Oncology Registered Nurse Jobs in South Carolina
Oncology Registered Nurse jobs in South Carolina are in strong demand, concentrated across hospital-based cancer centers, academic medical systems, and outpatient infusion clinics at every level from new graduate to oncology nurse navigator. The largest hiring activity is in Columbia, Greenville, and Charleston, where established systems like Prisma Health, MUSC Health, and Bon Secours make up a significant share of postings. Chemotherapy administration, palliative care coordination, and bone marrow transplant nursing are among the most consistently sought specialties. See the openings below and apply to the ones that match your experience.
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Inspire health. Serve with compassion. Be the difference.
Job Summary
Provides therapies in the oncology setting, which includes, but is not limited to chemotherapy, immunotherapy, monoclonal antibody therapy, blood product transfusions, radiation therapy, and bone marrow transplant. Demonstrates clinical competency utilizing evidence-based practices/research in all areas of the nursing process: assessment, planning, implementation, evaluation, and outcomes. Incorporates knowledge of safety protocols, cost containment and quality improvement throughout the nursing process. Identifies patient, unit, and organizational priorities and incorporates the nursing process. Adheres to all compliance and policy and procedure requirements of the organization including, but not limited to licensure renewal, assigned training, employee health screenings, time and attendance policy, dress code policy, patient confidentiality, infection control, and medication administration. This job may require additional training and certifications such as ACLS, PALS, chemotherapy/biotherapy, and transplant/cellular therapy curriculum. Demonstrates knowledge of regulatory agency requirements (JCAHO, DHEC). Provides care within the scope of the SC Nursing Practice Act. This setting may require staff to be scheduled for shift, weekend, holiday, and on-call work.Essential Functions
All team members are expected to be knowledgeable and compliant with Prisma Health's purpose: Inspire health. Serve with compassion. Be the difference.
Assists physicians with examinations, procedures and other activities related to direct patient care.
Arranges for patient appointments for diagnostic testing, consults, referrals and admission to the hospital.
Monitors and maintains stock of medical supplies and proper functioning of equipment.
Documents patients' vital statistics and other encounter data into patient chart and ensures that all required records are in the chart. Obtains brief medical history and chief complaint from patients.
Calls in prescriptions for patients according to physician order.
Prepares exam rooms with appropriate instruments, supplies, and equipment. Cleans exam rooms between procedures and exams.
Receives and returns clinically related telephone calls, screening and forwarding those requiring physician action.
Completes medical/physical history forms and other related information for insurance companies.
Informs physician of changes in schedule.
Uses advanced level nursing skills and telephone triage guidelines to assess and prioritize different types of conditions and symptoms including when to call 911.
Performs other duties as assigned.
Supervisory/Management Responsibilities
This is a non-management job that will report to a supervisor, manager, director or executive.
Minimum Requirements
Education - Associate' degree in Nursing. Bachelor's degree in Nursing preferred.
Experience - One (1) year experience as a registered nurse.
In Lieu Of
In lieu of one (1) year of registered nurse experience, will accept successful completion of the Prisma Health Nurse Residency Program or successful completion of a comparable residency from another organization.
In lieu of one (1) year of registered nurse experience, will accept 1 year of licensed practical nurse (LPN) experience.
Required Certifications, Registrations, Licenses
Holds a current RN compact/multistate license recognized by the NCSBN Compact State or is licensed to practice as an RN in the state the team member is working.
Knowledge, Skills and Abilities
Working knowledge of Patient Equip (vitals, suction, defib)
Work Shift
Day (United States of America)Location
Greer Medical CampusFacility
Greenville Memorial HospitalDepartment
Ambulatory Infusion Center-CIGreerShare your talent with us! Our vision is simple: to transform healthcare for the benefits of the communities we serve. The transformation of healthcare requires talented individuals in every role here at Prisma Health.
See All 23 Oncology Registered Nurse Jobs in South Carolina
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Find JobsOncology Registered Nurse Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Oncology Registered Nurse Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring



Top Industries Hiring
- Healthcare & Medical Services
What South Carolina Employers Look For
The qualifications that appear most often in oncology registered nurse jobs across South Carolina.
- Active South Carolina RN license or compact multistate license recognized in South Carolina
- Current BLS certification required, with ACLS or ONS chemotherapy certification preferred
- Associate or bachelor of science in nursing from an accredited program
- Minimum two years of oncology or medical-surgical nursing experience for most positions
- Oncology Certified Nurse credential preferred or required by several South Carolina health systems
- Proficiency with electronic health record platforms such as Epic or Cerner
Oncology Registered Nurse Jobs in South Carolina: Frequently Asked Questions
How do you become a oncology registered nurse in South Carolina?
You must hold an active RN license issued or recognized by the South Carolina Board of Nursing, obtained by passing the NCLEX-RN after completing an accredited nursing program. Most oncology positions in South Carolina then require bedside nursing experience before moving into a dedicated oncology unit. Earning the Oncology Certified Nurse credential, offered by the Oncology Nursing Certification Corporation, strengthens your candidacy significantly at South Carolina health systems.
How much do oncology registered nurses make in South Carolina?
Oncology registered nurses in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire oncology registered nurses in South Carolina?
Employers hiring oncology registered nurses in South Carolina right now include Prisma Health, Roper St. Francis Healthcare, and Lexington Health, based on current listings on Migrate Mate as of August 2026. South Carolina's largest academic and regional health systems consistently post the highest volume of oncology nursing openings across inpatient, outpatient, and infusion settings.
Which South Carolina cities have the most oncology registered nurse jobs?
Charleston, Columbia, and Rock Hill account for the most oncology registered nurse openings in South Carolina. Columbia and Charleston lead because of their large academic medical centers and comprehensive cancer programs, while Greenville's growth as an Upstate healthcare hub, anchored by Prisma Health and Bon Secours, drives a steady share of postings in that region.
Are there remote oncology registered nurse jobs in South Carolina?
Yes, but they're rare. About 0% of oncology registered nurse openings tied to South Carolina are remote or hybrid as of August 2026, reflecting how hands-on most oncology nursing roles are. The oncology nursing functions most likely to carry any remote component involve telephone triage, care navigation, or utilization review rather than direct patient care.
How can I get hired as a oncology registered nurse in South Carolina with little or no experience?
The most realistic entry path is completing a nurse residency program at a large South Carolina health system such as MUSC Health, Prisma Health, or Roper St. Francis, many of which accept new graduates into general medical-surgical or hematology-oncology units. Starting in a med-surg or infusion support role and requesting an internal transfer to oncology is a common ladder at these systems. Obtaining your South Carolina RN license promptly and pursuing ONS chemotherapy certification early signals commitment to hiring managers.
Where can I find and apply to oncology registered nurse jobs in South Carolina?
You can find and apply to oncology registered nurse jobs in South Carolina on Migrate Mate, which lists current openings from employers actively hiring in the state. Search the listings, find the roles that match your experience and specialty, and apply directly to the ones that fit.
See All 23 Oncology Registered Nurse Jobs in South Carolina
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