Manufacturing Operations Manager Jobs in Massachusetts
Manufacturing Operations Manager jobs in Massachusetts are in strong demand, concentrated in the state's life sciences, defense, and advanced manufacturing sectors, with openings at every level from first-time supervisors through senior plant directors. The busiest hiring markets are Greater Boston, the Merrimack Valley, and the Worcester metro, where employers like Raytheon Technologies, Thermo Fisher Scientific, and Boston Scientific maintain significant production and operations footprints. The most sought-after specialties in Massachusetts listings include lean manufacturing, GMP-compliant production management, and continuous improvement leadership. Find a role that fits below and apply directly.
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Job Description
Job Description
The Manufacturing Operations Supervisor is a critical first-line leadership role within Cell Manufacturing. This position is responsible for direct management of personnel executing GMP cell processing operations for adherent and suspension cell cultures. The candidate will have strong leadership skills, GMP expertise, and commitment to patients.
The Supervisor will work one of the following shifts:
Second Shift - Tuesday to Saturday, 2:30PM - 11PM
Second Shift - Sunday to Thursday, 2:30PM - 11PM
Key Duties and Responsibilities:
- Builds and develops an efficient team of 2-8 direct reports capable of consistently producing clinical cellular product or intermediates according to cGMP standards. Includes hiring, orienting, training and coaching of personnel.
- Ensures cGMP compliance through direct oversight and education of team members.
- Shares responsibility of scheduling of personnel in coordination with other Manufacturing leadership.
- Manages direct reports’ projects to achieve department and corporate goals, including managing timelines and leading group meetings.
- Leads, investigates, and collaborates with cross-functional stakeholders regarding quality systems, including quality events, deviations, CAPAs, change controls, and risk assessments.
- Creates, revises, and reviews controlled documents including Standard Operating Procedures (SOPs) and Batch Records for manufacturing.
- Receive and manage equipment alarms.
- Serves as a technical SME for the team, troubleshoots problems independently.
- Demonstrates the Vertex Phenotype behaviors: Lead by Example; Learn, Teach & Develop; Foster Exceptional Collaboration; Drive Breakthrough Results; and Promote Enterprise Thinking Other duties and projects as assign as required to meet departmental requirements.
Knowledge and Skills:
- Extensive GMP experience, including as a lead or trainer
- Minimum of 3 years of cell culture experience, ideally in both adherent and suspension cultures
- A minimum of 0-2 years direct supervisory experience
- Working knowledge of federal requirements for GMP manufacturing (21CFR 210,211) and Quality Systems (21CFR 820)
- Expertise in cell processing and culture technologies for clinical materials production required
- Experience with bioreactors for cell culture Excellent computer skills including Word, Excel, Project, Outlook, equipment interfaces and electronic quality systems
Environment:
- Works in a cleanroom and office setting
- Must be able to remain in a stationary position 50% during processing activities
- Frequently move about inside the cleanroom to accomplish process tasks Occasionally moves lab equipment and materials weighing up to 50 pounds.
At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pay Range:
$0 - $0Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
On-Site DesignatedFlex Eligibility Status:
In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
#LI-Onsite
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
Job Description
Job Description
The Manufacturing Operations Supervisor is a critical first-line leadership role within Cell Manufacturing. This position is responsible for direct management of personnel executing GMP cell processing operations for adherent and suspension cell cultures. The candidate will have strong leadership skills, GMP expertise, and commitment to patients.
The Supervisor will work one of the following shifts:
Second Shift - Tuesday to Saturday, 2:30PM - 11PM
Second Shift - Sunday to Thursday, 2:30PM - 11PM
Key Duties and Responsibilities:
- Builds and develops an efficient team of 2-8 direct reports capable of consistently producing clinical cellular product or intermediates according to cGMP standards. Includes hiring, orienting, training and coaching of personnel.
- Ensures cGMP compliance through direct oversight and education of team members.
- Shares responsibility of scheduling of personnel in coordination with other Manufacturing leadership.
- Manages direct reports’ projects to achieve department and corporate goals, including managing timelines and leading group meetings.
- Leads, investigates, and collaborates with cross-functional stakeholders regarding quality systems, including quality events, deviations, CAPAs, change controls, and risk assessments.
- Creates, revises, and reviews controlled documents including Standard Operating Procedures (SOPs) and Batch Records for manufacturing.
- Receive and manage equipment alarms.
- Serves as a technical SME for the team, troubleshoots problems independently.
- Demonstrates the Vertex Phenotype behaviors: Lead by Example; Learn, Teach & Develop; Foster Exceptional Collaboration; Drive Breakthrough Results; and Promote Enterprise Thinking Other duties and projects as assign as required to meet departmental requirements.
