Senior Clinical Data Manager Jobs in USA with Visa Sponsorship
Senior Clinical Data Manager roles attract H-1B and O-1 visa sponsorship from large pharmaceutical companies, CROs, and biotech firms. The position qualifies as a specialty occupation requiring a bachelor's degree or higher in life sciences, statistics, or a related field. For detailed occupation requirements, see the O*NET profile.
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For more than 100 years, Olympus has focused on making people’s lives healthier, safer and more fulfilling.
Every day, we live by our philosophy, True to Life, by advancing medical technologies and elevating the standard of patient care so people everywhere can fulfill their desires, dreams, and lives.
Our five Core Values empower us to achieve Our Purpose:
Patient Focus, Integrity, Innovation, Impact and Empathy.
Learn more about Life at Olympus: https://www.olympusamerica.com/careers.
Job Description
As part of the Medical and Scientific Affairs group, an integral delivery unit within the Global Clinical Affairs organization, the Senior Clinical Data Manager is accountable for driving timely and high-quality data management deliverables supporting the Olympus portfolio.
The Sr. Clinical Data Manager designs, develops, and maintains key data management deliverables used to collect, review, monitor, and ensure integrity of clinical data, oversees application of industry standards, data review and query management, and is accountable for quality study dataset release and consistency for submission data.
This position serves as a key liaison between clinical operations, biostatistics, and external vendor and is responsible for leading data management responsibilities for several concurrent clinical trials, utilizing the electronic data capture and management systems. This role manages trials in various stages, from planning, to start-up, conduct, closeout, and archiving. The role assists in the design and implementation of clinical data management processes with vendors, ensuring completeness, correctness, and consistency according to Siemens standards. This role collaborates with the Biostatistics and Clinical Operations team members, and other functions as applicable.
Job Duties
- Work collaboratively with other Data Managers, Programmers, Biostatisticians, Clinical Operations, Medical Directors, and Regulatory staff to meet project deliverables and timelines for clinical data acquisition, quality checking and reporting.
- Focus on study-start up and database amendment implementation.
- Study level coordination and hands-on CDM tasks, including clinical data review and reconciliation.
- Authors data management plans (DMPs), case report forms (CRFs), edit check specifications (ECs), Data Review Guidelines (DRGs), Data Quality Plans (DQPs), and data validation rules.
- Manage database design, build, testing, and validation activities with internal teams or CROs/vendors.
- Oversee data cleaning activities including query generation/resolution, data reconciliation (e.g., SAE, lab, coding), and data reviews.
- Conduct ongoing risk-based data reviews to ensure data quality and identify trends or issues early.
- Collaborate with cross-functional teams (Clinical Ops, Safety, Biostatistics, Programming, Regulatory).
- Manage timelines and deliverables for database locks (interim and final), ensuring audit readiness.
- Coordinate with EDC and other data vendors (e.g., ePRO, IRT, central labs), ensuring seamless integration and data flow.
- Represent data management in study team meetings and regulatory audits or inspections.
- Ensure completeness, correctness and consistency of clinical data and data structure across projects.
- Ensure accurate tracking and reporting of study metrics and timelines.
- Proactively drives quality and efficiency to meet timelines and milestones for data management, ensuring scientific and operational excellence in support of strategic imperatives and in collaboration with the cross functional study team(s).
- Provide guidance and training to CROs, vendors, investigators, and study coordinators on study requirements as applicable.
- Assist in the development, review and implementation of processes, policies, SOPs and associated documents affecting CDM.
- Mentor and train junior data managers or contractors as needed.
- Other duties as assigned.
Job Qualifications
Required:
- BS degree in a Biomedical Science or comparable field of study.
- Bachelor’s degree with a minimum of 8 years of global clinical data management experience, or a Master’s degree with a minimum of 6 years of experience.
- Prior experience in a sponsor, CRO, or medical device company.
- In-depth knowledge and experience with FDA regulations and familiarity with web-based Electronic Data Capture (EDC), clinical data management systems and industry wide coding dictionaries such as MedDRA.
- Strong expertise in implementing and maintaining systems for global trials (Specifically, Medidata Rave).
