Senior Clinical Project Manager Jobs in California
Senior Clinical Project Manager jobs in California are among the most active in the country, concentrated in the state's biopharma, medical device, and health system sectors, with openings at every level from associate PM through senior and director. The heaviest hiring is in the San Francisco Bay Area, San Diego, and Los Angeles, where companies like Genentech, Johnson and Johnson, and Kaiser Permanente maintain large clinical operations. The most in-demand specialties are oncology trials, regulatory submissions management, and decentralized clinical trial oversight. Find a role that fits below and apply directly.
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Showing 5 of 21+ Senior Clinical Project Manager jobs
Company Description
Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant® is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn , X (Twitter) and Facebook .
The Clinical Laboratory Scientist is responsible for performing high complexity laboratory testing (Next generation DNA sequencing) on patient specimens, performing quality control and quality assurance procedures, interpreting and reporting patient results, and complying with all applicable local, state and federal laboratory requirements. The work requires keeping meticulous and organized records, excellent attention to detail, the ability to multi-task, and be flexible with tasks and schedules.
Shift Details: Thursday-Monday; PM Shift 2:30pm-11pm PT
Essential Duties and Responsibilities:
- Perform laboratory tests, procedures and analyses per the laboratory’s standard operating procedures
- Review, interpret and report patient results in LIMS
- Independently identify and troubleshoot high complexity problems that adversely affect the test performance
- Perform, review and document laboratory quality control procedures
- Document all corrective actions taken when test systems deviate from the laboratory’s established performance specifications
- Perform and document routine preventive maintenance
- Assist with training of new laboratory personnel
- Maintain sufficient inventory of laboratory supplies for daily operations and prepare reagents required for testing
- Perform and document reagent qualification per the approved protocols
- Perform annual review of Standard Operating Procedures
- Report all concerns of test quality and/or safety to the Laboratory Supervisor or Safety Officer
- Participate in introduction of assay improvements, new assay configurations and validation
- Perform other miscellaneous laboratory duties as assigned and assist others as time allows
Qualifications:
EDUCATION AND EXPERIENCE
- California Clinical Laboratory Scientist Generalist license
- Bachelor of Arts or Science in Biomedical Laboratory Science, Clinical Science or related field
- Working knowledge of local, state, and federal laboratory regulations
- Able to integrate and apply feedback in a professional manner
- Able to prioritize and drive to results with a high emphasis on quality
- Ability to work as part of a team
PHYSICAL DEMANDS/WORKING ENVIRONMENT
- Hours and days may vary depending on operational needs
- Standing or sitting for long periods of time may be necessary.
- May be exposed to hazardous materials, blood specimens and instruments with moving parts, heating or freezing elements, and high speed centrifugation (Generally Laboratory and Client Services employees only)
- Repetitive manual pipetting may be necessary Some lifting (up to 25 pounds) may be necessary
AI & Digital Fluency
Demonstrate curiosity, sound judgment, and the ability to critically evaluate and responsibly leverage AI-enabled tools in accordance with company policies, ethical standards, and regulatory requirements to improve the efficiency, effectiveness, and quality of work.
Hybrid Work Model: This section is applicable to onsite employees who are eligible for hybrid work location as specified by management and related policies. Guardant has defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients.
Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.
Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to Peopleteam@guardanthealth.com
A background screening including criminal history is required for this role. GH will consider qualified applicants with criminal arrest or conviction histories in a manner consistent with applicable law including but not limited to the LA County Fair Chance Policies and the Fair Chance Act (Gov. Code Section 12952).
Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
All your information will be kept confidential according to EEO guidelines.
To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants .
Please visit our career page at: http://www.guardanthealth.com/jobs/
Company Description
Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant® is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn , X (Twitter) and Facebook .
The Clinical Laboratory Scientist is responsible for performing high complexity laboratory testing (Next generation DNA sequencing) on patient specimens, performing quality control and quality assurance procedures, interpreting and reporting patient results, and complying with all applicable local, state and federal laboratory requirements. The work requires keeping meticulous and organized records, excellent attention to detail, the ability to multi-task, and be flexible with tasks and schedules.
Shift Details: Thursday-Monday; PM Shift 2:30pm-11pm PT
Essential Duties and Responsibilities:
- Perform laboratory tests, procedures and analyses per the laboratory’s standard operating procedures
- Review, interpret and report patient results in LIMS
- Independently identify and troubleshoot high complexity problems that adversely affect the test performance
- Perform, review and document laboratory quality control procedures
- Document all corrective actions taken when test systems deviate from the laboratory’s established performance specifications
- Perform and document routine preventive maintenance
- Assist with training of new laboratory personnel
- Maintain sufficient inventory of laboratory supplies for daily operations and prepare reagents required for testing
- Perform and document reagent qualification per the approved protocols
- Perform annual review of Standard Operating Procedures
- Report all concerns of test quality and/or safety to the Laboratory Supervisor or Safety Officer
- Participate in introduction of assay improvements, new assay configurations and validation
- Perform other miscellaneous laboratory duties as assigned and assist others as time allows
Qualifications:
EDUCATION AND EXPERIENCE
- California Clinical Laboratory Scientist Generalist license
- Bachelor of Arts or Science in Biomedical Laboratory Science, Clinical Science or related field
- Working knowledge of local, state, and federal laboratory regulations
- Able to integrate and apply feedback in a professional manner
- Able to prioritize and drive to results with a high emphasis on quality
- Ability to work as part of a team
PHYSICAL DEMANDS/WORKING ENVIRONMENT
- Hours and days may vary depending on operational needs
- Standing or sitting for long periods of time may be necessary.
