Senior Level Quant Jobs
Senior level quant jobs put experienced professionals in charge of model architecture, research direction, and the teams or systems that turn analysis into decisions. Roles are concentrated in Investment & Asset Management, Technology & Software, and Banking & Financial Services, with 58% remote or hybrid availability, and employers like Two Sigma, JPMorganChase, and Chicago Trading Company hiring at this level now.
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INTRODUCTION
Working at Moffitt is both a career and a mission: to contribute to the prevention and cure of cancer.
As the only National Cancer Institute-designated Comprehensive Cancer Center based in Florida, Moffitt employs some of the best and brightest minds from around the world. Join a dedicated team of nearly 11,000 who are shaping the future we envision. Moffitt has been recognized as a Best and Brightest Company to Work For in the Nation and is continually named one of the Tampa Bay Times’ Top Workplaces.
SUMMARY
Associate Center Director of Physical & Quantitative Science
Moffitt Cancer Center (Moffitt), a stand-alone NCI-designated Comprehensive Cancer Center, is seeking a visionary and collaborative leader to serve as the Associate Center Director (ACD) and Division Chief of Physical & Quantitative Science. This newly reimagined, senior academic leadership role will be responsible for driving transformative research innovation in artificial intelligence (AI), machine learning, mathematical oncology, systems biology, biostatistics, and bioinformatics in oncology. The ACD is responsible for providing strategic vision, scientific leadership, and administrative oversight for the Division across multiple disciplines within the Departments of Biostatistics & Bioinformatics (Bios2), Integrated Mathematical Oncology (IMO), and Machine Learning (ML), as well as one or more future departments in the Division. This role offers a unique opportunity to shape and expand Moffitt’s strengths in physical and quantitative science through interdisciplinary research and strategic growth. A primary responsibility of this role will be to foster collaborations across research and clinical faculty and senior administration to build expertise, academic departments, research infrastructure, and team science partnerships that advance innovative approaches to advance cancer prevention, diagnosis, and treatment. This leader will have significant authority and responsibility for the academic and research mission of Moffitt, which has nationally recognized research programs in Clinical, Discovery, Physical & Quantitative, Population, and Translational Sciences. The ACD serves as an institutional leader to advance Moffitt’s singular mission to contribute to the prevention and cure of cancer.
Position highlights include the following:
- Advance impact and visibility of Moffitt’s Physical & Quantitative Science research at the local, state, national and international levels
- Further strengthen and grow exceptional physical and quantitative science research programs in the Departments of Biostatistics & Bioinformatics, Integrated Mathematical Oncology, Machine Learning, and one or more new academic departments
- Recruit talented faculty and staff dedicated to physical and quantitative research, leveraging highly competitive faculty recruitment packages
THE IDEAL CANDIDATE WILL:
- Have a national/international reputation in cancer-related physical and/or quantitative science research with an exceptional track record of peer reviewed extramural research funding
- Be a thought leader in the fields of physical and/or quantitative science who will anticipate and drive new research directions and opportunities
- Have exceptional leadership and mentorship skills to advance the careers of faculty, trainees, and staff
- Understand and advance catchment area needs through research
PRIMARY RESPONSIBILITIES FOR THE LEADERSHIP ROLE WILL INCLUDE:
- Administrative and academic leadership: Oversees the Division of Physical & Quantitative Science; as Division Chief, leads Chairs and Division Administration in a productive, collaborative academic research environment
- Scientific leadership: Works with other leaders to advance high impact transdisciplinary research across research and clinical departments and programs; provides guidance to Shared Resources (Cores) aligned with the Division of Physical & Quantitative Science; contributes to CCSG competing and non-competing applications; and mentors Core directors, faculty, trainees, and staff
- Center-wide leadership: Serves as member of the Research Executive Committee, the Research Institute Steering Committee, the Scientific Leadership Committee, and the Leadership Council; represents the Division of Physical & Quantitative Science in oversight and governance venues; ensures the Division of Physical & Quantitative Science develops and sustains robust shared initiatives with the Offices of Community Outreach & Engagement, Research Education & Training, and Research Career Development
- Maintains top tier research programs: Maintains active extramurally funded research programs; publishes original reports in high impact peer-reviewed journals; provides service to professional societies; and contributes to teaching and mentoring of faculty, staff, fellows, and graduate students
CREDENTIALS AND QUALIFICATIONS FOR ELIGIBLE CANDIDATES INCLUDE:
- Doctoral degree (PhD, DrPH, or equivalent) in systems biology, engineering, biomathematics, biostatistics, bioinformatics, machine learning, artificial intelligence, quantitative science, computer science, or a related field
- Senior Member/Professor rank is preferred, along with a history of academic excellence and sustained peer-reviewed extramural funding by NCI or other institutes of NIH
- Previous experience in a Cancer Center Support Grant (CCSG) leadership role, research program or other specific CCSG role, with experience in developing/reviewing the P30 grant as well as participation in program review
- Track record of successfully working across complex research and clinical environments
To formally apply, visit our internal careers page and apply to req R-78. Please be sure to attach a single PDF or Word file which includes your CV and cover letter. Review of applications will begin immediately.