- Proven leadership in managing full-cycle data management activities.
- Experience with risk mitigation and data quality strategies.
- In-depth knowledge of ICH-GCP, FDA/EMA regulations, and GCDMP.
- Strong expertise in implementing and maintaining systems for global medical device trials (Class II/III or combination products).
- Excellent stakeholder management skills with cross-cultural sensitivity and global collaboration experience.
- Strong experience in vendor management and system validation.
- Ability to collaborate effectively with the study team, cross-functional team members and external partners.
- Excellent verbal and written communication skills and interpersonal skills are required.
- Excellent analytical, organizational, and communication skills.
- Ability to manage multiple priorities in a fast-paced environment.
- Proficiency with clinical data systems and MS Office Suite.
- Position may require some travel.
- Candidates must be authorized to work in the U.S.
- Occasional meetings out of normal working hours will be required as this role supports a global team (EMEA, Japan, China, APAC).
Preferred:
- Experience with CDASH/SDTM standards preferred.
- Experience supporting PMA, IDE, or 510(k) submissions preferred.
Why join Olympus?
We offer a holistic employee experience supporting personal and professional well-being through meaningful work, equitable offerings, and a connected culture.
Equitable Offerings you can count on:
- Competitive salaries, annual bonus and 401(k)* with company match
- Comprehensive medical, dental, vision coverage effective on start date
- 24/7 Employee Assistance Program
- Free live and on-demand Wellbeing Programs
- Generous Paid Vacation and Sick Time
- Paid Parental Leave and Adoption Assistance*
- 12 Paid Holidays
- On-Site Child Daycare, Café, Fitness Center**
Connected Culture you can embrace:
- Work-life integrated culture that supports an employee centric mindset
- Offers onsite, hybrid and field work environments
- Paid volunteering and charitable donation/match programs
- Employee Resource Groups
- Dedicated Training Resources and Learning & Development Programs
-
Paid Educational Assistance
-
US Only
Center Valley, PA and Westborough, MA
Are you ready to be a part of our team?
Learn more about our benefits and incentives: https://www.olympusamerica.com/careers/benefits-perks.
The anticipated base pay range for this full-time position is $128,775.00 - $180,285.00 / year, plus potential for annual bonus (subject to plan eligibility and other requirements). This pay range represents the National Average of the range, and may vary depending on the location of the individual.
Olympus considers a variety of factors when determining actual compensation for this position, including level of experience, working location, and relevant education and certifications.
At Olympus, we are committed to Our Purpose of making people’s lives healthier, safer and more fulfilling. As a global medical technology company, we partner with healthcare professionals to provide best-in-class solutions and services for early detection, diagnosis and minimally invasive treatment, aiming to improve patient outcomes by elevating the standard of care in targeted disease states.
For more than 100 years, Olympus has pursued a goal of contributing to society by producing products designed with the purpose of delivering optimal outcomes for its customers around the world.
Headquartered in Tokyo, Japan, Olympus employs more than 31,000 employees worldwide in nearly 40 countries and regions. Olympus Corporation of the Americas, a wholly owned subsidiary of Olympus Corporation, is headquartered in Center Valley, Pennsylvania, USA, and employs more than 5,200 employees throughout locations in North and South America.
You Belong at Olympus
We are deeply committed to fostering a respectful, fair, and welcoming workplace for all individuals, perspectives, and lifestyles. We believe in fostering a non-discriminatory, inclusive work environment where everyone feels a sense of belonging, in full compliance with legal standards. Empathy and unity are core to our company culture, empowering employees to contribute fully and flourish. We warmly encourage all who wish to bring their talents to Olympus to apply.
Applicants Requesting Accommodations: Olympus is committed to the full inclusion of all qualified individuals. As part of this commitment, Olympus will ensure that persons with disabilities are provided reasonable accommodations for the hiring process. If reasonable accommodation is needed, please contact OCAAccommodations@olympus.com. If your disability impairs your ability to email, you may call our HR Compliance Manager at 1-888-Olympus (1-888-659-6787).
Let’s realize your potential, together.
