Registered Nurse Jobs in Durham, NC

Registered Nurse jobs in Durham are in strong demand, concentrated in the Duke University Medical Center corridor, Research Triangle Park's adjacent medical campuses, and the South Square and Southpoint areas, with hiring across academic medical centers, community health systems, and outpatient specialty clinics. Employers hiring right now include Duke Health, SP MANAGEMENT SERVICES, and PruittHealth. Find a role that fits below and apply directly.

Find Registered Nurse Jobs

Overview

Open roles147+
Top employerDuke Health
Work type100% On-site
Top credentialBLS Certification
Companies hiring41

Showing 5 of 147+ Registered Nurse jobs

US Department of Veterans Affairs
Registered Nurse (Wound/Ostomy Care)
We won't show you this job again
US Department of Veterans Affairs
New 1m ago
Registered Nurse (Wound/Ostomy Care)
US Department of Veterans Affairs
Durham, North Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
On-Site
Doctoral degree
10,000+

Have you applied for this role?

Yad Healthcare
RN No Frills Rate $44 hour
We won't show you this job again
Yad Healthcare
New 1m ago
RN No Frills Rate $44 hour
Yad Healthcare
Durham, North Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
High school diploma or GED
1,001-5,000

Have you applied for this role?

PruittHealth
Nurse Navigator- RN
We won't show you this job again
PruittHealth
New 1m ago
Nurse Navigator- RN
PruittHealth
Durham, North Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
On-Site
10,000+

Have you applied for this role?

Duke Health
Registered Nurse III (Experienced) - Duke University Hospital - Operating Room
We won't show you this job again
Duke Health
New 1m ago
Registered Nurse III (Experienced) - Duke University Hospital - Operating Room
Duke Health
Durham, North Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
BLS Certification
10,000+

Have you applied for this role?

Duke Health
New Grad or Experienced Registered Nurse (RN) - DMP 7w CTICU
We won't show you this job again
Duke Health
New 1m ago
New Grad or Experienced Registered Nurse (RN) - DMP 7w CTICU
Duke Health
Durham, North Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
BLS Certification
10,000+

Have you applied for this role?

See All 147+ Registered Nurse Jobs in Durham

Find roles in Durham that match your experience and apply in just a few clicks.

Find Registered Nurse Jobs

Registered Nurse Job Market in Durham

Who's Hiring

  • Duke Health
    Duke Health74
  • S
    SP MANAGEMENT SERVICES10
  • PruittHealth
    PruittHealth7
  • The Emily Program
    The Emily Program4
  • Treyburn Rehabilitation Center
    Treyburn Rehabilitation Center4

Top Industries Hiring

  • Healthcare & Medical Services15
  • Non-Profit & Social Services1

Registered Nurse Jobs in Durham: Frequently Asked Questions

How do I get a registered nurse job in Durham?

Durham's hiring concentrates in academic medical centers, large health systems, and community health clinics, particularly around the Duke University Medical Center district and the Research Triangle Park corridor. Candidates with ICU, oncology, or pediatric experience stand out in this market. Applying directly to health system career portals and targeting roles that match your unit specialty gives you the strongest edge with Durham's major employers.

Which companies hire registered nurses in Durham?

Durham registered nurse roles are posted by Duke Health, SP MANAGEMENT SERVICES, and PruittHealth and others right now, based on current listings on Migrate Mate as of July 2026. Durham's hiring base is anchored by large academic health systems and federally qualified community health centers that operate multiple sites across the city.

Are there remote registered nurse jobs in Durham?

Remote registered nurse roles are rare by nature because most positions require direct patient care in clinical settings. About 0% of registered nurse openings tied to Durham are remote or hybrid as of July 2026, and those positions tend to be in case management, utilization review, and triage nursing rather than bedside or procedural roles.

How can I get a registered nurse job in Durham with little or no experience?

The most realistic entry path in Durham is a new-graduate residency program, which several of the city's large health systems run specifically to train RNs in med-surg and telemetry before transitioning them to specialty units. Targeting community health clinics and outpatient primary care practices is a strong secondary option, as those settings often hire new graduates for lower-acuity roles and build clinical experience quickly.

Which industries hire the most registered nurses in Durham?

Durham registered nurse roles concentrate in Healthcare & Medical Services and Non-Profit & Social Services, based on current listings on Migrate Mate as of July 2026. Durham's position as home to a major academic medical center and a dense cluster of biotech and life sciences employers along the Research Triangle drives steady demand well beyond typical community hospital hiring.

See All 147+ Registered Nurse Jobs in Durham

Find roles in Durham that match your experience and apply in just a few clicks.

Find Registered Nurse Jobs