Senior Clinical Research Scientist Jobs
Senior Clinical Research Scientist jobs are open across pharmaceutical companies, biotech firms, CROs, and academic medical centers, from mid-level to principal and director, with specializations in oncology, immunology, and rare disease. Find a role that fits from the openings below and apply directly.
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INTRODUCTION
Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.
Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.
Legend Biotech is seeking a Senior Clinical Research Scientist as part of the Clinical Development team based in Somerset, NJ.
ROLE OVERVIEW
The Clinical Research Scientist (CS) in Clinical Development is an important role in the company supporting the development and life cycle of drug development projects. The Clinical Research Scientist will work closely with the Clinical Trial Lead/Medical Lead and Clinical Trial Manager to design and implement clinical trial protocols and manage sites, CROs and other associated work. In addition, the CS will support their manager to ensure program consistency & alignment across studies, working closely with cross-functional teams for achieving project goals, within timelines & with high quality. This clinical scientist will support early phase drug development in hematology/oncology.
KEY RESPONSIBILITIES
- Responsible to ensure the data review and cleaning activities meet the quality standards to support database locks in collaboration with data management and medical lead/clinical trial lead. Uses clinical and disease state knowledge to make recommendations for methods and strategy for data cleaning approach.
- Collaborate with other functions to successfully support the planning and execution of clinical studies. Provides independent leadership of all areas requiring clinical input with oversight from the assigned Clinical Trial Lead/Medical Lead, and provides innovative and quality solutions for assigned problems and tasks.
- Provides clinical input and strategic recommendations for the planning and implementation of assigned clinical trial(s) including investigator selection, patient recruitment, feasibility questionnaire, training PowerPoints, and supporting Ethics committee submissions.
- Contributes to the strategic planning, preparation, and review of clinical documents (Protocol, ICFs, CSR, investigator brochure). May lead certain documents or sections of documents, including incorporation of input from other cross-functional team members.
- Provides clinical input and strategic recommendations for regulatory documents needed for all stages of assigned trial lifecycle (IND documentation, HA briefing books, BLAs, and Orphan Drug Applications).
- Responsible for clinical portions of key data management/statistical documents (eg: Case Report Forms, edit checks, data review plan and reports).
- Contribute to the planning and execution of external meetings and internal stakeholder meetings (e.g., Ad Boards, IMs, Governance, DMCs, Regulatory Authority, Dose Escalation meeting); responds to or triages questions for appropriate escalations. May have a speaking role on meetings when appropriate.
- Supports their manager when asked to contribute to harmonization between clinical trials and process improvement initiatives.
- Typically, the clinical research scientist may have the authority to make decisions related to issuing data cleaning queries and can decide whether there is a need to escalate for further discussion with the medical lead. They may also be delegated tasks from the clinical trial lead/medical lead for which they have decision making authority e.g. comment resolution when leading document creation.
REQUIREMENTS
- At least a Bachelor's degree in life science discipline.
- Bachelor's degree with 4+ years'; or MS with 3+ years'; or PharmD/PhD with 2+ years of pharma experience in clinical development or related function.
- CAR-T cell therapy and/or hematology/oncology disease experience is a plus.
- Good interpersonal & communication skills, including oral, written and interpersonal.
- Ability to effectively manage conflicts and negotiations while providing impact and influence.
- Collaborative with the ability to operate across multiple geographies.
- Good leadership & organizational skills, analytical skills, and presentation skills.
- Creative problem-solving skills.
- Strong organizational and project management skill and the ability to multitask.
- Computer literacy required (MS word, MS excel, MS PowerPoint and MS Project).
- Oncology Therapeutic Experience preferred.
- Excellent working knowledge of GCP, FDA and ICH Guidelines.
Li-JR1
Li-Onsite
Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.
EEO STATEMENT
It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.
Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.
For information related to our privacy notice, please review: Legend Biotech Privacy Notice.
INTRODUCTION
Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.
Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.
Legend Biotech is seeking a Senior Clinical Research Scientist as part of the Clinical Development team based in Somerset, NJ.
