Systems Programmer Jobs
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Entity: CSL Behring
Job Category: Research Development & Sciences
Job Family: Clinical Programming
Job Type: Full Time
Location: King Of Prussia, Pennsylvania, United States
Employer Reference: R-278024
Job Description
Position Purpose:
The Senior EDC Programmer focuses on governance, review, and validation of deliverables to ensure alignment with CSL standards, regulatory requirements, and industry best practices. The incumbent applies strong expertise in leading and overseeing set-up and maintenance of Clinical Data Management Systems in addition to providing technical support. This individual supports cross-functional teams such as Statistics, Data Management and Standards by overseeing and ensuring the quality of clinical data build and programming activities across in-house, hybrid, and vendor-supported studies. The role will contribute to shaping future-state data capabilities by supporting initiatives around scalable
data platforms and AI-driven automation, enabling more efficient and intelligent use of clinical data.
Reporting Relationships:
This role reports to the Director, Statistical Programming Lead
Work Environment:
*** On site / Hybrid at CSL Behring requires a minimum of 3 days in the designated work location office weekly for this role. Relocation and mobility assistance is not provided.
Main Responsibilities and Accountabilities:
Drive activities related to the design, development, and maintenance of clinical study databases by applying advanced technical expertise in: CRF design; database build; edit check programming; report development; custom programming; system interface configuration; and the implementation of all relevant systems features to support high-quality, compliant clinical data management.
Collaborate with clinical study teams, Standards (CDASH/SDTM,CSL), and cross-functional stakeholders to define, implement, and continuously enhance data quality methods, acceptance criteria, and validation rules for eCRF and external data sources across all study models
Oversee the implementation and maintenance of data quality control frameworks, including validation check libraries and acceptance criteria for vendor and internally generated data, ensuring alignment with CSL standards and regulatory expectations
Govern and maintain a standardized library of reports and listings to support study teams, ensuring consistency, reusability, and efficiency across in-house, hybrid, and vendor-supported studies
Oversee the setup, automation, and monitoring of recurring data quality and operational reports across different models (in-house vs outsourced etc.)a ensuring accuracy, completeness, and timely availability of outputs
Partner with Data Management, Statistics, and vendors to review and validate clinical data deliverables, ensuring submission readiness in accordance with regulatory standards (e.g., SDTM, define.xml)
Lead the reporting solutions that provide insights into data quality, study progress, and key metrics to support informed decision-making
Ensure appropriate data structures, storage, and integration approaches that enable pooled analyses, traceability, and efficient retrieval of both current and legacy clinical data
Support the integration and governance of external data sources (e.g., IxRS, eDiaries, labs, ECG), ensuring data consistency, quality, and alignment with study requirements, while facilitating collaboration between internal teams and vendors
Contribute to innovation and future-state initiatives by supporting the development of scalable data platforms, automation strategies, and AI-enabled capabilities to enhance data processing, validation, and analytics
Job Qualifications and Experience Requirements:
Education
BSc in Computer Science, Mathematics, Statistics or related area with relevant experience
Medidata Rave Study Builder Certification is preferred
Experience
5+ years of relevant experience with clinical database design in EDC systems within a pharmaceutical or CRO environment
Exposure to in-house, hybrid, and/or vendor-supported study models
Familiarity/practical experience with CDISC standards, particularly CDASH, SDTM including data mapping, validation, and activities supporting submission readiness
Proficiency with EDC systems (e.g., Medidata Rave, Veeva Vault) and understanding of eCRF design and clinical data collection frameworks
Strong understanding of clinical data processes, including data standards, data flows, and integration of eCRF and external data sources, data quality oversight, validation processes, and vendor deliverable review
Proven ability to manage priorities, meet timelines, and operate effectively in a fast-paced and evolving environment
Ability to independently perform data migration activities for post-production study changes is preferred
Experience with C# is preferred and familiarity with SAS, Python, or R is a plus
Competencies
Good communication and analytical skills
Good planning and organizational skills
Ability to work successfully in a matrix organizational structure
Networking skills and ability to share knowledge and experience amongst colleagues
Fluent in English, oral and in writing
The expected base salary range for this position at hiring is $143,000 - $169,000. Please note this salary range reflects the minimum and maximum base pay that CSL expects to pay for this position at the listed for the Waltham, MA USA work location at the time of this posting. Individual base salary for a successful candidate is determined by qualifications, skill level, experience, competencies and other relevant factors. In addition to base salary, total compensation for this role may also include incentive compensation and equity.
