on Migrate Mate as of August 2026. South Carolina's largest academic medical systems and regional hospital networks consistently drive the majority of ICU nursing openings across the state.

Which South Carolina cities have the most icu registered nurse jobs?

Columbia, Rock Hill, and West Columbia lead South Carolina in icu registered nurse openings. Columbia's concentration of large teaching hospitals and Prisma Health's flagship campus drives high volume there, Charleston's openings reflect MUSC Health's academic medical center and growing coastal population, and Greenville's market is anchored by Prisma Health Greenville Memorial and the Bon Secours St. Francis system serving the upstate region.

Are there remote icu registered nurse jobs in South Carolina?

Yes, but they're rare. ICU nursing is a hands-on, bedside role that requires physical presence in a hospital setting, so fully remote positions are uncommon. About 0% of icu registered nurse openings tied to South Carolina are remote or hybrid as of August 2026, and those positions typically involve telehealth triage, remote patient monitoring oversight, or case management functions rather than direct bedside critical care.

How can I get hired as a icu registered nurse in South Carolina with little or no experience?

The most realistic path is applying directly to new graduate critical care residency programs, which MUSC Health, Prisma Health, and Bon Secours St. Francis run specifically to train nurses for ICU roles without prior critical care experience. Starting in a step-down or progressive care unit at a South Carolina community hospital is a strong alternative entry point. Holding an active South Carolina RN license, completing ACLS certification before applying, and demonstrating clinical hours in acute care settings during nursing school will all strengthen your candidacy significantly.

Where can I find and apply to icu registered nurse jobs in South Carolina?

You can find and apply to icu registered nurse jobs in South Carolina on Migrate Mate, which lists current openings across the state. Search the available roles, find the positions that match your experience and preferred location, and apply directly to the ones that fit.

See All 62 ICU Registered Nurse Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

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