Clinical Nurse Jobs in South Dakota
Clinical Nurse jobs in South Dakota are open across Rapid City, Sioux Falls, and Aberdeen and other South Dakota metros, with employers like Monument Health, Sanford Health, and Sioux Center Health hiring at every experience level. Find a role that fits below and apply directly.
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Careers With Purpose
Sanford Health is one of the largest and fastest-growing not-for-profit health systems in the United States. We're proud to offer many development and advancement opportunities to our nearly 50,000 members of the Sanford Family who are dedicated to the work of health and healing across our broad footprint.
Facility: Central Patient Building
Location: Sioux Falls, SD
Address: 1305 W 18th St, Sioux Falls, SD 57104, USA
Shift: 8 Hours - Day Shifts
Job Schedule: Full time
Weekly Hours: 40.00
Department Details
Core Responsibilities:
- Clinical Practice (Patient-Focused Care) – provides expert consultation for complex patient needs related to nutrition support and enteral feeding management.
- Professional Development – serves as a clinical expert, mentor and role model for nursing staff, while promoting best practices through education, coaching and clinical guidance.
- Evidence-Based Practice and Research – evaluates current research and translates evidence into practice through clinical guidelines, protocols and policies.
- Member of a group of Clinical Nurse Specialists that are clinical experts who have a passion for delivering excellence in quality, safety and patient experience.
Job Summary
The Clinical Nurse Specialist (CNS) is an expert clinician and advocate in a particular specialty or subspecialty of nursing practice, providing leadership in the professional practice setting. Provides expert clinical guidance in a specialized field and coordinates patient care quality initiatives. This position specializes in nutrition support and enteral feeding management.
Monitors the quality patient indicators utilizing evidence-based outcomes and the development and implementation of performance and quality improvement processes as necessary. Assesses a healthcare facility's nursing practice and its impact on patient outcomes. Uses the results of evaluation analysis to make or recommend process or structural changes, including policy, procedure, or protocol documentation as appropriate to clinical outcomes. Provides consultative care and guidance while serving as a consultant, mentor, coach, researcher, and educator to patients, families and employees. Facilitates/collaborates with multi-disciplinary teams that contribute to role development and, directly or indirectly advance nursing practice and health services. Develops evaluation strategies to demonstrate patient safety, cost effectiveness, cost benefit, and efficiency factors associated with nursing practice. Identifies expected outcomes that are achievable through implementation of evidence-based practices. Systematically enhances the quality and effectiveness of nursing practice.
Evaluates the practice environment and quality of nursing care rendered in relation to existing evidence, identifying opportunities for the generation and use of research. Formally disseminates research findings through activities such as presentation, publications, consultation and journal clubs. Uses research based data to assist with the development, implementation and evaluation for improved clinical practice for all ages, developmental needs, cultural, or psychosocial needs wherever needed. Also uses current healthcare research findings and other evidence to expand clinical knowledge, enhance role performance and increase knowledge of professional issues. Promotes the clinical practice by serving on hospital or community committees locally or nationally. Must be able to incorporate teaching/learning principles and adapt teaching to age groups. Must be able to work with growth and development needs of unique client populations.
Qualifications
Successful completion of a master’s, post-master’s, or doctorate from a Clinical Nurse Specialist (CNS) program accredited by the Commission on Collegiate Nursing Education (CCNE) or the National League for Nursing Accrediting Commission (NLNAC).
Demonstrated current competence and provision of care, treatment, or services to an adequate number of patients in the past twelve months or completion of an accredited CNS program in the past twelve months. Experience must correlate to the privileges requested.
If/When performing in the role of American Diabetes Association (ADA) Coordinator, academic and/or experiential preparation in program management and academic and/or experiential preparation in the care of people with chronic disease.
Certification as a Clinical Nurse Specialist (CNS) by the American Nurses Credentialing Center (ANCC) or an equivalent body as applicable to specialty area of practice. Current licensure by the applicable state. Current Drug Enforcement Administration (DEA) permit to prescribe controlled substances, if prescriptive privileges are sought.