Knowledge and Skills:
- Extensive GMP experience, including as a lead or trainer
- Minimum of 3 years of cell culture experience, ideally in both adherent and suspension cultures
- A minimum of 0-2 years direct supervisory experience
- Working knowledge of federal requirements for GMP manufacturing (21CFR 210,211) and Quality Systems (21CFR 820)
- Expertise in cell processing and culture technologies for clinical materials production required
- Experience with bioreactors for cell culture Excellent computer skills including Word, Excel, Project, Outlook, equipment interfaces and electronic quality systems
Environment:
- Works in a cleanroom and office setting
- Must be able to remain in a stationary position 50% during processing activities
- Frequently move about inside the cleanroom to accomplish process tasks Occasionally moves lab equipment and materials weighing up to 50 pounds.
At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pay Range:
$0 - $0Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
On-Site DesignatedFlex Eligibility Status:
In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
#LI-Onsite
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
See All 47 Manufacturing Operations Manager Jobs in Massachusetts
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Find JobsManufacturing Operations Manager Jobs by City in Massachusetts
Where Massachusetts roles are concentrated, by current openings.
Manufacturing Operations Manager Job Market in Massachusetts
A snapshot from current Massachusetts openings, updated as new roles post.
Who's Hiring
- Vertex Pharmaceuticals13
- Amazon6
- General Dynamics Mission Systems3
- EY2
- Pickle Robot Company2
Top Industries Hiring
- Science & Research
- Manufacturing
- Electronics & Hardware
What Massachusetts Employers Look For
The qualifications that appear most often in manufacturing operations manager jobs across Massachusetts.
- Bachelor's degree in engineering, operations management, or a related manufacturing discipline
- Proven experience leading production teams and managing plant-floor operations end to end
- Working knowledge of lean manufacturing, Six Sigma, or continuous improvement methodologies
- Familiarity with FDA or GMP compliance requirements common in Massachusetts life sciences facilities
- Demonstrated ability to manage budgets, capacity planning, and cross-functional department coordination
- Experience with ERP systems such as SAP or Oracle in a high-volume manufacturing environment
Manufacturing Operations Manager Jobs in Massachusetts: Frequently Asked Questions
How do you become a manufacturing operations manager in Massachusetts?
Most manufacturing operations managers in Massachusetts enter the role through a combination of a bachelor's degree in engineering, supply chain, or operations management and several years of progressive floor or supervisory experience. Massachusetts does not require a state-issued license for this role, but employers in the life sciences and defense sectors typically expect familiarity with GMP or ISO standards. Completing a Six Sigma or lean certification strengthens a candidacy significantly in this market.
How much do manufacturing operations managers make in Massachusetts?
Manufacturing operations managers in Massachusetts earn a median of about $148,050 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $99,920 for the lowest 10% to over $227,080 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire manufacturing operations managers in Massachusetts?
Employers hiring manufacturing operations managers in Massachusetts right now include Vertex Pharmaceuticals, Amazon, and General Dynamics Mission Systems, based on current listings on Migrate Mate as of September 2026. Massachusetts's concentration of medical device, biopharma, and defense contractors means many of the most active hiring companies operate regulated, high-precision production environments.
Which Massachusetts cities have the most manufacturing operations manager jobs?
Boston, Westborough, and Leominster have the most manufacturing operations manager openings in Massachusetts. Greater Boston anchors the market through its dense cluster of life sciences and defense manufacturers, while Worcester and the Merrimack Valley corridor support a strong base of industrial and advanced manufacturing employers that consistently post operations leadership roles.
Are there remote manufacturing operations manager jobs in Massachusetts?
Yes, but they're rare. About 36% of manufacturing operations manager openings tied to Massachusetts are remote or hybrid as of September 2026, reflecting that the role is fundamentally floor-based and requires physical presence for production oversight. The portions most likely to be performed remotely are planning, reporting, and cross-site coordination responsibilities at multi-location companies.
How can I get hired as a manufacturing operations manager in Massachusetts with little or no experience?
The most realistic entry path is moving into a production supervisor or manufacturing coordinator role first, then building toward operations management over time. Large Massachusetts employers in life sciences and defense, such as those in the Route 128 corridor, regularly hire for associate supervisor and process improvement analyst roles that do not require prior management experience. Earning a lean or Six Sigma Green Belt certification and targeting rotational or high-potential programs at mid-size Massachusetts manufacturers accelerates the path considerably.
Where can I find and apply to manufacturing operations manager jobs in Massachusetts?
You can find and apply to manufacturing operations manager jobs in Massachusetts on Migrate Mate, which lists current openings across the state. Search the listings, find roles that fit your background and target location, and apply directly to the ones that match.
See All 47 Manufacturing Operations Manager Jobs in Massachusetts
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