Clinical Site Manager Jobs
Clinical Site Manager jobs are open across pharmaceutical, biotechnology, and contract research organizations, from entry-level coordinator roles to senior and principal positions, with specializations in oncology trials, Phase I-IV studies, and regulatory compliance. Find a role that fits below and apply directly.
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The Position
The Opportunity
As a Clinical Site Manager specialising in Study Start-Up, you will be responsible for designing, planning, coordinating, and conducting all activities involved in initiating clinical research studies at assigned sites. You will work independently to ensure studies are delivered, recorded, and reported in accordance with protocols, standard operating procedures, and global regulatory guidelines.
In this role, you will:
- Lead end-to-end study start-up activities, driving site identification, selection, and activation to ensure clinical trials launch efficiently and are compliance-ready.
- Manage Ethics Committee (EC) and Competent Authority (CA) and/or InvestigationInstitutional Review Board (IRB) submissions, ensuring all trial documentation, local contracts, and institutional approvals meet stringent regulatory timelines.
- Act as the primary contact and clinical trial expert for start-up activities for assigned study site personnel, and coordinate necessary certifications.
- Develop critical study documentation, including informed consent documents, patient instruction guides, etc
- Collaborate cross-functionally with global, local, and virtual teams to help deliver top-tier clinical diagnostic solutions.
- Foster a culture of belonging by partnering across diverse regions, cultures, and time zones to build inclusive team environments.
You are a proactive, collaborative, and highly organised clinical research professional who thrives in a fast-paced, matrixed environment. You possess strong problem-solving skills, make sound independent decisions, and excel at managing external vendor relationships.
To be successful in this role, you bring:
- Education& Experience: A degree in a scientific discipline or related field (or equivalent combination of education and experience) combined with a proven track record in clinical operations or clinical trial coordination.
- Study Start-Up& Submission Expertise: Hands-on experience navigating diagnostic and medical device trials, specifically managing Ethics Committee (EC) and Competent Authority (CA) regulatory submissions.
- Stakeholder Engagement: Exceptional verbal and written communication skills (English) with a proven ability to build trusted relationships and influence cross-functional partners.
- German speaking is a plus.
Behaviors, competencies, and qualities of the ideal applicant.
- Exhibits the ability to make sound decisions and to analyze and solve problems; makes independent choices and takes responsibility
- Demonstrates flexibility and adaptability to perform in a fast-paced, matrixed environment where fluid, cross-team collaboration is cruci
The expected salary range for this position based on the primary location of Pleasanton 90,900 - 142,780 Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Who we are
A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.
Let’s build a healthier future, together.
Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this formAccommodations for Applicants.
The Position
The Opportunity
As a Clinical Site Manager specialising in Study Start-Up, you will be responsible for designing, planning, coordinating, and conducting all activities involved in initiating clinical research studies at assigned sites. You will work independently to ensure studies are delivered, recorded, and reported in accordance with protocols, standard operating procedures, and global regulatory guidelines.
In this role, you will:
- Lead end-to-end study start-up activities, driving site identification, selection, and activation to ensure clinical trials launch efficiently and are compliance-ready.
- Manage Ethics Committee (EC) and Competent Authority (CA) and/or InvestigationInstitutional Review Board (IRB) submissions, ensuring all trial documentation, local contracts, and institutional approvals meet stringent regulatory timelines.
- Act as the primary contact and clinical trial expert for start-up activities for assigned study site personnel, and coordinate necessary certifications.
- Develop critical study documentation, including informed consent documents, patient instruction guides, etc
- Collaborate cross-functionally with global, local, and virtual teams to help deliver top-tier clinical diagnostic solutions.
- Foster a culture of belonging by partnering across diverse regions, cultures, and time zones to build inclusive team environments.
You are a proactive, collaborative, and highly organised clinical research professional who thrives in a fast-paced, matrixed environment. You possess strong problem-solving skills, make sound independent decisions, and excel at managing external vendor relationships.
To be successful in this role, you bring:
- Education& Experience: A degree in a scientific discipline or related field (or equivalent combination of education and experience) combined with a proven track record in clinical operations or clinical trial coordination.
- Study Start-Up& Submission Expertise: Hands-on experience navigating diagnostic and medical device trials, specifically managing Ethics Committee (EC) and Competent Authority (CA) regulatory submissions.
- Stakeholder Engagement: Exceptional verbal and written communication skills (English) with a proven ability to build trusted relationships and influence cross-functional partners.
- German speaking is a plus.
Behaviors, competencies, and qualities of the ideal applicant.