It is the policy of Olympus to extend equal employment and advancement opportunity to all applicants and employees without regard to race, color, national origin (including language use restrictions), citizenship status, religious creed (including dress and grooming practices), age, sex (including pregnancy, childbirth, breastfeeding, medical conditions related to pregnancy, childbirth and/or breastfeeding), gender, gender identity and expression, sexual orientation, marital status, disability (physical or mental) and/or a medical condition, genetic information, ancestry, veteran status or service in the uniformed services, and any other characteristic protected by applicable federal, state or local law.
Posting Notes: || United States (US) || Pennsylvania (US-PA) || Center Valley || Medical Affairs
Workplace Flexibility: Remote
For more than 100 years, Olympus has focused on making people’s lives healthier, safer and more fulfilling.
Every day, we live by our philosophy, True to Life, by advancing medical technologies and elevating the standard of patient care so people everywhere can fulfill their desires, dreams, and lives.
Our five Core Values empower us to achieve Our Purpose:
Patient Focus, Integrity, Innovation, Impact and Empathy.
Learn more about Life at Olympus: https://www.olympusamerica.com/careers.
Job Description
As part of the Medical and Scientific Affairs group, an integral delivery unit within the Global Clinical Affairs organization, the Senior Clinical Data Manager is accountable for driving timely and high-quality data management deliverables supporting the Olympus portfolio.
The Sr. Clinical Data Manager designs, develops, and maintains key data management deliverables used to collect, review, monitor, and ensure integrity of clinical data, oversees application of industry standards, data review and query management, and is accountable for quality study dataset release and consistency for submission data.
This position serves as a key liaison between clinical operations, biostatistics, and external vendor and is responsible for leading data management responsibilities for several concurrent clinical trials, utilizing the electronic data capture and management systems. This role manages trials in various stages, from planning, to start-up, conduct, closeout, and archiving. The role assists in the design and implementation of clinical data management processes with vendors, ensuring completeness, correctness, and consistency according to Siemens standards. This role collaborates with the Biostatistics and Clinical Operations team members, and other functions as applicable.
Job Duties
- Work collaboratively with other Data Managers, Programmers, Biostatisticians, Clinical Operations, Medical Directors, and Regulatory staff to meet project deliverables and timelines for clinical data acquisition, quality checking and reporting.
- Focus on study-start up and database amendment implementation.
- Study level coordination and hands-on CDM tasks, including clinical data review and reconciliation.
- Authors data management plans (DMPs), case report forms (CRFs), edit check specifications (ECs), Data Review Guidelines (DRGs), Data Quality Plans (DQPs), and data validation rules.
- Manage database design, build, testing, and validation activities with internal teams or CROs/vendors.
- Oversee data cleaning activities including query generation/resolution, data reconciliation (e.g., SAE, lab, coding), and data reviews.
- Conduct ongoing risk-based data reviews to ensure data quality and identify trends or issues early.
- Collaborate with cross-functional teams (Clinical Ops, Safety, Biostatistics, Programming, Regulatory).
- Manage timelines and deliverables for database locks (interim and final), ensuring audit readiness.
- Coordinate with EDC and other data vendors (e.g., ePRO, IRT, central labs), ensuring seamless integration and data flow.
- Represent data management in study team meetings and regulatory audits or inspections.
- Ensure completeness, correctness and consistency of clinical data and data structure across projects.
- Ensure accurate tracking and reporting of study metrics and timelines.
- Proactively drives quality and efficiency to meet timelines and milestones for data management, ensuring scientific and operational excellence in support of strategic imperatives and in collaboration with the cross functional study team(s).
- Provide guidance and training to CROs, vendors, investigators, and study coordinators on study requirements as applicable.
- Assist in the development, review and implementation of processes, policies, SOPs and associated documents affecting CDM.
- Mentor and train junior data managers or contractors as needed.
- Other duties as assigned.
Job Qualifications
Required:
- BS degree in a Biomedical Science or comparable field of study.
- Bachelor’s degree with a minimum of 8 years of global clinical data management experience, or a Master’s degree with a minimum of 6 years of experience.
- Prior experience in a sponsor, CRO, or medical device company.
- In-depth knowledge and experience with FDA regulations and familiarity with web-based Electronic Data Capture (EDC), clinical data management systems and industry wide coding dictionaries such as MedDRA.