Questions regarding the opportunity may be directed to Chair of the Search Committee, Dr. Heather Jim at Heather.Jim@moffitt.org.
LOCATION
Tampa Bay Area
Moffitt Cancer Center is located in Tampa Florida, a thriving metropolitan city that provides its residents a high quality of life. The Tampa Bay area has become a hub for ground-breaking research, welcoming individuals from around the globe. This diverse city is characterized by a rich culture, year-round activities for all, beautiful beaches, amazing cuisine and more.
EQUAL EMPLOYMENT OPPORTUNITY
Moffitt is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, or protected veteran or disabled status. Moffitt seeks candidates whose skills and personal and professional experience have prepared them to contribute to our commitment to diversity and excellence.
SALARY RANGE
Salary ranges posted for this position represent the expected base pay range for the role. Actual compensation may vary based on location and a variety of job-related factors, including experience, skills, education, and internal equity among Team Members in similar positions.
We are committed to maintaining fair and equitable pay practices and regularly review compensation to ensure alignment across our workforce.
INTRODUCTION
Working at Moffitt is both a career and a mission: to contribute to the prevention and cure of cancer.
As the only National Cancer Institute-designated Comprehensive Cancer Center based in Florida, Moffitt employs some of the best and brightest minds from around the world. Join a dedicated team of nearly 11,000 who are shaping the future we envision. Moffitt has been recognized as a Best and Brightest Company to Work For in the Nation and is continually named one of the Tampa Bay Times’ Top Workplaces.
SUMMARY
Associate Center Director of Physical & Quantitative Science
Moffitt Cancer Center (Moffitt), a stand-alone NCI-designated Comprehensive Cancer Center, is seeking a visionary and collaborative leader to serve as the Associate Center Director (ACD) and Division Chief of Physical & Quantitative Science. This newly reimagined, senior academic leadership role will be responsible for driving transformative research innovation in artificial intelligence (AI), machine learning, mathematical oncology, systems biology, biostatistics, and bioinformatics in oncology. The ACD is responsible for providing strategic vision, scientific leadership, and administrative oversight for the Division across multiple disciplines within the Departments of Biostatistics & Bioinformatics (Bios2), Integrated Mathematical Oncology (IMO), and Machine Learning (ML), as well as one or more future departments in the Division. This role offers a unique opportunity to shape and expand Moffitt’s strengths in physical and quantitative science through interdisciplinary research and strategic growth. A primary responsibility of this role will be to foster collaborations across research and clinical faculty and senior administration to build expertise, academic departments, research infrastructure, and team science partnerships that advance innovative approaches to advance cancer prevention, diagnosis, and treatment. This leader will have significant authority and responsibility for the academic and research mission of Moffitt, which has nationally recognized research programs in Clinical, Discovery, Physical & Quantitative, Population, and Translational Sciences. The ACD serves as an institutional leader to advance Moffitt’s singular mission to contribute to the prevention and cure of cancer.
