Senior Clinical Project Manager Jobs in South Dakota
Senior Clinical Project Manager jobs in South Dakota concentrate in clinical research, health system operations, and pharmaceutical or medical device compliance, with demand anchored at the senior and lead levels across the state's growing healthcare sector. Sioux Falls, Rapid City, and Yankton are the primary hiring metros, where large employers such as Sanford Health, Monument Health, and Avera Health consistently recruit for this role. Therapeutic areas driving the most active searches include oncology trials, cardiovascular studies, and regulatory compliance oversight. Scan the live roles below and apply to whichever ones fit.
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Showing 5 of 68+ Senior Clinical Project Manager jobs
Work Schedule
Standard (Mon-Fri)Environmental Conditions
OfficeJob Description
Join Us as a Clinical Research Associate (Level II) – Make an Impact at the Forefront of Innovation
We have successfully supported the top 50 pharmaceutical companies and more than 750 biotechs, spanning 2,700 clinical trials across 100+ countries in the last five years.
As part of our global team, you'll have the opportunity to perform and coordinate all aspects of the clinical monitoring and site management process. As a Clinical Research Associate (Level II), you'll conduct remote or on-site visits to assess protocol and regulatory compliance and manage required documentation. You will manage procedures and guidelines from different sponsors and/or monitoring environments (i.e., FSO, FSP, Government, etc.). Acting as a site processes specialist, you will ensure that the trial is conducted in accordance with the approved protocol, ICH-GCP guidelines, applicable regulations, and SOPs to guarantee subjects' rights, well-being, and data reliability. You will ensure audit readiness and develop collaborative relationships with investigational sites. Detailed tasks and responsibilities assigned to your role are outlined in the task matrix.
Required Qualifications
- 1–2 years of traveling on-site monitoring experience.
- Therapeutic experience in at least one of the following: Oncology, Ophthalmology, Neurology, Cardiology, Rare Disease, Respiratory, Obesity, and/or Pulmonary.
- Candidates must live within 60 miles of the nearest major airport. Up to 80% travel is expected.
- Must be legally authorized to work in the United States without sponsorship.
- Must be able to pass a comprehensive background check, including a drug screening.
What You’ll Do:
- Monitors investigator sites with a risk-based monitoring approach: applies root cause analysis (RCA), critical thinking and problem-solving skills to identify site processes failure and corrective/preventive actions to bring the site into compliance and decrease risks.
- Ensures data accuracy through SDR, SDV and CRF review as applicable through on-site and remote monitoring activities.
- Assess investigational product through physical inventory and records review. Documents observations in reports and letters in a timely manner using approved business writing standards.
- Escalates observed deficiencies and issues to clinical management expeditiously and follow all issues through to resolution. May need to maintain regular contact between monitoring visits with investigative sites to confirm that the protocol is being followed, that previously identified issues are being resolved and that the data is being recorded in a timely manner.
- Conducts monitoring tasks in accordance with the approved monitoring plan. Participates in the investigator payment process. Ensures a shared responsibility with other project team members on issues/findings resolution. Investigates and follows-up on findings as applicable.
- Participates in investigator meetings as necessary. Identifies potential
- investigators in collaboration with the client company to ensure the acceptability of qualified investigative sites. Initiates clinical trial sites according to the relevant procedures to ensure compliance with the protocol and regulatory and ICH GCP obligations, making recommendations where warranted. Performs trial close out and retrieval of trial materials.
- Ensures that required essential documents are complete and in place, according to ICH-GCP and applicable regulations. Conducts on-site file reviews as per project specifications.
- Provides trial status tracking and progress update reports to the Clinical Team Manager (CTM) as required. Ensures study systems are updated per agreed study conventions (e.g. Clinical Trial Management System).
- Facilitates effective communication between investigative sites, the client company and the PPD project team through written, oral and/or electronic contacts.
- Responds to company, client and applicable regulatory requirements/audits/inspections.
