Principal Medical Writer Jobs
Principal Medical Writer jobs are open across pharmaceutical, biotech, CRO, and medical device companies, from associate to principal and director level, with specializations in regulatory submissions, clinical study reports, and scientific publications. Scan the live roles below and apply to whichever ones fit.
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Job ID: 2614238-OTHLOC-100000654856391
Location: Chantilly, VA, US
Date Posted: 2026-07-02
Category: Business Development
Subcategory: Proposal
Schedule: Full-Time
Shift: Day Job
Travel: Yes - 10% of the time
Minimum Clearance Required: TS.SCI
Clearance Level Must Be Able to Obtain: None
Potential for Remote Work: ORA_HYBRID
Description
SAIC is looking for a seasoned, cleared senior level Proposal Writer who is accomplished with writing original content for all sections of Federal RFx, with minimal oversight. This position offers hybrid work opportunities, with primary work to be completed in the Reston or Chantilly, Virginia areas. The candidate should be local to the Northern, Virginia area.
What You’ll Do
The Proposal Writer we seek is a principal-level proposal professional and is a key member of the Proposal Development Center (PDC). You will provide full lifecycle, Federal proposal support, from content planning, template development, and writing and editing key sections (resumes, past performance, and narrative volumes), through submission. You’ll also coach and mentor junior writers and participate in process improvement initiatives. You’ll share your wisdom in peer and color reviews and apply analytical skills to process efficiencies and proposal quality through the use of proprietary AI tool.
What You’ll Bring to the Table
In this role you will join the PDC family that enjoys a team culture, and collaborative engagement with all levels of proposal contributors and stakeholders.
You have a hunger for knowledge, a thirst for quality, and an eye for accuracy. You have strong critical thinking skills and easily digest technically complex information. You have experience with writing proposals or technical documents for the Federal Government. Each proposal offers you an opportunity to learn about exciting innovations that sustain and support our government, including our military.
Your strengths with the written word, communications, and the English language (grammar nerds welcomed and embraced), will be appreciated throughout the proposal development process. Your expertise weaving in win strategies, themes, and discriminators into proposal artifacts means you are making an impact to important solutions supporting our customers.
What SAIC Offers
We empower you to paint our proposals with your creative and analytical skills. SAIC is dedicated to your professional development and career growth with our mature mentor-protégé program and robust training opportunities (e.g., emerging technologies, including AI, leadership development, and industry best practices).
In this deadline-driven industry, we offer you competitive compensation, a flexible work schedule, and work-life balance.
Don’t take our word for it… some of SAIC’s recognition includes:
- Glassdoor’s Best Places to Work 2026, Glassdoor, 2026
- America’s Best Midsize Employers, TIME, 2024
- Forbes best Large Employers, Forbes, 2023
- Ranked #1 of Top Companies for Veterans - DiversityInc – 2022
- Ranked #7 of Top 25 Veteran Employers – Military.com - 2022
Day in the Life of a Proposal Writer
- You’ll interview candidates and SMEs, and engage with fellow contributors to develop proposal artifacts that are clear, concise, persuasive, compliant, and compelling
- You’ll ensure accurate content that is error free and aligned to RFx requirements, company process, capture strategies, and industry best practices
- You’ll peer review your teammates work, and ask them to review your work
- You may be a reviewer in our formal color reviews— sharing your crucial insight, knowledge, and expertise
- You’ll coach and mentor less experience writers
- You may be engaged in the earliest stages of capture strategy development
Qualifications
You Need to Have:
- BA or BS degree or higher (or equivalent) in Journalism, English, Business, Information Technology, Communication Arts, or other relevant fields
- 10 years of solid Federal proposal writing experience, preferably solutions-based proposals (8 years of experience with a Masters Degree)
- Must be a US Citizen
TS with active SCI investigation highly desirable for DMV area residents
We Really Wish You Would Have:
- Experience with FEDSIM/AAS, OTA, and Self-Scoring bids a plus
- Be a champion of AI tools for quality improvements and efficiency
- Knowledge of infrastructure modernization, applications/software development and sustainment, cloud solutions, warfighter solutions, and agile methodologies for defense, civilian, space, and National security sectors of the federal government
Target salary range: $120,001 - $160,000. The estimate displayed represents the typical salary range for this position based on experience and other factors.