ROLE OVERVIEW
The Clinical Research Scientist (CS) in Clinical Development is an important role in the company supporting the development and life cycle of drug development projects. The Clinical Research Scientist will work closely with the Clinical Trial Lead/Medical Lead and Clinical Trial Manager to design and implement clinical trial protocols and manage sites, CROs and other associated work. In addition, the CS will support their manager to ensure program consistency & alignment across studies, working closely with cross-functional teams for achieving project goals, within timelines & with high quality. This clinical scientist will support early phase drug development in hematology/oncology.
KEY RESPONSIBILITIES
- Responsible to ensure the data review and cleaning activities meet the quality standards to support database locks in collaboration with data management and medical lead/clinical trial lead. Uses clinical and disease state knowledge to make recommendations for methods and strategy for data cleaning approach.
- Collaborate with other functions to successfully support the planning and execution of clinical studies. Provides independent leadership of all areas requiring clinical input with oversight from the assigned Clinical Trial Lead/Medical Lead, and provides innovative and quality solutions for assigned problems and tasks.
- Provides clinical input and strategic recommendations for the planning and implementation of assigned clinical trial(s) including investigator selection, patient recruitment, feasibility questionnaire, training PowerPoints, and supporting Ethics committee submissions.
- Contributes to the strategic planning, preparation, and review of clinical documents (Protocol, ICFs, CSR, investigator brochure). May lead certain documents or sections of documents, including incorporation of input from other cross-functional team members.
- Provides clinical input and strategic recommendations for regulatory documents needed for all stages of assigned trial lifecycle (IND documentation, HA briefing books, BLAs, and Orphan Drug Applications).
- Responsible for clinical portions of key data management/statistical documents (eg: Case Report Forms, edit checks, data review plan and reports).
- Contribute to the planning and execution of external meetings and internal stakeholder meetings (e.g., Ad Boards, IMs, Governance, DMCs, Regulatory Authority, Dose Escalation meeting); responds to or triages questions for appropriate escalations. May have a speaking role on meetings when appropriate.
- Supports their manager when asked to contribute to harmonization between clinical trials and process improvement initiatives.
- Typically, the clinical research scientist may have the authority to make decisions related to issuing data cleaning queries and can decide whether there is a need to escalate for further discussion with the medical lead. They may also be delegated tasks from the clinical trial lead/medical lead for which they have decision making authority e.g. comment resolution when leading document creation.
REQUIREMENTS
- At least a Bachelor's degree in life science discipline.
- Bachelor's degree with 4+ years'; or MS with 3+ years'; or PharmD/PhD with 2+ years of pharma experience in clinical development or related function.
- CAR-T cell therapy and/or hematology/oncology disease experience is a plus.
- Good interpersonal & communication skills, including oral, written and interpersonal.
- Ability to effectively manage conflicts and negotiations while providing impact and influence.
- Collaborative with the ability to operate across multiple geographies.
- Good leadership & organizational skills, analytical skills, and presentation skills.
- Creative problem-solving skills.
- Strong organizational and project management skill and the ability to multitask.
- Computer literacy required (MS word, MS excel, MS PowerPoint and MS Project).
- Oncology Therapeutic Experience preferred.
- Excellent working knowledge of GCP, FDA and ICH Guidelines.
Li-JR1
Li-Onsite
Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.
EEO STATEMENT
It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.
Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.
For information related to our privacy notice, please review: Legend Biotech Privacy Notice.
See All 251+ Senior Clinical Research Scientist Jobs
Jump back to the full list of openings and apply to any senior clinical research scientist role that fits.
Find JobsSenior Clinical Research Scientist Job Market
A snapshot from current openings nationwide, updated as new roles post.
Who's Hiring
- AbbVie20
- Novartis7
- Genentech6
- Sanofi6
- St. Jude Children's Research Hospital6
Top Industries Hiring
- Biotechnology & Pharmaceuticals151
- Science & Research66
- Healthcare & Medical Services20
- Education18
- Medical Devices8
What Employers Look For
The qualifications that appear most often in senior clinical research scientist jobs.
