Oncology Registered Nurse Jobs in South Carolina
Oncology Registered Nurse jobs in South Carolina are in strong demand, concentrated across hospital-based cancer centers, academic medical systems, and outpatient infusion clinics at every level from new graduate to oncology nurse navigator. The largest hiring activity is in Columbia, Greenville, and Charleston, where established systems like Prisma Health, MUSC Health, and Bon Secours make up a significant share of postings. Chemotherapy administration, palliative care coordination, and bone marrow transplant nursing are among the most consistently sought specialties. See the openings below and apply to the ones that match your experience.
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Where South Carolina roles are concentrated, by current openings.
Oncology Registered Nurse Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- Prisma Health11
- Roper St. Francis Healthcare4
- Atrium Health3
- Advocate Aurora Health3
- HCA Healthcare Trident Hospital3
Top Industries Hiring
- Healthcare & Medical Services
What South Carolina Employers Look For
The qualifications that appear most often in oncology registered nurse jobs across South Carolina.
- Active South Carolina RN license or compact multistate license recognized in South Carolina
- Current BLS certification required, with ACLS or ONS chemotherapy certification preferred
- Associate or bachelor of science in nursing from an accredited program
- Minimum two years of oncology or medical-surgical nursing experience for most positions
- Oncology Certified Nurse credential preferred or required by several South Carolina health systems
- Proficiency with electronic health record platforms such as Epic or Cerner
Oncology Registered Nurse Jobs in South Carolina: Frequently Asked Questions
How do you become a oncology registered nurse in South Carolina?
You must hold an active RN license issued or recognized by the South Carolina Board of Nursing, obtained by passing the NCLEX-RN after completing an accredited nursing program. Most oncology positions in South Carolina then require bedside nursing experience before moving into a dedicated oncology unit. Earning the Oncology Certified Nurse credential, offered by the Oncology Nursing Certification Corporation, strengthens your candidacy significantly at South Carolina health systems.
How much do oncology registered nurses make in South Carolina?
Oncology registered nurses in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire oncology registered nurses in South Carolina?
Employers hiring oncology registered nurses in South Carolina right now include Prisma Health, Roper St. Francis Healthcare, and Atrium Health, based on current listings on Migrate Mate as of October 2026. South Carolina's largest academic and regional health systems consistently post the highest volume of oncology nursing openings across inpatient, outpatient, and infusion settings.
Which South Carolina cities have the most oncology registered nurse jobs?
Charleston, Greenville, and Rock Hill account for the most oncology registered nurse openings in South Carolina. Columbia and Charleston lead because of their large academic medical centers and comprehensive cancer programs, while Greenville's growth as an Upstate healthcare hub, anchored by Prisma Health and Bon Secours, drives a steady share of postings in that region.
How can I get hired as a oncology registered nurse in South Carolina with little or no experience?
The most realistic entry path is completing a nurse residency program at a large South Carolina health system such as MUSC Health, Prisma Health, or Roper St. Francis, many of which accept new graduates into general medical-surgical or hematology-oncology units. Starting in a med-surg or infusion support role and requesting an internal transfer to oncology is a common ladder at these systems. Obtaining your South Carolina RN license promptly and pursuing ONS chemotherapy certification early signals commitment to hiring managers.
Where can I find and apply to oncology registered nurse jobs in South Carolina?
You can find and apply to oncology registered nurse jobs in South Carolina on Migrate Mate, which lists current openings from employers actively hiring in the state. Search the listings, find the roles that match your experience and specialty, and apply directly to the ones that fit.
See All 29 Oncology Registered Nurse Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
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