Position highlights include the following:
- Advance impact and visibility of Moffitt’s Physical & Quantitative Science research at the local, state, national and international levels
- Further strengthen and grow exceptional physical and quantitative science research programs in the Departments of Biostatistics & Bioinformatics, Integrated Mathematical Oncology, Machine Learning, and one or more new academic departments
- Recruit talented faculty and staff dedicated to physical and quantitative research, leveraging highly competitive faculty recruitment packages
THE IDEAL CANDIDATE WILL:
- Have a national/international reputation in cancer-related physical and/or quantitative science research with an exceptional track record of peer reviewed extramural research funding
- Be a thought leader in the fields of physical and/or quantitative science who will anticipate and drive new research directions and opportunities
- Have exceptional leadership and mentorship skills to advance the careers of faculty, trainees, and staff
- Understand and advance catchment area needs through research
PRIMARY RESPONSIBILITIES FOR THE LEADERSHIP ROLE WILL INCLUDE:
- Administrative and academic leadership: Oversees the Division of Physical & Quantitative Science; as Division Chief, leads Chairs and Division Administration in a productive, collaborative academic research environment
- Scientific leadership: Works with other leaders to advance high impact transdisciplinary research across research and clinical departments and programs; provides guidance to Shared Resources (Cores) aligned with the Division of Physical & Quantitative Science; contributes to CCSG competing and non-competing applications; and mentors Core directors, faculty, trainees, and staff
- Center-wide leadership: Serves as member of the Research Executive Committee, the Research Institute Steering Committee, the Scientific Leadership Committee, and the Leadership Council; represents the Division of Physical & Quantitative Science in oversight and governance venues; ensures the Division of Physical & Quantitative Science develops and sustains robust shared initiatives with the Offices of Community Outreach & Engagement, Research Education & Training, and Research Career Development
- Maintains top tier research programs: Maintains active extramurally funded research programs; publishes original reports in high impact peer-reviewed journals; provides service to professional societies; and contributes to teaching and mentoring of faculty, staff, fellows, and graduate students
CREDENTIALS AND QUALIFICATIONS FOR ELIGIBLE CANDIDATES INCLUDE:
- Doctoral degree (PhD, DrPH, or equivalent) in systems biology, engineering, biomathematics, biostatistics, bioinformatics, machine learning, artificial intelligence, quantitative science, computer science, or a related field
- Senior Member/Professor rank is preferred, along with a history of academic excellence and sustained peer-reviewed extramural funding by NCI or other institutes of NIH
- Previous experience in a Cancer Center Support Grant (CCSG) leadership role, research program or other specific CCSG role, with experience in developing/reviewing the P30 grant as well as participation in program review
- Track record of successfully working across complex research and clinical environments
To formally apply, visit our internal careers page and apply to req R-78. Please be sure to attach a single PDF or Word file which includes your CV and cover letter. Review of applications will begin immediately.
Questions regarding the opportunity may be directed to Chair of the Search Committee, Dr. Heather Jim at Heather.Jim@moffitt.org.
LOCATION
Tampa Bay Area
Moffitt Cancer Center is located in Tampa Florida, a thriving metropolitan city that provides its residents a high quality of life. The Tampa Bay area has become a hub for ground-breaking research, welcoming individuals from around the globe. This diverse city is characterized by a rich culture, year-round activities for all, beautiful beaches, amazing cuisine and more.
EQUAL EMPLOYMENT OPPORTUNITY
Moffitt is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, or protected veteran or disabled status. Moffitt seeks candidates whose skills and personal and professional experience have prepared them to contribute to our commitment to diversity and excellence.
SALARY RANGE
Salary ranges posted for this position represent the expected base pay range for the role. Actual compensation may vary based on location and a variety of job-related factors, including experience, skills, education, and internal equity among Team Members in similar positions.
We are committed to maintaining fair and equitable pay practices and regularly review compensation to ensure alignment across our workforce.
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Who's Hiring
Top Industries Hiring
- Investment & Asset Management14
- Technology & Software6
- Banking & Financial Services4
- Fintech1
- Insurance1
Senior Level Quant Jobs: Frequently Asked Questions
How do I get a senior level quant job?
Senior level quant roles go to candidates who can demonstrate ownership of a full research or modeling pipeline, not just individual contributions. Employers at this level want to see publications, patents, or deployed models that moved the needle, plus evidence of mentoring junior staff or leading cross-functional projects. A deep specialization in a high-demand area, such as stochastic modeling, machine learning for finance, or derivatives pricing, sharpens your edge considerably.
Which companies hire senior level quants?
Companies hiring senior level quants right now include Two Sigma, JPMorganChase, and Chicago Trading Company, based on current listings on Migrate Mate as of November 2026. At this level, hiring tends to concentrate in firms where quantitative rigor drives core business decisions, including investment banks, proprietary trading shops, insurance carriers, and technology companies with large financial or risk modeling functions.
Are there remote senior level quant jobs?
Yes, though remote availability varies by employer and function. About 58% of senior level quant openings are remote or hybrid as of November 2026, with hybrid arrangements being more common at firms where model validation, risk oversight, or team collaboration require regular in-person engagement. Fully remote roles exist primarily in research-focused or independent contributor positions.
What makes a quant role senior level?
A senior quant role is defined by scope and ownership rather than task execution. At this level, you are expected to design the analytical framework, not just implement it, and to take accountability for model performance in production. Senior roles also carry explicit expectations around mentoring junior quants, contributing to hiring decisions, and communicating results to non-technical stakeholders such as portfolio managers, risk committees, or executive leadership.
Which industries hire the most senior level quants?
Senior level quant roles concentrate in Investment & Asset Management, Technology & Software, and Banking & Financial Services, based on current listings on Migrate Mate as of November 2026. These sectors drive demand because they rely on quantitative models to price risk, allocate capital, or optimize large-scale operations, functions that require the depth and judgment that only experienced quants bring.