Principal Engineer Visa Sponsorship Jobs in New Hampshire
Principal engineer visa sponsorship jobs in New Hampshire are concentrated around Manchester, Nashua, and the southern corridor near the Massachusetts border. Major employers include BAE Systems, Segra, and firms tied to the state's defense and advanced manufacturing sectors. The region's proximity to Boston expands your options without requiring relocation.
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Moderna is a pioneering biotechnology company focused on transforming the way medicines are made through its mRNA technology platform. The company develops vaccines and therapeutics across infectious diseases, cancer, rare diseases, and other serious health conditions. With a global team and a values-driven culture, Moderna is committed to delivering the greatest possible impact to people through mRNA medicines. Applicants are encouraged to learn more about the company at modernatx.com and through its official social media channels. Moderna maintains strict standards for recruitment and will never request payment or sensitive banking information during the hiring process, urging candidates to report suspected recruitment fraud to the designated company email or appropriate authorities.
Role Description
The Principal Scientist, Antibody Discovery and Engineering is a full-time, on-site role based in Lebanon, NH. This role leads the design, discovery, and optimization of antibodies to support Moderna’s mRNA-based therapeutics and vaccines. Day-to-day responsibilities include developing and refining antibody discovery strategies, overseeing experimental design, managing laboratory work and data analysis, and guiding antibody engineering campaigns to improve affinity, specificity, stability, and developability. The Principal Scientist collaborates closely with cross-functional teams in biology, bioinformatics, platform technology, and clinical development to move programs from early research through preclinical evaluation. The role also involves mentoring scientific staff, contributing to project planning and timelines, authoring technical documents and reports, and presenting findings to internal stakeholders and external partners as needed.
Qualifications
- Strong foundation in antibody discovery, protein engineering, and molecular biology techniques (e.g., phage or yeast display, hybridoma, B-cell cloning, expression and purification of antibodies).
- Expertise in assay development and data analysis for antibody characterization (e.g., binding, functional, biophysical assays; use of relevant analytical software and tools).
- Experience leading scientific projects and teams, including experimental design, troubleshooting, mentoring, and cross-functional collaboration.
- Proficiency in interpreting complex datasets, preparing technical reports, and communicating results clearly to both scientific and non-scientific audiences.
- Doctoral degree (Ph.D.) in immunology, molecular biology, biochemistry, biotechnology, or a related field, with substantial industry or equivalent experience in antibody discovery and engineering.
- Demonstrated track record of scientific contributions (e.g., publications, patents, or project leadership) in biologics or therapeutic antibodies.
- Ability to work on-site in a laboratory environment in Lebanon, NH, adhering to safety and quality standards and supporting a collaborative, inclusive culture.
- Experience in therapeutic development, particularly in oncology, infectious diseases, or immune-mediated conditions, and familiarity with regulatory considerations and developability assessments is beneficial.
Company Description
Moderna is a pioneering biotechnology company focused on transforming the way medicines are made through its mRNA technology platform. The company develops vaccines and therapeutics across infectious diseases, cancer, rare diseases, and other serious health conditions. With a global team and a values-driven culture, Moderna is committed to delivering the greatest possible impact to people through mRNA medicines. Applicants are encouraged to learn more about the company at modernatx.com and through its official social media channels. Moderna maintains strict standards for recruitment and will never request payment or sensitive banking information during the hiring process, urging candidates to report suspected recruitment fraud to the designated company email or appropriate authorities.
Role Description
The Principal Scientist, Antibody Discovery and Engineering is a full-time, on-site role based in Lebanon, NH. This role leads the design, discovery, and optimization of antibodies to support Moderna’s mRNA-based therapeutics and vaccines. Day-to-day responsibilities include developing and refining antibody discovery strategies, overseeing experimental design, managing laboratory work and data analysis, and guiding antibody engineering campaigns to improve affinity, specificity, stability, and developability. The Principal Scientist collaborates closely with cross-functional teams in biology, bioinformatics, platform technology, and clinical development to move programs from early research through preclinical evaluation. The role also involves mentoring scientific staff, contributing to project planning and timelines, authoring technical documents and reports, and presenting findings to internal stakeholders and external partners as needed.