- Maintains & completes administrative tasks such as expense reports and timesheets in a timely manner.
- Contributes to the project team by assisting in preparation of project publications/tools, and sharing ideas/suggestions with team members.
- Contributes to other project work and initiatives for process improvement, as required.
Education and Experience Requirements:
- Bachelor's degree in a life sciences related fieldor a Registered Nursing certification or equivalent and relevant formal academic / vocational qualification.
- Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 1 years as a clinical research monitor) or completion of PPD Drug Development Fellowship.
- Valid driver's license where applicable.
Knowledge, Skills and Abilities:
- Proven clinical monitoring skills
- Demonstrated understanding of medical/therapeutic area knowledge and medical terminology
- Demonstrated ability to attain and maintain a working knowledge of ICH GCPs, applicable regulations and procedural documents
- Well-developed critical thinking skills, including but not limited to: critical mindset, in-depthinvestigation for appropriate root cause analysis and problem solving
- Ability to manage Risk Based Monitoring concepts and processes
- Good oral and written communication skills, with the ability to communicate effectively with medical personnel
- Ability to maintain customer focus through the utilization of good listening skills, attention to detail and the ability to perceive customers’ underlying issues
- Good organizational and time management skills
- Effective interpersonal skills
- Attention to detail
- Ability to remain flexibile and adaptable in a wide range of scenarios
- Ability to work in a team or independently as required
- Good computer skills: solid knowledge of Microsoft Office and the ability to learn appropriate software
- Good English language and grammar skills
- Good presentation skills
Working Conditions and Environment:
- Work is performed in an office/ laboratory/clinical/and/or home office environment with exposure to electrical office equipment.
- Frequent drives to site locations. Frequent travel, generally 60-80% but more for some individuals. May also include extended overnight stays.
- Exposure to biological fluids with potential exposure to infectious organisms.
- Personal protective equipment required such as protective eyewear, garments and gloves.
- Exposure to fluctuating and/or extreme temperatures on rare occasions
Compensation and Benefits
The salary range estimated for this position based in Illinois is $66,800.00–$120,000.00.This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:
A choice of national medical and dental plans, and a national vision plan, including health incentive programs
Employee assistance and family support programs, including commuter benefits and tuition reimbursement
At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount
For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards
Work Schedule
Standard (Mon-Fri)Environmental Conditions
OfficeJob Description
Join Us as a Clinical Research Associate (Level II) – Make an Impact at the Forefront of Innovation
We have successfully supported the top 50 pharmaceutical companies and more than 750 biotechs, spanning 2,700 clinical trials across 100+ countries in the last five years.
As part of our global team, you'll have the opportunity to perform and coordinate all aspects of the clinical monitoring and site management process. As a Clinical Research Associate (Level II), you'll conduct remote or on-site visits to assess protocol and regulatory compliance and manage required documentation. You will manage procedures and guidelines from different sponsors and/or monitoring environments (i.e., FSO, FSP, Government, etc.). Acting as a site processes specialist, you will ensure that the trial is conducted in accordance with the approved protocol, ICH-GCP guidelines, applicable regulations, and SOPs to guarantee subjects' rights, well-being, and data reliability. You will ensure audit readiness and develop collaborative relationships with investigational sites. Detailed tasks and responsibilities assigned to your role are outlined in the task matrix.
Required Qualifications
- 1–2 years of traveling on-site monitoring experience.
- Therapeutic experience in at least one of the following: Oncology, Ophthalmology, Neurology, Cardiology, Rare Disease, Respiratory, Obesity, and/or Pulmonary.
- Candidates must live within 60 miles of the nearest major airport. Up to 80% travel is expected.
- Must be legally authorized to work in the United States without sponsorship.
- Must be able to pass a comprehensive background check, including a drug screening.
