RN Staff Nurse Jobs in South Dakota

RN Staff Nurse jobs in South Dakota are open across Sioux Falls, Rapid City, and Sd and other South Dakota metros, with employers like Sanford Health, Sioux Center Health, and Monument Health hiring at every experience level. Find a role that fits below and apply directly.

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Overview

Open roles267+
Top employerSanford Health
Top citySioux Falls, SD
Cities hiring31
Work type100% On-site
Top industryHealthcare

Showing 5 of 267+ RN Staff Nurse jobs

Monument Health
Registered Nurse
We won't show you this job again
Monument Health
New 6h ago
Registered Nurse
Monument Health
Rapid City, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
$29 - $37/hr
On-Site
Bachelor's

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Monument Health
Registered Nurse
We won't show you this job again
Monument Health
New 6h ago
Registered Nurse
Monument Health
Spearfish, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
$35 - $43/hr
On-Site
Bachelor's

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Monument Health
Registered Nurse
We won't show you this job again
Monument Health
New 10h ago
Registered Nurse
Monument Health
Rapid City, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
$35 - $43/hr
On-Site
Bachelor's

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Sanford Health
Registered Nurse
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Sanford Health
Added 2d ago
Registered Nurse
Sanford Health
Rapid City, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
$34 - $48/hr
On-Site
Bachelor's
10,000+

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Sanford Health
Registered Nurse
We won't show you this job again
Sanford Health
Added 3d ago
Registered Nurse
Sanford Health
Canton, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
$33 - $48/hr
On-Site
Bachelor's
10,000+

Have you applied for this role?

See All 267+ RN Staff Nurse Jobs in South Dakota

Find roles in South Dakota that match your experience and apply in just a few clicks.

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RN Staff Nurse Jobs by City in South Dakota

Where South Dakota roles are concentrated, by current openings.

Sioux Falls
98 jobs
Rapid City
55 jobs
Sd
36 jobs
Aberdeen
16 jobs
Chamberlain
8 jobs
Spearfish
7 jobs
Huron
6 jobs
Custer
3 jobs
Eureka
3 jobs

RN Staff Nurse Job Market in South Dakota

A snapshot from current South Dakota openings, updated as new roles post.

Who's Hiring

  • Sanford Health
    Sanford Health101
  • Sioux Center Health
    Sioux Center Health56
  • Monument Health
    Monument Health54
  • Sanford Bismarck
    Sanford Bismarck47
  • Huron Regional Medical Center
    Huron Regional Medical Center6

Top Industries Hiring

  • Healthcare & Medical Services265
  • Non-Profit & Social Services11

What South Dakota Employers Look For

The qualifications that appear most often in RN staff nurse jobs across South Dakota.

  • Active RN license in the state of employment or a compact multistate license
  • Current BLS certification required, ACLS often required for acute care settings
  • Associate or Bachelor of Science in Nursing from an accredited program
  • Minimum one to two years of clinical experience in a relevant care setting
  • Proficiency with electronic health record systems such as Epic or Cerner
  • Ability to assess, plan, implement, and evaluate patient care in fast-paced environments

RN Staff Nurse Jobs in South Dakota: Frequently Asked Questions

How many RN staff nurse jobs are there in South Dakota?

There are 267+ RN staff nurse openings in South Dakota on Migrate Mate as of June 2026, with the most roles in Sioux Falls, Rapid City, and Sd. New positions post regularly as employers across South Dakota hire.

How much do RN staff nurses make in South Dakota?

RN staff nurses in South Dakota earn a median of about $78,060 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $54,040 for the lowest 10% to over $98,220 for the top 10%. Pay rises with experience, specialty, and employer.

Which South Dakota cities have the most RN staff nurse jobs?

Sioux Falls, Rapid City, and Sd have the most RN staff nurse openings in South Dakota right now, with additional roles spread across smaller metros statewide.

Which companies hire RN staff nurses in South Dakota?

Employers hiring RN staff nurses in South Dakota include Sanford Health, Sioux Center Health, and Monument Health, based on current listings on Migrate Mate as of June 2026.

Are there remote RN staff nurse jobs in South Dakota?

Yes. About 0% of RN staff nurse openings tied to South Dakota are remote or hybrid as of June 2026. The rest are on-site roles based in South Dakota metros.

How do I apply for RN staff nurse jobs in South Dakota?

You can apply to RN staff nurse jobs in South Dakota directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Dakota location, then apply to each one that fits.

See All 267+ RN Staff Nurse Jobs in South Dakota

Find roles in South Dakota that match your experience and apply in just a few clicks.

Find RN Staff Nurse Jobs