Senior Clinical Project Manager Jobs in North Carolina
Senior Clinical Project Manager jobs in North Carolina are in strong and consistent demand, driven by the state's deep concentration of pharmaceutical manufacturers, contract research organizations, and academic medical centers serving clinical trials from early-phase through post-market. The heaviest hiring is in the Research Triangle (Raleigh-Durham-Chapel Hill), Charlotte, and Greensboro, where employers such as Syneos Health, Labcorp Drug Development, and Duke University Health System maintain substantial clinical operations. Oncology trials, rare disease studies, and regulatory submissions management are the most sought-after specialties. Find a role that fits below and apply directly.
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Showing 5 of 8+ Senior Clinical Project Manager jobs
California, US residents .
The job details are as follows:
Who We Are
We are the first publicly-traded biotech or pharmaceutical company to take the form of a public benefit corporation. Our public benefit purpose is to provide a brighter future for patients through the development of novel pharmaceutical therapies; and technologies that expand the availability of transplantable organs.
United Therapeutics (Nasdaq: UTHR) seeks to travel down the corridors of indifference to develop treatments for rare, deadly diseases. We were founded in 1996 by a family seeking a cure for their daughter’s pulmonary arterial hypertension (PAH). Today, we have six FDA-approved therapies that treat PAH, pulmonary hypertension associated with interstitial lung disease (PH-ILD) and neuroblastoma, a rare pediatric cancer. Our near-term pipeline seeks to develop additional therapies for PAH and pulmonary fibrosis (PF).
The cure for end-stage life-threatening diseases like PAH, PH-ILD, PF, and many others is an organ transplant, but only a small percentage of donated organs are available to address the vast need. For this reason, we are working to create manufactured organs to address the shortage of kidneys, hearts, lungs, and livers available for transplant. We believe an unlimited supply of tolerable, transplantable organs will eliminate the transplant waiting list and cure end-stage organ diseases for which transplant is not currently an option.
Who You Are
Imagine leading clinical studies that don't just meet milestones, but help redefine what's possible for patients waiting for better treatment options. As a Clinical Project Manager or Senior Clinical Project Manager, you'll have the autonomy to drive studies forward, the support of exceptional cross-functional teams, and a front-row seat to cutting-edge science. At United Therapeutics, our culture combines purpose, innovation, and determination with a genuine belief that work can be both meaningful and enjoyable. If you're a proactive problem-solver who thrives on ownership, collaboration, and making a real impact, you'll find both challenge and fulfillment here.
Work independently to ensure the success of a local or regional clinical trial. Provide oversight and coordination for the operational delivery of ongoing local or regional clinical trials to ensure all required timelines are met as well as adherence to budget, quality, and performance expectations.
- Utilize advanced expertise and serve as the primary study contact for study-related communication, coordinating with teams, management, and vendors
- Independently oversee the entire lifecycle of clinical trials, from start-up to close-out
- Direct local or regional clinical trials, ensuring cross-functional activities align with study objectives
- Administer study budgets and timelines, maintaining high-quality standards and performance metrics
- Identify, resolve, or escalate any concerns regarding study timelines and deliverables promptly
- Proactively escalate performance related concerns with appropriate line management
- Manage protocol deviations/violations diligently, reducing their occurrence through proactive collaboration
- Collaborate with Clinical Operations to monitor key performance indicators, enhancing study efficiency
- Provide consistent updates on study progress to the project team and management
- Manage insourcing / outsourcing partners, ensuring compliance with standards and expectations
- Contribute to the development of study concepts, protocols, and critical study documents
- Engage in the creation of policies, guidelines, and SOPs, contributing to the advancement of Clinical Operations and Study Management
- Assess and enhance current processes, recommending improvements to management
- Ensure study conduct aligns with SOPs, ICH/GCP guidelines, and local regulations
- Manage vendor relationships, including selection, negotiation, implementation, and statement of work (SOW) oversight
- Ensure comprehensive protocol and process training for all study team members
- Manage resources allocated to the study, excluding staff management
- Review and endorse team member transition plans as necessary
- Assist in the preparation of interim and primary analysis reports