- May be exposed to hazardous materials, blood specimens and instruments with moving parts, heating or freezing elements, and high speed centrifugation (Generally Laboratory and Client Services employees only)
- Repetitive manual pipetting may be necessary Some lifting (up to 25 pounds) may be necessary
AI & Digital Fluency
Demonstrate curiosity, sound judgment, and the ability to critically evaluate and responsibly leverage AI-enabled tools in accordance with company policies, ethical standards, and regulatory requirements to improve the efficiency, effectiveness, and quality of work.
Hybrid Work Model: This section is applicable to onsite employees who are eligible for hybrid work location as specified by management and related policies. Guardant has defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients.
Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.
Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to Peopleteam@guardanthealth.com
A background screening including criminal history is required for this role. GH will consider qualified applicants with criminal arrest or conviction histories in a manner consistent with applicable law including but not limited to the LA County Fair Chance Policies and the Fair Chance Act (Gov. Code Section 12952).
Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
All your information will be kept confidential according to EEO guidelines.
To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants .
Please visit our career page at: http://www.guardanthealth.com/jobs/
See All 21 Senior Clinical Project Manager Jobs in California
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Where California roles are concentrated, by current openings.
Senior Clinical Project Manager Job Market in California
A snapshot from current California openings, updated as new roles post.
Who's Hiring
What California Employers Look For
The qualifications that appear most often in senior clinical project manager jobs across California.
- Bachelor's or advanced degree in life sciences, nursing, or a related clinical field
- PMP or clinical research certification such as CCRP or CCRA strongly preferred
- Five or more years of clinical trial management experience across multiple phases
- Demonstrated experience managing cross-functional teams and CRO relationships
- Deep knowledge of FDA regulations, GCP guidelines, and ICH requirements
- Proficiency with clinical trial management systems such as Veeva Vault or Medidata Rave
Senior Clinical Project Manager Jobs in California: Frequently Asked Questions
How do you become a senior clinical project manager in California?
The most direct path is a bachelor's or advanced degree in a life science, nursing, or pharmacy field, followed by several years of hands-on clinical trial coordination or management experience. California does not require a state-issued license specific to clinical project management, but employers across the Bay Area and San Diego biotech corridor consistently expect a recognized clinical research credential such as the CCRP from ACRP or the CCRA from SOCRA. Building experience across multiple trial phases and therapeutic areas is the key differentiator at the senior level.
How much do senior clinical project managers make in California?
Senior clinical project managers in California earn a median of about $120,910 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $69,180 for the lowest 10% to over $188,560 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire senior clinical project managers in California?
Employers hiring senior clinical project managers in California right now include Success Education Colleges, PIH Health, and CenExel Clinical Research, based on current listings on Migrate Mate as of September 2026. California's dense concentration of biopharma headquarters, medical device companies, and large integrated health systems means openings appear consistently rather than seasonally.
Which California cities have the most senior clinical project manager jobs?
West Covina, Anaheim, and Whittier lead California for senior clinical project manager openings. The Bay Area's volume is driven by the biopharma and biotech headquarters clustered in South San Francisco and Foster City, San Diego pulls from its large medical device and early-phase oncology corridor, and Los Angeles hiring is anchored by major academic medical centers and health systems running their own sponsored trials.
Are there remote senior clinical project manager jobs in California?
Yes, and more than most clinical roles, because senior project management work centers on oversight, vendor management, and documentation rather than on-site patient contact. About 100% of senior clinical project manager openings tied to California are remote or hybrid as of September 2026, reflecting how much of the role can be performed from a home office. Startup and mid-size biotech sponsors in California tend to offer the most fully remote arrangements, while large health systems typically require on-site or hybrid presence.
How can I get hired as a senior clinical project manager in California with little or no experience?
The most realistic entry point is a clinical trial coordinator or clinical research associate role, which both feed directly into project management tracks. Large California biopharma employers like Genentech and Gilead Sciences, along with major contract research organizations operating in San Diego and the Bay Area, hire entry-level CRAs and coordinators and promote from within. Earning a CCRP credential early, even before accumulating years of experience, signals commitment and meets the qualification bar that California biotech recruiters screen for.
Where can I find and apply to senior clinical project manager jobs in California?
You can find and apply to senior clinical project manager jobs in California on Migrate Mate, which lists current openings across the state. Search the listings to see roles that match your experience and location, then apply directly to the ones that fit.
See All 21 Senior Clinical Project Manager Jobs in California
Find roles in California that match your experience and apply in just a few clicks.
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