Clinical Informatics Specialist Jobs in Massachusetts
Clinical Informatics Specialist jobs in Massachusetts are open across Boston and Cambridge and other Massachusetts metros, with employers like Dana-Farber Cancer Institute, Boston Medical Center, and Harvard Medical Faculty Physicians at Beth Israel Deaconess Medical Center hiring at every experience level. Find a role that fits below and apply directly.
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INTRODUCTION
We are seeking a highly skilled Clinical Informatics Specialist to play a pivotal role in the architecture and development of our canonical data model and transformation framework within the InterSystems ecosystem. Focus areas include data modeling, comprehensive documentation, and validating clinical workflows to ensure real-world clinical alignment. In this role, you will act as the bridge between clinical experts and technical engineering teams. You will be responsible for translating clinical needs into product requirements, defining complex data mappings, validating clinical logic, and ensuring our data models adhere to global HIT standards (FHIR, HL7v2, CDA, OMOP, etc.) while maintaining the highest standards of patient safety and data privacy.
ROLE AND RESPONSIBILITIES
- Data Modeling & Transformation Strategy
- Manage the governance of the canonical data model definition and maintenance processes in alignment with product strategy, ensuring it supports diverse clinical domains across the care continuum.
- Design and document detailed logic for data transformations and mappings between various healthcare data standards (e.g., HL7v2, C-CDA, FHIR, X12, OMOP, openEHR).
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Analyze emerging national and international Implementation Guides and regulatory standards, translating them into technical specifications for the engineering team to support future product capabilities.
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Clinical Terminology Management
- Serve as the subject matter expert on standard terminologies and code sets, (e.g., SNOMED CT, LOINC, ICD-10, CPT/HCPCS, RxNorm).
- Define concept maps and value sets to ensure semantic interoperability across the platform.
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Troubleshoot terminology binding issues that arise during data ingestion or exchange.
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Clinical Requirements & Translation
- Collaborate with clinical subject matter experts (SMEs) to gather requirements and translate "clinical intent" into precise technical specifications.
- Author functional specifications that allow engineers to build robust interoperability pipelines within InterSystems product suite.
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Act as a translator, explaining complex technical data constraints to clinicians and complex clinical workflows to engineers.
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Quality Assurance & Safety Validation
- Validate data models and transformation logic to ensure they are clinically sound and accurately reflect the patient story.
- Conduct clinical safety assessments on proposed data structures to identify and mitigate risks related to data loss, misinterpretation, or context stripping.
- Ensure all data designs comply with privacy regulations (HIPAA, GDPR) and data governance policies.
BASIC QUALIFICATIONS
Education & Experience
- Clinical Background: Clinical degree (MD, DO, RN, PharmD, NP/PA) with active or previous licensure preferred; OR equivalent deep domain experience in Health Informatics.
- Informatics Experience: 5+ years of experience in clinical informatics, data modeling, or interoperability analysis.
- InterSystems Expertise: Proven experience working within InterSystems IRIS for Health or HealthShare environments is highly desired. Experience with other major integration engines combined with a willingness to learn InterSystems technology will also be considered.
Technical Skills & Knowledge
- Standards: Deep mastery of HL7v2, C-CDA, and FHIR (resources, profiles, and implementation guides). Familiarity with OMOP CDM or openEHR archetypes is a strong plus.
- Terminologies: Proficiency with LOINC, SNOMED CT, ICD-10, and RxNorm browsers and hierarchy structures.
- Tools: Experience with mapping tools, SQL, and data modeling software.
- Regulatory: Understanding of ONC certification rules (USCDI), TEFCA, and CMS interoperability rules.
PREFERRED QUALIFICATIONS
Competencies
- Translation: Ability to demystify technical jargon for clinicians and clinical workflows for developers.
- Analytical Thinking: Strong capability to visualize data flows and identify edge cases in complex clinical scenarios.
- Communication: Excellent written and verbal communication skills for creating documentation and specifications.
We are an equal-opportunity employer and do not discriminate because of race, color, religion, sex, national origin, ancestry, marital status, veteran status, age, disability, sexual orientation or gender identity or expression or any other legally protected category. InterSystems is an E-Verify Employer in the United States.
InterSystems is providing a current good faith estimate of the anticipated base salary range for this position depending on a variety of factors including experience, education, skills, and performance. Other compensation may include a discretionary annual variable target incentive. The company also provides generous employee benefits including:
- Medical, vision, and dental insurance
- Short-term and long-term disability, and life insurance
- 401(k) Profit Sharing Contribution
- Paid Time Off and Holidays
- Parental Leave
- Tuition reimbursement
The estimated base compensation range for this role is: $120,000—$143,000 USD
ABOUT INTERSYSTEMS
InterSystems, a creative data technology provider, delivers a unified foundation for next-generation applications for healthcare, finance, manufacturing, and supply chain customers in more than 80 countries. Our data platforms solve interoperability, speed, and scalability problems for large organizations around the globe to unlock the power of data and allow people to perceive data in imaginative ways. Established in 1978, InterSystems is committed to excellence through its 24×7 support for customers and partners around the world. Privately held and headquartered in Boston, Massachusetts, InterSystems has 38 offices in 28 countries worldwide.
See All 8 Clinical Informatics Specialist Jobs in Massachusetts
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Find JobsClinical Informatics Specialist Jobs by City in Massachusetts
Where Massachusetts roles are concentrated, by current openings.
Clinical Informatics Specialist Job Market in Massachusetts
A snapshot from current Massachusetts openings, updated as new roles post.
Who's Hiring
- Dana-Farber Cancer Institute3