- Advanced degree (MS or PhD) in life sciences, pharmacy, or a related field
- Minimum five to eight years of clinical research experience in pharma, biotech, or CRO settings
- Direct experience authoring clinical study reports and regulatory submission documents
- Proficiency with electronic data capture systems such as Medidata Rave or Oracle Clinical
- Deep knowledge of ICH-GCP guidelines, FDA regulations, and GCP compliance standards
- Experience managing CRO relationships, site oversight, and cross-functional study teams
Tips for Your Senior Clinical Research Scientist Job Search
Tailor your CV to therapeutic area
Hiring teams screen for direct experience in their disease area, so list your oncology, CNS, or rare disease trials prominently rather than burying them under general research duties. Specific protocol numbers and phase experience signal immediate fit.
Highlight regulatory submission contributions clearly
Many senior clinical research scientist candidates undersell their NDA, BLA, or IND contributions. Specify your role in authoring clinical study reports, responding to agency queries, or preparing data packages, since reviewers scan for this language.
Apply early to roles that fit
Migrate Mate lists senior clinical research scientist openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Filter openings by study phase experience
Your phase experience matters as much as your title. When scanning listings, prioritize roles aligned with your Phase I through Phase III background so your application matches the team's current pipeline stage and hiring needs.
Prepare case examples of protocol deviations handled
Interviewers at the senior level almost always probe how you've managed protocol deviations, site issues, or data integrity problems. Have two or three concrete examples ready that walk through your decision-making and the outcome you drove.
Negotiate your scope of responsibility upfront
Before accepting an offer, clarify whether the role is purely execution-focused or includes study design, CRO oversight, or publication authorship. Senior clinical research scientist titles vary widely by company, and misaligned expectations are common.
Senior Clinical Research Scientist Jobs: Frequently Asked Questions
Which companies are hiring the most senior clinical research scientists?
The companies hiring the most senior clinical research scientists right now include AbbVie, Novartis, and Genentech, with the largest share of openings in California, Massachusetts, and Illinois, based on current listings on Migrate Mate as of June 2026. Large CROs and mid-size biotechs focused on oncology and rare disease tend to post the highest volume of openings consistently.
How many senior clinical research scientist jobs are remote?
About 14% of senior clinical research scientist openings are fully remote or hybrid as of June 2026, making it one of the more flexible roles in clinical development. Sub-specializations focused on data review, regulatory writing, and CRO oversight tend to offer the most remote flexibility, while roles requiring frequent site visits or lab access are more commonly on-site.
How do you become a senior clinical research scientist?
Start by earning an advanced degree in a life sciences field, then build hands-on experience in clinical trial coordination or data management at a pharma company, CRO, or academic research center. Progress through increasing protocol ownership, take on cross-functional team responsibilities, and deepen your expertise in a specific therapeutic area. Contributing to regulatory submissions or publications strengthens your path to senior-level roles.
Can you get hired as a senior clinical research scientist with limited experience?
Moving directly into a senior clinical research scientist role with limited experience is difficult because most employers require substantial hands-on trial management and regulatory exposure. The most practical path is to first secure a clinical research associate or clinical research scientist role, build phase-specific and therapeutic area expertise, lead increasingly complex studies, and then transition to senior positions after demonstrating independent study oversight and submission contributions.
What does the senior clinical research scientist interview process look like?
The process typically involves an initial screening call with a recruiter, followed by a technical interview with the hiring manager focused on your protocol experience, GCP knowledge, and regulatory submission history. Later rounds often include a panel interview with cross-functional team members from biostatistics, regulatory affairs, or clinical operations, and sometimes a case study or presentation on how you'd approach a study design or site management challenge.
Where can I find and apply to senior clinical research scientist jobs?
You can find and apply to senior clinical research scientist jobs on Migrate Mate, which lists current openings from across the United States. Find roles that match your therapeutic area and phase experience, then apply directly to each listing that fits.
See All 251+ Senior Clinical Research Scientist Jobs
Jump back to the full list of openings and apply to any senior clinical research scientist role that fits.
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