Clinical Informatics Specialist Jobs in North Carolina
Clinical Informatics Specialist jobs in North Carolina are in strong and sustained demand, concentrated in academic medical centers, large integrated health systems, and health-tech firms across the Research Triangle and Charlotte metro areas, with openings at every level from entry-level analyst to senior implementation lead. The heaviest hiring comes from institutions like Duke Health, UNC Health, and Atrium Health, which have invested heavily in electronic health record optimization, clinical decision support, and population health analytics. The most sought-after specialties are Epic implementation and optimization, data governance, and interoperability. Find a role that fits below and apply directly.
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This position is hybrid but requires frequent onsite presence/1-2 weeks onsite per month. Candidates not local, must be willing to relocate to the area.
Essential Job Function:
- Leads the activities related to the development, organization, direction, and promotion of informatics initiatives.
- Facilitates adoption of EMRs and builds relationships with internal and external clinicians to promote technology adoption and clinical practice standards.
- Directs clinical and operational improvement teams in developing and refining clinical designs, requirements, and workflows. May lead clinical and operational improvement teams, direct documentation of designs, requirements, and workflows and translating these requirements into specifications for the IT team. Facilitates stakeholder and governance approval of these designs.
- Supports system-wide projects and initiatives to ensure that implementation and redesign of IT systems are maximally effective. Ensures IT systems are designed to meet the clinical goals of high reliability care and a seamless experience for patients and providers.
- Actively participates in safety initiatives and implements risk-mitigating measures as appropriate, ensuring compliance with all position-related requirements.
- Serves as a key liaison to information systems, communicating to establish priorities and devise targeted approaches for service lines and specific physician concerns.
- Works collaboratively across the organization to ensure quality, facilitate and implement change, and mentor and support informatics capabilities development.
- Contributes to the creation and maintenance of knowledge base articles and/or technical and procedural documentation as needed. May coordinate the development and delivery of educational content and training for internal and external physicians, support staff, and IHS team members in partnership with IHS training team, super users, and other clinical support leaders.
- Serves as expert for clinical applications and data use.
- Supervises and trains lower level Informaticists.
- May perform additional duties as assigned.
Required:
- Bachelors degree
- Requires a licensed healthcare professional including Registered Nurse, Medical Technologist, Physical Therapist, Occupational Therapist, or equivalent with comparable education, clinical training, and scope of practice.
- Degree in Clinical Informatics.
- Master’s in public health, master’s in business, or substantial experience commensurate with such degrees.
Required:
- 5 years in clinical informatics and Epic Clinical Applications.
- 5 years of experience in a complex healthcare setting.
- Proficient knowledge and demonstrated experience of relevant regulatory requirements, such as HITECH, HIPAA Privacy Security and other CMS regulations and guidelines.
- In-depth knowledge of clinical practice, health care administration; patient safety; information and data management systems and associated software applications and configurations.
- Mastery of skills required to support the build and management of data systems and the ability to analyze complex data sets to address clinical, operational, and personnel management issues.
- Change management, project management skills, including financial and budget management, scheduling and resource management.
- Proficient in Quality improvement and IT methodologies. Agile, LEAN, product, Agil, ITIL.
Required:
- License and Certification in applicable clinical field.
- Licensure in the state if required by the state board.
- Quality, safety or process improvement certification (examples: Agile, LEAN) or similar comparable experience.
- Board certification Clinical Informatics.
- Epic certifications.
This position is hybrid but requires frequent onsite presence/1-2 weeks onsite per month. Candidates not local, must be willing to relocate to the area.
Essential Job Function:
- Leads the activities related to the development, organization, direction, and promotion of informatics initiatives.
- Facilitates adoption of EMRs and builds relationships with internal and external clinicians to promote technology adoption and clinical practice standards.
- Directs clinical and operational improvement teams in developing and refining clinical designs, requirements, and workflows. May lead clinical and operational improvement teams, direct documentation of designs, requirements, and workflows and translating these requirements into specifications for the IT team. Facilitates stakeholder and governance approval of these designs.
- Supports system-wide projects and initiatives to ensure that implementation and redesign of IT systems are maximally effective. Ensures IT systems are designed to meet the clinical goals of high reliability care and a seamless experience for patients and providers.
- Actively participates in safety initiatives and implements risk-mitigating measures as appropriate, ensuring compliance with all position-related requirements.
- Serves as a key liaison to information systems, communicating to establish priorities and devise targeted approaches for service lines and specific physician concerns.
- Works collaboratively across the organization to ensure quality, facilitate and implement change, and mentor and support informatics capabilities development.
- Contributes to the creation and maintenance of knowledge base articles and/or technical and procedural documentation as needed. May coordinate the development and delivery of educational content and training for internal and external physicians, support staff, and IHS team members in partnership with IHS training team, super users, and other clinical support leaders.
- Serves as expert for clinical applications and data use.
- Supervises and trains lower level Informaticists.
- May perform additional duties as assigned.