Qualifications
- Strong foundation in antibody discovery, protein engineering, and molecular biology techniques (e.g., phage or yeast display, hybridoma, B-cell cloning, expression and purification of antibodies).
- Expertise in assay development and data analysis for antibody characterization (e.g., binding, functional, biophysical assays; use of relevant analytical software and tools).
- Experience leading scientific projects and teams, including experimental design, troubleshooting, mentoring, and cross-functional collaboration.
- Proficiency in interpreting complex datasets, preparing technical reports, and communicating results clearly to both scientific and non-scientific audiences.
- Doctoral degree (Ph.D.) in immunology, molecular biology, biochemistry, biotechnology, or a related field, with substantial industry or equivalent experience in antibody discovery and engineering.
- Demonstrated track record of scientific contributions (e.g., publications, patents, or project leadership) in biologics or therapeutic antibodies.
- Ability to work on-site in a laboratory environment in Lebanon, NH, adhering to safety and quality standards and supporting a collaborative, inclusive culture.
- Experience in therapeutic development, particularly in oncology, infectious diseases, or immune-mediated conditions, and familiarity with regulatory considerations and developability assessments is beneficial.
Principal Engineer Job Roles in New Hampshire
See all 118+ Principal Engineer Jobs in New Hampshire
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Search Principal Engineer Jobs in New HampshirePrincipal Engineer Jobs in New Hampshire: Frequently Asked Questions
Which companies sponsor visas for principal engineers in New Hampshire?
BAE Systems, headquartered in Nashua, is one of the most active sponsors for senior engineering roles in the state, particularly in defense electronics and systems engineering. Oracle, Segra, and various semiconductor and advanced manufacturing firms operating in the southern New Hampshire corridor also have established H-1B visa sponsorship histories for principal-level positions. Larger employers with dedicated immigration teams are your most reliable starting point.
Which visa types are most common for principal engineer roles in New Hampshire?
The H-1B is the most common visa category for principal engineers in New Hampshire, given that the role typically requires a bachelor's degree or higher in computer science, electrical engineering, or a related field, satisfying the specialty occupation requirement. Candidates with extraordinary ability in engineering may also qualify for the O-1A. Australians should note the E-3 visa as an alternative that avoids the H-1B lottery entirely.
Which cities in New Hampshire have the most principal engineer sponsorship jobs?
Nashua and Manchester account for the majority of principal engineer sponsorship activity in New Hampshire. Nashua benefits from a concentration of defense contractors and aerospace firms, while Manchester supports a growing technology and software sector. Bedford and Merrimack also host engineering-heavy employers. The southern tier of the state, bordering Massachusetts, sees the densest hiring due to its access to Boston-area talent pipelines and infrastructure.
How to find principal engineer visa sponsorship jobs in New Hampshire?
Migrate Mate filters job listings specifically by visa sponsorship availability, making it straightforward to search for principal engineer roles in New Hampshire without sorting through positions that don't offer sponsorship. You can narrow results by location and seniority level to focus on employers actively hiring at the principal level. Given the concentration of defense and technology employers in the Nashua-Manchester corridor, filtering by those cities on Migrate Mate is a practical starting point.
Are there state-specific considerations for principal engineer roles and visa sponsorship in New Hampshire?
New Hampshire has no state income tax, which affects prevailing wage calculations and total compensation benchmarking used in H-1B Labor Condition Applications. The state's defense sector requires security clearances for many principal engineering roles, and clearance eligibility is restricted to U.S. citizens and certain permanent residents, which can limit options at some employers. University of New Hampshire and Dartmouth College also feed engineering talent pipelines, though most visa-sponsored hires come from industry rather than direct academic pipelines.
What is the prevailing wage for sponsored principal engineer jobs in New Hampshire?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.