- Boston Medical Center1

- Harvard Medical Faculty Physicians at Beth Israel Deaconess Medical Center1

- IPSEN1

- InterSystems1

Top Industries Hiring
- Biotechnology & Pharmaceuticals5
- Healthcare & Medical Services2
- Technology & Software1
What Massachusetts Employers Look For
The qualifications that appear most often in clinical informatics specialist jobs across Massachusetts.
- Experience with Epic, Cerner, or another major EHR platform at the analyst or build level
- Bachelor's degree in health informatics, nursing, health information management, or a related clinical field
- Ability to gather clinical workflow requirements and translate them into system configuration or design documentation
- Familiarity with HL7, FHIR, or clinical data exchange standards
- RHIA, RHIT, or a relevant EHR vendor certification such as Epic certification
- Experience supporting end users through system upgrades, go-lives, or optimization projects
Clinical Informatics Specialist Jobs in Massachusetts: Frequently Asked Questions
How many clinical informatics specialist jobs are there in Massachusetts?
There are 8+ clinical informatics specialist openings in Massachusetts on Migrate Mate as of June 2026, with the most roles in Boston and Cambridge. New positions post regularly as employers across Massachusetts hire.
Which Massachusetts cities have the most clinical informatics specialist jobs?
Boston and Cambridge have the most clinical informatics specialist openings in Massachusetts right now, with additional roles spread across smaller metros statewide.
Which companies hire clinical informatics specialists in Massachusetts?
Employers hiring clinical informatics specialists in Massachusetts include Dana-Farber Cancer Institute, Boston Medical Center, and Harvard Medical Faculty Physicians at Beth Israel Deaconess Medical Center, based on current listings on Migrate Mate as of June 2026.
Are there remote clinical informatics specialist jobs in Massachusetts?
Yes. About 50% of clinical informatics specialist openings tied to Massachusetts are remote or hybrid as of June 2026. The rest are on-site roles based in Massachusetts metros.
How do I apply for clinical informatics specialist jobs in Massachusetts?
You can apply to clinical informatics specialist jobs in Massachusetts directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred Massachusetts location, then apply to each one that fits.
See All 8 Clinical Informatics Specialist Jobs in Massachusetts
Find roles in Massachusetts that match your experience and apply in just a few clicks.
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