Required:
- Bachelors degree
- Requires a licensed healthcare professional including Registered Nurse, Medical Technologist, Physical Therapist, Occupational Therapist, or equivalent with comparable education, clinical training, and scope of practice.
- Degree in Clinical Informatics.
- Master’s in public health, master’s in business, or substantial experience commensurate with such degrees.
Required:
- 5 years in clinical informatics and Epic Clinical Applications.
- 5 years of experience in a complex healthcare setting.
- Proficient knowledge and demonstrated experience of relevant regulatory requirements, such as HITECH, HIPAA Privacy Security and other CMS regulations and guidelines.
- In-depth knowledge of clinical practice, health care administration; patient safety; information and data management systems and associated software applications and configurations.
- Mastery of skills required to support the build and management of data systems and the ability to analyze complex data sets to address clinical, operational, and personnel management issues.
- Change management, project management skills, including financial and budget management, scheduling and resource management.
- Proficient in Quality improvement and IT methodologies. Agile, LEAN, product, Agil, ITIL.
Required:
- License and Certification in applicable clinical field.
- Licensure in the state if required by the state board.
- Quality, safety or process improvement certification (examples: Agile, LEAN) or similar comparable experience.
- Board certification Clinical Informatics.
- Epic certifications.
See All 12 Clinical Informatics Specialist Jobs in North Carolina
Find roles in North Carolina that match your experience and apply in just a few clicks.
Find JobsClinical Informatics Specialist Jobs by City in North Carolina
Where North Carolina roles are concentrated, by current openings.
Clinical Informatics Specialist Job Market in North Carolina
A snapshot from current North Carolina openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Healthcare & Medical Services
What North Carolina Employers Look For
The qualifications that appear most often in clinical informatics specialist jobs across North Carolina.
- Bachelor's degree in health informatics, nursing, health information management, or a related clinical field
- Experience with Epic, Cerner, or another major EHR platform in a clinical or implementation role
- RHIA, CAHIMS, or CPHIMS certification recognized by the American Health Information Management Association
- Demonstrated ability to translate clinical workflows into system configuration or analytical requirements
- Familiarity with HL7, FHIR, or other healthcare interoperability standards used in enterprise environments
- Strong communication skills for collaborating with clinical staff, IT teams, and North Carolina health system leadership
Clinical Informatics Specialist Jobs in North Carolina: Frequently Asked Questions
How do you become a clinical informatics specialist in North Carolina?
Most clinical informatics specialists in North Carolina enter the field through a combination of clinical or health IT experience and a bachelor's or master's degree in health informatics, nursing informatics, or a related discipline. North Carolina does not require a state-issued license specific to this role, but employers strongly prefer candidates who hold the CAHIMS or CPHIMS credential through the American Health Information Management Association or have completed Epic or Cerner certification. Graduate programs at UNC Chapel Hill and Duke University are common pathways for candidates building formal informatics credentials.
Which companies hire clinical informatics specialists in North Carolina?
Employers hiring clinical informatics specialists in North Carolina right now include Cone Health, CVS Health, and Novant Health, based on current listings on Migrate Mate as of October 2026. North Carolina's concentration of large academic medical centers and integrated health systems means that many openings are tied to ongoing EHR optimization, clinical decision support, and population health initiatives rather than one-off project needs.
Which North Carolina cities have the most clinical informatics specialist jobs?
Greensboro, North Carolina, and Sylva account for the largest share of clinical informatics specialist openings in North Carolina. The Research Triangle draws the highest volume because Duke Health, UNC Health, and WakeMed are all headquartered or anchored there, while Charlotte's growth reflects Atrium Health's scale and the concentration of regional hospital networks and health-tech vendors expanding into the Carolinas.
Are there remote clinical informatics specialist jobs in North Carolina?
Yes, and more than most clinical roles, because clinical informatics work centers on data analysis, system configuration, training design, and documentation rather than direct patient care. About 86% of clinical informatics specialist openings tied to North Carolina are remote or hybrid as of October 2026, reflecting how well the work adapts to distributed teams. Roles focused on EHR build, reporting, and workflow analysis are the most likely to be fully remote or hybrid.
How can I get hired as a clinical informatics specialist in North Carolina with little or no experience?
The most realistic entry path is moving laterally from a clinical or health IT role, such as medical coding, nursing, health information technician, or IT support, into an informatics analyst or EHR specialist position. Large North Carolina health systems including UNC Health and Atrium Health regularly post associate or junior analyst roles that do not require prior informatics titles. Completing an Epic or Cerner end-user training program and earning the CAHIMS credential through AHIMA signals readiness to hiring teams and opens doors even without a formal informatics background.
Where can I find and apply to clinical informatics specialist jobs in North Carolina?
You can find and apply to clinical informatics specialist jobs in North Carolina on Migrate Mate, which lists current openings from health systems, hospitals, and health-tech employers across the state. Find roles that fit your background and apply directly from each listing.
See All 12 Clinical Informatics Specialist Jobs in North Carolina
Find roles in North Carolina that match your experience and apply in just a few clicks.
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