Privileging documents and related credentialing requirements will supersede this job description in defining minimum qualifications, criteria, and scope of practice, if variation between documents exists.
Benefits
Sanford Health offers an attractive benefits package for qualifying full-time and part-time employees. Depending on eligibility, a variety of benefits include health insurance, dental insurance, vision insurance, life insurance, a 401(k) retirement plan, work/life balance benefits, and a generous time off package to maintain a healthy home-work balance. For more information about Total Rewards, visit https://sanfordcareers.com/benefits.
Sanford is an EEO/AA Employer M/F/Disability/Vet. If you are an individual with a disability and would like to request an accommodation for help with your online application, please call 1-877-673-0854 or send an email to talent@sanfordhealth.org.
Sanford Health has a Drug Free Workplace Policy. An accepted offer will require a drug screen and pre-employment background screening as a condition of employment.
Req Number: R-0250335
Job Function: Advanced Practice Provider
Featured: No
Careers With Purpose
Sanford Health is one of the largest and fastest-growing not-for-profit health systems in the United States. We're proud to offer many development and advancement opportunities to our nearly 50,000 members of the Sanford Family who are dedicated to the work of health and healing across our broad footprint.
Facility: Central Patient Building
Location: Sioux Falls, SD
Address: 1305 W 18th St, Sioux Falls, SD 57104, USA
Shift: 8 Hours - Day Shifts
Job Schedule: Full time
Weekly Hours: 40.00
Department Details
Core Responsibilities:
- Clinical Practice (Patient-Focused Care) – provides expert consultation for complex patient needs related to nutrition support and enteral feeding management.
- Professional Development – serves as a clinical expert, mentor and role model for nursing staff, while promoting best practices through education, coaching and clinical guidance.
- Evidence-Based Practice and Research – evaluates current research and translates evidence into practice through clinical guidelines, protocols and policies.
- Member of a group of Clinical Nurse Specialists that are clinical experts who have a passion for delivering excellence in quality, safety and patient experience.
Job Summary
The Clinical Nurse Specialist (CNS) is an expert clinician and advocate in a particular specialty or subspecialty of nursing practice, providing leadership in the professional practice setting. Provides expert clinical guidance in a specialized field and coordinates patient care quality initiatives. This position specializes in nutrition support and enteral feeding management.
Monitors the quality patient indicators utilizing evidence-based outcomes and the development and implementation of performance and quality improvement processes as necessary. Assesses a healthcare facility's nursing practice and its impact on patient outcomes. Uses the results of evaluation analysis to make or recommend process or structural changes, including policy, procedure, or protocol documentation as appropriate to clinical outcomes. Provides consultative care and guidance while serving as a consultant, mentor, coach, researcher, and educator to patients, families and employees. Facilitates/collaborates with multi-disciplinary teams that contribute to role development and, directly or indirectly advance nursing practice and health services. Develops evaluation strategies to demonstrate patient safety, cost effectiveness, cost benefit, and efficiency factors associated with nursing practice. Identifies expected outcomes that are achievable through implementation of evidence-based practices. Systematically enhances the quality and effectiveness of nursing practice.
Evaluates the practice environment and quality of nursing care rendered in relation to existing evidence, identifying opportunities for the generation and use of research. Formally disseminates research findings through activities such as presentation, publications, consultation and journal clubs. Uses research based data to assist with the development, implementation and evaluation for improved clinical practice for all ages, developmental needs, cultural, or psychosocial needs wherever needed. Also uses current healthcare research findings and other evidence to expand clinical knowledge, enhance role performance and increase knowledge of professional issues. Promotes the clinical practice by serving on hospital or community committees locally or nationally. Must be able to incorporate teaching/learning principles and adapt teaching to age groups. Must be able to work with growth and development needs of unique client populations.
Qualifications
Successful completion of a master’s, post-master’s, or doctorate from a Clinical Nurse Specialist (CNS) program accredited by the Commission on Collegiate Nursing Education (CCNE) or the National League for Nursing Accrediting Commission (NLNAC).