- Organize and oversee Investigator Meetings, ensuring effective coordination
- Perform all other duties as required
Education and Experience requirements for Clinical Project Manager II level:
- Bachelor’s degree in related field and 8+ years of related clinical study management or project management experience in CRO/pharmaceutical operations and development
- Master’s degree in related field and 6+ years of related clinical study management or project management experience in CRO/pharmaceutical operations and development
Education and Experience requirements for Senior Clinical Project Manager level:
- Bachelor’s degree in related field and 10+ years of related clinical study management or project management experience in CRO/pharmaceutical operations and development
- Master’s degree in related field and 8+ years of related clinical study management or project management experience in CRO/pharmaceutical operations and development
- Ability to interact and communicate effectively, both verbally and in writing, within and outside clinical operations, with colleagues, upper management, Key Opinion Leaders, vendor personnel, and clinical investigators and site personnel
- Strong working knowledge of GCP/ICH regulations and guidelines
- Strong overall scientific and clinical/medical research background
- Experience and comfort in working both independently and as part of a cross-functional team
- Proficiency with MS Office Suite including Word, Excel, PowerPoint, and Outlook
- Experience with EDC and CTMS systems
- Commitment and ability to handle high workloads, demanding situations, and deadlines
- Ability to proactively identify potential issues and formulate potential course(s) of action
Preferred Qualifications
- Master’s degree
- 3+ years of related experience as a CRA, Clinical Manager, and/or Project Manager in the biopharmaceutical industry highly preferred
- RN - Registered Nurse - State Licensure and/or Compact State Licensure
- Previous experience with all phases of clinical research
- Demonstrated leadership experience as evidenced by the ability to motivate teams, provide advanced planning analysis, provide strategic guidance by evaluating risks against departmental deliverables
Job Location & Travel
This position will be located at our Durham, NC office with a hybrid schedule of 4 days in office and the option to work 1 day each week from home. In office requirements could change based on business needs. This position may travel up to 30%.
Eligible employees may participate in the Company’s comprehensive benefits suite of programs, including medical / dental / vision / prescription coverage, employee wellness resources, savings plans (401k and ESPP), paid time off & paid parental leave benefits, disability benefits, and more. For additional information on Company benefits, please visit https://www.unither.com/careers/benefits-and-amenities
United Therapeutics Corporation is an Equal Opportunity Employer, including veterans and individuals with disabilities.
California, US residents .
The job details are as follows:
Who We Are
We are the first publicly-traded biotech or pharmaceutical company to take the form of a public benefit corporation. Our public benefit purpose is to provide a brighter future for patients through the development of novel pharmaceutical therapies; and technologies that expand the availability of transplantable organs.
United Therapeutics (Nasdaq: UTHR) seeks to travel down the corridors of indifference to develop treatments for rare, deadly diseases. We were founded in 1996 by a family seeking a cure for their daughter’s pulmonary arterial hypertension (PAH). Today, we have six FDA-approved therapies that treat PAH, pulmonary hypertension associated with interstitial lung disease (PH-ILD) and neuroblastoma, a rare pediatric cancer. Our near-term pipeline seeks to develop additional therapies for PAH and pulmonary fibrosis (PF).
The cure for end-stage life-threatening diseases like PAH, PH-ILD, PF, and many others is an organ transplant, but only a small percentage of donated organs are available to address the vast need. For this reason, we are working to create manufactured organs to address the shortage of kidneys, hearts, lungs, and livers available for transplant. We believe an unlimited supply of tolerable, transplantable organs will eliminate the transplant waiting list and cure end-stage organ diseases for which transplant is not currently an option.
Who You Are
Imagine leading clinical studies that don't just meet milestones, but help redefine what's possible for patients waiting for better treatment options. As a Clinical Project Manager or Senior Clinical Project Manager, you'll have the autonomy to drive studies forward, the support of exceptional cross-functional teams, and a front-row seat to cutting-edge science. At United Therapeutics, our culture combines purpose, innovation, and determination with a genuine belief that work can be both meaningful and enjoyable. If you're a proactive problem-solver who thrives on ownership, collaboration, and making a real impact, you'll find both challenge and fulfillment here.
