Project Director Visa Sponsorship Jobs in Massachusetts
Massachusetts is a strong market for project directors, with major employers across life sciences, higher education, defense, and technology concentrated in Boston, Cambridge, and the Route 128 corridor. Companies like Biogen, Raytheon Technologies, MIT, and Mass General Brigham regularly hire senior project leadership and have established visa sponsorship infrastructure for international candidates.
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Get Access To All JobsWhat if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner?
About Pioneering Medicines:
Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production.
This role can be remote or at our Cambridge, MA site. If over 30 miles from our Cambridge site a travel cadence will be set at time of offer (about monthly).
Position Summary:
We are seeking a highly motivated and experienced DMPK project representative to join our growing team. This leadership role will provide scientific and strategic DMPK guidance across our biologics portfolio, supporting a wide range of therapeutic modalities including monoclonal antibodies, bispecifics, fusion proteins, and innovative targeted-delivery platforms.
The ideal candidate brings deep expertise in DMPK, bioanalysis (BA), and immunogenicity science, with a proven ability to influence discovery and development strategies for biologics. You will collaborate closely with multi-disciplinary teams to optimize candidate selection, design and execute preclinical studies, and ensure regulatory readiness. This is a high-impact role requiring strong analytical thinking, scientific rigor, and exceptional communication skills.
Key Responsibilities:
- Serve as the DMPK representative on cross-functional discovery teams to guide PK, BA and immunogenicity strategies that support project decisions and milestones.
- Design and lead in vitro and in vivo PK/BA/Immunogenicity studies to characterize biologics properties and support candidate progression.
- Interpret study data, identify issues, and proactively troubleshoot technical challenges.
- Collaborate with internal and external stakeholders to plan and execute DMPK deliverables with high quality and efficiency.
- Collaborate with PK/PD modelers to establish PK/PD correlations and guide preclinical study design.
- Contribute to the selection of preclinical toxicology species and develop the toxicokinetic plan to support IND filing.
- Support human dose projections based on preclinical data to guide candidate selection.
- Author DMPK and BA sections of regulatory submissions (e.g., INDs, Investigator's Brochures), and respond to regulatory queries.
- Contribute to the development of DMPK/BA functional processes and procedures focused on CRO interactions and organizational efficiency.
- Provide operational oversight for quality and performance of DMPK activities, including interactions with CROs and external project support.
- Contribute to the selection and qualification of CROs and external vendors.
- Engage closely with internal stakeholders and companies within the Flagship ecosystem.
Qualifications
- PhD. in pharmaceutical sciences, biochemistry, or related field with 8+ years of relevant industry experience; or M.S. with 12+ years; or B.S. with 14+ years.
- Proven track record representing DMPK in biologics discovery and/or development programs.
- Extensive hands-on experience with PK, BA, and immunogenicity assessment of biologics.
- Deep understanding of biologics development workflows; familiarity with small molecules or novel modalities is a plus.
- Working knowledge of regulatory expectations and experience contributing to submissions.
- Strong publication and/or patent record demonstrating scientific leadership.
- Demonstrated success in cross-functional team environments, with strong collaboration, communication, and presentation skills.
- Experience in managing CROs and external study oversight.
- Adaptable, detail-oriented, and able to manage multiple priorities in a fast-paced setting.
About Flagship
Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond.
What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our team of scientists, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and create breakthroughs for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been named four times to Fast Company's annual list of the World's Most Innovative Companies.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
The salary range for this role is $148,000 - $236,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.
What if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner?
About Pioneering Medicines:
Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production.
This role can be remote or at our Cambridge, MA site. If over 30 miles from our Cambridge site a travel cadence will be set at time of offer (about monthly).
Position Summary:
We are seeking a highly motivated and experienced DMPK project representative to join our growing team. This leadership role will provide scientific and strategic DMPK guidance across our biologics portfolio, supporting a wide range of therapeutic modalities including monoclonal antibodies, bispecifics, fusion proteins, and innovative targeted-delivery platforms.
The ideal candidate brings deep expertise in DMPK, bioanalysis (BA), and immunogenicity science, with a proven ability to influence discovery and development strategies for biologics. You will collaborate closely with multi-disciplinary teams to optimize candidate selection, design and execute preclinical studies, and ensure regulatory readiness. This is a high-impact role requiring strong analytical thinking, scientific rigor, and exceptional communication skills.