- Strong expertise in implementing and maintaining systems for global trials (Specifically, Medidata Rave).
- Proven leadership in managing full-cycle data management activities.
- Experience with risk mitigation and data quality strategies.
- In-depth knowledge of ICH-GCP, FDA/EMA regulations, and GCDMP.
- Strong expertise in implementing and maintaining systems for global medical device trials (Class II/III or combination products).
- Excellent stakeholder management skills with cross-cultural sensitivity and global collaboration experience.
- Strong experience in vendor management and system validation.
- Ability to collaborate effectively with the study team, cross-functional team members and external partners.
- Excellent verbal and written communication skills and interpersonal skills are required.
- Excellent analytical, organizational, and communication skills.
- Ability to manage multiple priorities in a fast-paced environment.
- Proficiency with clinical data systems and MS Office Suite.
- Position may require some travel.
- Candidates must be authorized to work in the U.S.
- Occasional meetings out of normal working hours will be required as this role supports a global team (EMEA, Japan, China, APAC).
Preferred:
- Experience with CDASH/SDTM standards preferred.
- Experience supporting PMA, IDE, or 510(k) submissions preferred.
Why join Olympus?
We offer a holistic employee experience supporting personal and professional well-being through meaningful work, equitable offerings, and a connected culture.
Equitable Offerings you can count on:
- Competitive salaries, annual bonus and 401(k)* with company match
- Comprehensive medical, dental, vision coverage effective on start date
- 24/7 Employee Assistance Program
- Free live and on-demand Wellbeing Programs
- Generous Paid Vacation and Sick Time
- Paid Parental Leave and Adoption Assistance*
- 12 Paid Holidays
- On-Site Child Daycare, Café, Fitness Center**
Connected Culture you can embrace:
- Work-life integrated culture that supports an employee centric mindset
- Offers onsite, hybrid and field work environments
- Paid volunteering and charitable donation/match programs
- Employee Resource Groups
- Dedicated Training Resources and Learning & Development Programs
-
Paid Educational Assistance
-
US Only
Center Valley, PA and Westborough, MA
Are you ready to be a part of our team?
Learn more about our benefits and incentives: https://www.olympusamerica.com/careers/benefits-perks.
The anticipated base pay range for this full-time position is $128,775.00 - $180,285.00 / year, plus potential for annual bonus (subject to plan eligibility and other requirements). This pay range represents the National Average of the range, and may vary depending on the location of the individual.
Olympus considers a variety of factors when determining actual compensation for this position, including level of experience, working location, and relevant education and certifications.
At Olympus, we are committed to Our Purpose of making people’s lives healthier, safer and more fulfilling. As a global medical technology company, we partner with healthcare professionals to provide best-in-class solutions and services for early detection, diagnosis and minimally invasive treatment, aiming to improve patient outcomes by elevating the standard of care in targeted disease states.
For more than 100 years, Olympus has pursued a goal of contributing to society by producing products designed with the purpose of delivering optimal outcomes for its customers around the world.
Headquartered in Tokyo, Japan, Olympus employs more than 31,000 employees worldwide in nearly 40 countries and regions. Olympus Corporation of the Americas, a wholly owned subsidiary of Olympus Corporation, is headquartered in Center Valley, Pennsylvania, USA, and employs more than 5,200 employees throughout locations in North and South America.
You Belong at Olympus
We are deeply committed to fostering a respectful, fair, and welcoming workplace for all individuals, perspectives, and lifestyles. We believe in fostering a non-discriminatory, inclusive work environment where everyone feels a sense of belonging, in full compliance with legal standards. Empathy and unity are core to our company culture, empowering employees to contribute fully and flourish. We warmly encourage all who wish to bring their talents to Olympus to apply.
Applicants Requesting Accommodations: Olympus is committed to the full inclusion of all qualified individuals. As part of this commitment, Olympus will ensure that persons with disabilities are provided reasonable accommodations for the hiring process. If reasonable accommodation is needed, please contact OCAAccommodations@olympus.com. If your disability impairs your ability to email, you may call our HR Compliance Manager at 1-888-Olympus (1-888-659-6787).