Work independently to ensure the success of a local or regional clinical trial. Provide oversight and coordination for the operational delivery of ongoing local or regional clinical trials to ensure all required timelines are met as well as adherence to budget, quality, and performance expectations.
- Utilize advanced expertise and serve as the primary study contact for study-related communication, coordinating with teams, management, and vendors
- Independently oversee the entire lifecycle of clinical trials, from start-up to close-out
- Direct local or regional clinical trials, ensuring cross-functional activities align with study objectives
- Administer study budgets and timelines, maintaining high-quality standards and performance metrics
- Identify, resolve, or escalate any concerns regarding study timelines and deliverables promptly
- Proactively escalate performance related concerns with appropriate line management
- Manage protocol deviations/violations diligently, reducing their occurrence through proactive collaboration
- Collaborate with Clinical Operations to monitor key performance indicators, enhancing study efficiency
- Provide consistent updates on study progress to the project team and management
- Manage insourcing / outsourcing partners, ensuring compliance with standards and expectations
- Contribute to the development of study concepts, protocols, and critical study documents
- Engage in the creation of policies, guidelines, and SOPs, contributing to the advancement of Clinical Operations and Study Management
- Assess and enhance current processes, recommending improvements to management
- Ensure study conduct aligns with SOPs, ICH/GCP guidelines, and local regulations
- Manage vendor relationships, including selection, negotiation, implementation, and statement of work (SOW) oversight
- Ensure comprehensive protocol and process training for all study team members
- Manage resources allocated to the study, excluding staff management
- Review and endorse team member transition plans as necessary
- Assist in the preparation of interim and primary analysis reports
- Organize and oversee Investigator Meetings, ensuring effective coordination
- Perform all other duties as required
Education and Experience requirements for Clinical Project Manager II level:
- Bachelor’s degree in related field and 8+ years of related clinical study management or project management experience in CRO/pharmaceutical operations and development
- Master’s degree in related field and 6+ years of related clinical study management or project management experience in CRO/pharmaceutical operations and development
Education and Experience requirements for Senior Clinical Project Manager level:
- Bachelor’s degree in related field and 10+ years of related clinical study management or project management experience in CRO/pharmaceutical operations and development
- Master’s degree in related field and 8+ years of related clinical study management or project management experience in CRO/pharmaceutical operations and development
- Ability to interact and communicate effectively, both verbally and in writing, within and outside clinical operations, with colleagues, upper management, Key Opinion Leaders, vendor personnel, and clinical investigators and site personnel
- Strong working knowledge of GCP/ICH regulations and guidelines
- Strong overall scientific and clinical/medical research background
- Experience and comfort in working both independently and as part of a cross-functional team
- Proficiency with MS Office Suite including Word, Excel, PowerPoint, and Outlook
- Experience with EDC and CTMS systems
- Commitment and ability to handle high workloads, demanding situations, and deadlines
- Ability to proactively identify potential issues and formulate potential course(s) of action
Preferred Qualifications
- Master’s degree
- 3+ years of related experience as a CRA, Clinical Manager, and/or Project Manager in the biopharmaceutical industry highly preferred
- RN - Registered Nurse - State Licensure and/or Compact State Licensure
- Previous experience with all phases of clinical research
- Demonstrated leadership experience as evidenced by the ability to motivate teams, provide advanced planning analysis, provide strategic guidance by evaluating risks against departmental deliverables
Job Location & Travel
This position will be located at our Durham, NC office with a hybrid schedule of 4 days in office and the option to work 1 day each week from home. In office requirements could change based on business needs. This position may travel up to 30%.