What You’ll Do:
- Monitors investigator sites with a risk-based monitoring approach: applies root cause analysis (RCA), critical thinking and problem-solving skills to identify site processes failure and corrective/preventive actions to bring the site into compliance and decrease risks.
- Ensures data accuracy through SDR, SDV and CRF review as applicable through on-site and remote monitoring activities.
- Assess investigational product through physical inventory and records review. Documents observations in reports and letters in a timely manner using approved business writing standards.
- Escalates observed deficiencies and issues to clinical management expeditiously and follow all issues through to resolution. May need to maintain regular contact between monitoring visits with investigative sites to confirm that the protocol is being followed, that previously identified issues are being resolved and that the data is being recorded in a timely manner.
- Conducts monitoring tasks in accordance with the approved monitoring plan. Participates in the investigator payment process. Ensures a shared responsibility with other project team members on issues/findings resolution. Investigates and follows-up on findings as applicable.
- Participates in investigator meetings as necessary. Identifies potential
- investigators in collaboration with the client company to ensure the acceptability of qualified investigative sites. Initiates clinical trial sites according to the relevant procedures to ensure compliance with the protocol and regulatory and ICH GCP obligations, making recommendations where warranted. Performs trial close out and retrieval of trial materials.
- Ensures that required essential documents are complete and in place, according to ICH-GCP and applicable regulations. Conducts on-site file reviews as per project specifications.
- Provides trial status tracking and progress update reports to the Clinical Team Manager (CTM) as required. Ensures study systems are updated per agreed study conventions (e.g. Clinical Trial Management System).
- Facilitates effective communication between investigative sites, the client company and the PPD project team through written, oral and/or electronic contacts.
- Responds to company, client and applicable regulatory requirements/audits/inspections.
- Maintains & completes administrative tasks such as expense reports and timesheets in a timely manner.
- Contributes to the project team by assisting in preparation of project publications/tools, and sharing ideas/suggestions with team members.
- Contributes to other project work and initiatives for process improvement, as required.
Education and Experience Requirements:
- Bachelor's degree in a life sciences related fieldor a Registered Nursing certification or equivalent and relevant formal academic / vocational qualification.
- Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 1 years as a clinical research monitor) or completion of PPD Drug Development Fellowship.
- Valid driver's license where applicable.
Knowledge, Skills and Abilities:
- Proven clinical monitoring skills
- Demonstrated understanding of medical/therapeutic area knowledge and medical terminology
- Demonstrated ability to attain and maintain a working knowledge of ICH GCPs, applicable regulations and procedural documents
- Well-developed critical thinking skills, including but not limited to: critical mindset, in-depthinvestigation for appropriate root cause analysis and problem solving
- Ability to manage Risk Based Monitoring concepts and processes
- Good oral and written communication skills, with the ability to communicate effectively with medical personnel
- Ability to maintain customer focus through the utilization of good listening skills, attention to detail and the ability to perceive customers’ underlying issues
- Good organizational and time management skills
- Effective interpersonal skills
- Attention to detail
- Ability to remain flexibile and adaptable in a wide range of scenarios
- Ability to work in a team or independently as required
- Good computer skills: solid knowledge of Microsoft Office and the ability to learn appropriate software
- Good English language and grammar skills
- Good presentation skills
Working Conditions and Environment:
- Work is performed in an office/ laboratory/clinical/and/or home office environment with exposure to electrical office equipment.
- Frequent drives to site locations. Frequent travel, generally 60-80% but more for some individuals. May also include extended overnight stays.
- Exposure to biological fluids with potential exposure to infectious organisms.
- Personal protective equipment required such as protective eyewear, garments and gloves.
- Exposure to fluctuating and/or extreme temperatures on rare occasions
Compensation and Benefits
The salary range estimated for this position based in Illinois is $66,800.00–$120,000.00.This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:
A choice of national medical and dental plans, and a national vision plan, including health incentive programs
Employee assistance and family support programs, including commuter benefits and tuition reimbursement
At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount
For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards
See All 68 Senior Clinical Project Manager Jobs in South Dakota
Find roles in South Dakota that match your experience and apply in just a few clicks.
