Business Operations Leader Jobs in Massachusetts
Business Operations Leader jobs in Massachusetts are open across Boston, Marlborough, and Natick and other Massachusetts metros, with employers like American Eagle Outfitters, Beth Israel Lahey Health, and Quest Diagnostics hiring at every experience level. Find a role that fits below and apply directly.
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Job title: mRNA CoE Operational Excellence Leader - Vaccines
Location: Waltham, MA
About the job
As Function OE Leader within our Vaccine mRNA team you’ll take ownership on improvement & performance initiatives. Ready to get started?
Join the team protecting half a billion lives every year with next-gen science, mRNA innovation, and AI-driven breakthroughs. In Vaccines, you’ll help advance prevention on a global scale - and shape the future of immunization.
The Function OE Leader is responsible for supporting the deployment of the VRD Excellence Model (VRD EM) within their assigned function, in alignment with the global OE strategy. This role empowers operational teams to take ownership on improvement & performance initiatives by providing coaching, training, and methodological support. The Function OE Leader fosters an impact-driven and improvement-oriented culture by enabling teams to apply OE principles, tools, and routines effectively to achieve function ambitions.
Main Responsibilities:
1) Operational Excellence Deployment within the function
- Conduct diagnostics and/or gap analyses (business case) with operational teams to identify improvement opportunities.
- Propose the most appropriate methodology for each improvement initiative within the function.
- Ensure that each improvement initiative within the function complies with the core principles of Operational Excellence.
- Support or lead improvement initiatives within the function when specific OE competencies are required.
- Proactively support function performance and measure the impact of the initiative.
- Guarantee the practical problem-solving (standard improvement) process and ensure consistency in the implementation of improvement ideas.
- Monitor and report Progress of OE activities (improvement initiatives, level 2 practical problem-solving, and improvement ideas) to the Head of Function OE.
- Ensure sustainability of improvements by integrating them into function performance management routines.
- Identify impacts, define change strategy, check the gaps for efficient adoption, etc.
2) Capability Building within the function
- Identify individual OE development needs required to implement the function improvement initiatives. Build the training plan in alignment with the function’s Operational Excellence roadmap improvement priorities.
- Deliver OE training and coaching to improvement initiative leaders and members based on the defined training plan.
- Conduct skill assessment and validation for initiative leaders.
- Promote feedback culture and continuous learning mindset.
- Ensure adoption and application of OE standards, routines, and methodologies.
3) Cross-functional Collaboration
- Participate in transversal and cross-functional initiatives impacting the function.
- Share best practices and contribute to harmonization of OE efforts across functions.
- Contribute to the OE community by promoting the replication of effective approaches.
4) Knowledge Management
- Perform return-on-experience process and support capitalization efforts from past initiatives.
- Identify, document, and share lessons learned and successful practices.
Expected key impacts:
- Improved Function performance through better use of OE levers by operational teams.
- Enhanced OE capabilities by developing operational teams’ skills in OE methodologies, tools and standards core principles.
- Stronger adoption of OE culture driven by active involvement of operational teams in improvement efforts.
- Sustainable change enabled by teams becoming autonomous in applying OE principles.
Job Complexity (main elements defining the complexity of the job):
- Matrix Collaboration: Operate as change agent and business partner influence without direct authority within a matrix organization.
- Cultural & Behavioral Change: continuous improvement is still maturing.
- Drives mindset shifts and OE adoption in environments where.
- Stakeholder Management: Engages a wide range of stakeholders—from shopfloor to leadership—each with differing expectations, levels of engagement, and resistance to change.
- Sustainability of Impact: Ensures OE initiatives are not one-offs but integrated into business routines, with long-term adoption and measurable performance impact.
About You:
Education/Experience:
- Bachelor’s or master’s degree (e.g., Engineering, Life Sciences, Business or relevant field), with at least 5 years of experience in Operational Excellence.
Basic Qualifications:
- Operational excellence, agile and Lean methodologies experiences.
- Experience working in a matrix and cross-functional environment.
- Workshop animation: Skill in leading interactive and structured workshops to co-build solutions with teams.
- Project management: Ability to plan and execute projects, including risk mitigation, timeline tracking, and stakeholder alignment (finance management, resource management, business case…).
- Problem solving: Strong root cause analysis and structured problem-resolution capabilities.
Desirable Qualifications:
- Change management: Familiar with change models and techniques to foster adoption and engagement.
- Training & coaching: Competency in educational training design, storytelling, and facilitation techniques to transfer knowledge and inspire teams.
- Data analysis: Proficient in analyzing performance data to inform decisions and monitor impact.
- Ability to bridge digital innovation with operational excellence.
Why Choose Us?
- Bring the miracles of science to life alongside a supportive, future-focused team.
- Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
- Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
- Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
Sanofi US Services and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.
See All 15 Business Operations Leader Jobs in Massachusetts
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Find JobsBusiness Operations Leader Jobs by City in Massachusetts
Where Massachusetts roles are concentrated, by current openings.
Business Operations Leader Job Market in Massachusetts
A snapshot from current Massachusetts openings, updated as new roles post.
Who's Hiring
- American Eagle Outfitters4

- Beth Israel Lahey Health2

- Quest Diagnostics2

- Breaktime1

- Cystic Fibrosis Foundation1

Top Industries Hiring
- Retail5
- Healthcare & Medical Services4
- Technology & Software2
- Biotechnology & Pharmaceuticals1
What Massachusetts Employers Look For
The qualifications that appear most often in business operations leader jobs across Massachusetts.
- 5 or more years of progressive experience in business operations or strategy roles
- Demonstrated ability to lead cross-functional initiatives and align diverse stakeholders
- Proficiency with business intelligence tools such as Tableau, Looker, or Power BI
- Experience with process improvement methodologies including Lean or Six Sigma
- Bachelor's degree in business administration, operations management, or a related field
- Strong financial acumen including budgeting, forecasting, and cost analysis
Business Operations Leader Jobs in Massachusetts: Frequently Asked Questions
How many business operations leader jobs are there in Massachusetts?
There are 15+ business operations leader openings in Massachusetts on Migrate Mate as of June 2026, with the most roles in Boston, Marlborough, and Natick. New positions post regularly as employers across Massachusetts hire.
How much do business operations leaders make in Massachusetts?
Business operations leaders in Massachusetts earn a median of about $127,220 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $60,700 for the lowest 10% to over $314,780 for the top 10%. Pay rises with experience, specialty, and employer.
Which Massachusetts cities have the most business operations leader jobs?
Boston, Marlborough, and Natick have the most business operations leader openings in Massachusetts right now, with additional roles spread across smaller metros statewide.
Which companies hire business operations leaders in Massachusetts?
Employers hiring business operations leaders in Massachusetts include American Eagle Outfitters, Beth Israel Lahey Health, and Quest Diagnostics, based on current listings on Migrate Mate as of June 2026.
Are there remote business operations leader jobs in Massachusetts?
Yes. About 27% of business operations leader openings tied to Massachusetts are remote or hybrid as of June 2026. The rest are on-site roles based in Massachusetts metros.
How do I apply for business operations leader jobs in Massachusetts?
You can apply to business operations leader jobs in Massachusetts directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred Massachusetts location, then apply to each one that fits.
See All 15 Business Operations Leader Jobs in Massachusetts
Find roles in Massachusetts that match your experience and apply in just a few clicks.
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