Eligible employees may participate in the Company’s comprehensive benefits suite of programs, including medical / dental / vision / prescription coverage, employee wellness resources, savings plans (401k and ESPP), paid time off & paid parental leave benefits, disability benefits, and more. For additional information on Company benefits, please visit https://www.unither.com/careers/benefits-and-amenities
United Therapeutics Corporation is an Equal Opportunity Employer, including veterans and individuals with disabilities.
See All 8 Senior Clinical Project Manager Jobs in North Carolina
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Find JobsSenior Clinical Project Manager Jobs by City in North Carolina
Where North Carolina roles are concentrated, by current openings.
Senior Clinical Project Manager Job Market in North Carolina
A snapshot from current North Carolina openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Healthcare & Medical Services
- Biotechnology & Pharmaceuticals
- Consulting & Professional Services
What North Carolina Employers Look For
The qualifications that appear most often in senior clinical project manager jobs across North Carolina.
- Bachelor's or advanced degree in life sciences, nursing, or a related clinical field
- PMP or CAPM certification preferred by most North Carolina clinical employers
- Minimum five years of clinical trial management experience under ICH-GCP guidelines
- Proficiency with clinical trial management systems such as Veeva Vault or Oracle Siebel
- Demonstrated ability to manage cross-functional teams across multiple concurrent studies
- Strong working knowledge of FDA regulations and IND/NDA submission processes
Senior Clinical Project Manager Jobs in North Carolina: Frequently Asked Questions
How do you become a senior clinical project manager in North Carolina?
The typical path starts with a bachelor's degree in a life science, nursing, or health-related field, followed by several years of hands-on clinical trial coordination or monitoring experience. North Carolina does not require a state-issued license specific to clinical project management, but the Project Management Professional certification and ACRP or SOCRA clinical research credentials are widely expected by Research Triangle and Charlotte employers. Advancing from a CRA or CRC role at a local CRO or academic medical center is the most common route.
How much do senior clinical project managers make in North Carolina?
Senior clinical project managers in North Carolina earn a median of about $100,820 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $61,570 for the lowest 10% to over $164,050 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire senior clinical project managers in North Carolina?
Employers hiring senior clinical project managers in North Carolina right now include サイネオス・ヘルス, IQVIA, and Uniphar, based on current listings on Migrate Mate as of September 2026. North Carolina's dense cluster of CROs and biopharma companies in the Research Triangle Park area makes it one of the most active hiring markets for this role in the Southeast.
Which North Carolina cities have the most senior clinical project manager jobs?
The cities with the most senior clinical project manager openings in North Carolina are North Carolina, Durham, and Garner. The Research Triangle anchors most of this demand because Research Triangle Park hosts the North American headquarters of multiple global CROs and biopharma companies, while Charlotte's growing life sciences corridor and academic medical campuses in Greensboro and Winston-Salem contribute a steady share of postings.
Are there remote senior clinical project manager jobs in North Carolina?
Yes, and more than most clinical roles, because senior clinical project managers spend much of their time on planning, vendor oversight, and documentation rather than direct site visits. About 88% of senior clinical project manager openings tied to North Carolina are remote or hybrid as of September 2026, reflecting the desk-heavy nature of senior-level trial oversight. Site initiation and monitoring visit responsibilities are the portions most likely to require in-person presence.
How can I get hired as a senior clinical project manager in North Carolina with little or no experience?
The most realistic entry point is a clinical research coordinator or CRA I role at one of the Research Triangle's large CROs, such as Syneos Health or Labcorp Drug Development, both of which run structured associate CRA programs for candidates without prior industry experience. A SOCRA or ACRP entry-level certification strengthens an application considerably. Candidates with nursing backgrounds or lab research experience from institutions like Duke, UNC-Chapel Hill, or Wake Forest can often move laterally into trial coordination before progressing toward project management.
Where can I find and apply to senior clinical project manager jobs in North Carolina?
You can find and apply to senior clinical project manager jobs in North Carolina directly on Migrate Mate, which lists current openings from employers hiring in the state right now. Search the available roles, identify the ones that match your experience and preferred location or work arrangement, and apply directly to each position that fits.
See All 8 Senior Clinical Project Manager Jobs in North Carolina
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