#LI-HYBRID
About CSL Behring
CSL Behring is a global biotherapeutics leader driven by our promise to save lives. Focused on serving patients' needs by using the latest technologies, we discover, develop and deliver innovative therapies for people living with conditions in the immunology, hematology, cardiovascular and metabolic, respiratory, and transplant therapeutic areas. We use three strategic scientific platforms of plasma fractionation, recombinant protein technology, and cell and gene therapy to support continued innovation and continually refine ways in which products can address unmet medical needs and help patients lead full lives.
CSL Behring operates one of the world's largest plasma collection networks, CSL Plasma. Our parent company, CSL, headquartered in Melbourne, Australia, employs 32,000 people, and delivers its lifesaving therapies to people in more than 100 countries.
To learn more about CSL, CSL Behring, CSL Seqirus and CSL Vifor visit https://www.csl.com/ and CSL Plasma at https://www.cslplasma.com/.
Our Benefits
For more information on CSL benefits visit How CSL Supports Your Well-being | CSL.
You Belong at CSL
At CSL, Inclusion and Belonging is at the core of our mission and who we are. It fuels our innovation day in and day out. By celebrating our differences and creating a culture of curiosity and empathy, we are able to better understand and connect with our patients and donors, foster strong relationships with our stakeholders, and sustain a diverse workforce that will move our company and industry into the future.
To learn more about inclusion and belonging visit https://www.csl.com/careers/inclusion-and-belonging
Equal Opportunity Employer
CSL is an Equal Opportunity Employer. If you are an individual with a disability and need a reasonable accommodation for any part of the application process, please visit https://www.csl.com/accessibility-statement.
Entity: CSL Behring
Job Category: Research Development & Sciences
Job Family: Clinical Programming
Job Type: Full Time
Location: King Of Prussia, Pennsylvania, United States
Employer Reference: R-278024
Job Description
Position Purpose:
The Senior EDC Programmer focuses on governance, review, and validation of deliverables to ensure alignment with CSL standards, regulatory requirements, and industry best practices. The incumbent applies strong expertise in leading and overseeing set-up and maintenance of Clinical Data Management Systems in addition to providing technical support. This individual supports cross-functional teams such as Statistics, Data Management and Standards by overseeing and ensuring the quality of clinical data build and programming activities across in-house, hybrid, and vendor-supported studies. The role will contribute to shaping future-state data capabilities by supporting initiatives around scalable
data platforms and AI-driven automation, enabling more efficient and intelligent use of clinical data.
Reporting Relationships:
This role reports to the Director, Statistical Programming Lead
Work Environment:
*** On site / Hybrid at CSL Behring requires a minimum of 3 days in the designated work location office weekly for this role. Relocation and mobility assistance is not provided.
Main Responsibilities and Accountabilities:
Drive activities related to the design, development, and maintenance of clinical study databases by applying advanced technical expertise in: CRF design; database build; edit check programming; report development; custom programming; system interface configuration; and the implementation of all relevant systems features to support high-quality, compliant clinical data management.