Find JobsSenior Clinical Project Manager Jobs by City in South Dakota
Where South Dakota roles are concentrated, by current openings.
Senior Clinical Project Manager Job Market in South Dakota
A snapshot from current South Dakota openings, updated as new roles post.
Who's Hiring
- Monument Health13
- Sanford Health11
- CVS Health2
- Sanford Bismarck2
- The Bancorp2
Top Industries Hiring
- Healthcare & Medical Services28
- Technology & Software3
- Consulting & Professional Services3
- Construction & Real Estate2
- Banking & Financial Services2
What South Dakota Employers Look For
The qualifications that appear most often in senior clinical project manager jobs across South Dakota.
- Active PMP or CAPM certification recognized by South Dakota healthcare employers
- Bachelor's degree in life sciences, nursing, or a related clinical field required
- Minimum five years of clinical trial or research project management experience preferred
- Demonstrated experience managing multi-site clinical studies from initiation through closeout
- Proficiency with clinical trial management systems such as Veeva, Medidata, or Oracle
- Strong knowledge of ICH-GCP guidelines and FDA regulatory submission requirements
Senior Clinical Project Manager Jobs in South Dakota: Frequently Asked Questions
How do you become a senior clinical project manager in South Dakota?
Most senior clinical project managers in South Dakota enter through a bachelor's degree in nursing, life sciences, or public health, then build years of hands-on clinical trial or research coordination experience at institutions like Sanford Health or Avera Health. South Dakota does not require a state-issued license specific to this role, but earning a Project Management Professional certification from PMI and completing GCP training significantly strengthens candidacy at the senior level.
How much do senior clinical project managers make in South Dakota?
Senior clinical project managers in South Dakota earn a median of about $82,250 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $58,000 for the lowest 10% to over $130,400 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire senior clinical project managers in South Dakota?
Companies currently hiring senior clinical project managers in South Dakota include Monument Health, Sanford Health, and CVS Health, per current listings on Migrate Mate as of July 2026. South Dakota's largest integrated health systems, particularly those in Sioux Falls, tend to post the most consistent senior-level openings tied to sponsored trials and quality improvement initiatives.
Which South Dakota cities have the most senior clinical project manager jobs?
Sioux Falls, Rapid City, and Pierre account for the most senior clinical project manager openings in South Dakota. Sioux Falls leads because it is home to the headquarters and major clinical operations of Sanford Health and Avera Health, while Rapid City and Yankton follow based on Monument Health's regional presence and satellite research programs tied to the larger Sioux Falls networks.
Are there remote senior clinical project manager jobs in South Dakota?
Yes, and more than many clinical roles, because senior project management work centers on planning, vendor oversight, and documentation rather than direct patient contact. About 11% of senior clinical project manager openings tied to South Dakota are remote or hybrid as of July 2026, reflecting broader flexibility for experienced professionals in this field. Roles focused on regulatory submissions, data review, and multi-site trial coordination are the most likely to offer fully remote arrangements.
How can I get hired as a senior clinical project manager in South Dakota with little or no experience?
The most realistic entry path is starting as a clinical research coordinator or study coordinator at Sanford Health, Avera Health, or Monument Health, all of which post coordinator-level roles that build the trial management foundation employers want at the senior level. Completing a certified clinical research associate program and volunteering on institutional review board committees at South Dakota State University or the University of South Dakota can accelerate the transition from coordinator to project manager before pursuing senior positions.
Where can I find and apply to senior clinical project manager jobs in South Dakota?
You can find and apply to senior clinical project manager jobs in South Dakota on Migrate Mate, which lists current openings across the state. Search the available roles, identify the ones that match your background and preferred location, and apply directly to the positions that fit.
See All 68 Senior Clinical Project Manager Jobs in South Dakota
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