Regional Sales Manager Jobs in Chicago, IL
Regional Sales Manager jobs in Chicago are concentrated in the Loop, River North, and the Fulton Market corridor, with strong demand from companies in distribution, technology, financial services, and healthcare. Employers hiring right now include Jobot, Abbott, and Fortinet. See the openings below and apply to the ones that match your experience.
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Job Description
Join Amgen’s Mission of Serving Patients
At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
What you will do
Let’s do this. Let’s change the world. In this vital role, you will lead the regional sales organization for UPLIZNA in Neurology (gMG and NMOSD), translating brand strategy into focused execution and delivering results through a high-performing team.
The Regional Sales Director (RSD) is accountable for the leadership, performance and development of the UPLIZNA Neurology sales organization across the assigned region. This leader will establish regional strategy, create clarity around priorities and expectations, and develop District Managers and field teams to execute with excellence. The RSD will operate as a senior commercial leader and strategic business partner, using market insights, customer understanding and cross-functional collaboration to identify opportunities, remove barriers and drive sustainable performance in a complex rare disease marketplace.
- Lead the region as a business, translating UPLIZNA brand priorities into a focused regional strategy, clear execution imperatives, measurable standards and disciplined operating rhythms.
- Deliver business results through others by equipping District Managers as force multipliers, setting clear performance expectations, using leading indicators to identify opportunities and risks early, and driving timely action and accountability.
- Coach and develop District Managers through a consistent observe, diagnose, practice and follow-up approach that strengthens leadership capability, business acumen, coaching quality, decision-making and representative performance.
- Build and sustain a high-performing, inclusive and compliant culture grounded in Amgen values, patient focus, operational excellence, accountability, scientific integrity and clear, credible leadership communication.
- Attract, select, onboard, retain and develop future-ready talent; establish meaningful development priorities for leaders and maintain strong succession and bench plans for critical roles across the region.
- Synthesize performance data, access dynamics, customer needs, competitive signals and field intelligence to generate decision-ready insights, identify root causes and dynamically adjust regional plans and resources.
- Maintain deep knowledge of gMG and NMOSD, the UPLIZNA clinical profile, the treatment landscape and evolving customer and market dynamics, translating that understanding into relevant regional strategy and field direction.
- Develop strong relationships with key customers and stakeholders and provide visible leadership at priority regional and national congresses, conferences and other strategic customer engagements.
- Lead with an enterprise mindset, appropriately and compliantly orchestrating Marketing, Market Access, Patient Services, Medical, Training, Commercial Operations, HR and other partners around shared brand and business objectives.
- Anticipate, adapt and lead through change by monitoring early signals, clarifying what is changing and why, making thoughtful start-stop trade-offs, and keeping teams focused, aligned and accountable through ambiguity.
- Allocate regional resources, operating expenses and program investments to the highest-priority opportunities, balancing patient impact, business performance, risk and established budget expectations.
- Ensure all regional activities are conducted in accordance with applicable laws, regulations, company policies and Amgen compliance, ethics and safety standards, reinforcing responsible performance and appropriate business conduct.
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The Regional Sales Director professional we seek is a strategic, results-oriented people leader with these qualifications.
Basic Qualifications:
Doctorate degree and 4 years of collective account management, sales, marketing and/or commercial experience
OR
Master’s degree and 8 years of collective account management, sales, marketing and/or commercial experience
OR
Bachelor’s degree and 10 years of collective account management, sales, marketing and/or commercial experience
In addition to meeting at least one of the above requirements, candidates must have at least 4 years of experience directly managing people and/or leadership experience leading teams, projects or programs, or directing the allocation of resources. Managerial experience may run concurrently with the required commercial experience referenced above.
Preferred Qualifications:
- Bachelor’s degree required; advanced degree or MBA preferred.
- 5+ years of sales leadership experience, with demonstrated success developing people leaders and delivering business results through multi-level field organizations.
- 10+ years of biotech/pharmaceutical commercial experience; rare disease, neurology, specialty biologic and/or buy-and-bill experience strongly preferred.
- Demonstrated success attracting and developing talent, building succession pipelines, creating healthy high-performance cultures and leading organizations through growth and change.
- Strong insight and strategic agility, including the ability to synthesize multiple data sources and market signals, diagnose business drivers and translate insights into focused regional strategy and resource decisions.
- Proven ability to translate brand priorities into clear execution standards, leading indicators, operating rhythms and timely performance actions.
- Strong executive presence and communication skills, with the ability to simplify complex strategy, inspire followership and influence stakeholders at varying organizational levels.
- Demonstrated enterprise mindset and ability to orchestrate cross-functional partners in a complex matrix environment while maintaining clear decision rights, accountability and compliant ways of working.
- Strong understanding of the U.S. pharmaceutical regulatory and compliance environment.
- Requires approximately 60% travel, including some overnight and weekend commitments.
- Proficient in Microsoft Office.
- Professional, proactive demeanor.
- Strong interpersonal skills.
- Excellent written and verbal communication skills.
What you can expect of us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.
and make a lasting impact with the Amgen team.
careers.amgen.com
In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadline
Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
Sponsorship
Sponsorship for this role is not guaranteed.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
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Who's Hiring



Top Industries Hiring
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Regional Sales Manager Jobs in Chicago: Frequently Asked Questions
How do I get a regional sales manager job in Chicago?
The strongest path is targeting Chicago's dominant hiring sectors: enterprise software, medical devices, commercial real estate services, and industrial distribution. Roles concentrate in the Loop, River North, and along the Fulton Market corridor. Candidates with a proven book of business in the Midwest, existing relationships with Chicago-area buyers, and experience managing teams across a multi-state territory have a clear edge over generalist applicants.
Which companies hire regional sales managers in Chicago?
Companies currently hiring regional sales managers in Chicago include Jobot, Abbott, and Fortinet, per current listings on Migrate Mate as of November 2026. Chicago's mix of Fortune 500 headquarters, major healthcare systems, and a dense cluster of B2B software and logistics firms makes it one of the most active markets in the Midwest for this role.
Are there remote regional sales manager jobs in Chicago?
Yes, though regional sales manager roles are less remote-friendly than most, since the work typically involves in-person client meetings and territory travel. About 88% of regional sales manager openings tied to Chicago are remote or hybrid as of November 2026, and those tend to be roles where account management and forecasting are heavier than field selling. Inside sales leadership and SaaS-focused roles represent the largest share of remote-eligible openings in the Chicago market.
How can I get a regional sales manager job in Chicago with little or no experience?
The most realistic entry path is moving up from a senior account executive or territory sales rep role at a Chicago employer, then making the case for a team lead or player-coach position. Mid-size B2B distributors headquartered in the suburbs, along with Chicago's many SaaS and health tech startups, regularly promote strong individual contributors into first-time management roles. Building a track in Midwest territory sales and getting comfortable with pipeline reporting tools gives candidates a concrete advantage when applying locally.
Which industries hire the most regional sales managers in Chicago?
The sectors hiring the most regional sales managers in Chicago are Staffing & Recruiting, Retail, and Automotive, based on current listings on Migrate Mate as of November 2026. Chicago's role as a Midwest logistics hub, combined with its concentration of healthcare organizations and enterprise technology firms headquartered downtown, keeps demand for sales leadership consistently high across those sectors.
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