Collaborate with clinical study teams, Standards (CDASH/SDTM,CSL), and cross-functional stakeholders to define, implement, and continuously enhance data quality methods, acceptance criteria, and validation rules for eCRF and external data sources across all study models
Oversee the implementation and maintenance of data quality control frameworks, including validation check libraries and acceptance criteria for vendor and internally generated data, ensuring alignment with CSL standards and regulatory expectations
Govern and maintain a standardized library of reports and listings to support study teams, ensuring consistency, reusability, and efficiency across in-house, hybrid, and vendor-supported studies
Oversee the setup, automation, and monitoring of recurring data quality and operational reports across different models (in-house vs outsourced etc.)a ensuring accuracy, completeness, and timely availability of outputs
Partner with Data Management, Statistics, and vendors to review and validate clinical data deliverables, ensuring submission readiness in accordance with regulatory standards (e.g., SDTM, define.xml)
Lead the reporting solutions that provide insights into data quality, study progress, and key metrics to support informed decision-making
Ensure appropriate data structures, storage, and integration approaches that enable pooled analyses, traceability, and efficient retrieval of both current and legacy clinical data
Support the integration and governance of external data sources (e.g., IxRS, eDiaries, labs, ECG), ensuring data consistency, quality, and alignment with study requirements, while facilitating collaboration between internal teams and vendors
Contribute to innovation and future-state initiatives by supporting the development of scalable data platforms, automation strategies, and AI-enabled capabilities to enhance data processing, validation, and analytics
Job Qualifications and Experience Requirements:
Education
BSc in Computer Science, Mathematics, Statistics or related area with relevant experience
Medidata Rave Study Builder Certification is preferred
Experience
5+ years of relevant experience with clinical database design in EDC systems within a pharmaceutical or CRO environment
Exposure to in-house, hybrid, and/or vendor-supported study models
Familiarity/practical experience with CDISC standards, particularly CDASH, SDTM including data mapping, validation, and activities supporting submission readiness
Proficiency with EDC systems (e.g., Medidata Rave, Veeva Vault) and understanding of eCRF design and clinical data collection frameworks
Strong understanding of clinical data processes, including data standards, data flows, and integration of eCRF and external data sources, data quality oversight, validation processes, and vendor deliverable review
Proven ability to manage priorities, meet timelines, and operate effectively in a fast-paced and evolving environment
Ability to independently perform data migration activities for post-production study changes is preferred
Experience with C# is preferred and familiarity with SAS, Python, or R is a plus
Competencies
Good communication and analytical skills
Good planning and organizational skills
Ability to work successfully in a matrix organizational structure
Networking skills and ability to share knowledge and experience amongst colleagues
Fluent in English, oral and in writing
The expected base salary range for this position at hiring is $143,000 - $169,000. Please note this salary range reflects the minimum and maximum base pay that CSL expects to pay for this position at the listed for the Waltham, MA USA work location at the time of this posting. Individual base salary for a successful candidate is determined by qualifications, skill level, experience, competencies and other relevant factors. In addition to base salary, total compensation for this role may also include incentive compensation and equity.
#LI-HYBRID
About CSL Behring
CSL Behring is a global biotherapeutics leader driven by our promise to save lives. Focused on serving patients' needs by using the latest technologies, we discover, develop and deliver innovative therapies for people living with conditions in the immunology, hematology, cardiovascular and metabolic, respiratory, and transplant therapeutic areas. We use three strategic scientific platforms of plasma fractionation, recombinant protein technology, and cell and gene therapy to support continued innovation and continually refine ways in which products can address unmet medical needs and help patients lead full lives.
CSL Behring operates one of the world's largest plasma collection networks, CSL Plasma. Our parent company, CSL, headquartered in Melbourne, Australia, employs 32,000 people, and delivers its lifesaving therapies to people in more than 100 countries.
To learn more about CSL, CSL Behring, CSL Seqirus and CSL Vifor visit https://www.csl.com/ and CSL Plasma at https://www.cslplasma.com/.
Our Benefits
For more information on CSL benefits visit How CSL Supports Your Well-being | CSL.
You Belong at CSL
At CSL, Inclusion and Belonging is at the core of our mission and who we are. It fuels our innovation day in and day out. By celebrating our differences and creating a culture of curiosity and empathy, we are able to better understand and connect with our patients and donors, foster strong relationships with our stakeholders, and sustain a diverse workforce that will move our company and industry into the future.
To learn more about inclusion and belonging visit https://www.csl.com/careers/inclusion-and-belonging
Equal Opportunity Employer
CSL is an Equal Opportunity Employer. If you are an individual with a disability and need a reasonable accommodation for any part of the application process, please visit https://www.csl.com/accessibility-statement.