Demonstrated current competence and provision of care, treatment, or services to an adequate number of patients in the past twelve months or completion of an accredited CNS program in the past twelve months. Experience must correlate to the privileges requested.
If/When performing in the role of American Diabetes Association (ADA) Coordinator, academic and/or experiential preparation in program management and academic and/or experiential preparation in the care of people with chronic disease.
Certification as a Clinical Nurse Specialist (CNS) by the American Nurses Credentialing Center (ANCC) or an equivalent body as applicable to specialty area of practice. Current licensure by the applicable state. Current Drug Enforcement Administration (DEA) permit to prescribe controlled substances, if prescriptive privileges are sought.
Privileging documents and related credentialing requirements will supersede this job description in defining minimum qualifications, criteria, and scope of practice, if variation between documents exists.
Benefits
Sanford Health offers an attractive benefits package for qualifying full-time and part-time employees. Depending on eligibility, a variety of benefits include health insurance, dental insurance, vision insurance, life insurance, a 401(k) retirement plan, work/life balance benefits, and a generous time off package to maintain a healthy home-work balance. For more information about Total Rewards, visit https://sanfordcareers.com/benefits.
Sanford is an EEO/AA Employer M/F/Disability/Vet. If you are an individual with a disability and would like to request an accommodation for help with your online application, please call 1-877-673-0854 or send an email to talent@sanfordhealth.org.
Sanford Health has a Drug Free Workplace Policy. An accepted offer will require a drug screen and pre-employment background screening as a condition of employment.
Req Number: R-0250335
Job Function: Advanced Practice Provider
Featured: No
See All 52 Clinical Nurse Jobs in South Dakota
Find roles in South Dakota that match your experience and apply in just a few clicks.
Find Clinical Nurse JobsClinical Nurse Jobs by City in South Dakota
Where South Dakota roles are concentrated, by current openings.
Clinical Nurse Job Market in South Dakota
A snapshot from current South Dakota openings, updated as new roles post.
Who's Hiring
- Monument Health21
- Sanford Health16
- Sioux Center Health12
- Aegis Therapies1
- Huron Regional Medical Center1
Top Industries Hiring
- Healthcare & Medical Services52
- Non-Profit & Social Services2
What South Dakota Employers Look For
The qualifications that appear most often in clinical nurse jobs across South Dakota.
- Active registered nurse (RN) license in the state of employment
- Current BLS certification required at time of hire
- Associate or Bachelor of Science in Nursing from an accredited program
- One to two years of acute care or specialty unit experience preferred
- ACLS certification required for critical care, telemetry, and procedural roles
- Proficiency with electronic health record systems such as Epic or Cerner
Clinical Nurse Jobs in South Dakota: Frequently Asked Questions
How many clinical nurse jobs are there in South Dakota?
There are 52+ clinical nurse openings in South Dakota on Migrate Mate as of June 2026, with the most roles in Rapid City, Sioux Falls, and Aberdeen. New positions post regularly as employers across South Dakota hire.
How much do clinical nurses make in South Dakota?
Clinical nurses in South Dakota earn a median of about $78,060 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $54,040 for the lowest 10% to over $98,220 for the top 10%. Pay rises with experience, specialty, and employer.
Which South Dakota cities have the most clinical nurse jobs?
Rapid City, Sioux Falls, and Aberdeen have the most clinical nurse openings in South Dakota right now, with additional roles spread across smaller metros statewide.
Which companies hire clinical nurses in South Dakota?
Employers hiring clinical nurses in South Dakota include Monument Health, Sanford Health, and Sioux Center Health, based on current listings on Migrate Mate as of June 2026.
Are there remote clinical nurse jobs in South Dakota?
Yes. About 0% of clinical nurse openings tied to South Dakota are remote or hybrid as of June 2026. The rest are on-site roles based in South Dakota metros.
How do I apply for clinical nurse jobs in South Dakota?
You can apply to clinical nurse jobs in South Dakota directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Dakota location, then apply to each one that fits.
See All 52 Clinical Nurse Jobs in South Dakota
Find roles in South Dakota that match your experience and apply in just a few clicks.
Find Clinical Nurse Jobs