Registered Nurse Jobs in Durham, NC
Registered Nurse jobs in Durham are in strong demand, concentrated in the Duke University Medical Center corridor, Research Triangle Park's adjacent medical campuses, and the South Square and Southpoint areas, with hiring across academic medical centers, community health systems, and outpatient specialty clinics. Employers hiring right now include Duke Health, Maxim Healthcare, and US Department of Veterans Affairs. Find a role that fits below and apply directly.
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What you can expect
Location: 2301 Erwin Rd, Durham, 27710, NC
Duke University Hospital’s Neonatal Intensive Care Unit (NICU) is a high-acuity, high-volume neonatal program that provides care for more than 1,000 infants each year. The unit includes the Special Care Nursery, Transitional Care Nursery, and Intensive Care Nursery, offering a full spectrum of neonatal care. Patient populations include critically ill and medically complex newborns, including extremely low birth weight infants, infants with congenital and genetic anomalies, and those requiring long-term or palliative support. Nurses work within a multidisciplinary team in a collaborative, family-centered care environment.
Schedule:
- Full time, three 12-hour shifts per week
- Rotating day and night shifts: 7 a.m. – 7:30 p.m. and 7 p.m. – 7:30 a.m.
- Minimum of 2–4 weekend shifts per four-week scheduling period
Incentives & Total Rewards:
- Relocation Assistance: $3,000. Relocation is offered to employees relocating from a permanent residence located at least 50 miles from Duke University Hospital. A permanent residence is typically defined as the address listed on a valid government-issued ID (e.g., driver’s license). Temporary housing, such as dormitories or student apartments, does not qualify.
- Total Rewards: A comprehensive set of pay and benefits designed to support your well-being, professional growth, and work-life balance. Learn more here.
How you will make an impact
- Plan, provide, and document professional nursing care in accordance with provider orders, established policies, and procedures, while ensuring safe and developmentally appropriate care for neonatal patients.
- Utilize the nursing process to assess, plan, implement, and evaluate individualized care for neonatal patients and their families in a high-acuity environment.
- Collaborate with neonatologists and the interdisciplinary team to support optimal patient outcomes and continuity of care.
- Delegate and supervise care activities for licensed and unlicensed personnel and monitor patient status to initiate timely interventions.
- Participate in orientation, ongoing education, performance improvement, and shared governance activities while supporting families through education and emotional support.
What you will need
- Graduation from an accredited Bachelor’s Degree in Nursing (or higher), Associate’s Degree in Nursing, or Nursing Diploma program
- BSN required within seven years of start date if not already obtained
- Current or eligible North Carolina RN licensure or compact RN license required
- BLS certification required prior to start date
Duke is an Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex (including pregnancy and pregnancy related conditions), sexual orientation or military status.
Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas — an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.
Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.
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Who's Hiring
- Duke Health151

- Maxim Healthcare17

- US Department of Veterans Affairs17

Registered Nurse Jobs in Durham: Frequently Asked Questions
How do I get a registered nurse job in Durham?
Durham's hiring concentrates in academic medical centers, large health systems, and community health clinics, particularly around the Duke University Medical Center district and the Research Triangle Park corridor. Candidates with ICU, oncology, or pediatric experience stand out in this market. Applying directly to health system career portals and targeting roles that match your unit specialty gives you the strongest edge with Durham's major employers.
Which companies hire registered nurses in Durham?
Durham registered nurse roles are posted by Duke Health, Maxim Healthcare, and US Department of Veterans Affairs and others right now, based on current listings on Migrate Mate as of September 2026. Durham's hiring base is anchored by large academic health systems and federally qualified community health centers that operate multiple sites across the city.
Are there remote registered nurse jobs in Durham?
Remote registered nurse roles are rare by nature because most positions require direct patient care in clinical settings. About 0% of registered nurse openings tied to Durham are remote or hybrid as of September 2026, and those positions tend to be in case management, utilization review, and triage nursing rather than bedside or procedural roles.
How can I get a registered nurse job in Durham with little or no experience?
The most realistic entry path in Durham is a new-graduate residency program, which several of the city's large health systems run specifically to train RNs in med-surg and telemetry before transitioning them to specialty units. Targeting community health clinics and outpatient primary care practices is a strong secondary option, as those settings often hire new graduates for lower-acuity roles and build clinical experience quickly.
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