Systems Programmer Jobs by Experience Level
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Find Systems Programmer JobsSystems Programmer Job Market
Who's Hiring
Top Industries Hiring
- Technology & Software
- Consulting & Professional Services
- Staffing & Recruiting
- Banking & Financial Services
- Insurance
What Employers Look For
The qualifications that appear most often in systems programmer jobs.
- Proficiency in C or C++ for systems-level development and performance-critical code
- Experience with operating system internals such as memory management, scheduling, or device drivers
- Familiarity with assembly language and low-level debugging tools like GDB or JTAG
- Bachelor's degree in computer science, computer engineering, or a closely related field
- Experience with real-time operating systems or embedded platforms such as VxWorks or FreeRTOS
- Knowledge of version control, build systems, and continuous integration pipelines in Linux environments
Tips for Your Systems Programmer Job Search
Tailor your resume to the stack
Systems programmer roles vary sharply by environment. Highlight whether your experience is in bare-metal, kernel-level, or application-layer systems, and name the specific OS, architecture, or firmware you worked with. Generic software engineer resumes rarely clear the filter.
Show ownership of low-level complexity
Hiring managers want evidence you have debugged memory corruption, optimized interrupt handlers, or tuned scheduler behavior, not just that you know the concepts. Describe a specific problem you owned end-to-end and the measurable outcome it produced.
Target clearance-required roles strategically
Many systems programmer openings in defense and government contracting list an active clearance as preferred, not required. If you hold one, lead with it early in your resume. If you are clearance-eligible, apply and state that plainly in your cover note.
Apply early to roles that fit
Migrate Mate lists systems programmer openings from across the United States in one place, so you can find roles that match your experience level and specialization and apply directly to each listing.
Prepare for architecture and design questions
Systems programmer interviews almost always include a whiteboard or verbal design round focused on concurrency, memory models, or IPC mechanisms. Practice explaining trade-offs between design choices out loud, not just arriving at a correct answer.
Negotiate around equity and total comp
In systems engineering roles at product companies, base salary often has a tighter band than equity. Before accepting an offer, ask for the vesting schedule, cliff, and the most recent 409A valuation so you can compare the full package accurately.
Systems Programmer Jobs: Frequently Asked Questions
Which companies are hiring the most systems programmers?
The companies hiring the most systems programmers right now include The Building People, Jobot, and Ensono, with the largest share of openings in Texas, Arizona, and New Jersey, based on current listings on Migrate Mate as of August 2026. Defense contractors, semiconductor firms, and large cloud infrastructure teams consistently post the highest volume of systems programmer roles.
How many systems programmer jobs are remote?
About 55% of systems programmer openings are fully remote or hybrid as of August 2026, which is lower than the broader software engineering average because many roles involve classified systems, specialized hardware, or on-site lab access. Roles focused on pure software systems, compilers, or distributed infrastructure tend to offer the most remote flexibility.
How do you become a systems programmer?
Start by building a strong foundation in C or C++ and studying operating system concepts such as process scheduling, virtual memory, and file systems. Work through projects that touch hardware directly, such as writing a bootloader, a simple OS kernel, or a device driver. Contributing to open-source systems projects gives you verifiable, reviewable work to show employers. Internships or junior roles in embedded or infrastructure teams are the most common entry points.
Can you get a systems programmer job with little experience?
Yes, entry-level systems programmer roles exist, but they require demonstrating hands-on technical depth rather than just coursework. Build projects that show low-level work: a custom memory allocator, a toy file system, or kernel module experiments on Linux. Employers hiring at the junior level care more about whether you can read and reason about systems code than about years of professional experience.
What does the systems programmer interview process look like?
Most systems programmer interview processes include an initial technical screen covering C or C++ fundamentals, a coding round focused on low-level problem solving such as bit manipulation or memory layout, and a systems design discussion around concurrency, IPC, or OS internals. Some employers add a take-home component or a debugging exercise using core dumps or performance profiles. Final rounds typically involve a team interview assessing communication and architectural reasoning.
Where can I find and apply to systems programmer jobs?
You can find and apply to systems programmer jobs on Migrate Mate, which lists current openings from across the United States in one place. Search the listings to find roles that match your experience level and specialization, then apply directly to each one that fits.
See All 81 Systems Programmer Jobs
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