- Exhibits the ability to make sound decisions and to analyze and solve problems; makes independent choices and takes responsibility
- Demonstrates flexibility and adaptability to perform in a fast-paced, matrixed environment where fluid, cross-team collaboration is cruci
The expected salary range for this position based on the primary location of Pleasanton 90,900 - 142,780 Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Who we are
A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.
Let’s build a healthier future, together.
Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this formAccommodations for Applicants.
Clinical Site Manager Jobs by Experience Level
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Find Clinical Site Manager JobsClinical Site Manager Job Market
Who's Hiring
Top Industries Hiring
- Healthcare & Medical Services
What Employers Look For
The qualifications that appear most often in clinical site manager jobs.
- Bachelor's degree in life sciences, nursing, or a related clinical field
- Minimum two to five years of clinical research monitoring experience
- Working knowledge of ICH-GCP guidelines and FDA regulatory requirements
- Experience conducting site initiation visits, interim monitoring visits, and closeout visits
- Proficiency with electronic data capture systems and clinical trial management systems
- Current ACRP or SoCRA certification preferred or required by many sponsors
Tips for Your Clinical Site Manager Job Search
Tailor your resume to ICH-GCP
Clinical site manager postings almost always screen for ICH-GCP compliance knowledge. Pull exact language from the job description and mirror it in your resume's experience bullets so your application clears automated screening before a recruiter reads it.
Highlight your site activation numbers
Hiring managers want to see how many sites you've initiated, closed, or maintained concurrently. Replace vague responsibilities with concrete outputs: sites activated per trial, protocol deviations resolved, or inspection-ready closeout rates you personally drove.
Target postings by therapeutic area
Oncology, CNS, and rare-disease trials require different site management skills and sponsor relationships. Filter openings by therapeutic area rather than title alone so you apply to roles where your protocol familiarity and site relationships actually transfer.
Apply early to roles that fit
Migrate Mate lists clinical site manager openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Prepare for competency-based interviews
Expect scenario questions about managing a non-compliant investigator, handling a protocol deviation mid-study, or rescuing a site behind on enrollment. Prepare two or three detailed examples from your own trials so your answers are specific and verifiable, not theoretical.
Negotiate travel expectations upfront
Many clinical site manager roles require 50-75% travel, but the actual requirement varies widely by sponsor and portfolio size. Ask directly in the final interview round how travel is calculated, whether it's weekly or project-based, and whether there's flexibility during site steady-state phases.
Clinical Site Manager Jobs: Frequently Asked Questions
Which companies are hiring the most clinical site managers?
The companies hiring the most clinical site managers right now include The IMA, National University, and IQVIA, with the largest share of openings in California, Missouri, and Ohio, based on current listings on Migrate Mate as of November 2026. Contract research organizations and large pharmaceutical sponsors tend to post the highest volume of openings year-round.
How many clinical site manager jobs are remote?
About 15% of clinical site manager openings are fully remote or hybrid as of November 2026, though most roles still require significant on-site presence at investigator sites. Regulatory affairs-adjacent site management roles and sponsor-side oversight positions tend to offer the greatest remote flexibility compared to field-based CRA and monitoring roles.
How do you become a clinical site manager?
Start with a bachelor's degree in a life sciences or nursing field, then gain hands-on experience as a clinical research associate conducting site monitoring visits. Build familiarity with ICH-GCP guidelines, EDC platforms, and FDA inspection readiness. Earning a certification from ACRP or SoCRA strengthens your application, and moving into a senior CRA or lead monitor role is the most common path to a site manager title.
Can you get a clinical site manager job with little experience?
Entry-level site management roles typically require at least some prior clinical research or site coordination experience, but coordinator and junior CRA positions are designed as stepping stones. Emphasize any exposure to IRB submissions, informed consent processes, or source document verification. Contract research organizations often hire junior monitors and promote internally, making them a practical starting point for candidates building toward a site manager role.
What does the clinical site manager interview process look like?
The process typically starts with a recruiter screening call focused on monitoring experience and therapeutic area background, followed by a competency-based interview with a hiring manager or clinical operations lead. Final rounds often include a panel interview with cross-functional stakeholders and a scenario exercise where you walk through how you'd handle a protocol deviation or a struggling site. Some sponsors ask for a portfolio of monitoring visit reports or site metrics.
Where can I find and apply to clinical site manager jobs?
You can find and apply to clinical site manager jobs on Migrate Mate, which lists current openings from across the United States in one place. Find roles that match your therapeutic area background and seniority level, then apply directly to each listing.
See All 102+ Clinical Site Manager Jobs
Find roles that match your experience and apply in just a few clicks.
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