Let’s realize your potential, together.
It is the policy of Olympus to extend equal employment and advancement opportunity to all applicants and employees without regard to race, color, national origin (including language use restrictions), citizenship status, religious creed (including dress and grooming practices), age, sex (including pregnancy, childbirth, breastfeeding, medical conditions related to pregnancy, childbirth and/or breastfeeding), gender, gender identity and expression, sexual orientation, marital status, disability (physical or mental) and/or a medical condition, genetic information, ancestry, veteran status or service in the uniformed services, and any other characteristic protected by applicable federal, state or local law.
Posting Notes: || United States (US) || Pennsylvania (US-PA) || Center Valley || Medical Affairs
How to Get Visa Sponsorship as a Senior Clinical Data Manager
Target CROs and large pharma first
Contract research organizations like ICON, Parexel, and Covance sponsor H-1B visas regularly and have established immigration infrastructure. Large pharmaceutical companies operate similarly. Both are more likely to sponsor than smaller biotech startups.
Lead with CDISC and CDASH expertise
Employers filing H-1B petitions must demonstrate specialty occupation requirements. Fluency in CDISC standards, CDASH, and SDTM directly supports that argument by showing the role demands specialized, degree-level clinical data knowledge.
Get CCDM certification before applying
The Society for Clinical Data Management's CCDM credential signals professional-level expertise. Certified candidates often move faster through employer review, and the credential can strengthen the specialty occupation case in an H-1B petition.
Understand the H-1B lottery timeline early
H-1B registration opens in March for an October start date. Confirm whether a prospective employer participates in cap-exempt filings or has prior approval history, so you're not caught off guard by a six-month gap between offer and start.
Clarify degree equivalency if your background is international
U.S. immigration requires a bachelor's equivalent in a relevant field. If your degree is from outside the U.S., get a credential evaluation from a NACES-approved evaluator before applying. It removes a common point of friction in the petition process.
Negotiate immigration support explicitly in your offer
Not all employers cover legal fees or offer premium processing by default. Before signing, confirm what immigration support is included. Premium processing cuts USCIS review to 15 business days and matters significantly if your current status has a hard deadline.
Senior Clinical Data Manager jobs are hiring across the US. Find yours.
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Get Access To All JobsFrequently Asked Questions
Does a Senior Clinical Data Manager role qualify for H-1B sponsorship?
Yes. Senior Clinical Data Manager is a well-established specialty occupation under H-1B criteria because it requires a bachelor's degree or higher in life sciences, biostatistics, health informatics, or a related field. Employers at CROs and pharmaceutical companies sponsor this title regularly, and USCIS has a consistent approval history for it.
What degree do I need for employers to sponsor my visa in this role?
Most employers require a bachelor's degree in life sciences, statistics, nursing, health informatics, or a closely related field. A master's degree strengthens both your candidacy and the specialty occupation argument in the H-1B petition. Unrelated degrees are harder to support unless accompanied by substantial directly relevant work experience.
Are there visa options beyond H-1B for clinical data professionals?
Yes. Candidates with exceptional recognition in the field may qualify for the O-1A visa, which requires evidence of sustained national or international distinction and has no lottery. Australian citizens can pursue the E-3 visa. Canadian and Mexican nationals may qualify under the TN visa category, which lists biological scientists but requires careful role-framing.
How competitive is the H-1B lottery for clinical data management roles?
The general H-1B pool receives far more registrations than the 65,000 available slots, resulting in selection rates around 25% in recent years. However, candidates with a U.S. master's degree or higher enter a separate 20,000-slot pool with meaningfully better odds. Employers with cap-exempt status, such as certain academic medical centers, avoid the lottery entirely.
Where can I find Senior Clinical Data Manager jobs that offer visa sponsorship?
Migrate Mate filters specifically for roles that include visa sponsorship, so you're not sorting through hundreds of listings that don't apply to your situation. The platform is built for international professionals and covers clinical data roles at CROs, biotech firms, and pharmaceutical companies that actively support H-1B and other work visas.
What is the prevailing wage requirement for sponsored Senior Clinical Data Manager jobs?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.
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