Job ID: 2614238-OTHLOC-100000654856391
Location: Chantilly, VA, US
Date Posted: 2026-07-02
Category: Business Development
Subcategory: Proposal
Schedule: Full-Time
Shift: Day Job
Travel: Yes - 10% of the time
Minimum Clearance Required: TS.SCI
Clearance Level Must Be Able to Obtain: None
Potential for Remote Work: ORA_HYBRID
Description
SAIC is looking for a seasoned, cleared senior level Proposal Writer who is accomplished with writing original content for all sections of Federal RFx, with minimal oversight. This position offers hybrid work opportunities, with primary work to be completed in the Reston or Chantilly, Virginia areas. The candidate should be local to the Northern, Virginia area.
What You’ll Do
The Proposal Writer we seek is a principal-level proposal professional and is a key member of the Proposal Development Center (PDC). You will provide full lifecycle, Federal proposal support, from content planning, template development, and writing and editing key sections (resumes, past performance, and narrative volumes), through submission. You’ll also coach and mentor junior writers and participate in process improvement initiatives. You’ll share your wisdom in peer and color reviews and apply analytical skills to process efficiencies and proposal quality through the use of proprietary AI tool.
What You’ll Bring to the Table
In this role you will join the PDC family that enjoys a team culture, and collaborative engagement with all levels of proposal contributors and stakeholders.
You have a hunger for knowledge, a thirst for quality, and an eye for accuracy. You have strong critical thinking skills and easily digest technically complex information. You have experience with writing proposals or technical documents for the Federal Government. Each proposal offers you an opportunity to learn about exciting innovations that sustain and support our government, including our military.
Your strengths with the written word, communications, and the English language (grammar nerds welcomed and embraced), will be appreciated throughout the proposal development process. Your expertise weaving in win strategies, themes, and discriminators into proposal artifacts means you are making an impact to important solutions supporting our customers.
What SAIC Offers
We empower you to paint our proposals with your creative and analytical skills. SAIC is dedicated to your professional development and career growth with our mature mentor-protégé program and robust training opportunities (e.g., emerging technologies, including AI, leadership development, and industry best practices).
In this deadline-driven industry, we offer you competitive compensation, a flexible work schedule, and work-life balance.
Don’t take our word for it… some of SAIC’s recognition includes:
- Glassdoor’s Best Places to Work 2026, Glassdoor, 2026
- America’s Best Midsize Employers, TIME, 2024
- Forbes best Large Employers, Forbes, 2023
- Ranked #1 of Top Companies for Veterans - DiversityInc – 2022
- Ranked #7 of Top 25 Veteran Employers – Military.com - 2022
Day in the Life of a Proposal Writer
- You’ll interview candidates and SMEs, and engage with fellow contributors to develop proposal artifacts that are clear, concise, persuasive, compliant, and compelling
- You’ll ensure accurate content that is error free and aligned to RFx requirements, company process, capture strategies, and industry best practices
- You’ll peer review your teammates work, and ask them to review your work
- You may be a reviewer in our formal color reviews— sharing your crucial insight, knowledge, and expertise
- You’ll coach and mentor less experience writers
- You may be engaged in the earliest stages of capture strategy development
Qualifications
You Need to Have:
- BA or BS degree or higher (or equivalent) in Journalism, English, Business, Information Technology, Communication Arts, or other relevant fields
- 10 years of solid Federal proposal writing experience, preferably solutions-based proposals (8 years of experience with a Masters Degree)
- Must be a US Citizen
TS with active SCI investigation highly desirable for DMV area residents
We Really Wish You Would Have:
- Experience with FEDSIM/AAS, OTA, and Self-Scoring bids a plus
- Be a champion of AI tools for quality improvements and efficiency
- Knowledge of infrastructure modernization, applications/software development and sustainment, cloud solutions, warfighter solutions, and agile methodologies for defense, civilian, space, and National security sectors of the federal government
Target salary range: $120,001 - $160,000. The estimate displayed represents the typical salary range for this position based on experience and other factors.
Principal Medical Writer Jobs by Experience Level
Top Cities Hiring Principal Medical Writers
Explore principal medical writer openings in the cities hiring most right now.