Key Responsibilities:
- Serve as the DMPK representative on cross-functional discovery teams to guide PK, BA and immunogenicity strategies that support project decisions and milestones.
- Design and lead in vitro and in vivo PK/BA/Immunogenicity studies to characterize biologics properties and support candidate progression.
- Interpret study data, identify issues, and proactively troubleshoot technical challenges.
- Collaborate with internal and external stakeholders to plan and execute DMPK deliverables with high quality and efficiency.
- Collaborate with PK/PD modelers to establish PK/PD correlations and guide preclinical study design.
- Contribute to the selection of preclinical toxicology species and develop the toxicokinetic plan to support IND filing.
- Support human dose projections based on preclinical data to guide candidate selection.
- Author DMPK and BA sections of regulatory submissions (e.g., INDs, Investigator's Brochures), and respond to regulatory queries.
- Contribute to the development of DMPK/BA functional processes and procedures focused on CRO interactions and organizational efficiency.
- Provide operational oversight for quality and performance of DMPK activities, including interactions with CROs and external project support.
- Contribute to the selection and qualification of CROs and external vendors.
- Engage closely with internal stakeholders and companies within the Flagship ecosystem.
Qualifications
- PhD. in pharmaceutical sciences, biochemistry, or related field with 8+ years of relevant industry experience; or M.S. with 12+ years; or B.S. with 14+ years.
- Proven track record representing DMPK in biologics discovery and/or development programs.
- Extensive hands-on experience with PK, BA, and immunogenicity assessment of biologics.
- Deep understanding of biologics development workflows; familiarity with small molecules or novel modalities is a plus.
- Working knowledge of regulatory expectations and experience contributing to submissions.
- Strong publication and/or patent record demonstrating scientific leadership.
- Demonstrated success in cross-functional team environments, with strong collaboration, communication, and presentation skills.
- Experience in managing CROs and external study oversight.
- Adaptable, detail-oriented, and able to manage multiple priorities in a fast-paced setting.
About Flagship
Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond.
What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our team of scientists, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and create breakthroughs for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been named four times to Fast Company's annual list of the World's Most Innovative Companies.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
The salary range for this role is $148,000 - $236,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.
Project Director Job Roles in Massachusetts
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Search Project Director Jobs in MassachusettsProject Director Jobs in Massachusetts: Frequently Asked Questions
Which companies sponsor visas for project directors in Massachusetts?
Life sciences firms like Biogen, Moderna, and Sanofi Genzyme, defense contractors like Raytheon Technologies and General Dynamics, and academic medical centers like Mass General Brigham and Dana-Farber Cancer Institute are among the more active sponsors for senior project leadership roles in Massachusetts. Large technology employers in the Boston and Cambridge corridor also have established sponsorship programs for project director-level positions.
Which visa types are most common for project director roles in Massachusetts?
The H-1B visa is the most common visa for project directors in Massachusetts, as the role typically requires a bachelor's degree or higher in a relevant field, meeting the specialty occupation standard. Candidates with extraordinary achievement may pursue the O-1A. Intracompany transferees at multinational firms, particularly in life sciences and defense, sometimes qualify for the L-1A managerial classification depending on their specific responsibilities.
How to find project director visa sponsorship jobs in Massachusetts?
Migrate Mate filters job listings specifically by visa sponsorship availability, making it straightforward to browse project director roles in Massachusetts without sifting through positions that don't support international candidates. You can narrow results to Massachusetts and the project director category to surface openings at life sciences, defense, and technology employers that have active H-1B sponsorship histories in the state.
Which cities in Massachusetts have the most project director sponsorship jobs?
Boston and Cambridge account for the highest concentration of sponsored project director roles, driven by the Seaport biotech cluster, major hospital systems, and universities. The Route 128 corridor, including Waltham, Lexington, and Burlington, is a secondary hub with significant activity from defense contractors and technology companies. Worcester also has a smaller but growing presence through its medical and academic institutions.
Are there state-specific considerations for project directors seeking visa sponsorship in Massachusetts?
Massachusetts employers in life sciences and defense often have dedicated immigration counsel and structured onboarding for sponsored employees, which can make the process more predictable at established firms. The density of research universities, including MIT, Harvard, and Boston University, also creates a pipeline of project management talent that employers draw from, so candidates with sector-specific credentials in biotech, clinical operations, or defense program management tend to be more competitive for sponsored roles.
What is the prevailing wage for sponsored project director jobs in Massachusetts?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.