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Find Principal Medical Writer JobsPrincipal Medical Writer Job Market
Who's Hiring
- サイネオス・ヘルス96
- Syneos Health3
- Northrop Grumman3
- SAIC2
- Ionis Pharmaceuticals2
Top Industries Hiring
- Science & Research
- Biotechnology & Pharmaceuticals
- Healthcare & Medical Services
What Employers Look For
The qualifications that appear most often in principal medical writer jobs.
- Advanced degree in life sciences, pharmacy, or a related field plus substantial medical writing experience
- Demonstrated authorship of regulatory documents including clinical study reports and module 2 summaries
- Deep knowledge of ICH guidelines, FDA regulations, and EMA submission requirements
- Proficiency with document management systems and structured authoring tools such as eCTD publishing platforms
- Experience leading cross-functional teams across clinical, regulatory, and statistical functions
- AMWA or RAC certification preferred for senior regulatory medical writing positions
Tips for Your Principal Medical Writer Job Search
Tailor your resume to submission type
Hiring managers for principal medical writer roles distinguish between regulatory writers and publications writers. Separate your experience by document type, such as CSRs, INDs, and NDAs, so reviewers can immediately see where your depth lives.
Apply early to roles that fit
Migrate Mate lists principal medical writer openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Quantify your regulatory document output
Instead of listing 'authored regulatory documents,' specify the number of submissions you contributed to, the therapeutic areas covered, and whether they reached approval. Reviewers at this level expect demonstrated ownership, not general participation.
Filter openings by therapeutic area fit
Principal medical writer postings often require disease-area expertise in oncology, CNS, or rare disease. Prioritize roles where your therapeutic background matches, since a strong fit there outweighs slight gaps in document type experience.
Prepare a writing sample for each document type
Many hiring processes for this role include a practical writing exercise or request a blinded sample. Have a CSR executive summary, a publications abstract, and a regulatory section ready to share, each representing your independent work.
Negotiate scope before discussing title
At the principal level, your leverage is document ownership and cross-functional lead responsibilities. Clarify in late-stage interviews which submission programs you will own end to end, then use that scope to anchor your compensation conversation.
Principal Medical Writer Jobs: Frequently Asked Questions
Which companies are hiring the most principal medical writers?
The companies hiring the most principal medical writers right now include サイネオス・ヘルス, Syneos Health, and Northrop Grumman, with the largest share of openings in North Carolina, Virginia, and Massachusetts, based on current listings on Migrate Mate as of July 2026. CROs and large pharma companies tend to post the most consistent volume at this seniority level.
How many principal medical writer jobs are remote?
About 75% of principal medical writer openings are fully remote or hybrid as of July 2026, reflecting the document-centric nature of the role. Regulatory writing and publications positions tend to offer the highest remote availability, while roles requiring frequent on-site collaboration with clinical or biostatistics teams are more likely to be hybrid.
How do you become a principal medical writer?
You typically start with an advanced degree in a life sciences field, then build document authorship experience across clinical study reports, regulatory summaries, and scientific publications. Progressing to the principal level requires demonstrating ownership of full submissions, leading author teams, and developing expertise in a specific therapeutic area. Pursuing AMWA certification and contributing to cross-functional regulatory strategy accelerates advancement.
Can you get hired as a principal medical writer with limited experience?
Breaking in at the principal level without direct regulatory writing experience is difficult, but candidates who hold a PhD and have published peer-reviewed clinical research can sometimes transition into publications-focused roles first. From there, moving into regulatory writing at a CRO builds the submission experience hiring managers expect. Freelance regulatory projects are another way to build a documented authorship portfolio before applying to full-time principal roles.
What does the principal medical writer interview process look like?
The process typically includes an initial screening with HR, a technical interview with a medical writing lead or regulatory affairs director, and a practical writing exercise where you draft or critique a document excerpt. Final rounds often involve a presentation to a cross-functional panel. Interviewers focus on your submission experience, your approach to author team management, and how you handle conflicting input from clinical and statistical stakeholders.
Where can I find and apply to principal medical writer jobs?
You can find and apply to principal medical writer jobs on Migrate Mate, which lists current openings from across the United States in one place. Search for roles that match your therapeutic area and document type experience, then apply directly to each listing that fits.
See All 109+ Principal Medical Writer Jobs
Find roles that match your experience and apply in just a few clicks.
Find Principal Medical Writer Jobs